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1. 发明申请

WO2017078819A3 CUFF ELECTRODE WITH LYSING AGENT 审中-公开
标题翻译： CUFF电极与溶剂
公开(公告)号：WO2017078819A3
公开(公告)日：2017-07-13
申请号：PCT/US2016046802
申请日：2016-08-12
申请人： UNIV SOUTHERN CALIFORNIA , HUNTINGTON MEDICAL RES INST
发明人： MENG ELLIS , PIKOV VICTOR
IPC分类号： A61N1/05 , A61M5/14
CPC分类号： A61N1/0556 , A61B5/04001 , A61B5/6877 , A61B2562/125
摘要： A new class of peripheral nerve interfaces that combines microfluidics with microelectronics. A peripheral nerve interface that allows intraneural targeting through the combined use and sequential application of lysing agents and neurotrophic factors.
摘要翻译：一类将微流体与微电子相结合的外周神经接口。外周神经界面，通过裂解剂和神经营养因子的联合使用和顺序应用，允许神经内靶向。

2. 发明申请

WO2010096651A2 DRUG DELIVERY DEVICE WITH IN-PLANE BANDPASS REGULATION CHECK VALVE IN HEAT-SHRINK PACKAGING 审中-公开
标题翻译：具有平面内压力调节装置的药物输送装置在热收缩包装中检查阀
公开(公告)号：WO2010096651A2
公开(公告)日：2010-08-26
申请号：PCT/US2010024730
申请日：2010-02-19
申请人： UNIV SOUTHERN CALIFORNIA , MENG ELLIS , MANN RONALEE LO
发明人： MENG ELLIS , MANN RONALEE LO
IPC分类号： A61M37/00 , A61M5/14 , A61M31/00 , A61M39/22
CPC分类号： A61M5/00 , A61F9/0017 , A61M5/14276 , A61M5/16881 , A61M2039/2413 , A61M2039/242 , A61M2210/0612
摘要： A drug delivery device may include a drug reservoir configured to contain and controllably deliver a fluidic drug. A tube may be configured to deliver the fluid from the drug reservoir through a lumen in the tube to another location. A valve wholly within the lumen of the tube may regulates the flow of the fluid through the tube without substantially diverting the direction in which the fluid flows through the tube. The valve may contain only a single member which moves during operation of the valve. The valve may be configured to regulate the flow of fluid in a bandpass manner by allowing fluid to flow through the valve only when the pressure of the fluid is above a minimum and below a maximum. The valve may be held in place within the tube solely by frictional force between the valve and a wall of the tube.
摘要翻译：药物递送装置可以包括被配置为容纳和可控地递送流体药物的药物储存器。管可以被配置成将来自药物储存器的流体通过管中的管腔输送到另一位置。完全在管腔中的阀可以调节流体通过管的流动，而不会使流体流过管的方向基本上转向。阀可以仅包含在阀操作期间移动的单个构件。阀可以被配置为通过仅当流体的压力高于最小值并且低于最大值时允许流体流过阀门才能以带通方式调节流体的流动。阀可以仅通过阀和管壁之间的摩擦力保持在管内的适当位置。

3. 发明申请

WO2011119886A3 MICROELECTROMECHANICAL (MEMS) PRESSURE TRANSDUCER 审中-公开
标题翻译：微电子（MEMS）压力传感器
公开(公告)号：WO2011119886A3
公开(公告)日：2012-04-19
申请号：PCT/US2011029866
申请日：2011-03-24
申请人： UNIV SOUTHERN CALIFORNIA , GUTIERREZ CHRISTIAN A , MENG ELLIS
发明人： GUTIERREZ CHRISTIAN A , MENG ELLIS
IPC分类号： G01L7/18 , B81B1/00 , G01L7/00 , G01L9/00
CPC分类号： G01L11/00 , G01L11/02 , G01L11/04 , Y10T29/49002
摘要： A pressure transducer for measuring pressure may include an all-polymer chamber that has no dimension greater than 1 mm. There may be fluid within the chamber, a gaseous bubble trapped within the fluid, and electrodes in contact with the fluid. The electrodes may enable a measurement of changes in the impedance of the fluid caused by changes in the volume of the gaseous bubble caused by changes in the pressure to be measured. The pressure transducer may be made by depositing the chamber, placing the fluid within the chamber, and generating the gaseous bubble within the fluid with electrolysis.
摘要翻译：用于测量压力的压力传感器可以包括没有尺寸大于1mm的全聚合物室。室内可能存在流体，被捕获在流体内的气泡和与流体接触的电极。电极可以测量由待测量的压力变化引起的气泡体积变化引起的流体阻抗的变化。压力传感器可以通过沉积室，将流体放置在室内，并通过电解产生流体内的气泡来制造。

