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1. 发明申请

WO2007121133A3 ELECTROMAGNETIC STIMULATION FOR TISSUE AFFECTED BY NEURONAL DYSFUNCTION, DEGRADATION, DAMAGE, AND/OR NECROSIS 审中-公开
标题翻译：由神经功能丧失，降解，损伤和/或坏死影响的组织的电磁刺激
公开(公告)号：WO2007121133A3
公开(公告)日：2008-06-26
申请号：PCT/US2007066220
申请日：2007-04-09
申请人： NORTHSTAR NEUROSCIENCE INC , FOWLER BRAD , GLINER BRADFORD EVAN , HIMES DAVID
发明人： FOWLER BRAD , GLINER BRADFORD EVAN , HIMES DAVID
IPC分类号： A61N2/04
CPC分类号： A61N2/006 , A61N1/36017 , A61N1/36025 , A61N1/36082
摘要： Electromagnetic signal delivery for tissue affected by neuronal dysfunction, degradation, damage, and/or necrosis, and associated systems and methods are disclosed. A method in accordance with one embodiment of the invention includes identifying an affected region, with the affected region including neuronal tissue that, at least during a pre-dysfunctional period, was in neural communication with neuronal tissue in a dysfunctional region. The affected tissue can be functionally adversely affected by neuronal dysfunction in the dysfunctional region. The method can further include applying electromagnetic signals to the neuronal tissue in the affected region. For example, the electromagnetic signals can be applied to a hypo-active neural region that is not physically damaged, and has been identified as likely to recover at least in part as a result of electromagnetic signals. Signals can be applied at sub-threshold levels to cortical and/or subcortical regions.
摘要翻译：公开了由神经元功能障碍，降解，损伤和/或坏死以及相关系统和方法影响的组织的电磁信号传递。根据本发明的一个实施例的方法包括识别受影响的区域，其中受影响的区域包括神经元组织，至少在功能失调之前期间，与功能障碍区域中的神经元组织进行神经交流。受影响的组织可能在功能障碍区域的神经元功能障碍中受功能不良的影响。该方法还可以包括将电磁信号应用于受影响区域中的神经元组织。例如，电磁信号可以应用于没有物理损坏的低活性神经区域，并且已被鉴定为可能至少部分地由于电磁信号而恢复。信号可以在亚阈值水平应用于皮层和/或皮质下区域。

2. 发明申请

WO2007090054A3 SYSTEMS AND METHODS FOR VARYING ELECTROMAGNETIC AND ADJUNCTIVE NEURAL THERAPIES 审中-公开
标题翻译：改变电磁和相关神经治疗的系统和方法
公开(公告)号：WO2007090054A3
公开(公告)日：2009-03-26
申请号：PCT/US2007061125
申请日：2007-01-26
申请人： NORTHSTAR NEUROSCIENCE INC , GLINER BRADFORD EVAN , BALZER JEFFREY , FOWLER BRAD , SLOAN LEIF R
发明人： GLINER BRADFORD EVAN , BALZER JEFFREY , FOWLER BRAD , SLOAN LEIF R
IPC分类号： A61N1/18
CPC分类号： A61N1/36082 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/36017 , A61N1/36025 , A61N1/37247
摘要： Systems and methods for varying electromagnetic and adjunctive neural therapies are disclosed. A method in accordance with one embodiment includes applying electromagnetic signals to a target neural population of a patient over a first period of time in accordance with a first mode (e.g., including signal delivery to the central nervous system or peripheral nervous system, via implanted or non-implanted devices). The method can further include applying electromagnetic stimulation to the patient over a second period of time in accordance with a second mode different than the first mode. Varying the mode between the first period of time and second period of time can increase the efficacy and/or longevity of the stimulation. Systems in accordance with other embodiments can support multiple signal delivery devices.
摘要翻译：公开了用于改变电磁和辅助神经疗法的系统和方法。根据一个实施例的方法包括根据第一模式（例如，包括通过植入的或通过植入的中枢神经系统或周围神经系统的信号传递）向第一时间段的患者的目标神经群体施加电磁信号非植入设备）。该方法还可以包括根据与第一模式不同的第二模式在第二时间段内向患者施加电磁刺激。改变第一时间段和第二时间段之间的模式可以增加刺激的功效和/或寿命。根据其他实施例的系统可以支持多个信号传递装置。

