专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2008017055A3 METHODS FOR TREATING NEUROLOGICAL DISORDERS, INCLUDING NEUROPSYCHIATRIC AND NEUROPSYCHOLOGICAL DISORDERS, AND ASSOCIATED SYSTEMS 审中-公开
标题翻译：治疗神经病变的方法，包括神经病学和神经病学疾病及相关系统
公开(公告)号：WO2008017055A3
公开(公告)日：2008-12-18
申请号：PCT/US2007075129
申请日：2007-08-02
申请人： NORTHSTAR NEUROSCIENCE INC , FOWLER BRAD , GLINER BRADFORD EVAN , SHEFIELD W DOUGLAS , SLOAN LEIF R
发明人： FOWLER BRAD , GLINER BRADFORD EVAN , SHEFIELD W DOUGLAS , SLOAN LEIF R
IPC分类号： A61N1/00
CPC分类号： A61N1/36082
摘要： Methods for treating neurological disorders, including neuropsychiatric and neuropsychological disorders, and associated systems are disclosed. One such method includes identifying one or more neural populations, including a cortical target neural population, associated with a neurological condition. The method can further include comparing a patient-specific measure of a characteristic parameter for a selected one of the neural populations with a target measure for the same parameter. If the patient-specific measure differs from the target measure by at least a target amount, the method can include selecting an electrical signal polarity, frequency, or both polarity and frequency based at least in part on the difference between the patient-specific measure and the target measure. The method can further include applying electrical signals to the target neural population at the selected signal polarity, frequency, or both polarity and frequency to reduce the difference between the patient- specific measure and the target measure.
摘要翻译：公开了治疗神经系统疾病，包括神经精神和神经心理障碍以及相关系统的方法。一种这样的方法包括鉴定与神经病症相关的一个或多个神经群体，包括皮质靶神经群体。该方法还可以包括将针对所选择的一个神经群体的特征参数的患者特异性测量与相同参数的目标测量进行比较。如果患者特异性测量与目标测量值不同至少目标量，则该方法可以包括至少部分地基于患者特异性测量值与患者特异性测量值之间的差异来选择电信号极性，频率或极性和频率两者目标措施。该方法还可以包括以选定的信号极性，频率或极性和频率将电信号施加到目标神经群体，以减少患者特异性测量与目标测量之间的差异。

2. 发明申请

WO2007090054A3 SYSTEMS AND METHODS FOR VARYING ELECTROMAGNETIC AND ADJUNCTIVE NEURAL THERAPIES 审中-公开
标题翻译：改变电磁和相关神经治疗的系统和方法
公开(公告)号：WO2007090054A3
公开(公告)日：2009-03-26
申请号：PCT/US2007061125
申请日：2007-01-26
申请人： NORTHSTAR NEUROSCIENCE INC , GLINER BRADFORD EVAN , BALZER JEFFREY , FOWLER BRAD , SLOAN LEIF R
发明人： GLINER BRADFORD EVAN , BALZER JEFFREY , FOWLER BRAD , SLOAN LEIF R
IPC分类号： A61N1/18
CPC分类号： A61N1/36082 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36017 , A61N1/36025 , A61N1/37247
摘要： Systems and methods for varying electromagnetic and adjunctive neural therapies are disclosed. A method in accordance with one embodiment includes applying electromagnetic signals to a target neural population of a patient over a first period of time in accordance with a first mode (e.g., including signal delivery to the central nervous system or peripheral nervous system, via implanted or non-implanted devices). The method can further include applying electromagnetic stimulation to the patient over a second period of time in accordance with a second mode different than the first mode. Varying the mode between the first period of time and second period of time can increase the efficacy and/or longevity of the stimulation. Systems in accordance with other embodiments can support multiple signal delivery devices.
摘要翻译：公开了用于改变电磁和辅助神经疗法的系统和方法。根据一个实施例的方法包括根据第一模式（例如，包括通过植入的或通过植入的中枢神经系统或周围神经系统的信号传递）向第一时间段的患者的目标神经群体施加电磁信号非植入设备）。该方法还可以包括根据与第一模式不同的第二模式在第二时间段内向患者施加电磁刺激。改变第一时间段和第二时间段之间的模式可以增加刺激的功效和/或寿命。根据其他实施例的系统可以支持多个信号传递装置。