4. 发明申请

WO2010141118A3 MEMS ELECTROCHEMICAL BELLOWS ACTUATOR 审中-公开
标题翻译： MEMS电化学发光二极管激光器
公开(公告)号：WO2010141118A3
公开(公告)日：2011-03-10
申请号：PCT/US2010024808
申请日：2010-02-19
申请人： UNIV SOUTHERN CALIFORNIA , MENG ELLIS , LI PO-YING , HOANG TUAN
发明人： MENG ELLIS , LI PO-YING , HOANG TUAN
IPC分类号： A61M31/00 , A61F2/14 , A61F9/00 , A61M37/00 , F04B45/02
CPC分类号： A61M5/14276 , A61M2210/0612
摘要： An implantable fluid delivery system may include a fluid reservoir configured to hold a supply of fluid, to dispense that fluid under the control of an actuator, and to be implanted within the body of a living host. An actuator within the fluid reservoir may cause the fluid to be controllably dispensed from the fluid reservoir. The actuator may include a bellows configured to expand in a direction when inflated. The bellows may have folds with surfaces which run substantially perpendicular to the direction of expansion in a collapsed state and which define a stacked set of convolutions. Each convolution may have a collapsed height of no more than 1 mm and a width perpendicular to the direction of expansion of no more than 8 mm. Electrodes may be configured to come in electrical contact with an electrolyte within the bellows and to cause electricity to run through the electrolyte, thereby causing the electrolyte to break down into a gas and, in turn, to cause the bellows to expand. Methods of making the bellows which utilize stacked sheets are also disclosed.
摘要翻译：可植入流体输送系统可以包括被配置为保持流体供应的流体储存器，以在致动器的控制下分配该流体并且植入到活体的体内。流体储存器内的致动器可以使流体从流体储存器被可控地分配。致动器可以包括构造成在膨胀的方向上膨胀的波纹管。波纹管可以具有折叠，其表面在折叠状态下基本上垂直于膨胀方向延伸，并且限定了一组堆叠的卷积。每个卷积可以具有不大于1mm的折叠高度和垂直于不大于8mm的膨胀方向的宽度。电极可以被配置为与波纹管内的电解质电接触并导致电流穿过电解质，从而导致电解质分解成气体，从而导致波纹管膨胀。还公开了制造利用堆叠片材的波纹管的方法。

5. 发明申请

WO2007106557A3 MEMS DEVICE FOR DELIVERY OF THERAPEUTIC AGENTS 审中-公开
标题翻译：用于输送治疗剂的MEMS装置
公开(公告)号：WO2007106557A3
公开(公告)日：2008-01-03
申请号：PCT/US2007006530
申请日：2007-03-14
申请人： UNIV SOUTHERN CALIFORNIA
发明人： MENG ELLIS
IPC分类号： A61M5/142 , A61F9/00 , A61M31/00 , F15C5/00
CPC分类号： A61F9/0017 , A61K9/0024 , A61K9/0097 , A61M5/14276 , A61M5/14593 , A61M5/155 , A61M5/16877 , A61M5/16881 , A61M37/00 , A61M2005/14204 , A61M2205/0244 , A61M2205/3507 , A61M2207/00 , A61M2210/0612 , B81B2201/058 , B81C1/00119 , B81C2201/019 , F04B43/043 , F16K99/0001 , F16K99/0005 , F16K99/0034 , F16K99/0057 , F16K2099/008 , F16K2099/0088 , Y10T29/49236
摘要： An implantable device (200) for delivering a therapeutic agent to a patient is provided. The device includes a reservoir (390) configured to contain a liquid comprising the therapeutic agent. The device further includes a cannula (110) in fluid communication with the reservoir. The cannula has an outlet configured to be in fluid communication with the patient. The device further includes a first electrode and a second electrode, at least one of the first electrode and the second electrode is planar. The device further includes a material in electrical communication with the first and second electrodes. A voltage applied between the first electrode and the second electrode produces gas from the material, the gas forcing the liquid to flow from the reservoir to the outlet.
摘要翻译：提供了一种用于将治疗剂递送至患者的可植入装置（200）。该装置包括构造成容纳包含治疗剂的液体的贮存器（390）。该装置还包括与储存器流体连通的插管（110）。套管具有被配置为与患者流体连通的出口。该装置还包括第一电极和第二电极，第一电极和第二电极中的至少一个是平面的。该装置还包括与第一和第二电极电连通的材料。施加在第一电极和第二电极之间的电压从材料产生气体，气体迫使液体从储存器流出到出口。

