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1. 发明申请

WO03026734A3 METHOD AND APPARATUS FOR SECURING AND/OR IDENTIFYING A LINK TO A PERCUTANEOUS PROBE 审中-公开
标题翻译：用于保护和/或识别与胰腺探针的连接的方法和装置
公开(公告)号：WO03026734A3
公开(公告)日：2003-08-14
申请号：PCT/US0231169
申请日：2002-09-27
申请人： VERTIS NEUROSCIENCE INC , LEYDE KENT , HARRIS JOHN F , LEONARD PAUL C , GLINER BRADFORD EVAN
发明人： LEYDE KENT , HARRIS JOHN F , LEONARD PAUL C , GLINER BRADFORD EVAN
IPC分类号： A61B5/05 , A61H39/00 , A61H39/08 , A61N20060101 , A61N1/00 , A61N1/05 , A61N1/08 , A61N1/18 , A61N1/36
CPC分类号： A61N1/08 , A61N1/0551 , A61N1/36114
摘要： A method and apparatus for administering percutaneous electrical therapy to a recipient. The apparatus can include an electrical coupler having a coupling member configured to be removably positioned at least proximate to a percutaneous probe. The coupling member canbe coupleable to a source of therapeutic electrical signals via a therapeutic signal transmission link to transmit the therapeutic electrical signals to the recipient. The apparatus can further include a status signal transmission link at least proximate to the therapeutic signal transmission link and coupleable to a status signal emitter. The status signal transmission link can be at leasttamper-resistant and/or tamper-evident, and can be configured to transmit a status signal having a first characteristic value when the status signal transmission link is in a first condition and asecond characteristic value when the status signal transmission link has been altered from a first condition to a second condition.
摘要翻译：一种用于向接受者施用经皮电疗法的方法和装置。该装置可以包括具有耦合构件的电耦合器，该耦合构件构造成可移除地定位成至少靠近经皮探针。耦合构件可以通过治疗信号传输链路耦合到治疗电信号源，以将治疗电信号传送到接收者。该装置还可以包括至少靠近治疗信号传输链路并可耦合到状态信号发射器的状态信号传输链路。状态信号传输链路可以是至少防篡改和/或防篡改的，并且可以被配置为当状态信号传输链路处于第一状态时发送具有第一特征值的状态信号，并且当状态信号传输链路的状态信号传输链路已经从第一状态改变到第二状态。

2. 发明申请

WO03035163A3 METHODS AND APPARATUS FOR EFFECTUATING A LASTING CHANGE IN A NEURAL-FUNCTION OF A PATIENT 审中-公开
标题翻译：用于实现患者的神经功能的持续变化的方法和设备
公开(公告)号：WO03035163A3
公开(公告)日：2003-09-18
申请号：PCT/US0231127
申请日：2002-09-27
申请人： VERTIS NEUROSCIENCE INC , GLINER BRADFORD EVAN , FOWLER BRAD , FIRLIK ANDREW D , BALZER JEFFREY , LEVY ALAN J
发明人： GLINER BRADFORD EVAN , FOWLER BRAD , FIRLIK ANDREW D , BALZER JEFFREY , LEVY ALAN J
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36017 , A61N1/3605 , A61N1/36082 , A61N1/36103 , A61N1/3756
摘要： The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Certain embodiments of methods in accordance with the invention electrically stimulate the brain at a stimulation site where neuroplasticity is occurring or is expected to occur. The stimulation site may be different than the region in the brain where neural activity is typically present to perform the particular neural function according to the functional organization of the brain. In one embodiment in which neuroplasticity related to the neural-function occurs in the brain, the method can include identifying the location where such neuroplasticity is present or expected to occur. In an alternative embodiment in which neuroplasticity is not occurring in the brain, an alternative aspect is to induce neuroplasticity at a stimulation site where it is expected to occur. Several embodiments of these methods that are expected to produce a lasting effect on the intended neural activity at the stimulation site use electrical pulses that increase the resting membrane potential of neurons at the stimulation site to a subthreshold level.
摘要翻译：以下公开描述了用于治疗或以其他方式实现患者的神经功能改变的颅内电刺激的若干方法和装置。根据本发明的方法的某些实施例在神经可塑性正在发生或预期发生的刺激部位电刺激大脑。刺激部位可以不同于大脑中存在神经活动以根据大脑的功能组织执行特定神经功能的区域。在其中与神经功能相关的神经可塑性发生在脑中的一个实施例中，该方法可以包括识别存在或预期发生这种神经可塑性的位置。在脑中没有发生神经可塑性的替代实施方式中，可选择的方面是在预期发生的刺激部位诱导神经可塑性。预期这些方法的几个实施方案对刺激部位处的预期神经活动产生持久效应使用电刺激，其将刺激部位处神经元的静息膜电位增加至亚阈值水平。

