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1. 发明申请

WO2005002664A2 METHODS AND APPARATUS FOR EFFECTUATING A LASTING CHANGE IN A NEURAL-FUNCTION OF A PATIENT 审中-公开
标题翻译：用于实现患者的神经功能的持续变化的方法和设备
公开(公告)号：WO2005002664A2
公开(公告)日：2005-01-13
申请号：PCT/US2004020398
申请日：2004-06-24
申请人： NORTHSTAR NEUROSCIENCE INC , FIRLIK ANDREW D , BALZER JEFFREY , GLINER BRADFORD EVAN , LEVY ALAN J
发明人： FIRLIK ANDREW D , BALZER JEFFREY , GLINER BRADFORD EVAN , LEVY ALAN J
IPC分类号： A61N20060101 , A61N1/05 , A61N1/08 , A61N1/18 , A61N1/34 , A61N1/36 , A61N1/375 , A61N
CPC分类号： A61N1/36017 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/08 , A61N1/36021 , A61N1/36025 , A61N1/36071 , A61N1/36082 , A61N1/36103 , A61N1/3756
摘要： Methods and apparatus for treating an impaired neural function in a brain of a patient. In one embodiment, a method for treating a neural function in a brain of a patient includes determining a therapy period during which a plurality of therapy sessions are to be performed to recover functional ability corresponding to the neural function. The method continues by identifying a stimulation site in or on the brain of the patient associated with the neural function, and positioning an electrode at least proximate to the identified stimulation site. The patient is then treated by providing electrical stimulation treatments to the stimulation site. The treatment can comprise delivering electrical stimulation signals to the electrode during the therapy sessions. After expiration of the therapy period, the method includes preventing electrical stimulation signals from being delivered to the stimulation site.
摘要翻译：用于治疗患者脑中受损的神经功能的方法和设备。在一个实施方案中，用于治疗患者脑中的神经功能的方法包括确定治疗期，在该治疗期期间将执行多个治疗期以恢复对应于神经功能的功能性能力。该方法通过识别与神经功能相关的患者大脑中或其上的刺激位点并将电极至少靠近识别的刺激位点定位。然后通过向刺激部位提供电刺激治疗来治疗患者。治疗可以包括在治疗期间将电刺激信号传递到电极。治疗期结束后，该方法包括防止电刺激信号传递到刺激部位。

2. 发明申请

WO03035163A3 METHODS AND APPARATUS FOR EFFECTUATING A LASTING CHANGE IN A NEURAL-FUNCTION OF A PATIENT 审中-公开
标题翻译：用于实现患者的神经功能的持续变化的方法和设备
公开(公告)号：WO03035163A3
公开(公告)日：2003-09-18
申请号：PCT/US0231127
申请日：2002-09-27
申请人： VERTIS NEUROSCIENCE INC , GLINER BRADFORD EVAN , FOWLER BRAD , FIRLIK ANDREW D , BALZER JEFFREY , LEVY ALAN J
发明人： GLINER BRADFORD EVAN , FOWLER BRAD , FIRLIK ANDREW D , BALZER JEFFREY , LEVY ALAN J
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36017 , A61N1/3605 , A61N1/36082 , A61N1/36103 , A61N1/3756
摘要： The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Certain embodiments of methods in accordance with the invention electrically stimulate the brain at a stimulation site where neuroplasticity is occurring or is expected to occur. The stimulation site may be different than the region in the brain where neural activity is typically present to perform the particular neural function according to the functional organization of the brain. In one embodiment in which neuroplasticity related to the neural-function occurs in the brain, the method can include identifying the location where such neuroplasticity is present or expected to occur. In an alternative embodiment in which neuroplasticity is not occurring in the brain, an alternative aspect is to induce neuroplasticity at a stimulation site where it is expected to occur. Several embodiments of these methods that are expected to produce a lasting effect on the intended neural activity at the stimulation site use electrical pulses that increase the resting membrane potential of neurons at the stimulation site to a subthreshold level.
摘要翻译：以下公开描述了用于治疗或以其他方式实现患者的神经功能改变的颅内电刺激的若干方法和装置。根据本发明的方法的某些实施例在神经可塑性正在发生或预期发生的刺激部位电刺激大脑。刺激部位可以不同于大脑中存在神经活动以根据大脑的功能组织执行特定神经功能的区域。在其中与神经功能相关的神经可塑性发生在脑中的一个实施例中，该方法可以包括识别存在或预期发生这种神经可塑性的位置。在脑中没有发生神经可塑性的替代实施方式中，可选择的方面是在预期发生的刺激部位诱导神经可塑性。预期这些方法的几个实施方案对刺激部位处的预期神经活动产生持久效应使用电刺激，其将刺激部位处神经元的静息膜电位增加至亚阈值水平。

