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1. 发明申请

WO2010051383A2 A DEVICE AND METHOD FOR DELIVERY OF A DRUG DEPOT 审中-公开
标题翻译：一种用于递送药物库的设备和方法
公开(公告)号：WO2010051383A2
公开(公告)日：2010-05-06
申请号：PCT/US2009/062612
申请日：2009-10-29
申请人： WARSAW ORTHOPEDIC, INC. , SIMONTON, Thomas A. , MCKAY, William F. , HADDOCK, Sean M. , ZANELLA, John Myers
发明人： SIMONTON, Thomas A. , MCKAY, William F. , HADDOCK, Sean M. , ZANELLA, John Myers
IPC分类号： A61M5/178 , A61M5/00
CPC分类号： A61M25/00 , A61B5/04001 , A61B5/4893 , A61M25/007 , A61M25/0084
摘要： Drug depot delivery devices and methods are provided for delivering one or more drug depots to one or more sites beneath the skin of a patient with or without repositioning the cannula. The device has a cannula capable of insertion to the site beneath the skin of the patient and one or more side port openings for delivering a drug depot. The side port openings are spaced a distance from the blunt tip, which will allow the user to implant at a set distance from a nerve. The device may also include an electronic monitor for detecting the proximity of the tip of the cannula to a nerve. In some embodiments, a method of delivering a drug depot is provided by detecting the nerve and delivering the drug depot at or near the nerve.
摘要翻译：提供了药物贮库递送装置和方法，用于在将套管重新定位或不重新定位的情况下将一个或多个药物贮库递送至患者皮肤下方的一个或多个部位。该装置具有能够插入患者皮肤下方部位的套管和用于输送药物仓库的一个或多个侧口开口。侧端口开口与钝头间隔开一定距离，这将允许使用者在离神经设定的距离处植入。该装置还可以包括用于检测套管的尖端与神经的接近程度的电子监视器。在一些实施方案中，递送药物长效制剂的方法通过检测神经并将药物长效制剂递送到神经处或神经附近来提供。

2. 发明申请

WO2010053786A2 DRUG DEPOT DELIVERY DEVICE AND METHODS 审中-公开
标题翻译：药物递送装置和方法
公开(公告)号：WO2010053786A2
公开(公告)日：2010-05-14
申请号：PCT/US2009/062374
申请日：2009-10-28
申请人： WARSAW ORTHOPEDIC, INC. , SIMONTON, Thomas A. , MCKAY, William F.
发明人： SIMONTON, Thomas A. , MCKAY, William F.
IPC分类号： A61M5/178 , A61M5/00
CPC分类号： A61M31/007 , A61B17/3468 , A61M37/0069
摘要： Drug depot delivery devices and methods for delivering a drug depot to a site beneath the skin of a patient are provided. In various embodiments, a device for delivering a drug depot to a site beneath the skin of patient is provided, the device comprising: a cannula capable of insertion to the site beneath the skin of the patient and having an opening for passage of the drug depot; a drug cartridge comprising at least two chambers, wherein each chamber is configured to store and release a drug depot into the cannula when the cannula is aligned with a first chamber and the plunger. In some embodiments, the drug depot delivery device and methods provide dial-a-dose technology for delivering the drug depot to the target tissue site.
摘要翻译：提供了用于将药剂库递送到患者皮肤下方的部位的药物库递送装置和方法。在各种实施例中，提供了一种用于将药物储存器递送到患者皮肤下方的部位的装置，该装置包括：能够插入到患者皮肤下方的位置并具有用于药物库的通过的开口的套管 ; 药筒，其包括至少两个腔室，其中每个腔室配置成当所述插管与第一腔室和所述柱塞对准时，将药物储存器储存并释放到所述套管中。在一些实施方案中，药物贮库递送装置和方法提供用于将药物贮库递送至目标组织部位的拨号技术。

