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1. 发明申请

WO2019006178A1 RECONFIGURABLE BIOSIGNAL PROCESSING ARCHITECTURE 审中-公开
公开(公告)号：WO2019006178A1
公开(公告)日：2019-01-03
申请号：PCT/US2018/040106
申请日：2018-06-28
申请人： HI LLC
发明人： LARA, Antonio, H. , SANDLER, Roman , ROBINSON, Brian, S. , ANDERSON, Kristopher , WENTZ, Christian , KOENE, Randal , STANTON, John, W. , PETERSON, Erik, J.
IPC分类号： A61N2/00 , A61N1/00
CPC分类号： A61N1/0534 , A61B5/04012 , A61B5/04014 , A61B5/048 , A61B5/4082 , A61B5/4094 , A61B5/4836 , A61B5/7225 , A61B5/7257 , A61N1/0531 , A61N1/36064 , A61N1/36067 , A61N1/36082 , A61N1/37252 , A61N1/3787
摘要： Devices, systems, and methods herein relate to processing biosignal data. These systems and methods may obtain sensor data from a plurality of electrodes and may also be used to augment cortical function, treat neurological disease, and provide insight and analysis of biological processes and/or clinical therapeutic outcomes. An implantable biosignal processing system may comprise a lead having at least one biosignal sensor configured to transmit biosignal data based on electrophysiological activity of a subject. A first processing system may be coupled to the biosignal sensor and comprise a plurality of analog signal processing circuits configured to be selectively powered based on a selectable treatment mode. A second processing system in communication with the first processing system and may comprise a plurality of digital signal processing circuits configured to be selectively powered based on the treatment mode. A neurostimulator may stimulate tissue according to the set of biosignal characteristics.

2. 发明申请

WO2018187080A1 DEEP BRAIN STIMULATION IN EARLY STAGE PARKINSON'S 审中-公开
公开(公告)号：WO2018187080A1
公开(公告)日：2018-10-11
申请号：PCT/US2018/024469
申请日：2018-03-27
申请人： VANDERBILT UNIVERSITY
发明人： CHARLES, David , HACKER, Mallory , KONRAD, Peter
IPC分类号： A61N1/36
CPC分类号： A61N1/36067 , A61N1/36
摘要： The present disclosure relates to the treatment of patients with Parkinson's Disease using subthalmic nucleus deep brain stimulation to a specific region of the brain. By positioning the electrode in the margin of the dorsal-lateral and anterior region of the subthalamic nucleus, improved benefits are obtained.

3. 发明申请

WO2017116760A1 CONTROLLER FOR NERVE STIMULATION CIRCUIT AND ASSOCIATED SYSTEMS AND METHODS 审中-公开
标题翻译：神经刺激电路的控制器及相关系统和方法
公开(公告)号：WO2017116760A1
公开(公告)日：2017-07-06
申请号：PCT/US2016/067217
申请日：2016-12-16
申请人： NEVRO CORP.
发明人： ILLEGEMS, Paul , PARKER, Jon
IPC分类号： A61N1/36 , A61N1/05 , A61N1/02 , A61N1/08
CPC分类号： A61N1/36021 , A61N1/0551 , A61N1/32 , A61N1/3605 , A61N1/36067 , A61N1/36071 , A61N1/37211 , G05F3/262
摘要： Disclosed is a voltage monitoring circuit for use in detecting if a voltage supplied to current-generating circuit is sufficient to allow the current-generating circuit to produce a desired current. In one embodiment the circuit is designed for use in an implantable device that is configured to deliver therapeutic pulses to a patient. The voltage monitoring circuit is configured to produce a signal if a supplied voltage is insufficient to allow a current-generating circuit to deliver a requested current to a set of electrodes. In one embodiment, the voltage monitoring circuit detects a change in a difference between the voltage at a node in the current- generating circuit and the supplied voltage.
摘要翻译：公开了一种用于检测提供给电流生成电路的电压是否足以允许电流生成电路产生期望电流的电压监控电路。在一个实施例中，电路被设计用于被配置为将治疗脉冲传递给患者的可植入装置中。电压监视电路被配置为如果所提供的电压不足以允许电流生成电路向一组电极传送所请求的电流则生成信号。在一个实施例中，电压监测电路检测电流产生电路中的节点处的电压与所供应的电压之间的差异的变化。