3. 发明申请

WO2008017055A3 METHODS FOR TREATING NEUROLOGICAL DISORDERS, INCLUDING NEUROPSYCHIATRIC AND NEUROPSYCHOLOGICAL DISORDERS, AND ASSOCIATED SYSTEMS 审中-公开
标题翻译：治疗神经病变的方法，包括神经病学和神经病学疾病及相关系统
公开(公告)号：WO2008017055A3
公开(公告)日：2008-12-18
申请号：PCT/US2007075129
申请日：2007-08-02
申请人： NORTHSTAR NEUROSCIENCE INC , FOWLER BRAD , GLINER BRADFORD EVAN , SHEFIELD W DOUGLAS , SLOAN LEIF R
发明人： FOWLER BRAD , GLINER BRADFORD EVAN , SHEFIELD W DOUGLAS , SLOAN LEIF R
IPC分类号： A61N1/00
CPC分类号： A61N1/36082
摘要： Methods for treating neurological disorders, including neuropsychiatric and neuropsychological disorders, and associated systems are disclosed. One such method includes identifying one or more neural populations, including a cortical target neural population, associated with a neurological condition. The method can further include comparing a patient-specific measure of a characteristic parameter for a selected one of the neural populations with a target measure for the same parameter. If the patient-specific measure differs from the target measure by at least a target amount, the method can include selecting an electrical signal polarity, frequency, or both polarity and frequency based at least in part on the difference between the patient-specific measure and the target measure. The method can further include applying electrical signals to the target neural population at the selected signal polarity, frequency, or both polarity and frequency to reduce the difference between the patient- specific measure and the target measure.
摘要翻译：公开了治疗神经系统疾病，包括神经精神和神经心理障碍以及相关系统的方法。一种这样的方法包括鉴定与神经病症相关的一个或多个神经群体，包括皮质靶神经群体。该方法还可以包括将针对所选择的一个神经群体的特征参数的患者特异性测量与相同参数的目标测量进行比较。如果患者特异性测量与目标测量值不同至少目标量，则该方法可以包括至少部分地基于患者特异性测量值与患者特异性测量值之间的差异来选择电信号极性，频率或极性和频率两者目标措施。该方法还可以包括以选定的信号极性，频率或极性和频率将电信号施加到目标神经群体，以减少患者特异性测量与目标测量之间的差异。

4. 发明申请

WO2008073420A3 SYSTEMS AND METHODS FOR TREATING PATIENT HYPERTONICITY 审中-公开
标题翻译：用于治疗患者HYPERONICITY的系统和方法
公开(公告)号：WO2008073420A3
公开(公告)日：2008-10-09
申请号：PCT/US2007025311
申请日：2007-12-11
申请人： NORTHSTAR NEUROSCIENCE INC , GLINER BRADFORD EVAN , FOWLER BRAD , HULVERSHORN JUSTIN , SLOAN LEIF R
发明人： GLINER BRADFORD EVAN , FOWLER BRAD , HULVERSHORN JUSTIN , SLOAN LEIF R
IPC分类号： A61N1/05
CPC分类号： A61N1/36082 , A61N1/0531 , A61N2/006
摘要： Systems and methods for treating patient hypertonicity are disclosed. A method in accordance with one embodiment includes identifying a cortical target neural population associated with hypertonicity in a patient, and reducing or eliminating patient hypertonicity by applying electromagnetic signals to the target neural population. In further particular embodiments, the electromagnetic signals are first electromagnetic signals, and the method can further include reducing or eliminating an additional patient dysfunction by applying second electromagnetic signals.
摘要翻译：公开了用于治疗患者高渗性的系统和方法。根据一个实施例的方法包括：识别与患者中的高渗性相关的皮层目标神经群体;以及通过将电磁信号应用于目标神经群体来减少或消除患者高张性。在进一步的特定实施例中，电磁信号是第一电磁信号，并且该方法还可以包括通过施加第二电磁信号来减少或消除额外的患者功能障碍。

