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1. 发明申请

WO2009086313A3 COMPOSITIONS AND METHODS FOR REPAIR OF CONNECTIVE TISSUE 审中-公开
公开(公告)号：WO2009086313A3
公开(公告)日：2009-07-09
申请号：PCT/US2008/088041
申请日：2008-12-22
申请人： ZIMMER ORTHOBIOLOGICS, INC. , WANG, Hali , YAO, Jian, Q.
发明人： WANG, Hali , YAO, Jian, Q.
IPC分类号： A61L27/24 , A61L27/54
摘要： Compositions and methods for repairing a ruptured connective tissue are disclosed. The composition may include a first biocompatible material to provide a scaffold for connective tissue cell growth and tissue repair. This first biocompatible material may withstand a tensile load of up to 250 N. The composition may also include a second biocompatible material including at least one bioactive agent that can stimulate connective tissue cell growth and tissue repair. The method may include positioning a first end of the first biocompatible material adjacent a first end of a ruptured connective tissue, positioning a second end of the first biocompatible material adjacent a second end of the ruptured connective tissue, and anchoring the first biocompatible material to the first and second tendon ends. The method may alternatively comprise or further include positioning a second biocompatible material between the first and second ends of the ruptured connective tissue.

2. 发明申请

WO2008079194A1 METHOD OF OBTAINING VIABLE SMALL TISSUE PARTICLES AND USE FOR TISSUE REPAIR 审中-公开
标题翻译：获得可见的小组织颗粒的方法和用于组织修复的方法
公开(公告)号：WO2008079194A1
公开(公告)日：2008-07-03
申请号：PCT/US2007/025252
申请日：2007-12-11
申请人： ZIMMER ORTHOBIOLOGICS, INC. , YAO, Jian, Q. , ZAPOROJAN, Victor
发明人： YAO, Jian, Q. , ZAPOROJAN, Victor
IPC分类号： A61F2/02 , A61K35/12
CPC分类号： A61K35/32 , A61K9/14 , A61K38/4833 , A61K2300/00
摘要： The invention provides a composition including isolated small living tissue particles, a method of making the tissue particles, and a method of using the composition to ameliorate a tissue defect. The tissue particles are composed of cells and their associated extracellular molecules and are sized, in certain embodiments, to be smaller than about 1 mm. Another aspect of the inventive tissue particles is the large percentage of viable cells. In certain embodiments, the tissue particles are made from cartilage and the composition may also contain additives such as adhesives, solutions, and bioactive agents.
摘要翻译：本发明提供包含分离的小生物体组织颗粒的组合物，制备组织颗粒的方法，以及使用该组合物改善组织缺陷的方法。组织颗粒由细胞及其相关的细胞外分子组成，并且在某些实施方案中尺寸设定为小于约1mm。本发明组织颗粒的另一方面是大量的活细胞。在某些实施方案中，组织颗粒由软骨制成，并且组合物还可以含有添加剂，例如粘合剂，溶液和生物活性剂。

3. 发明申请

WO2009100065A3 METHOD OF REMOVING UNDESIRED TISSUE FROM CONNECTIVE TISSUE 审中-公开
标题翻译：从连接组织中去除不良组织的方法
公开(公告)号：WO2009100065A3
公开(公告)日：2010-05-14
申请号：PCT/US2009032961
申请日：2009-02-03
申请人： ZIMMER ORTHOBIOLOGICS INC , XIAN HAI-QING , WANG HALI , LIU HUI , YAO JIAN Q , GAO JIZONG
发明人： XIAN HAI-QING , WANG HALI , LIU HUI , YAO JIAN Q , GAO JIZONG
IPC分类号： A61L27/36
CPC分类号： A61K38/4826 , A61K38/465 , C12Y301/01003 , C12Y304/21004
摘要： A method of removing undesired tissue from a connective tissue is provided that includes stretching the connective tissue and peeling away the undesired tissue. Some methods include soaking the connective tissue in a solution prior to and/or subsequent to stretching and peeling away the undesired tissue. The solution may include a detergent, an enzyme, a salt solution, an organic solvent, and combinations thereof.
摘要翻译：提供从结缔组织中去除不想要的组织的方法，其包括拉伸结缔组织并剥离不想要的组织。一些方法包括在拉伸和/或剥离不想要的组织之前和/或之后将结缔组织浸泡在溶液中。溶液可以包括洗涤剂，酶，盐溶液，有机溶剂及其组合。