4. 发明申请

WO2017062508A1 Method and System for Neuromodulation and Stimulation 审中-公开
标题翻译：神经调节和刺激的方法和系统
公开(公告)号：WO2017062508A1
公开(公告)日：2017-04-13
申请号：PCT/US2016/055576
申请日：2016-10-05
申请人： MC10, INC.
发明人： GHAFFARI, Roozbeh , PATEL, Shyamal
IPC分类号： A61B5/04 , A61B5/01 , A61N1/36 , A61N1/04
CPC分类号： A61N1/36139 , A61B5/0024 , A61B5/01 , A61B5/021 , A61B5/024 , A61B5/02405 , A61B5/02438 , A61B5/04004 , A61B5/0488 , A61B5/0533 , A61B5/0816 , A61B5/1118 , A61B5/112 , A61B5/4815 , A61B5/4836 , A61B5/7275 , A61B2560/0242 , A61F7/00 , A61M5/14276 , A61M5/1723 , A61M21/02 , A61M2021/0027 , A61M2021/0044 , A61M2021/0066 , A61M2205/3523 , A61M2205/3553 , A61M2205/3584 , A61M2205/8243 , A61M2230/06 , A61M2230/30 , A61M2230/42 , A61M2230/50 , A61M2230/60 , A61M2230/62 , A61M2230/65 , A61N1/36067 , A61N1/36071 , A61N1/36114 , A61N1/36117 , A61N5/0622 , A61N7/00 , A63B22/0023 , A63B22/0076 , A63B22/02 , A63B22/025 , A63B22/04 , A63B22/0605 , A63B22/0664 , A63B24/0062 , A63B24/0075 , A63B24/0087 , A63B2024/0065 , A63B2024/0078 , A63B2024/0093 , A63B2071/0081 , A63B2071/0625 , A63B2220/18 , A63B2220/30 , A63B2220/40 , A63B2220/805 , A63B2225/20 , A63B2225/50 , A63B2230/045 , A63B2230/06 , A63B2230/062 , A63B2230/10 , A63B2230/42 , A63B2230/425 , A63B2230/50 , A63B2230/60 , G06F19/00 , G06F19/3481 , A61M2230/005
摘要： A system for controlling a therapeutic device and/or environmental parameters can include one or more body worn sensor devices that detect and report one or more physical, physiological, or biological parameters of a person in an environment. The sensor devices can communicate sensor data indicative of the one or more physical, physiological, or biological parameters of a person to an external hub that processes the data and communicates with the therapeutic device to provide a therapy (e.g., neuromodulation, neurostimulation, or drug delivery) as a function of the sensor data. In some embodiments, the therapeutic device can be implanted in the person. In some embodiments, the therapeutic device can be in contact with the skin of the person. The sensor devices can also communicate to the hub that communicates with one or more devices to change the environment as a function of the sensor data.
摘要翻译：用于控制治疗装置和/或环境参数的系统可以包括一个或多个身体磨损的传感器装置，其检测并报告环境中的人的一个或多个身体，生理或生物参数。传感器装置可以将指示人的一个或多个物理，生理或生物学参数的传感器数据传达到处理数据并与治疗装置通信以提供治疗（例如，神经调节，神经刺激或药物作为传感器数据的函数。在一些实施例中，治疗装置可以植入人中。在一些实施例中，治疗装置可以与人的皮肤接触。传感器设备还可以与与一个或多个设备通信的集线器通信，以根据传感器数据来改变环境。

5. 发明申请

WO2016201366A1 SYSTEMS AND METHODS FOR PERIPHERAL NERVE STIMULATION TO TREAT TREMOR WITH DETACHABLE THERAPY AND MONITORING UNITS 审中-公开
标题翻译：用于外切治疗和监测单位治疗TREMOR的外周神经刺激的系统和方法
公开(公告)号：WO2016201366A1
公开(公告)日：2016-12-15
申请号：PCT/US2016/037080
申请日：2016-06-10
申请人： CALA HEALTH, INC.
发明人： WONG, Serena, HanYing , ROSENBLUTH, Kathryn, H. , HAMNER, Samuel, Richard , CHIDESTER, Paula, Jean , DELP, Scott, Lee , SANGER, Terence, D.
IPC分类号： A61N1/02 , A61N1/04 , A61N1/36
CPC分类号： A61N1/0456 , A61N1/0476 , A61N1/0484 , A61N1/0496 , A61N1/321 , A61N1/36014 , A61N1/36017 , A61N1/36057 , A61N1/36067 , A61N1/36125 , A61N1/36139 , A61N1/37247 , A61N1/37252
摘要： A system and method for providing therapy to a patient can include a monitoring unit and a therapy unit. The monitoring unit can have a user interface and one or more sensors to measure patient data. The therapy unit can have a stimulator for generating electrical stimulation and a microcontroller for controlling the generation of the electrical stimulation based on the measured patient data.
摘要翻译：用于向患者提供治疗的系统和方法可以包括监测单元和治疗单元。监测单元可以具有用户界面和一个或多个传感器来测量患者数据。治疗单元可以具有用于产生电刺激的刺激器和用于基于所测量的患者数据来控制电刺激的产生的微控制器。