3. 发明申请

WO2004066820A3 SYSTEMS AND METHODS FOR REDUCING THE LIKELIHOOD OF INDUCING COLLATERAL NEURAL ACTIVITY DURING NEURAL STIMULATION THRESHOLD TEST PROCEDURES 审中-公开
标题翻译：在神经刺激阈值测试程序期间减少感染性神经活动的兴趣的系统和方法
公开(公告)号：WO2004066820A3
公开(公告)日：2005-07-07
申请号：PCT/US2004002251
申请日：2004-01-26
申请人： NORTHSTAR NEUROSCIENCE INC , GLINER BRADFORD EVAN , LEYDE KENT
发明人： GLINER BRADFORD EVAN , LEYDE KENT
IPC分类号： A61B20060101 , A61N1/05 , A61N1/18 , A61N1/34 , A61N1/36 , A61N1/375
CPC分类号： A61N1/0534 , A61N1/0531 , A61N1/0551 , A61N1/0553 , A61N1/36017 , A61N1/36025 , A61N1/36071 , A61N1/36082 , A61N1/36185 , A61N1/375 , A61N1/3756 , A61N1/3787
摘要： Test procedures for determining a neural stimulation threshold of a patient. In one embodiment, the procedure includes applying a test stimulation signal to the patient and monitoring the patient for a response to the test stimulation signal. The procedure can further include determining a first neural stimulation threshold and calculating a second neural stimulation threshold. The first neural stimulation threshold corresponds to the lowest intensity test stimulation signal that evokes a patient response. The second neural stimulation threshold corresponds to a treatment stimulation signal directed toward affecting a neural activity within the patient.
摘要翻译：用于确定患者的神经刺激阈值的测试程序。在一个实施例中，该过程包括将测试刺激信号应用于患者并监测患者对测试刺激信号的响应。该过程还可以包括确定第一神经刺激阈值并计算第二神经刺激阈值。第一神经刺激阈值对应于唤起患者反应的最低强度测试刺激信号。第二神经刺激阈值对应于针对影响患者内的神经活动的治疗刺激信号。

4. 发明申请

WO2007090054A3 SYSTEMS AND METHODS FOR VARYING ELECTROMAGNETIC AND ADJUNCTIVE NEURAL THERAPIES 审中-公开
标题翻译：改变电磁和相关神经治疗的系统和方法
公开(公告)号：WO2007090054A3
公开(公告)日：2009-03-26
申请号：PCT/US2007061125
申请日：2007-01-26
申请人： NORTHSTAR NEUROSCIENCE INC , GLINER BRADFORD EVAN , BALZER JEFFREY , FOWLER BRAD , SLOAN LEIF R
发明人： GLINER BRADFORD EVAN , BALZER JEFFREY , FOWLER BRAD , SLOAN LEIF R
IPC分类号： A61N1/18
CPC分类号： A61N1/36082 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36017 , A61N1/36025 , A61N1/37247
摘要： Systems and methods for varying electromagnetic and adjunctive neural therapies are disclosed. A method in accordance with one embodiment includes applying electromagnetic signals to a target neural population of a patient over a first period of time in accordance with a first mode (e.g., including signal delivery to the central nervous system or peripheral nervous system, via implanted or non-implanted devices). The method can further include applying electromagnetic stimulation to the patient over a second period of time in accordance with a second mode different than the first mode. Varying the mode between the first period of time and second period of time can increase the efficacy and/or longevity of the stimulation. Systems in accordance with other embodiments can support multiple signal delivery devices.
摘要翻译：公开了用于改变电磁和辅助神经疗法的系统和方法。根据一个实施例的方法包括根据第一模式（例如，包括通过植入的或通过植入的中枢神经系统或周围神经系统的信号传递）向第一时间段的患者的目标神经群体施加电磁信号非植入设备）。该方法还可以包括根据与第一模式不同的第二模式在第二时间段内向患者施加电磁刺激。改变第一时间段和第二时间段之间的模式可以增加刺激的功效和/或寿命。根据其他实施例的系统可以支持多个信号传递装置。