3. 发明申请

WO2011159869A2 BONE REPLACEMENT MATERIAL MIXING AND DELIVERY DEVICES AND METHODS OF USE 审中-公开
标题翻译：骨替代材料混合和递送装置及其使用方法
公开(公告)号：WO2011159869A2
公开(公告)日：2011-12-22
申请号：PCT/US2011/040642
申请日：2011-06-16
申请人： WARSAW ORTHOPEDIC, INC. , MCKAY, William F.
发明人： MCKAY, William F.
IPC分类号： A61M5/14 , B01F3/00 , A61M5/178 , A61L24/00
CPC分类号： A61B17/8833 , A61B2017/8838
摘要： Bone cement mixing and delivery devices and methods of using the devices are provided. The bone cement mixing and delivery devices and methods comprise a container having a bottom opening that can be sealed by a spacer in a syringe where movement of the plunger of the syringe moves the spacer away from the bottom opening in the container to dispense bone cement into the syringe. In some embodiments, the devices and methods increases efficiency and reduce the mess associated with transferring the bone cement to the syringe for delivery to a patient.
摘要翻译：提供了骨水泥混合输送装置及其使用方法。骨水泥混合和递送装置和方法包括具有底部开口的容器，该底部开口可以通过注射器中的间隔件密封，其中注射器的柱塞的移动使垫片远离容器中的底部开口移动以将骨水泥分配到注射器。在一些实施例中，装置和方法提高了效率并减少了将骨粘固剂转移到注射器以用于递送给患者的混乱。

4. 发明申请

WO2008109807A2 BONE VOID FILLER 审中-公开
标题翻译：骨填充物
公开(公告)号：WO2008109807A2
公开(公告)日：2008-09-12
申请号：PCT/US2008/056169
申请日：2008-03-07
申请人： WARSAW ORTHOPEDIC, INC. , MCKAY, William F.
发明人： MCKAY, William F.
IPC分类号： A61L27/12 , A61L27/24 , A61L27/58
CPC分类号： A61L27/24 , A61L27/12 , A61L27/46 , A61L27/505 , A61L27/54 , A61L27/56 , A61L2300/258 , A61L2300/402 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/602 , A61L2300/64
摘要： A novel composition and kit for a bone void filler are provided. The improved bone void filler includes a porous, collagen scaffolding admixed with calcium phosphate and at least one stabilizer agent. Optionally, the bone void filler further includes at least one bioactive agent.
摘要翻译：提供了一种用于骨空隙填充剂的新型组合物和试剂盒。改进的骨空隙填充剂包括与磷酸钙混合的多孔胶原支架和至少一种稳定剂。任选地，骨空隙填充剂还包含至少一种生物活性剂。

5. 发明申请

WO2008076671A2 A BIODEGRADABLE OSTEOGENIC POROUS BIOMEDICAL IMPLANT WITH IMPERMEABLE MEMBRANE 审中-公开
标题翻译：可生物降解的卵泡生物医学植入物
公开(公告)号：WO2008076671A2
公开(公告)日：2008-06-26
申请号：PCT/US2007/086771
申请日：2007-12-07
申请人： WARSAW ORTHOPEDIC, INC , MCKAY, William F.
发明人： MCKAY, William F.
IPC分类号： A61L27/34 , A61L27/46 , A61L27/56
CPC分类号： A61L24/0015 , A61C8/0006 , A61F2/28 , A61F2/2803 , A61F2/2846 , A61F2/44 , A61F2002/2817 , A61F2002/2825 , A61F2002/2853 , A61F2002/2892 , A61F2002/30062 , A61F2002/30153 , A61F2002/30677 , A61F2210/0004 , A61F2230/0019 , A61F2310/00179 , A61F2310/00293 , A61F2310/00365 , A61L24/0036 , A61L24/0042 , A61L24/02 , A61L24/046 , A61L24/102 , A61L27/12 , A61L27/18 , A61L27/24 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/252 , A61L2300/402 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/62 , C08L67/04
摘要： A biomedical implant is disclosed with osteogenic factors and a solid impermeable membrane occluding a portion of its surface for the generation of new bone growth at the target site of the implant. The implant is porous, bioresorbable, and forms a three dimensional architectural scaffold for the formation of new bone tissue. The implant is formed with a polymer or collagen, bone morphogenetic protein and ceramic particles.
摘要翻译：公开了一种生物医学植入物，其具有成骨因素，并且固体不渗透膜封闭其表面的一部分，用于在植入物的靶位点产生新的骨生长。植入物是多孔的，生物可再吸收的，并且形成用于形成新骨组织的三维建筑支架。植入物由聚合物或胶原，骨形态发生蛋白和陶瓷颗粒形成。