6. 发明申请

WO2016132258A1 APPARATUS AND METHOD FOR TREATING NEUROLOGICAL DISORDERS 审中-公开
标题翻译：装置和治疗神经病的方法
公开(公告)号：WO2016132258A1
公开(公告)日：2016-08-25
申请号：PCT/IB2016/050735
申请日：2016-02-11
申请人： ARLOTTI, Mattia , PRIORI, Alberto , ROSSI, Lorenzo
发明人： ARLOTTI, Mattia , PRIORI, Alberto , ROSSI, Lorenzo
IPC分类号： A61N1/36 , A61B5/00
CPC分类号： A61N1/3606 , A61B5/048 , A61B5/4076 , A61B5/4082 , A61B5/4836 , A61B5/7257 , A61N1/0534 , A61N1/36064 , A61N1/36067 , A61N1/36071 , A61N1/36082
摘要： The present invention concerns an apparatus for treating neurological disorders comprising (i) at least one electrode implantable in the brain of a patient and (ii) a processing and stimulation device connected to the at least one electrode, wherein the processing and stimulation device comprises (a) at least one stimulation module adapted to generate a stimulation signal to be sent to the at least one electrode, the stimulation signal being characterised by a plurality of parameters, (b) at least one acquisition module of a signal characteristic of cerebral activity coming from the brain of the patient adapted to determine its power in at least one frequency band, and (c) at least one control module of at least one parameter of the stimulation signal as a function of the power of the signal characteristic of cerebral activity acquired, based on a transfer function having a saturating trend, wherein the transfer function is such as to set the at least one parameter (Va,Vd,Vf) of the stimulation signal (Vstim) differently dependent on a plurality of power ranges, by keeping the at least one parameter within a predetermined stimulation range ([Vi_HighThreshold;Vi_LowThreshold]) with i = a,d,f.
摘要翻译：本发明涉及一种用于治疗神经障碍的装置，包括（i）至少一个可植入患者脑部的电极和（ii）连接至该至少一个电极的处理和刺激装置，其中所述处理和刺激装置包括 a）至少一个刺激模块，其适于产生要发送到所述至少一个电极的刺激信号，所述刺激信号由多个参数表征，（b）至少一个具有脑活动特征的信号获取模块适于确定其在至少一个频带中的功率的患者的脑部，以及（c）至少一个控制模块，所述至少一个控制模块作为所获取的脑活动特征信号的功率的刺激信号的至少一个参数基于具有饱和趋势的传递函数，其中所述传递函数用于设置所述st的至少一个参数（Va，Vd，Vf）通过使i = a，d，f中的至少一个参数保持在预定的刺激范围（[Vi_HighThreshold; Vi_LowThreshold]）内，不同地取决于多个功率范围的模拟信号（Vstim）。