5. 发明申请

WO2008017055A3 METHODS FOR TREATING NEUROLOGICAL DISORDERS, INCLUDING NEUROPSYCHIATRIC AND NEUROPSYCHOLOGICAL DISORDERS, AND ASSOCIATED SYSTEMS 审中-公开
标题翻译：治疗神经病变的方法，包括神经病学和神经病学疾病及相关系统
公开(公告)号：WO2008017055A3
公开(公告)日：2008-12-18
申请号：PCT/US2007075129
申请日：2007-08-02
申请人： NORTHSTAR NEUROSCIENCE INC , FOWLER BRAD , GLINER BRADFORD EVAN , SHEFIELD W DOUGLAS , SLOAN LEIF R
发明人： FOWLER BRAD , GLINER BRADFORD EVAN , SHEFIELD W DOUGLAS , SLOAN LEIF R
IPC分类号： A61N1/00
CPC分类号： A61N1/36082
摘要： Methods for treating neurological disorders, including neuropsychiatric and neuropsychological disorders, and associated systems are disclosed. One such method includes identifying one or more neural populations, including a cortical target neural population, associated with a neurological condition. The method can further include comparing a patient-specific measure of a characteristic parameter for a selected one of the neural populations with a target measure for the same parameter. If the patient-specific measure differs from the target measure by at least a target amount, the method can include selecting an electrical signal polarity, frequency, or both polarity and frequency based at least in part on the difference between the patient-specific measure and the target measure. The method can further include applying electrical signals to the target neural population at the selected signal polarity, frequency, or both polarity and frequency to reduce the difference between the patient- specific measure and the target measure.
摘要翻译：公开了治疗神经系统疾病，包括神经精神和神经心理障碍以及相关系统的方法。一种这样的方法包括鉴定与神经病症相关的一个或多个神经群体，包括皮质靶神经群体。该方法还可以包括将针对所选择的一个神经群体的特征参数的患者特异性测量与相同参数的目标测量进行比较。如果患者特异性测量与目标测量值不同至少目标量，则该方法可以包括至少部分地基于患者特异性测量值与患者特异性测量值之间的差异来选择电信号极性，频率或极性和频率两者目标措施。该方法还可以包括以选定的信号极性，频率或极性和频率将电信号施加到目标神经群体，以减少患者特异性测量与目标测量之间的差异。

6. 发明申请

WO2008073420A3 SYSTEMS AND METHODS FOR TREATING PATIENT HYPERTONICITY 审中-公开
标题翻译：用于治疗患者HYPERONICITY的系统和方法
公开(公告)号：WO2008073420A3
公开(公告)日：2008-10-09
申请号：PCT/US2007025311
申请日：2007-12-11
申请人： NORTHSTAR NEUROSCIENCE INC , GLINER BRADFORD EVAN , FOWLER BRAD , HULVERSHORN JUSTIN , SLOAN LEIF R
发明人： GLINER BRADFORD EVAN , FOWLER BRAD , HULVERSHORN JUSTIN , SLOAN LEIF R
IPC分类号： A61N1/05
CPC分类号： A61N1/36082 , A61N1/0531 , A61N2/006
摘要： Systems and methods for treating patient hypertonicity are disclosed. A method in accordance with one embodiment includes identifying a cortical target neural population associated with hypertonicity in a patient, and reducing or eliminating patient hypertonicity by applying electromagnetic signals to the target neural population. In further particular embodiments, the electromagnetic signals are first electromagnetic signals, and the method can further include reducing or eliminating an additional patient dysfunction by applying second electromagnetic signals.
摘要翻译：公开了用于治疗患者高渗性的系统和方法。根据一个实施例的方法包括：识别与患者中的高渗性相关的皮层目标神经群体;以及通过将电磁信号应用于目标神经群体来减少或消除患者高张性。在进一步的特定实施例中，电磁信号是第一电磁信号，并且该方法还可以包括通过施加第二电磁信号来减少或消除额外的患者功能障碍。

