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1. 发明申请

WO2010051383A2 A DEVICE AND METHOD FOR DELIVERY OF A DRUG DEPOT 审中-公开
标题翻译：一种用于递送药物库的设备和方法
公开(公告)号：WO2010051383A2
公开(公告)日：2010-05-06
申请号：PCT/US2009/062612
申请日：2009-10-29
申请人： WARSAW ORTHOPEDIC, INC. , SIMONTON, Thomas A. , MCKAY, William F. , HADDOCK, Sean M. , ZANELLA, John Myers
发明人： SIMONTON, Thomas A. , MCKAY, William F. , HADDOCK, Sean M. , ZANELLA, John Myers
IPC分类号： A61M5/178 , A61M5/00
CPC分类号： A61M25/00 , A61B5/04001 , A61B5/4893 , A61M25/007 , A61M25/0084
摘要： Drug depot delivery devices and methods are provided for delivering one or more drug depots to one or more sites beneath the skin of a patient with or without repositioning the cannula. The device has a cannula capable of insertion to the site beneath the skin of the patient and one or more side port openings for delivering a drug depot. The side port openings are spaced a distance from the blunt tip, which will allow the user to implant at a set distance from a nerve. The device may also include an electronic monitor for detecting the proximity of the tip of the cannula to a nerve. In some embodiments, a method of delivering a drug depot is provided by detecting the nerve and delivering the drug depot at or near the nerve.
摘要翻译：提供了药物贮库递送装置和方法，用于在将套管重新定位或不重新定位的情况下将一个或多个药物贮库递送至患者皮肤下方的一个或多个部位。该装置具有能够插入患者皮肤下方部位的套管和用于输送药物仓库的一个或多个侧口开口。侧端口开口与钝头间隔开一定距离，这将允许使用者在离神经设定的距离处植入。该装置还可以包括用于检测套管的尖端与神经的接近程度的电子监视器。在一些实施方案中，递送药物长效制剂的方法通过检测神经并将药物长效制剂递送到神经处或神经附近来提供。

2. 发明申请

WO2007127655A3 DILATING STYLET AND CANNULA 审中-公开
公开(公告)号：WO2007127655A3
公开(公告)日：2007-11-08
申请号：PCT/US2007/066917
申请日：2007-04-19
申请人： WARSAW ORTHOPEDIC, INC. , SIMONTON, Thomas A. , JUSTIS, Jeff R. , HADDOCK, Sean M. , KINNANE, Keith M.
发明人： SIMONTON, Thomas A. , JUSTIS, Jeff R. , HADDOCK, Sean M. , KINNANE, Keith M.
IPC分类号： A61B17/34 , A61B19/00 , A61B17/16
摘要： An instrument set is provided that has a tapered configuration that facilitates the insertion of the instrument set into a patient. Said set comprises a stylet (200) and a cannula (100) having a body (102) and a distal end (106).

3. 发明申请

WO2010054085A2 MULTIPLE COMPONENT MIXING AND DELIVERY SYSTEM 审中-公开
标题翻译：多组分混合和输送系统
公开(公告)号：WO2010054085A2
公开(公告)日：2010-05-14
申请号：PCT/US2009/063406
申请日：2009-11-05
申请人： WARSAW ORTHOPEDIC, INC. , SIMONTON, Thomas A. , HADDOCK, Sean M. , LI, Lehmann K.
发明人： SIMONTON, Thomas A. , HADDOCK, Sean M. , LI, Lehmann K.
IPC分类号： B01F13/00
CPC分类号： B01F15/0205 , B01F7/00075 , B01F11/0082 , B01F11/0091 , B01F13/002 , B01F13/0023 , B01F15/0215 , B01F15/0223 , B01F15/0279 , B01F2215/0027 , B01F2215/0029
摘要： A multiple component cartridge includes a barrel defining a chamber and a longitudinal axis. A first plunger is disposed within the chamber and in sealing engagement with the barrel. The first plunger includes at least one member and is movable relative to the barrel such that the at least one member is configured for movement relative to the first plunger to facilitate passage of at least a first component through the first plunger. A second plunger is disposed within the chamber and in sealing engagement with the barrel. The second plunger includes at least one member and is movable relative to the barrel such that the at least one member of the second plunger is configured for movement relative to the second plunger to facilitate passage of at least a second component through the second plunger.
摘要翻译：多组分筒包括限定腔室和纵向轴线的筒体。第一柱塞设置在腔室内并与筒体密封接合。所述第一柱塞包括至少一个构件并且可相对于所述筒运动，使得所述至少一个构件构造成用于相对于所述第一柱塞运动，以促进至少第一构件穿过所述第一柱塞。第二柱塞设置在腔室内并且与筒体密封接合。所述第二柱塞包括至少一个构件并且可相对于所述筒运动，使得所述第二柱塞的所述至少一个构件构造成用于相对于所述第二柱塞移动，以促进至少第二构件穿过所述第二柱塞。 / p>