4. 发明申请

WO2009158634A2 SCAFFOLD COATED AND/OR IMPREGNATED WITH AT LEAST ONE BIOACTIVE AGENT FOR TISSUE REPAIR AND OTHER MEDICAL APPLICATIONS 审中-公开
标题翻译：用于组织修复和其他医学应用的至少一种生物活性剂的SCAFFOLD涂层和/或
公开(公告)号：WO2009158634A2
公开(公告)日：2009-12-30
申请号：PCT/US2009/048885
申请日：2009-06-26
申请人： ZIMMER ORTHOBIOLOGICS, INC. , XIAN, Hai-Qing , YAO, Jian, Q. , WANG, Hali , DAHESHIA, Massoud , LIU, Hui
发明人： XIAN, Hai-Qing , YAO, Jian, Q. , WANG, Hali , DAHESHIA, Massoud , LIU, Hui
IPC分类号： A61L27/22 , A61L27/54
CPC分类号： A61L27/22 , A61L27/54 , A61L2300/252 , A61L2300/414 , A61L2300/426 , A61L2300/43 , A61L2300/64
摘要： A system and method for producing a scaffold coated and/or impregnated with at least one bioactive agent. This is accomplished by culturing at least one cell in the same medium as a scaffold, but without physical contact between the at least one cell and the scaffold. The system includes a container having a surface defining an interior compartment. A medium is disposed within the interior compartment. At least one cell is disposed within the medium, the at least one cell being capable of producing at least one bioactive agent. Further, a scaffold is disposed within the medium. The scaffold is physically separated from the at least one cell such that there is no contact between the scaffold and the at least one cell. Thus, as the at least one cell produces at least one bioactive agent, such as a growth factor, the at least one bioactive agent enters the medium, and contacts and coats and/or impregnates the scaffold. However, due to the physical separation of the scaffold and at least one cell, the at least one cell is prevented from contacting and coating and/or impregnating the scaffold. Thus, only the desired bioactive agent or agents coat and/or impregnate the scaffold.
摘要翻译：用于生产用至少一种生物活性剂包被和/或浸渍的支架的系统和方法。这是通过在与支架相同的培养基中培养至少一个细胞，但是在至少一个细胞和支架之间没有物理接触来实现的。该系统包括具有限定内部隔间的表面的容器。介质设置在内部隔室内。至少一个细胞设置在培养基内，所述至少一个细胞能够产生至少一种生物活性剂。此外，在培养基内设置支架。骨架与至少一个细胞物理分离，使得支架与至少一个细胞之间不存在接触。因此，由于至少一个细胞产生至少一种生物活性剂，例如生长因子，所述至少一种生物活性剂进入培养基，并接触并涂覆和/或浸渍支架。然而，由于支架和至少一个电池的物理分离，防止了至少一个电池接触和涂覆和/或浸渍支架。因此，只有所需的生物活性剂或试剂包衣和/或浸渍支架。