5. 发明申请

WO2005011805A3 APPARATUS AND METHODS FOR APPLYING NEURAL STIMULATION TO A PATIENT 审中-公开
标题翻译：用于向患者施用神经刺激的装置和方法
公开(公告)号：WO2005011805A3
公开(公告)日：2005-10-27
申请号：PCT/US2004025010
申请日：2004-08-02
申请人： NORTHSTAR NEUROSCIENCE INC , FOWLER BRAD , GLINER BRADFORD EVAN
发明人： FOWLER BRAD , GLINER BRADFORD EVAN
IPC分类号： A61N20060101 , A61N1/05 , A61N1/18 , A61N1/36
CPC分类号： A61N1/36082 , A61N1/0531 , A61N1/0539
摘要： Systems and methods for neural stimulation may include a stimulus unit; a first electrode assembly having a first set of contacts; and a second set of contacts. The stimulus unit can be an implantable pulse generator including a first terminal that can be biased at a first signal polarity and a second terminal that can be biased at a second signal polarity. The first electrode assembly includes a support member configured to be placed at the stimulation site, the first set of contacts carried by the support member, and a first lead configured to be attached to the first terminal of the implantable pulse generator for biasing the surface contacts at the first polarity. The second set of contacts is detached from the surface electrode assembly. The second set of contacts can be one or more conductive elements fixed to or forming portions of the implantable pulse generator, or a separate electrode array.
摘要翻译：用于神经刺激的系统和方法可以包括刺激单元; 具有第一组触点的第一电极组件; 和第二组联系人。刺激单元可以是植入式脉冲发生器，其包括可被偏置在第一信号极性的第一端子和可被偏置在第二信号极性的第二端子。第一电极组件包括被配置为放置在刺激部位处的支撑构件，第一组触头由支撑构件承载，第一引线被构造为附接到可植入脉冲发生器的第一端子，用于偏置表面触点在第一极性。第二组触点与表面电极组件分开。第二组触点可以是固定到可植入脉冲发生器或形成可植入脉冲发生器的一部分的一个或多个导电元件，或单独的电极阵列。

6. 发明申请

WO2006053114A3 ELECTRODE CONFIGURATIONS FOR REDUCING INVASIVENESS AND /OR ENHANCING NEURAL STIMULATION EFFICACY, AND ASSOCIATED METHODS 审中-公开
标题翻译：用于减少入侵和/或增强神经刺激效能的电极配置及相关方法
公开(公告)号：WO2006053114A3
公开(公告)日：2006-10-05
申请号：PCT/US2005040714
申请日：2005-11-10
申请人： NORTHSTAR NEUROSCIENCE INC , FOWLER BRAD , GLINER BRADFORD EVAN
发明人： FOWLER BRAD , GLINER BRADFORD EVAN
IPC分类号： A61N1/08 , A61N1/10 , A61N1/20 , A61N1/32 , A61N1/34 , A61N1/40
CPC分类号： A61N1/0529 , A61N1/0531 , A61N1/36017 , A61N1/36082
摘要： Electrode configurations for reducing invasiveness and/or enhancing neural stimulation efficacy, and associated methods, are disclosed. A method in accordance with one embodiment of the invention for treating a brain disorder includes identifying a target neural structure within a patient's skull and implanting an electrode device within the patient's skull so that an axis that is generally normal to the skull proximate to the electrode device and that passes through at least one electrical contact of the electrode device is offset from the target neural structure. The method further includes stimulating the target neural structure by applying an electrical signal to the at least one electrical contact. In particular embodiments, the electrode device can be positioned between, along, across, or adjacent to a fissure, recess, groove, and/or vascular structure of the patient's brain.
摘要翻译：公开了用于降低侵入性和/或增强神经刺激功效的电极配置及相关方法。根据用于治疗脑疾病的本发明的一个实施例的方法包括识别患者颅骨内的目标神经结构并将电极装置植入患者的颅骨内，使得通常垂直于颅骨的靠近电极装置的轴线并且通过电极装置的至少一个电接触偏离目标神经结构。该方法还包括通过向至少一个电触点施加电信号来刺激目标神经结构。在特定实施例中，电极装置可以位于患者大脑的裂缝，凹槽，凹槽和/或血管结构之间，沿着，横过或相邻。