3. 发明申请

WO2008073420A3 SYSTEMS AND METHODS FOR TREATING PATIENT HYPERTONICITY 审中-公开
标题翻译：用于治疗患者HYPERONICITY的系统和方法
公开(公告)号：WO2008073420A3
公开(公告)日：2008-10-09
申请号：PCT/US2007025311
申请日：2007-12-11
申请人： NORTHSTAR NEUROSCIENCE INC , GLINER BRADFORD EVAN , FOWLER BRAD , HULVERSHORN JUSTIN , SLOAN LEIF R
发明人： GLINER BRADFORD EVAN , FOWLER BRAD , HULVERSHORN JUSTIN , SLOAN LEIF R
IPC分类号： A61N1/05
CPC分类号： A61N1/36082 , A61N1/0531 , A61N2/006
摘要： Systems and methods for treating patient hypertonicity are disclosed. A method in accordance with one embodiment includes identifying a cortical target neural population associated with hypertonicity in a patient, and reducing or eliminating patient hypertonicity by applying electromagnetic signals to the target neural population. In further particular embodiments, the electromagnetic signals are first electromagnetic signals, and the method can further include reducing or eliminating an additional patient dysfunction by applying second electromagnetic signals.
摘要翻译：公开了用于治疗患者高渗性的系统和方法。根据一个实施例的方法包括：识别与患者中的高渗性相关的皮层目标神经群体;以及通过将电磁信号应用于目标神经群体来减少或消除患者高张性。在进一步的特定实施例中，电磁信号是第一电磁信号，并且该方法还可以包括通过施加第二电磁信号来减少或消除额外的患者功能障碍。

4. 发明申请

WO2005011805A3 APPARATUS AND METHODS FOR APPLYING NEURAL STIMULATION TO A PATIENT 审中-公开
标题翻译：用于向患者施用神经刺激的装置和方法
公开(公告)号：WO2005011805A3
公开(公告)日：2005-10-27
申请号：PCT/US2004025010
申请日：2004-08-02
申请人： NORTHSTAR NEUROSCIENCE INC , FOWLER BRAD , GLINER BRADFORD EVAN
发明人： FOWLER BRAD , GLINER BRADFORD EVAN
IPC分类号： A61N20060101 , A61N1/05 , A61N1/18 , A61N1/36
CPC分类号： A61N1/36082 , A61N1/0531 , A61N1/0539
摘要： Systems and methods for neural stimulation may include a stimulus unit; a first electrode assembly having a first set of contacts; and a second set of contacts. The stimulus unit can be an implantable pulse generator including a first terminal that can be biased at a first signal polarity and a second terminal that can be biased at a second signal polarity. The first electrode assembly includes a support member configured to be placed at the stimulation site, the first set of contacts carried by the support member, and a first lead configured to be attached to the first terminal of the implantable pulse generator for biasing the surface contacts at the first polarity. The second set of contacts is detached from the surface electrode assembly. The second set of contacts can be one or more conductive elements fixed to or forming portions of the implantable pulse generator, or a separate electrode array.
摘要翻译：用于神经刺激的系统和方法可以包括刺激单元; 具有第一组触点的第一电极组件; 和第二组联系人。刺激单元可以是植入式脉冲发生器，其包括可被偏置在第一信号极性的第一端子和可被偏置在第二信号极性的第二端子。第一电极组件包括被配置为放置在刺激部位处的支撑构件，第一组触头由支撑构件承载，第一引线被构造为附接到可植入脉冲发生器的第一端子，用于偏置表面触点在第一极性。第二组触点与表面电极组件分开。第二组触点可以是固定到可植入脉冲发生器或形成可植入脉冲发生器的一部分的一个或多个导电元件，或单独的电极阵列。