5. 发明申请

WO2009086313A2 COMPOSITIONS AND METHODS FOR REPAIR OF CONNECTIVE TISSUE 审中-公开
标题翻译：组合物和修复连接组织的方法
公开(公告)号：WO2009086313A2
公开(公告)日：2009-07-09
申请号：PCT/US2008088041
申请日：2008-12-22
申请人： ZIMMER ORTHOBIOLOGICS INC , WANG HALI , YAO JIAN Q
发明人： WANG HALI , YAO JIAN Q
IPC分类号： A61L27/24 , A61L27/54
CPC分类号： A61L27/24 , A61L27/52 , A61L27/54 , A61L2300/414
摘要： Compositions and methods for repairing a ruptured connective tissue are disclosed. The composition may include a first biocompatible material to provide a scaffold for connective tissue cell growth and tissue repair. This first biocompatible material may withstand a tensile load of up to 250 N. The composition may also include a second biocompatible material including at least one bioactive agent that can stimulate connective tissue cell growth and tissue repair. The method may include positioning a first end of the first biocompatible material adjacent a first end of a ruptured connective tissue, positioning a second end of the first biocompatible material adjacent a second end of the ruptured connective tissue, and anchoring the first biocompatible material to the first and second tendon ends. The method may alternatively comprise or further include positioning a second biocompatible material between the first and second ends of the ruptured connective tissue.
摘要翻译：公开了用于修复破裂的结缔组织的组合物和方法。组合物可以包括第一生物相容性材料，以提供用于结缔组织细胞生长和组织修复的支架。该第一生物相容性材料可以承受高达250N的拉伸载荷。组合物还可以包括第二生物相容性材料，其包括至少一种可刺激结缔组织细胞生长和组织修复的生物活性剂。该方法可以包括将第一生物相容性材料的第一端邻近破裂的结缔组织的第一端定位，将第一生物相容性材料的第二端邻近破裂的结缔组织的第二端定位，并将第一生物相容性材料锚定到第一和第二肌腱末端。该方法可以可选地包括或进一步包括将第二生物相容性材料定位在破裂的结缔组织的第一和第二端之间。

6. 发明申请

WO2008147692A1 DIFFERENTIALLY PROCESSED TISSUE AND PROCESSING METHODS THEREOF 审中-公开
标题翻译：不同加工组织及其加工方法
公开(公告)号：WO2008147692A1
公开(公告)日：2008-12-04
申请号：PCT/US2008/063582
申请日：2008-05-14
申请人： ZIMMER ORTHOBIOLOGICS, INC. , YAO, Jian, Q. , XIAN, Hai-Qing , GAO, Jizong , BRISTOL, Rodney , ZAPOROJAN, Victor , WANG, Hali , LIU, Hul
发明人： YAO, Jian, Q. , XIAN, Hai-Qing , GAO, Jizong , BRISTOL, Rodney , ZAPOROJAN, Victor , WANG, Hali , LIU, Hul
IPC分类号： A61L27/14 , A61L31/10 , A61L27/36 , A61L27/38 , A61F2/00
CPC分类号： A61L27/3608 , A61L27/3604 , A61L27/3683
摘要： A method of preparing an implantable biological device having a first tissue part and a second tissue part includes exposing the first tissue part to a first preparation method and preventing exposure of the second biological tissue part to the first preparation method. Preventing exposure of the second biological tissue part to the first preparation method may be achieved using an embedding technique, a coating technique, a covering technique, or physical isolation. The method may further include exposing the second tissue part to a second preparation method and preventing exposure of the first biological tissue part to the second preparation method. An apparatus for preparing an implantable biologic device includes an enclosure having first and second chambers separated by a partition member wherein a substantial portion of the first tissue part is within the first chamber and a substantial portion of the second tissue part is within the second chamber.
摘要翻译：制备具有第一组织部分和第二组织部分的可植入生物装置的方法包括将第一组织部分暴露于第一制备方法并防止第二生物组织部分暴露于第一制备方法。可以使用嵌入技术，涂覆技术，覆盖技术或物理隔离来防止第二生物组织部分暴露于第一制备方法。该方法可以进一步包括将第二组织部分暴露于第二制备方法并防止第一生物组织部分暴露于第二制备方法。一种用于制备可植入生物装置的装置，包括具有由分隔构件分开的第一和第二腔室的外壳，其中所述第一组织部分的大部分位于所述第一腔室内，并且所述第二组织部分的大部分位于所述第二腔室内。