6. 发明申请

WO2007146595A2 COMPOSITIONS AND METHODS FOR DIAGNOSIS OF AXIAL PAIN WITH OR WITHOUT RADICULOPATHY 审中-公开
标题翻译：用于诊断具有或不具有RADICULOPATHY的轴向疼痛的组合物和方法
公开(公告)号：WO2007146595A2
公开(公告)日：2007-12-21
申请号：PCT/US2007/070019
申请日：2007-05-31
申请人： WARSAW ORTHOPEDIC, INC , MCKAY, William F. , TRIEU, Hai H. , ROY, Josee , GROSS, Jeffrey M. , DRAPEAU, Susan J. , SCHENDEL, Michael J. , WALSH, Andrew J., L.
发明人： MCKAY, William F. , TRIEU, Hai H. , ROY, Josee , GROSS, Jeffrey M. , DRAPEAU, Susan J. , SCHENDEL, Michael J. , WALSH, Andrew J., L.
IPC分类号： A61K51/00 , A61K49/06 , A61K49/00
CPC分类号： A61K49/0004 , A61K49/00
摘要： The invention provides methods and composition developed to be used with imaging techniques and useful for diagnosis and monitoring the pain generator(s) of axial pain with or without radiculopathy and methods for screening therapeutic compounds potentially useful for treating axial pain with or without radiculopathy. Alternatively, degenerated discs can be monitored and treated before occurrence of a pathological pain condition. Pain markers and markers of degeneration include markers of neuronal, vascular, immune and matrix elements.
摘要翻译：本发明提供了与成像技术一起使用并且可用于诊断和监测具有或不具有神经根病变的轴痛的疼痛发生器的方法和组合以及用于筛选潜在地可用于治疗具有或不具有神经根病变的轴向疼痛的治疗化合物的方法和组合物。或者，可以在发生病理性疼痛状况之前监测和治疗退化的椎间盘。疼痛标记和变性标记包括神经元，血管，免疫和基质元件的标记。

7. 发明申请

WO2010050935A1 DEVICES CONTAINING DEMINERALIZED BONE MATRIX PARTICLES 审中-公开
标题翻译：含有骨化骨质颗粒的装置
公开(公告)号：WO2010050935A1
公开(公告)日：2010-05-06
申请号：PCT/US2008/081544
申请日：2008-10-29
申请人： WARSAW ORTHOPEDIC, INC. , DRAPEAU, Susan J. , REMSEN, Kathy L. , MCKAY, William F. , SHIMKO, Daniel
发明人： DRAPEAU, Susan J. , REMSEN, Kathy L. , MCKAY, William F. , SHIMKO, Daniel
IPC分类号： A61L27/40 , A61L24/00 , A61L31/00 , A61L27/00
CPC分类号： A61L27/3608 , A61L27/365 , A61L27/48 , A61L2430/02
摘要： Described are medical implant devices that include bone-derived particles. These and potentially other materials are held together in a three-dimensionally stable structure such as a porous, resilient sheet, by an ionically-crosslinked polysaccharide gel. Also described are methods for making and using such medical devices.
摘要翻译：描述了包括骨源颗粒的医用植入装置。这些和潜在的其它材料通过离子交联的多糖凝胶一起保持在三维稳定的结构中，例如多孔，弹性片。还描述了制造和使用这种医疗装置的方法。

8. 发明申请

WO2009120484A3 PHARMACEUTICAL GELS AND METHODS FOR DELIVERING THERAPEUTIC AGENTS TO A SITE BENEATH THE SKIN 审中-公开
公开(公告)号：WO2009120484A3
公开(公告)日：2009-10-01
申请号：PCT/US2009/036482
申请日：2009-03-09
申请人： WARSAW ORTHOPEDIC, INC. , MCKAY, William F. , ZANELLA, John Myers
发明人： MCKAY, William F. , ZANELLA, John Myers
IPC分类号： A61K9/06 , A61P29/00 , A61P23/02 , A61P25/00
摘要： Pharmaceutical gels and methods for delivering a therapeutic agent to a target tissue site beneath the skin of a patient are provided, the gel being capable of adhering to the target tissue site and comprising one or more biodegradable depots containing an effective amount of the therapeutic agent. In various embodiments, the gel is sprayable and hardens after contacting the target tissue site.