7. 发明申请

WO2007121129A3 SYSTEM AND METHODS FOR APPLYING SIGNALS TO NEURAL POPULATIONS 审中-公开
标题翻译：将信号应用于神经人口的系统和方法
公开(公告)号：WO2007121129A3
公开(公告)日：2008-07-03
申请号：PCT/US2007066213
申请日：2007-04-09
申请人： NORTHSTAR NEUROSCIENCE INC , PASCUAL-LEONE ALVARO , GLINER BRADFORD EVAN , HIMES DAVID , SLOAN LEIF R
发明人： PASCUAL-LEONE ALVARO , GLINER BRADFORD EVAN , HIMES DAVID , SLOAN LEIF R
IPC分类号： A61N1/00 , A61B5/05 , G06N3/12
CPC分类号： A61N1/36171 , A61N1/36082 , A61N1/36103 , A61N1/3615
摘要： Systems and methods for applying signals, including contralesional electromagnetic signals, to neural populations, are disclosed. A particular method can be directed to treating a patient having a subject neural population in a first (e.g., ipsilesional) hemisphere of the brain, with the subject neural population having, or previously having, a functionality capable of being improved. The method can include directing an application of electromagnetic signals at least proximate to a target neural population at a second (e.g., contralesional) hemisphere of the brain to at least constrain a functionality of the target neural population, which has transcallosal communication with the first hemisphere.
摘要翻译：公开了将信号（包括对数电磁信号）应用于神经群体的系统和方法。具体方法可以涉及在脑的第一（例如ipsilesional）半球中治疗具有受试者神经群体的患者，其中受试者神经群体具有或预先具有能够改善的功能。该方法可以包括将电磁信号的应用引导至少接近于脑的第二（例如，对抗性）半球处的目标神经群体，以至少约束目标神经群体的功能，其与第一半球具有蜕皮通讯。

8. 发明申请

WO2004036765A3 NEURAL STIMULATION SYSTEM AND METHOD RESPONSIVE TO COLLATERAL NEURAL ACTIVITY 审中-公开
标题翻译：神经刺激系统和方法对孤立性神经活动的反应
公开(公告)号：WO2004036765A3
公开(公告)日：2005-03-03
申请号：PCT/US0332599
申请日：2003-10-15
申请人： NORTHSTAR NEUROSCIENCE INC , GLINER BRADFORD EVAN
发明人： GLINER BRADFORD EVAN
IPC分类号： A61B5/0484 , A61B5/0488 , A61B5/11 , A61N1/05 , A61N1/34 , A61N1/36 , A61N1/375 , A61N1/10 , A61N1/08 , A61N1/18 , A61N1/20 , A61N1/32
CPC分类号： A61N1/36185 , A61B5/0484 , A61B5/0488 , A61B5/1104 , A61B5/4094 , A61N1/0531 , A61N1/0534 , A61N1/0551 , A61N1/0553 , A61N1/36017 , A61N1/36025 , A61N1/36071 , A61N1/36082 , A61N1/375 , A61N1/3756
摘要： A neural stimulation system responsive to collateral neural activity that may arise in association with a neural stimulation procedure includes a stimulation interface configured to deliver stimulation signals to a target neural population, a monitoring interface positioned to receive signals corresponding to a neural activity within the target neural population, a stimulus unit coupled to deliver stimulation singals to the stimulation interface, and a sensing unit coupled to the monitoring device and the stimulus unit. The neural stimulation procedure may be directed toward rehabilitating, restoring, and/or enhancing one or more neural functions by facilitating and/or effectuating a neuroplastic change or reorganization; and/or affecting a neurological condition that exists on a continuous or essentially continuous basis absent the stimulation procedure. The sensing unit determines whether evidence of an collateral neural activity exists, whereupon the stimulus unit attempts to abate the collateral neural activity.
摘要翻译：响应于与神经刺激过程相关联的附带神经活动的神经刺激系统包括被配置为将刺激信号传递到目标神经群体的刺激界面，定位成接收对应于目标神经元内的神经活动的信号的监测界面人口，耦合以将刺激信号传递到刺激界面的刺激单元，以及耦合到监视设备和刺激单元的感测单元。神经刺激过程可以通过促进和/或实现神经损伤的改变或重组而针对康复，恢复和/或增强一个或多个神经功能; 和/或影响在没有刺激过程的情况下以连续或基本连续的方式存在的神经病症。感知单元确定是否存在附带神经活动的证据，因此刺激单位试图减轻旁路神经活动。