6. 发明申请

WO2010099210A4 FLEXIBLE POLYMER-BASED ENCAPSULATED-FLUID DEVICES 审中-公开
标题翻译：柔性基于聚合物的渗透流体装置
公开(公告)号：WO2010099210A4
公开(公告)日：2011-02-24
申请号：PCT/US2010025248
申请日：2010-02-24
申请人： UNIV SOUTHERN CALIFORNIA , GUTIERREZ CHRISTIAN A , MENG ELLIS
发明人： GUTIERREZ CHRISTIAN A , MENG ELLIS
IPC分类号： A61F2/68 , A61F2/74
CPC分类号： G01L1/20 , G01D1/00 , G01D15/00 , G01D21/00 , G01L9/18
摘要： Embodiments of the present disclosure are directed to MEMS-based medical devices including a flexible housing that forms a chamber for encapsulating a fluid or liquid. The devices also include encapsulated electrodes, portions of which are exposed to the fluid or liquid within the chamber for sensing and/or physical actuation (controlled movement). Such medical devices can function specifically as: contact force sensors; and/or out-of-plane actuators. Device function is enabled by the encapsulation of liquid within the microchamber. Depending on the kind of electrical input applied, the encapsulated electrodes can function as electrochemical sensing elements; and/or electrolytic generation electrodes. Devices according to the present disclosure can have a fluidic coupling to the external environment or can be isolated. Fluidic isolation from the surrounding environment can be accomplished by the inclusion of an annular-plate stiction valve within the device. Related methods of use and fabrication are also described.
摘要翻译：本公开的实施例涉及基于MEMS的医疗装置，其包括形成用于封装流体或液体的腔室的柔性壳体。这些装置还包括封装的电极，其部分暴露于腔室内的流体或液体，用于感测和/或物理致动（受控运动）。这样的医疗设备可以具有如下功能：接触力传感器; 和/或平面外致动器。通过在微型仓中将液体封装起来可以实现器件功能。根据施加的电气输入种类，封装的电极可以用作电化学传感元件; 和/或电解生成电极。根据本公开的装置可以具有与外部环境的流体耦合或者可以被隔离。与周围环境的流体隔离可以通过在设备内包括环形板静止阀来实现。还描述了相关的使用和制造方法。

7. 发明申请

WO2010099210A3 FLEXIBLE POLYMER-BASED ENCAPSULATED-FLUID DEVICES 审中-公开
标题翻译：基于柔性聚合物的包封流体装置
公开(公告)号：WO2010099210A3
公开(公告)日：2011-01-06
申请号：PCT/US2010025248
申请日：2010-02-24
申请人： UNIV SOUTHERN CALIFORNIA , GUTIERREZ CHRISTIAN A , MENG ELLIS
发明人： GUTIERREZ CHRISTIAN A , MENG ELLIS
IPC分类号： A61F2/68 , A61F2/74
CPC分类号： G01L1/20 , G01D1/00 , G01D15/00 , G01D21/00 , G01L9/18
摘要： Embodiments of the present disclosure are directed to MEMS-based medical devices including a flexible housing that forms a chamber for encapsulating a fluid or liquid. The devices also include encapsulated electrodes, portions of which are exposed to the fluid or liquid within the chamber for sensing and/or physical actuation (controlled movement). Such medical devices can function specifically as: contact force sensors; and/or out-of-plane actuators. Device function is enabled by the encapsulation of liquid within the microchamber. Depending on the kind of electrical input applied, the encapsulated electrodes can function as electrochemical sensing elements; and/or electrolytic generation electrodes. Devices according to the present disclosure can have a fluidic coupling to the external environment or can be isolated. Fluidic isolation from the surrounding environment can be accomplished by the inclusion of an annular-plate stiction valve within the device. Related methods of use and fabrication are also described.
摘要翻译：本公开的实施例涉及基于MEMS的医疗装置，其包括形成用于封装流体或液体的腔室的柔性外壳。该装置还包括封装电极，其部分暴露于腔室内的流体或液体用于感测和/或物理致动（受控移动）。这种医疗设备可以具体用作：接触力传感器; 和/或平面外致动器。装置功能通过微室内液体的封装来实现。取决于所施加的电输入的种类，封装的电极可以用作电化学感测元件; 和/或电解生成电极。根据本公开的装置可以具有到外部环境的流体耦合或可以被隔离。通过在设备内部包括环形板静摩擦阀可以实现与周围环境的流体隔离。还描述了相关的使用和制造方法。