7. 发明申请

WO2004036765A3 NEURAL STIMULATION SYSTEM AND METHOD RESPONSIVE TO COLLATERAL NEURAL ACTIVITY 审中-公开
标题翻译：神经刺激系统和方法对孤立性神经活动的反应
公开(公告)号：WO2004036765A3
公开(公告)日：2005-03-03
申请号：PCT/US0332599
申请日：2003-10-15
申请人： NORTHSTAR NEUROSCIENCE INC , GLINER BRADFORD EVAN
发明人： GLINER BRADFORD EVAN
IPC分类号： A61B5/0484 , A61B5/0488 , A61B5/11 , A61N1/05 , A61N1/34 , A61N1/36 , A61N1/375 , A61N1/10 , A61N1/08 , A61N1/18 , A61N1/20 , A61N1/32
CPC分类号： A61N1/36185 , A61B5/0484 , A61B5/0488 , A61B5/1104 , A61B5/4094 , A61N1/0531 , A61N1/0534 , A61N1/0551 , A61N1/0553 , A61N1/36017 , A61N1/36025 , A61N1/36071 , A61N1/36082 , A61N1/375 , A61N1/3756
摘要： A neural stimulation system responsive to collateral neural activity that may arise in association with a neural stimulation procedure includes a stimulation interface configured to deliver stimulation signals to a target neural population, a monitoring interface positioned to receive signals corresponding to a neural activity within the target neural population, a stimulus unit coupled to deliver stimulation singals to the stimulation interface, and a sensing unit coupled to the monitoring device and the stimulus unit. The neural stimulation procedure may be directed toward rehabilitating, restoring, and/or enhancing one or more neural functions by facilitating and/or effectuating a neuroplastic change or reorganization; and/or affecting a neurological condition that exists on a continuous or essentially continuous basis absent the stimulation procedure. The sensing unit determines whether evidence of an collateral neural activity exists, whereupon the stimulus unit attempts to abate the collateral neural activity.
摘要翻译：响应于与神经刺激过程相关联的附带神经活动的神经刺激系统包括被配置为将刺激信号传递到目标神经群体的刺激界面，定位成接收对应于目标神经元内的神经活动的信号的监测界面人口，耦合以将刺激信号传递到刺激界面的刺激单元，以及耦合到监视设备和刺激单元的感测单元。神经刺激过程可以通过促进和/或实现神经损伤的改变或重组而针对康复，恢复和/或增强一个或多个神经功能; 和/或影响在没有刺激过程的情况下以连续或基本连续的方式存在的神经病症。感知单元确定是否存在附带神经活动的证据，因此刺激单位试图减轻旁路神经活动。

8. 发明申请

WO2007121133A3 ELECTROMAGNETIC STIMULATION FOR TISSUE AFFECTED BY NEURONAL DYSFUNCTION, DEGRADATION, DAMAGE, AND/OR NECROSIS 审中-公开
标题翻译：由神经功能丧失，降解，损伤和/或坏死影响的组织的电磁刺激
公开(公告)号：WO2007121133A3
公开(公告)日：2008-06-26
申请号：PCT/US2007066220
申请日：2007-04-09
申请人： NORTHSTAR NEUROSCIENCE INC , FOWLER BRAD , GLINER BRADFORD EVAN , HIMES DAVID
发明人： FOWLER BRAD , GLINER BRADFORD EVAN , HIMES DAVID
IPC分类号： A61N2/04
CPC分类号： A61N2/006 , A61N1/36017 , A61N1/36025 , A61N1/36082
摘要： Electromagnetic signal delivery for tissue affected by neuronal dysfunction, degradation, damage, and/or necrosis, and associated systems and methods are disclosed. A method in accordance with one embodiment of the invention includes identifying an affected region, with the affected region including neuronal tissue that, at least during a pre-dysfunctional period, was in neural communication with neuronal tissue in a dysfunctional region. The affected tissue can be functionally adversely affected by neuronal dysfunction in the dysfunctional region. The method can further include applying electromagnetic signals to the neuronal tissue in the affected region. For example, the electromagnetic signals can be applied to a hypo-active neural region that is not physically damaged, and has been identified as likely to recover at least in part as a result of electromagnetic signals. Signals can be applied at sub-threshold levels to cortical and/or subcortical regions.
摘要翻译：公开了由神经元功能障碍，降解，损伤和/或坏死以及相关系统和方法影响的组织的电磁信号传递。根据本发明的一个实施例的方法包括识别受影响的区域，其中受影响的区域包括神经元组织，至少在功能失调之前期间，与功能障碍区域中的神经元组织进行神经交流。受影响的组织可能在功能障碍区域的神经元功能障碍中受功能不良的影响。该方法还可以包括将电磁信号应用于受影响区域中的神经元组织。例如，电磁信号可以应用于没有物理损坏的低活性神经区域，并且已被鉴定为可能至少部分地由于电磁信号而恢复。信号可以在亚阈值水平应用于皮层和/或皮质下区域。