3. 发明申请

WO2007090054A3 SYSTEMS AND METHODS FOR VARYING ELECTROMAGNETIC AND ADJUNCTIVE NEURAL THERAPIES 审中-公开
标题翻译：改变电磁和相关神经治疗的系统和方法
公开(公告)号：WO2007090054A3
公开(公告)日：2009-03-26
申请号：PCT/US2007061125
申请日：2007-01-26
申请人： NORTHSTAR NEUROSCIENCE INC , GLINER BRADFORD EVAN , BALZER JEFFREY , FOWLER BRAD , SLOAN LEIF R
发明人： GLINER BRADFORD EVAN , BALZER JEFFREY , FOWLER BRAD , SLOAN LEIF R
IPC分类号： A61N1/18
CPC分类号： A61N1/36082 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36017 , A61N1/36025 , A61N1/37247
摘要： Systems and methods for varying electromagnetic and adjunctive neural therapies are disclosed. A method in accordance with one embodiment includes applying electromagnetic signals to a target neural population of a patient over a first period of time in accordance with a first mode (e.g., including signal delivery to the central nervous system or peripheral nervous system, via implanted or non-implanted devices). The method can further include applying electromagnetic stimulation to the patient over a second period of time in accordance with a second mode different than the first mode. Varying the mode between the first period of time and second period of time can increase the efficacy and/or longevity of the stimulation. Systems in accordance with other embodiments can support multiple signal delivery devices.
摘要翻译：公开了用于改变电磁和辅助神经疗法的系统和方法。根据一个实施例的方法包括根据第一模式（例如，包括通过植入的或通过植入的中枢神经系统或周围神经系统的信号传递）向第一时间段的患者的目标神经群体施加电磁信号非植入设备）。该方法还可以包括根据与第一模式不同的第二模式在第二时间段内向患者施加电磁刺激。改变第一时间段和第二时间段之间的模式可以增加刺激的功效和/或寿命。根据其他实施例的系统可以支持多个信号传递装置。

4. 发明申请

WO02072194A3 METHODS AND APPARATUS FOR EFFECTUATING A LASTING CHANGE IN A NEURAL-FUNCTION OF A PATIENT 审中-公开
标题翻译：影响患者神经功能变化的方法和装置
公开(公告)号：WO02072194A3
公开(公告)日：2003-03-06
申请号：PCT/US0207077
申请日：2002-03-07
申请人： VERTIS NEUROSCIENCE INC , FIRLIK ANDREW D , BALZER JEFFREY , GLINER BRADFORD E , LEVY ALAN J , MORGAN CARLTON B
发明人： FIRLIK ANDREW D , BALZER JEFFREY , GLINER BRADFORD E , LEVY ALAN J , MORGAN CARLTON B
IPC分类号： A61N1/05 , A61N1/36 , A61N1/375
CPC分类号： A61N1/375 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36017 , A61N1/36025 , A61N1/36082 , A61N1/36103 , A61N1/3756
摘要： The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Several embodiments of methods in accordance with the invention are directed toward enhancing or otherwise inducing a lasting change in neural activity to effectuate a particular neural-function. Such lasting change in neural activity is defined as "neuroplasticity". The methods in accordance with the invention can be used to treat brain damage (e.g., stroke, trauma, etc.), brain disease (e.g., Alzheimer's, Pick's, Parkinson's, etc.), and/or brain disorders (e.g., epilepsy, depression, etc.). The methods in accordance with the invention can also be used to enhance neural-function of normal, healthy brains (e.g., learning, memory, etc.), or to control sensory functions (e.g., pain). Certain embodiments of methods in accordance with the invention electrically stimulate the brain at a stimulation site where neuroplasticity is occurring. The stimulation site may be different than the region in the brain where neural activity is typically present to perform the particular neural function according to the functional organization of the brain. In one embodiment in which neuroplasticity related to the neural-function occurs in the brain, the maethod can include identifying the location where such neuroplasticity is present. In an alternative embodiment in which neuroplasticity is not occurring in the brain, an alternative aspect is to induce neuroplasticity at a stimulation site where it is expected to occur. Several embodiments of these methods that are expected to produce a lasting effect on the intended neural activity at the stimulation site use electrical pulses that increase the resting membrane potential of neurons at the stimulation site to a subthreshold level.
摘要翻译：以下公开内容描述了用于治疗或以其他方式实现患者神经功能变化的颅内电刺激的几种方法和装置。根据本发明的方法的几个实施方案旨在增强或以其他方式诱导神经活动的持续变化以实现特定的神经功能。这种神经活动的持续变化被定义为“神经可塑性”。根据本发明的方法可用于治疗脑损伤（例如中风，创伤等），脑疾病（例如阿尔茨海默氏症，皮克病，帕金森氏病等）和/或脑部疾病（例如癫痫，抑郁症等）。根据本发明的方法还可以用于增强正常，健康的大脑（例如学习，记忆等）的神经功能，或用于控制感觉功能（例如疼痛）。根据本发明的方法的某些实施方案在发生神经可塑性的刺激部位电刺激脑。刺激部位可能不同于大脑中通常存在神经活动的区域，以根据脑的功能组织来执行特定的神经功能。在与神经功能相关的神经可塑性发生在脑中的一个实施方案中，该方法可以包括鉴定存在这种神经可塑性的位置。在脑中不发生神经可塑性的替代实施方案中，替代方面是在预期发生的刺激位点处诱导神经可塑性。预期对刺激部位的预期神经活动产生持久影响的这些方法的若干实施方案使用增加刺激部位的神经元的静息膜电位至亚阈值水平的电脉冲。

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