7. 发明申请

WO2016083460A1 A LEAD AND A SYSTEM FOR MEDICAL APPLICATIONS 审中-公开
标题翻译：一种用于医疗应用的领导和系统
公开(公告)号：WO2016083460A1
公开(公告)日：2016-06-02
申请号：PCT/EP2015/077662
申请日：2015-11-25
申请人： MEDTRONIC BAKKEN RESEARCH CENTER B.V.
发明人： YOUNG, Edward Willem Albert , OUCHOUCHE, Sébastien Jody , DECKERS, Sjaak
IPC分类号： A61N1/05
CPC分类号： A61N1/0534 , A61B5/0478 , A61B2562/0209 , A61B2562/043 , A61N1/36067 , A61N1/36096 , H05K1/028
摘要： In some examples, the present disclosure relates to an implantable medica lead and medical device systems employing such leads for medical applications, such as, e.g., neural stimulation, deep brain stimulation, and/or sensing of bioelectrical signals. In one example, the lead includes a thin film configured to be secured to at least a portion of a carrier core, wherein the thin film has a distal end, a proximal end, and at least one electrode between the proximal end and the distal end; and at least one fixation element configured to secure the distal end of the thin film to the carrier core, wherein the fixation element comprises at least one of a distal extension portion of the thin film at least partially wrapped around the carrier core distal to the at least one electode or a jacket tube located around the carrier core and the thin film.
摘要翻译：在一些示例中，本公开涉及一种可植入医学线和医疗装置系统，该系统采用这种导线用于医疗应用，例如神经刺激，深部脑刺激和/或生物电信号的感测。在一个示例中，引线包括被配置为固定到载体芯的至少一部分的薄膜，其中薄膜具有远端，近端和在近端和远端之间的至少一个电极 ; 以及至少一个固定元件，其被配置为将所述薄膜的远端固定到所述承载芯，其中所述固定元件包括所述薄膜的远侧延伸部分中的至少一个至少部分地绕所述托架芯部远离所述托架芯部位于载体芯和薄膜周围的至少一个电极或护套管。

8. 发明申请

WO2016081099A1 ELECTRODE SELECTION FOR ELECTRICAL STIMULATION THERAPY 审中-公开
标题翻译：电刺激治疗电极选择
公开(公告)号：WO2016081099A1
公开(公告)日：2016-05-26
申请号：PCT/US2015/055542
申请日：2015-10-14
申请人： MEDTRONIC, INC.
发明人： KAEMMERER, William F. , DANI, Siddharth , CONNELLY, Allison T.
IPC分类号： A61N1/36 , A61N1/372 , A61N1/05
CPC分类号： A61N1/36185 , A61N1/0534 , A61N1/36064 , A61N1/36067 , A61N1/36075 , A61N1/36096 , A61N1/36139 , A61N1/37235 , A61N1/37247
摘要： In one example, a method includes selecting, by one or more processors and based on a representation of sensed electrical signals for a particular patient and a plurality of representations of sensed electrical signals for a plurality of other patients, a combination of electrodes of a plurality of combinations of one or more implantable electrodes for delivery of electrical stimulation to the particular patient.
摘要翻译：在一个示例中，一种方法包括通过一个或多个处理器并且基于针对特定患者的感测电信号的表示和多个其他患者的感测电信号的多个表示来选择多个电极的组合一个或多个可植入电极的组合，用于向特定患者传递电刺激。