9. 发明申请

WO2007047852A3 SYSTEMS AND METHODS FOR PATIENT INTERACTIVE NEURAL STIMULATION AND/OR CHEMICAL SUBSTANCE DELIVERY 审中-公开
标题翻译：用于患者交互神经刺激和/或化学物质递送的系统和方法
公开(公告)号：WO2007047852A3
公开(公告)日：2007-11-29
申请号：PCT/US2006040908
申请日：2006-10-18
申请人： NORTHSTAR NEUROSCIENCE INC , FIRLIK ANDREW D , GLINER BRADFORD EVAN , SHEFFIELD W DOUGLAS , SLOAN LEIF R
发明人： FIRLIK ANDREW D , GLINER BRADFORD EVAN , SHEFFIELD W DOUGLAS , SLOAN LEIF R
IPC分类号： A61N1/00
CPC分类号： A61N1/36067 , A61B5/16 , A61B5/18 , A61B5/7275 , A61F2002/704 , A61M5/14276 , A61M5/1723 , A61M2205/05 , A61M2205/50 , A61M2230/63 , A61N1/0531 , A61N1/36003 , A61N1/36014 , A61N1/36017 , A61N1/36025 , A61N1/36082 , A61N1/361 , A61N1/36103 , A61N1/36139 , A61N1/372 , G06F19/3481
摘要： Systems and methods for patient interactive neural stimulation and/or chemical substance delivery are disclosed. A method in accordance with one embodiment of the invention includes affecting a target neural population of the patient by providing to the patient at least one of an electromagnetic signal and a chemical substance. The method can further include detecting at least one characteristic of the patient, with the characteristic at least correlated with the patient's performance of an adjunctive therapy task that is performed in association with affecting the target neural population. The method can still further include controlling at least one parameter in accordance with which the target neural population is affected, based at least in part on the detected characteristic.
摘要翻译：公开了用于患者交互式神经刺激和/或化学物质递送的系统和方法。根据本发明的一个实施例的方法包括通过向患者提供电磁信号和化学物质中的至少一个来影响患者的目标神经群体。该方法还可以包括检测患者的至少一个特征，其特征至少与患者执行与影响目标神经群体相关联的辅助治疗任务的执行相关。该方法还可以进一步包括至少部分地基于所检测到的特征来控制与目标神经群体受影响相关的至少一个参数。

10. 发明申请

WO2005002664A2 METHODS AND APPARATUS FOR EFFECTUATING A LASTING CHANGE IN A NEURAL-FUNCTION OF A PATIENT 审中-公开
标题翻译：用于实现患者的神经功能的持续变化的方法和设备
公开(公告)号：WO2005002664A2
公开(公告)日：2005-01-13
申请号：PCT/US2004020398
申请日：2004-06-24
申请人： NORTHSTAR NEUROSCIENCE INC , FIRLIK ANDREW D , BALZER JEFFREY , GLINER BRADFORD EVAN , LEVY ALAN J
发明人： FIRLIK ANDREW D , BALZER JEFFREY , GLINER BRADFORD EVAN , LEVY ALAN J
IPC分类号： A61N20060101 , A61N1/05 , A61N1/08 , A61N1/18 , A61N1/34 , A61N1/36 , A61N1/375 , A61N
CPC分类号： A61N1/36017 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/08 , A61N1/36021 , A61N1/36025 , A61N1/36071 , A61N1/36082 , A61N1/36103 , A61N1/3756
摘要： Methods and apparatus for treating an impaired neural function in a brain of a patient. In one embodiment, a method for treating a neural function in a brain of a patient includes determining a therapy period during which a plurality of therapy sessions are to be performed to recover functional ability corresponding to the neural function. The method continues by identifying a stimulation site in or on the brain of the patient associated with the neural function, and positioning an electrode at least proximate to the identified stimulation site. The patient is then treated by providing electrical stimulation treatments to the stimulation site. The treatment can comprise delivering electrical stimulation signals to the electrode during the therapy sessions. After expiration of the therapy period, the method includes preventing electrical stimulation signals from being delivered to the stimulation site.
摘要翻译：用于治疗患者脑中受损的神经功能的方法和设备。在一个实施方案中，用于治疗患者脑中的神经功能的方法包括确定治疗期，在该治疗期期间将执行多个治疗期以恢复对应于神经功能的功能性能力。该方法通过识别与神经功能相关的患者大脑中或其上的刺激位点并将电极至少靠近识别的刺激位点定位。然后通过向刺激部位提供电刺激治疗来治疗患者。治疗可以包括在治疗期间将电刺激信号传递到电极。治疗期结束后，该方法包括防止电刺激信号传递到刺激部位。

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