8. 发明申请

WO2009089094A8 IMPLANTABLE DRUG-DELIVERY DEVICES, AND APPARATUS AND METHODS FOR REFILLING THE DEVICES 审中-公开
标题翻译：可植入药物递送装置，以及用于重新装备装置的装置和方法
公开(公告)号：WO2009089094A8
公开(公告)日：2009-10-22
申请号：PCT/US2009030019
申请日：2009-01-02
申请人： UNIV SOUTHERN CALIFORNIA , MENG ELLIS , HUMAYUN MARK , LO RONALEE , LEE PO-YING , SAATI SALOOMEH
发明人： MENG ELLIS , HUMAYUN MARK , LO RONALEE , LEE PO-YING , SAATI SALOOMEH
IPC分类号： A61M5/158 , A61F7/00
CPC分类号： A61M5/427 , A61F9/0017 , A61M5/14276 , A61M5/158 , A61M5/46 , A61M39/0208 , A61M2005/14284 , A61M2039/0238 , A61M2205/3523 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/6054 , A61M2205/6063 , A61M2209/045 , A61M2210/0612
摘要： In various embodiments, a refill needle (120) is employed in refilling drug-delivery devices. The refill needle (120) encompasses a hollow shaft (212) which may extend from a proximal end (200) of the needle to a proximal end (216) of a terminating tip (208). The refill needle includes at least one fluid exit port (220) positioned along the shaft (212), e.g. near the tip (208) and a means (224) suitable for limiting an extent of entry of the refill needle into the entry port (116) of a drug -delivery device (100).
摘要翻译：在各种实施例中，使用补充针（120）来重新填充药物递送装置。再填充针（120）包围可从针的近端（200）延伸到终止尖端（208）的近端（216）的空心轴（212）。再填充针包括沿轴（212）定位的至少一个流体出口（220），例如。靠近尖端（208）和适于限制再填充针进入药物输送装置（100）的入口（116）的程度的装置（224）。

9. 发明申请

WO2009089094A3 IMPLANTABLE DRUG-DELIVERY DEVICES, AND APPARATUS AND METHODS FOR REFILLING THE DEVICES 审中-公开
标题翻译：可植入药物递送装置，以及用于重新装备装置的装置和方法
公开(公告)号：WO2009089094A3
公开(公告)日：2009-09-03
申请号：PCT/US2009030019
申请日：2009-01-02
申请人： UNIV SOUTHERN CALIFORNIA , MENG ELLIS , HUMAYUN MARK , LO RONALEE , LEE PO-YING , SAATI SALOOMEH
发明人： MENG ELLIS , HUMAYUN MARK , LO RONALEE , LEE PO-YING , SAATI SALOOMEH
IPC分类号： A61M5/158 , A61F7/00
CPC分类号： A61M5/427 , A61F9/0017 , A61M5/14276 , A61M5/158 , A61M5/46 , A61M39/0208 , A61M2005/14284 , A61M2039/0238 , A61M2205/3523 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/6054 , A61M2205/6063 , A61M2209/045 , A61M2210/0612
摘要： In various embodiments, a refill needle (120) is employed in refilling drug-delivery devices. The refill needle (120) encompasses a hollow shaft (212) which extends from a proximal end (200) of the needle to a proximal end (216) terminating in a tip (208). The refill needle includes at least one fluid exit port (220) positioned along the shaft (212), e.g. near the tip (208) and a means (224) suitable for limiting an extent of entry of the refill needle into the entry port (116) of a drug-delivery device (100).
摘要翻译：在各种实施例中，使用补充针（120）来重新填充药物递送装置。再充填针（120）包括从针的近端（200）延伸到终止于尖端（208）的近端（216）的中空轴（212）。再填充针包括沿轴（212）定位的至少一个流体出口（220），例如。靠近尖端（208）和适于限制再填充针进入药物递送装置（100）的入口（116）的程度的装置（224）。

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