7. 发明申请

WO2009158634A3 SCAFFOLD COATED AND/OR IMPREGNATED WITH AT LEAST ONE BIOACTIVE AGENT FOR TISSUE REPAIR AND OTHER MEDICAL APPLICATIONS 审中-公开
标题翻译：用于组织修复和其他医疗应用的至少一种生物活性剂的SCAFFOLD涂层和/或
公开(公告)号：WO2009158634A3
公开(公告)日：2010-08-12
申请号：PCT/US2009048885
申请日：2009-06-26
申请人： ZIMMER ORTHOBIOLOGICS INC , XIAN HAI-QING , YAO JIAN Q , WANG HALI , DAHESHIA MASSOUD , LIU HUI
发明人： XIAN HAI-QING , YAO JIAN Q , WANG HALI , DAHESHIA MASSOUD , LIU HUI
IPC分类号： A61L27/22 , A61L27/54
CPC分类号： A61L27/22 , A61L27/54 , A61L2300/252 , A61L2300/414 , A61L2300/426 , A61L2300/43 , A61L2300/64
摘要： A system and method for producing a scaffold coated and/or impregnated with at least one bioactive agent. This is accomplished by culturing at least one cell in the same medium as a scaffold, but without physical contact between the at least one cell and the scaffold. The system includes a container having a surface defining an interior compartment. A medium is disposed within the interior compartment. At least one cell is disposed within the medium, the at least one cell being capable of producing at least one bioactive agent. Further, a scaffold is disposed within the medium. The scaffold is physically separated from the at least one cell such that there is no contact between the scaffold and the at least one cell. Thus, as the at least one cell produces at least one bioactive agent, such as a growth factor, the at least one bioactive agent enters the medium, and contacts and coats and/or impregnates the scaffold. However, due to the physical separation of the scaffold and at least one cell, the at least one cell is prevented from contacting and coating and/or impregnating the scaffold. Thus, only the desired bioactive agent or agents coat and/or impregnate the scaffold.
摘要翻译：用于生产用至少一种生物活性剂包被和/或浸渍的支架的系统和方法。这是通过在相同的培养基中培养作为支架的至少一个细胞，但是在至少一个细胞和支架之间没有物理接触来实现的。该系统包括具有限定内部隔间的表面的容器。介质设置在内部隔室内。至少一个细胞设置在培养基内，所述至少一个细胞能够产生至少一种生物活性剂。此外，在培养基内设置支架。骨架与至少一个细胞物理分离，使得支架与至少一个细胞之间不存在接触。因此，由于至少一个细胞产生至少一种生物活性剂，例如生长因子，所述至少一种生物活性剂进入培养基，并接触并涂覆和/或浸渍支架。然而，由于支架和至少一个电池的物理分离，所以防止了至少一个电池接触和涂覆和/或浸渍支架。因此，只有所需的生物活性剂或药剂包衣和/或浸渍支架。

8. 发明申请

WO2008154149A3 TISSUE PROCESSING FOR NONIMMUNOGENIC IMPLANTS 审中-公开
标题翻译：非发育性植入物的组织加工
公开(公告)号：WO2008154149A3
公开(公告)日：2009-11-12
申请号：PCT/US2008064653
申请日：2008-05-23
申请人： ZIMMER ORTHOBIOLOGICS INC , WANG HALI , LIU HUI , XIAN HAI-QING , YAO JIAN Q , ZAPOROJAN VICTOR
发明人： WANG HALI , LIU HUI , XIAN HAI-QING , YAO JIAN Q , ZAPOROJAN VICTOR
IPC分类号： A61L27/36 , A61K35/32 , A61K35/34 , A61K35/36 , A61K35/44
CPC分类号： A61L27/3654 , A61K35/32 , A61K35/34 , A61K35/44 , A61L27/3633 , A61L27/3687 , A61L2430/40
摘要： Methods for processing tissues to render them suitable for implantation, e.g., in an orthopedic site. Tissues are rendered substantially acellular and substantially nonimmunogenic by exposure to processes that result in cell lysis 12, increasing permeability of the extracellular matrix 14, degrading the debris from lysis 16, and removing the debris 18. Methods of forming tissue implants, kits for processing tissue implants, and methods of using tissue implants are also disclosed.
摘要翻译：用于处理组织以使其适合植入的方法，例如在矫形部位。组织通过暴露于导致细胞裂解12，增加细胞外基质14的渗透性，降解碎裂16和去除碎屑的过程而呈现基本上无细胞并且基本上是非免疫原性的。形成组织植入物的方法，用于处理组织的试剂盒植入物和使用组织植入物的方法也被公开。