4. 发明申请

WO2010053786A2 DRUG DEPOT DELIVERY DEVICE AND METHODS 审中-公开
标题翻译：药物递送装置和方法
公开(公告)号：WO2010053786A2
公开(公告)日：2010-05-14
申请号：PCT/US2009/062374
申请日：2009-10-28
申请人： WARSAW ORTHOPEDIC, INC. , SIMONTON, Thomas A. , MCKAY, William F.
发明人： SIMONTON, Thomas A. , MCKAY, William F.
IPC分类号： A61M5/178 , A61M5/00
CPC分类号： A61M31/007 , A61B17/3468 , A61M37/0069
摘要： Drug depot delivery devices and methods for delivering a drug depot to a site beneath the skin of a patient are provided. In various embodiments, a device for delivering a drug depot to a site beneath the skin of patient is provided, the device comprising: a cannula capable of insertion to the site beneath the skin of the patient and having an opening for passage of the drug depot; a drug cartridge comprising at least two chambers, wherein each chamber is configured to store and release a drug depot into the cannula when the cannula is aligned with a first chamber and the plunger. In some embodiments, the drug depot delivery device and methods provide dial-a-dose technology for delivering the drug depot to the target tissue site.
摘要翻译：提供了用于将药剂库递送到患者皮肤下方的部位的药物库递送装置和方法。在各种实施例中，提供了一种用于将药物储存器递送到患者皮肤下方的部位的装置，该装置包括：能够插入到患者皮肤下方的位置并具有用于药物库的通过的开口的套管 ; 药筒，其包括至少两个腔室，其中每个腔室配置成当所述插管与第一腔室和所述柱塞对准时，将药物储存器储存并释放到所述套管中。在一些实施方案中，药物贮库递送装置和方法提供用于将药物贮库递送至目标组织部位的拨号技术。

5. 发明申请

WO2012027182A2 DRUG STORAGE AND DELIVERY DEVICE HAVING A RETAINING MEMBER 审中-公开
标题翻译：具有保留部件的药物储存和递送装置
公开(公告)号：WO2012027182A2
公开(公告)日：2012-03-01
申请号：PCT/US2011/048205
申请日：2011-08-18
申请人： WARSAW ORTHOPEDIC, INC. , SIMONTON, Thomas A. , MCKAY, William
发明人： SIMONTON, Thomas A. , MCKAY, William
IPC分类号： A61M5/14 , A61B17/34 , A61J1/06
CPC分类号： A61M37/0069
摘要： Drug depot storage and delivery devices and methods for delivering a drug depot to a site beneath the skin of a patient are provided. In various embodiments, the drug depot storage and delivery device comprises a retaining member that in an open position allows delivery of the drug depot from the drug cartridge to the target tissue site. In various embodiments, the drug depot storage and delivery device comprises a retaining member that in a closed position reduces or prevents delivery of the drug depot from the drug cartridge to the target tissue site.
摘要翻译：提供了药物仓库储存和递送装置以及用于将药物库递送至患者皮肤下方的部位的方法。在各种实施例中，药物贮库储存和递送装置包括保持构件，该保持构件在打开位置允许药物贮库从药筒输送到目标组织部位。在各种实施例中，药物贮库储存和递送装置包括保持构件，该保持构件在关闭位置中减少或防止药物贮库从药物筒递送到目标组织部位。

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