9. 发明申请

WO2016071236A1 VORRICHTUNG UND VERFAHREN ZUR EFFEKTIVEN NICHT-INVASIVEN DESYNCHRONISIERENDEN NEUROSTIMULATION 审中-公开
标题翻译： DEVICE AND METHOD FOR THE有效的无创不同步NEURO刺激
公开(公告)号：WO2016071236A1
公开(公告)日：2016-05-12
申请号：PCT/EP2015/075297
申请日：2015-10-30
申请人： FORSCHUNGSZENTRUM JÜLICH GMBH
发明人： TASS, Peter, Alexander , POPOVYCH, Oleksandr , XENAKIS, Markos
IPC分类号： A61N1/36 , A61M21/00 , A61N2/00 , A61B5/00
CPC分类号： A61N1/36025 , A61B5/0476 , A61B5/4064 , A61B5/4076 , A61B5/4082 , A61B5/4088 , A61B5/4094 , A61B5/4836 , A61M21/00 , A61M2021/0022 , A61M2021/0027 , A61M2021/0055 , A61M2021/0066 , A61M2021/0072 , A61N1/36014 , A61N1/3603 , A61N1/36064 , A61N1/36067 , A61N1/36082 , A61N1/361 , A61N1/36103 , A61N1/36139 , A61N1/36175 , A61N1/36178 , A61N2/006
摘要： Die Erfindung betrifft eine Vorrichtung zur Unterdrückung einer krankhaft synchronen und oszillatorischen neuronalen Aktivität, umfassend - eine nicht-invasive Stimulationseinheit zur Stimulation von Neuronen im Hirn und/ oder Rückenmark des Patienten, die eine krankhaft synchrone und oszillatorische neuronale Aktivität aufweisen, mit Reizen, wobei die Reize dazu ausgelegt sind, bei einer Verabreichung an den Patienten die krankhaft synchrone und oszillatorische neuronale Aktivität zu unterdrücken, - eine Messeinheit zum Aufnehmen von Messsignalen, die eine neuronale Aktivität der stimulierten Neuronen wiedergeben, und - eine Steuer- und Analyseeinheit zur Steuerung der Stimulationseinheit und zur Analyse der Messsignale, wobei die Steuer- und Analyseeinheit derart ausgestaltet ist, dass sie - die Stimulationseinheit derart ansteuert, dass die Stimulationseinheit Reize appliziert, - anhand der in Reaktion auf die Applikation der Reize aufgenommenen Messsignale den Stimulationserfolg überprüft, und - falls der Stimulationserfolg nicht ausreichend ist, eine oder mehrere Stimulationspausen in die Applikation der Reize einfügt oder eine oder mehrere Stimulationspausen verlängert, wobei während der Stimulationspausen keine Reize appliziert werden, welche die krankhaft synchrone und oszillatorische neuronale Aktivität unterdrücken könnten.
摘要翻译：本发明涉及一种用于包括病态同步和振荡神经活动的抑制的装置 - 一种非侵入性的刺激单元，其用于在患者中，其中有一个病态同步和振荡的神经元活性，刺激的脑和/或脊髓的神经元的刺激，所述刺激适合于抑制病理性同步和振荡的神经元活动时施用于患者， - 测量单元，用于接收表示受刺激神经的神经元活动的测量信号，以及 - 控制和分析单元，用于控制所述刺激单元和对于测量信号的分析，其中，所述控制和分析单元被设计为使得它 - 控制，使得所述刺激单元施加的刺激，所述刺激单元 - 基于响应于所述刺激信号的测量Stimulationser应用程序所接收到的成功验证;以及 - 如果所述刺激的成功是不充分的，一个或在刺激或扩展，一个或多个刺激的间隔，其中，在刺激期间暂停没有施加的刺激，这可能抑制病理性同步和振荡的神经元活动的应用程序插入多重刺激暂停。

10. 发明申请

WO2016033159A1 SYSTEM AND METHOD FOR BRAIN STIMULATION FOR IMPROVEMENT OF MOTOR SYMPTOMS IN PARKINSON'S DISEASE AND OTHER MOVEMENT DISORDERS 审中-公开
标题翻译：用于改善帕金森病和其他运动障碍中的汽车症状的脑刺激的系统和方法
公开(公告)号：WO2016033159A1
公开(公告)日：2016-03-03
申请号：PCT/US2015/046900
申请日：2015-08-26
申请人： THE JOHNS HOPKINS UNIVERSITY
发明人： SHADMEHR, Reza , SALIMPOUR, Yousef , MARI, Zoltan
IPC分类号： A61N1/04 , A61N1/18
CPC分类号： A61N1/36132 , A61N1/20 , A61N1/36025 , A61N1/36067 , A61N1/36103 , A61N1/36125
摘要： An embodiment in accordance with the present invention is directed to a system and device for applying electrical direct current transcranially to the brain that is combined with a behavioral activity consisting of an isometric force production task. The device is non-invasive or implantable and serves to improve motor symptoms in Parkinson's disease (PD) and other movement disorders. During the stimulation, the patient is engaged in a behavioral task using a system consisting of two force transducers and a controller. The patient holds the transducers, one in each hand, and is engaged in a task that requires the brain to assign forces to each arm so that the sum of the forces matches an instructed amount. In an electrode placement specifically for PD, bilateral primary motor cortices are simultaneously stimulated according to a specific algorithm that depends on the forces that the PD affected individual produces in the behavioral task.
摘要翻译：根据本发明的实施例涉及一种用于将电流直流电应用于大脑的系统和装置，其与由等张力生产任务组成的行为活动组合。该装置是非侵入性的或可植入的并且用于改善帕金森病（PD）和其他运动障碍中的运动症状。在刺激期间，患者使用由两个力传感器和控制器组成的系统进行行为任务。患者保持换能器，每只手中的一个，并且从事一项任务，要求大脑将力分配给每个手臂，使得力的总和与指示的量相匹配。在专门用于PD的电极放置中，双侧主动脉皮质同时根据具体的算法进行刺激，该算法取决于受影响个体在行为任务中产生的力。

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