5. 发明申请

WO2007121133A3 ELECTROMAGNETIC STIMULATION FOR TISSUE AFFECTED BY NEURONAL DYSFUNCTION, DEGRADATION, DAMAGE, AND/OR NECROSIS 审中-公开
标题翻译：由神经功能丧失，降解，损伤和/或坏死影响的组织的电磁刺激
公开(公告)号：WO2007121133A3
公开(公告)日：2008-06-26
申请号：PCT/US2007066220
申请日：2007-04-09
申请人： NORTHSTAR NEUROSCIENCE INC , FOWLER BRAD , GLINER BRADFORD EVAN , HIMES DAVID
发明人： FOWLER BRAD , GLINER BRADFORD EVAN , HIMES DAVID
IPC分类号： A61N2/04
CPC分类号： A61N2/006 , A61N1/36017 , A61N1/36025 , A61N1/36082
摘要： Electromagnetic signal delivery for tissue affected by neuronal dysfunction, degradation, damage, and/or necrosis, and associated systems and methods are disclosed. A method in accordance with one embodiment of the invention includes identifying an affected region, with the affected region including neuronal tissue that, at least during a pre-dysfunctional period, was in neural communication with neuronal tissue in a dysfunctional region. The affected tissue can be functionally adversely affected by neuronal dysfunction in the dysfunctional region. The method can further include applying electromagnetic signals to the neuronal tissue in the affected region. For example, the electromagnetic signals can be applied to a hypo-active neural region that is not physically damaged, and has been identified as likely to recover at least in part as a result of electromagnetic signals. Signals can be applied at sub-threshold levels to cortical and/or subcortical regions.
摘要翻译：公开了由神经元功能障碍，降解，损伤和/或坏死以及相关系统和方法影响的组织的电磁信号传递。根据本发明的一个实施例的方法包括识别受影响的区域，其中受影响的区域包括神经元组织，至少在功能失调之前期间，与功能障碍区域中的神经元组织进行神经交流。受影响的组织可能在功能障碍区域的神经元功能障碍中受功能不良的影响。该方法还可以包括将电磁信号应用于受影响区域中的神经元组织。例如，电磁信号可以应用于没有物理损坏的低活性神经区域，并且已被鉴定为可能至少部分地由于电磁信号而恢复。信号可以在亚阈值水平应用于皮层和/或皮质下区域。

6. 发明申请

WO2006053114A3 ELECTRODE CONFIGURATIONS FOR REDUCING INVASIVENESS AND /OR ENHANCING NEURAL STIMULATION EFFICACY, AND ASSOCIATED METHODS 审中-公开
标题翻译：用于减少入侵和/或增强神经刺激效能的电极配置及相关方法
公开(公告)号：WO2006053114A3
公开(公告)日：2006-10-05
申请号：PCT/US2005040714
申请日：2005-11-10
申请人： NORTHSTAR NEUROSCIENCE INC , FOWLER BRAD , GLINER BRADFORD EVAN
发明人： FOWLER BRAD , GLINER BRADFORD EVAN
IPC分类号： A61N1/08 , A61N1/10 , A61N1/20 , A61N1/32 , A61N1/34 , A61N1/40
CPC分类号： A61N1/0529 , A61N1/0531 , A61N1/36017 , A61N1/36082
摘要： Electrode configurations for reducing invasiveness and/or enhancing neural stimulation efficacy, and associated methods, are disclosed. A method in accordance with one embodiment of the invention for treating a brain disorder includes identifying a target neural structure within a patient's skull and implanting an electrode device within the patient's skull so that an axis that is generally normal to the skull proximate to the electrode device and that passes through at least one electrical contact of the electrode device is offset from the target neural structure. The method further includes stimulating the target neural structure by applying an electrical signal to the at least one electrical contact. In particular embodiments, the electrode device can be positioned between, along, across, or adjacent to a fissure, recess, groove, and/or vascular structure of the patient's brain.
摘要翻译：公开了用于降低侵入性和/或增强神经刺激功效的电极配置及相关方法。根据用于治疗脑疾病的本发明的一个实施例的方法包括识别患者颅骨内的目标神经结构并将电极装置植入患者的颅骨内，使得通常垂直于颅骨的靠近电极装置的轴线并且通过电极装置的至少一个电接触偏离目标神经结构。该方法还包括通过向至少一个电触点施加电信号来刺激目标神经结构。在特定实施例中，电极装置可以位于患者大脑的裂缝，凹槽，凹槽和/或血管结构之间，沿着，横过或相邻。