9. 发明申请

WO2007047852A3 SYSTEMS AND METHODS FOR PATIENT INTERACTIVE NEURAL STIMULATION AND/OR CHEMICAL SUBSTANCE DELIVERY 审中-公开
标题翻译：用于患者交互神经刺激和/或化学物质递送的系统和方法
公开(公告)号：WO2007047852A3
公开(公告)日：2007-11-29
申请号：PCT/US2006040908
申请日：2006-10-18
申请人： NORTHSTAR NEUROSCIENCE INC , FIRLIK ANDREW D , GLINER BRADFORD EVAN , SHEFFIELD W DOUGLAS , SLOAN LEIF R
发明人： FIRLIK ANDREW D , GLINER BRADFORD EVAN , SHEFFIELD W DOUGLAS , SLOAN LEIF R
IPC分类号： A61N1/00
CPC分类号： A61N1/36067 , A61B5/16 , A61B5/18 , A61B5/7275 , A61F2002/704 , A61M5/14276 , A61M5/1723 , A61M2205/05 , A61M2205/50 , A61M2230/63 , A61N1/0531 , A61N1/36003 , A61N1/36014 , A61N1/36017 , A61N1/36025 , A61N1/36082 , A61N1/361 , A61N1/36103 , A61N1/36139 , A61N1/372 , G06F19/3481
摘要： Systems and methods for patient interactive neural stimulation and/or chemical substance delivery are disclosed. A method in accordance with one embodiment of the invention includes affecting a target neural population of the patient by providing to the patient at least one of an electromagnetic signal and a chemical substance. The method can further include detecting at least one characteristic of the patient, with the characteristic at least correlated with the patient's performance of an adjunctive therapy task that is performed in association with affecting the target neural population. The method can still further include controlling at least one parameter in accordance with which the target neural population is affected, based at least in part on the detected characteristic.
摘要翻译：公开了用于患者交互式神经刺激和/或化学物质递送的系统和方法。根据本发明的一个实施例的方法包括通过向患者提供电磁信号和化学物质中的至少一个来影响患者的目标神经群体。该方法还可以包括检测患者的至少一个特征，其特征至少与患者执行与影响目标神经群体相关联的辅助治疗任务的执行相关。该方法还可以进一步包括至少部分地基于所检测到的特征来控制与目标神经群体受影响相关的至少一个参数。

10. 发明申请

WO2005002664A2 METHODS AND APPARATUS FOR EFFECTUATING A LASTING CHANGE IN A NEURAL-FUNCTION OF A PATIENT 审中-公开
标题翻译：用于实现患者的神经功能的持续变化的方法和设备
公开(公告)号：WO2005002664A2
公开(公告)日：2005-01-13
申请号：PCT/US2004020398
申请日：2004-06-24
申请人： NORTHSTAR NEUROSCIENCE INC , FIRLIK ANDREW D , BALZER JEFFREY , GLINER BRADFORD EVAN , LEVY ALAN J
发明人： FIRLIK ANDREW D , BALZER JEFFREY , GLINER BRADFORD EVAN , LEVY ALAN J
IPC分类号： A61N20060101 , A61N1/05 , A61N1/08 , A61N1/18 , A61N1/34 , A61N1/36 , A61N1/375 , A61N
CPC分类号： A61N1/36017 , A61N1/0531 , A61N1/0534 , A61N1/0539 , A61N1/08 , A61N1/36021 , A61N1/36025 , A61N1/36071 , A61N1/36082 , A61N1/36103 , A61N1/3756
摘要： Methods and apparatus for treating an impaired neural function in a brain of a patient. In one embodiment, a method for treating a neural function in a brain of a patient includes determining a therapy period during which a plurality of therapy sessions are to be performed to recover functional ability corresponding to the neural function. The method continues by identifying a stimulation site in or on the brain of the patient associated with the neural function, and positioning an electrode at least proximate to the identified stimulation site. The patient is then treated by providing electrical stimulation treatments to the stimulation site. The treatment can comprise delivering electrical stimulation signals to the electrode during the therapy sessions. After expiration of the therapy period, the method includes preventing electrical stimulation signals from being delivered to the stimulation site.
摘要翻译：用于治疗患者脑中受损的神经功能的方法和设备。在一个实施方案中，用于治疗患者脑中的神经功能的方法包括确定治疗期，在该治疗期期间将执行多个治疗期以恢复对应于神经功能的功能性能力。该方法通过识别与神经功能相关的患者大脑中或其上的刺激位点并将电极至少靠近识别的刺激位点定位。然后通过向刺激部位提供电刺激治疗来治疗患者。治疗可以包括在治疗期间将电刺激信号传递到电极。治疗期结束后，该方法包括防止电刺激信号传递到刺激部位。

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