9. 发明申请

WO2009014996A3 MEDICAL DEVICES AND METHODS FOR CUTTING AND SUTURING BIOLOGICAL TISSUE 审中-公开
公开(公告)号：WO2009014996A3
公开(公告)日：2009-01-29
申请号：PCT/US2008/070406
申请日：2008-07-18
申请人： ZIMMER ORTHOBIOLOGICS, INC. , ZAPOROJAN, Victor , YAO, Jian Q. , BRISTOL, Rodney , LIU, Hui , WANG, Hali , XIAN, Hai-Qing
发明人： ZAPOROJAN, Victor , YAO, Jian Q. , BRISTOL, Rodney , LIU, Hui , WANG, Hali , XIAN, Hai-Qing
IPC分类号： A61B17/04 , A61B17/32
摘要： Medical devices (100, 200, 400) for cutting and suturing biological tissue generally include a shaft (102) and first and second guide members (108, 110) each including a first portion (112, 114) coupled to the shaft (102) at a first location and a second portion (116, 118) coupled to the shaft (102) at a second location. The first portions (112, 114) are movable along the shaft (102) relative to the second portions (116, 118), and the first and second guide members (108, 110) define an arcuate profile and are configured to flex in response to such movement. When used to cut tissue, the medical device (100) may further include a blade (106) positioned between the first and second guide members (108, 110). When used to suture tissue, one or more suture guides (240) may be provided on the first guide member (108) for directing a suture needle through tissue proximate the first guide member (108). Methods of repairing and replacing a meniscus using the medical devices (100, 200, 400) are also provided.

10. 发明申请

WO2009085769A3 COMPOSITIONS AND METHODS FOR REPAIR OF CONNECTIVE TISSUE 审中-公开
标题翻译：组合物和修复连接组织的方法
公开(公告)号：WO2009085769A3
公开(公告)日：2010-03-25
申请号：PCT/US2008087016
申请日：2008-12-16
申请人： ZIMMER ORTHOBIOLOGICS INC , WANG HALI , YAO JIAN Q
发明人： WANG HALI , YAO JIAN Q
IPC分类号： A61L27/24 , A61L27/54
CPC分类号： A61L27/24 , A61L27/52 , A61L27/54 , A61L2300/414
摘要： A composition and method for repairing a ruptured connective tissue are disclosed. The composition includes a first biocompatible material to provide a scaffold for connective tissue cell growth and tissue repair. This first biocompatible material may withstand a tensile load of up to 250 N. The composition may also include a second biocompatible material including at least one bioactive agent that can stimulate connective tissue cell growth and tissue repair. The method includes positioning a first end of the first biocompatible material adjacent a first end of a ruptured connective tissue, and positioning a second end of the first biocompatible material adjacent a second end of the ruptured connective tissue. The method may also include positioning the second biocompatible material between the first and second ends of the ruptured connective tissue.
摘要翻译：公开了一种用于修复破裂的结缔组织的组合物和方法。组合物包括第一生物相容性材料以提供用于结缔组织细胞生长和组织修复的支架。该第一生物相容性材料可以承受高达250N的拉伸载荷。组合物还可以包括第二生物相容性材料，其包括至少一种可刺激结缔组织细胞生长和组织修复的生物活性剂。该方法包括将第一生物相容性材料的第一端邻近破裂的结缔组织的第一端定位，并将第一生物相容性材料的第二端邻近破裂的结缔组织的第二端定位。该方法还可以包括将第二生物相容性材料定位在破裂的结缔组织的第一和第二端之间。

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