7. 发明申请

WO03035163A3 METHODS AND APPARATUS FOR EFFECTUATING A LASTING CHANGE IN A NEURAL-FUNCTION OF A PATIENT 审中-公开
标题翻译：用于实现患者的神经功能的持续变化的方法和设备
公开(公告)号：WO03035163A3
公开(公告)日：2003-09-18
申请号：PCT/US0231127
申请日：2002-09-27
申请人： VERTIS NEUROSCIENCE INC , GLINER BRADFORD EVAN , FOWLER BRAD , FIRLIK ANDREW D , BALZER JEFFREY , LEVY ALAN J
发明人： GLINER BRADFORD EVAN , FOWLER BRAD , FIRLIK ANDREW D , BALZER JEFFREY , LEVY ALAN J
IPC分类号： A61N1/05 , A61N1/36
CPC分类号： A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36017 , A61N1/3605 , A61N1/36082 , A61N1/36103 , A61N1/3756
摘要： The following disclosure describes several methods and apparatus for intracranial electrical stimulation to treat or otherwise effectuate a change in neural-functions of a patient. Certain embodiments of methods in accordance with the invention electrically stimulate the brain at a stimulation site where neuroplasticity is occurring or is expected to occur. The stimulation site may be different than the region in the brain where neural activity is typically present to perform the particular neural function according to the functional organization of the brain. In one embodiment in which neuroplasticity related to the neural-function occurs in the brain, the method can include identifying the location where such neuroplasticity is present or expected to occur. In an alternative embodiment in which neuroplasticity is not occurring in the brain, an alternative aspect is to induce neuroplasticity at a stimulation site where it is expected to occur. Several embodiments of these methods that are expected to produce a lasting effect on the intended neural activity at the stimulation site use electrical pulses that increase the resting membrane potential of neurons at the stimulation site to a subthreshold level.
摘要翻译：以下公开描述了用于治疗或以其他方式实现患者的神经功能改变的颅内电刺激的若干方法和装置。根据本发明的方法的某些实施例在神经可塑性正在发生或预期发生的刺激部位电刺激大脑。刺激部位可以不同于大脑中存在神经活动以根据大脑的功能组织执行特定神经功能的区域。在其中与神经功能相关的神经可塑性发生在脑中的一个实施例中，该方法可以包括识别存在或预期发生这种神经可塑性的位置。在脑中没有发生神经可塑性的替代实施方式中，可选择的方面是在预期发生的刺激部位诱导神经可塑性。预期这些方法的几个实施方案对刺激部位处的预期神经活动产生持久效应使用电刺激，其将刺激部位处神经元的静息膜电位增加至亚阈值水平。

8. 发明申请

WO2006053143A3 ELECTRICAL TREATMENT OF MOVEMENT DISORDERS 审中-公开
标题翻译：电动治疗运动障碍
公开(公告)号：WO2006053143A3
公开(公告)日：2007-04-26
申请号：PCT/US2005040777
申请日：2005-11-10
申请人： NORTHSTAR NEUROSCIENCE INC , WYLER ALLEN , FOWLER BRAD
发明人： WYLER ALLEN , FOWLER BRAD
IPC分类号： A61N1/00
CPC分类号： A61N1/36067 , A61N1/0531 , A61N1/0534
摘要： Methods and systems for treating movement disorders are disclosed. A method in accordance with one embodiment can include determining that the movement disorder affects the patient's gait, oral functioning, and/or other functioning, and applying electrical stimulation proximate to the interhemispheric fissure, the Sylvian fissure, or between the two fissures, respectively. In another embodiment, the method can include selecting at least one neural process from among a plurality of processes sequentially carried out by a patient to cause a muscle movement in the patient (e.g., a planning process, an initiation process, and an execution process), and applying electrical stimulation to a location of the patient's brain associated with the at least one neural process.
摘要翻译：公开了用于治疗运动障碍的方法和系统。根据一个实施例的方法可以包括确定运动障碍影响患者的步态，口腔功能和/或其他功能，以及分别在大脑间裂隙，西尔维亚裂缝或两个裂缝之间施加电刺激。在另一个实施例中，该方法可以包括从由患者依次执行的多个进程中选择至少一个神经过程以引起患者的肌肉运动（例如，计划过程，发起过程和执行过程）并且将电刺激施加到与所述至少一个神经过程相关联的患者脑部的位置。