9. 发明申请

WO2009079211A1 A TENDON AND LIGAMENT REPAIR SHEET AND METHODS OF USE 审中-公开
标题翻译： TENDON和LIGAMENT维修表和使用方法
公开(公告)号：WO2009079211A1
公开(公告)日：2009-06-25
申请号：PCT/US2008/085408
申请日：2008-12-03
申请人： WARSAW ORTHOPEDIC, INC. , MCKAY, William F.
发明人： MCKAY, William F.
IPC分类号： A61F2/08
CPC分类号： A61F2/08
摘要： Methods and device for treating or healing an injured tendon or ligament is disclosed. The device, a tendon and ligament repair sheet (1), has a porous layer (2) and a denser layer (3), and optionally a therapeutic agent in the porous layer, the denser layer or both. The repair sheet is made from a resorbable or non-resorbable polymer. The repair sheet is securely attached to the injured tendon, ligament, muscle, or bone and has a suture pull out strength of at least 3N. If the injury involve severing of a ligament or tendon, one should place the severed ends in close proximity to each other and securely attach the repair sheet to both sides of the severed tendon or ligament at a distance from the injury so that the repair sheet remains securely attached to the tendon, ligament, muscle, or bone while the tissue is healing.
摘要翻译：公开了治疗或愈合损伤的肌腱或韧带的方法和装置。该装置，腱和韧带修复片（1）具有多孔层（2）和更致密的层（3），并且任选地在多孔层中的治疗剂，更致密的层或两者都是。修复片由可再吸收或不可吸收的聚合物制成。修复片牢固地附着在受伤的肌腱，韧带，肌肉或骨骼上，并具有至少3N的缝合线拔出强度。如果损伤涉及切断韧带或肌腱，则应将切断的末端彼此靠近，并将修复片牢固地附接到断裂的肌腱或韧带的两侧，距伤口一定距离处，使修复片保留当组织愈合时，牢固地附着于腱，韧带，肌肉或骨骼。

10. 发明申请

WO2008089164A1 COMPOSITIONS AND METHODS INDUCING FIBROSIS 审中-公开
标题翻译：组合物和诱导纤维化的方法
公开(公告)号：WO2008089164A1
公开(公告)日：2008-07-24
申请号：PCT/US2008/051035
申请日：2008-01-15
申请人： WARSAW ORTHOPEDIC, INC. , DRAPEAU, Susan J. , MCKAY, William F.
发明人： DRAPEAU, Susan J. , MCKAY, William F.
IPC分类号： A61K38/18 , A61P19/02
CPC分类号： A61K38/1841 , A61K38/1858 , A61K38/1875 , A61K38/191 , A61K38/2006 , A61K38/204 , A61K38/212 , A61K38/4886 , A61L27/227 , A61L27/50 , A61L2400/06 , A61L2430/34
摘要： Methods and compositions for treating soft tissue defects are provided. The composition, which is injectable directly into the tissue adjacent to the defect, comprises a fibrosis inducing factor in a carrier. The method includes preparing the composition comprising a fibrosis inducing factor in a carrier and delivering the composition into the tissue adjacent to the defect. Alternatively, a carrier matrix may be disposed in or near the defect, a pump capable of delivering an effective amount of a fibrosis inducing factor may be provided, and the pump is fluidly connected to the carrier matrix.
摘要翻译：提供了治疗软组织缺陷的方法和组合物。直接注射到与缺损相邻的组织中的组合物在载体中包含纤维化诱导因子。该方法包括在载体中制备包含纤维化诱导因子的组合物，并将组合物输送到与缺损相邻的组织中。或者，可以将载体基质设置在缺陷中或附近，可以提供能够递送有效量的纤维化诱导因子的泵，并且泵与载体基质流体连接。

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