9. 发明申请

WO2006019764A3 SYSTEMS AND METHODS FOR ENHANCING OR AFFECTING NEURAL STIMULATION EFFICIENCY AND/OR EFFICACY 审中-公开
标题翻译：用于增强或影响神经刺激效率和/或功效的系统和方法
公开(公告)号：WO2006019764A3
公开(公告)日：2006-12-07
申请号：PCT/US2005024766
申请日：2005-07-15
申请人： NORTHSTAR NEUROSCIENCE INC , GLINER BRADFORD , WYLER ALLEN , FOWLER BRAD , SHEFFIELD DOUGLAS W , KUNTZ RICHARD , LEYDE KENT
发明人： GLINER BRADFORD , WYLER ALLEN , FOWLER BRAD , SHEFFIELD DOUGLAS W , KUNTZ RICHARD , LEYDE KENT
IPC分类号： A61N1/06
CPC分类号： A61N1/36135 , A61N1/0531 , A61N1/0534 , A61N1/3606 , A61N1/36064 , A61N1/36067 , A61N1/36082 , A61N1/36103 , A61N1/36146 , A61N1/37252
摘要： Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy are disclosed. In one embodiment, a system and/or method may apply electromagnetic stimulation to a patient's nervous system over a first time domain according to a first set of stimulation parameters, and over a second time domain according to a second set of stimulation parameters. The first and second time domains may be sequential, simultaneous, or nested. Stimulation parameters may vary in accordance with one or more types of duty cycle, amplitude, pulse repetition frequency, pulse width, spatiotemporal, and/or polarity variations. Stimulation may be applied at subthreshold, threshold, and/or suprathreshold levels in one or more periodic, aperiodic (e.g., chaotic), and/or pseudo-random manners. In some embodiments stimulation may comprise a burst pattern having an interburst frequency corresponding to an intrinsic brainwave frequency, and regular and/or varying intraburst stimulation parameters. Stimulation signals providing reduced power consumption with at least adequate symptomatic relief may be applied prior to moderate or significant power source depletion.
摘要翻译：公开了用于增强或影响神经刺激效率和/或功效的系统和方法。在一个实施例中，系统和/或方法可以根据第一组刺激参数在第一时域上将电磁刺激应用于患者的神经系统，并且根据第二组刺激参数在第二时域上应用电磁刺激。第一和第二时间域可以是顺序的，同时的或嵌套的。刺激参数可以根据一种或多种类型的占空比，幅度，脉冲重复频率，脉冲宽度，时空和/或极性变化而变化。刺激可以以一个或多个周期性，非周期性（例如混沌）和/或伪随机方式在亚阈值，阈值和/或超阈值水平应用。在一些实施例中，刺激可以包括具有对应于内在脑波频率的内爆频率的突发模式，以及规则和/或变化的内爆刺激参数。在适度或显着的电源耗尽之前可以应用提供至少充分症状缓解的减少功率消耗的刺激信号。

10. 发明申请

WO2006019766A3 METHODS AND SYSTEMS FOR INTRACRANIAL NEUROSTIMULATION AND/OR SENSING 审中-公开
标题翻译：用于颅内神经刺激和/或感测的方法和系统
公开(公告)号：WO2006019766A3
公开(公告)日：2006-12-07
申请号：PCT/US2005024768
申请日：2005-07-15
申请人： NORTHSTAR NEUROSCIENCE INC , LOWRY MD DAVID WARREN , FOWLER BRAD , THOMPSON GENE
发明人： LOWRY MD DAVID WARREN , FOWLER BRAD , THOMPSON GENE
IPC分类号： A61N1/05
CPC分类号： A61N1/0539 , A61N1/0531 , A61N1/0534 , A61N1/36017 , A61N1/36025 , A61N1/375
摘要： Methods and systems for intracranial neurostimulation and/or sensing are disclosed. An intracranial signal transmission system in accordance with an embodiment of the invention includes a generally electrically insulating support body having a head portion configured to be positioned at least proximate to an outer surface of a patient's skull, and a shaft portion configured to extend into an aperture in the patient's skull. The system can further include at least one electrical contact portion carried by the support body. The at least one electrical contact portion can be positioned to transfer electrical signals to, from, or both to and from the patient's brain via the aperture in the patient's skull.
摘要翻译：公开了用于颅内神经刺激和/或感测的方法和系统。根据本发明的一个实施例的颅内信号传输系统包括：大致电绝缘的支撑体，其具有配置成至少靠近患者颅骨的外表面定位的头部;以及轴部分，其构造成延伸到孔中在病人的头骨。该系统还可以包括由支撑体携带的至少一个电接触部分。所述至少一个电接触部分可以被定位成经由患者颅骨中的孔向患者大脑传递去往和来自患者大脑的电信号。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式