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1. 发明申请

WO2019097492A1 REDUCTION OF OXIDATIVE STRESS DERIVED FROM THE PROCESS OF HEMODIALYSIS BY COVALENT CONJUGATION OF MOLECULES WITH HIGH ANTIOXIDANT POWER ON THE FIBER CONSTITUTING THE DIALYTIC MEMBRANE: POST-PRODUCTION PROCESS OF THE CARTRIDGE 审中-公开
公开(公告)号：WO2019097492A1
公开(公告)日：2019-05-23
申请号：PCT/IB2018/059097
申请日：2018-11-19
申请人： UNIVERSITÀ DELLA CALABRIA
发明人： PUOCI, Francesco , PEZZI, Vincenzo , PARISI, Ilaria Ortensia , AMONE, Fabio , MALIVINDI, Rocco , SCRIVANO, Luca , MELICCHIO, Alessandro , PERRI, Anna , LOFARO, Danilo
IPC分类号： B01D71/68 , A61M1/16
CPC分类号： A61M1/1621 , A61M2207/00
摘要： The present invention relates to a process for the preparation of dialysis cartridges functionalized with antioxidant molecules and to functionalized dialysis cartridges which can be obtained with such process.

2. 发明申请

WO2019069040A1 TUBES AND THEIR MANUFACTURE 审中-公开
公开(公告)号：WO2019069040A1
公开(公告)日：2019-04-11
申请号：PCT/GB2018/000115
申请日：2018-08-21
申请人： SMITHS MEDICAL INTERNATIONAL LIMITED
发明人： BATEMAN, Timothy , FIELD, Stephen, James
IPC分类号： A61M16/04 , B29C70/00 , F16L11/08 , A61M25/00
CPC分类号： A61M16/0465 , A61M16/0425 , A61M16/0427 , A61M16/0434 , A61M16/0463 , A61M2207/00
摘要： An inner cannula (3) of a tracheostomy tube (1) has a wall (33, 133) mainly of ePTFE and a reinforcing rib (34, 134) extending along the length of its shaft (30). The rib (34, 134) is of a thermoplastic and is mechanically retained with the wall (33, 133) by flow of the ePTFE around the rib or through recesses (140) in the rib.

3. 发明申请

WO2018195394A1 CATHETER SNUGGER SYSTEM AND METHOD 审中-公开
公开(公告)号：WO2018195394A1
公开(公告)日：2018-10-25
申请号：PCT/US2018/028519
申请日：2018-04-20
申请人： GRIFFITH, Donald
发明人： GRIFFITH, Donald
IPC分类号： A61F2/958 , A61M5/32 , A61M25/01 , A61M25/02 , A61M29/02 , A61M29/04
CPC分类号： A61M25/04 , A61J15/0015 , A61J15/0042 , A61J15/0049 , A61J15/0057 , A61J15/0065 , A61J15/0073 , A61M25/007 , A61M25/10 , A61M25/1036 , A61M27/00 , A61M2025/028 , A61M2207/00 , A61M2210/1085
摘要： A device for snugging a balloon of a catheter against an inner wall of an intra-corporeal lumen or surface serviced by the catheter includes a hollow column having a top end and a bottom end, forming a throughway sized to accommodate a tube of the catheter, and a flange extending from the bottom end of the hollow column generally perpendicularly to length of the hollow column. A slit is formed in the hollow column and the flange through which the hollow column is connectable to the tube of the catheter. The catheter is tugged to contact the balloon to the inner wall of the lumen, and the device is fixed to the tube of the catheter atop the skin of a body serviced by the catheter to tension pressure of the balloon against the inner wall.

4. 发明申请

WO2018169683A1 HEMOSTASIS VALVES AND METHODS FOR MAKING AND USING HEMOSTASIS VALVES 审中-公开
公开(公告)号：WO2018169683A1
公开(公告)日：2018-09-20
申请号：PCT/US2018/020202
申请日：2018-02-28
申请人： BOSTON SCIENTIFIC SCIMED, INC. , BOSTON SCIENTIFIC LIMITED
发明人： AGRAWAL, Sumit , BHATNAGAR, Mayank , TOMAR, Peeyush , NAYAK, Poornachandra , CHABRA, Anshul
IPC分类号： A61M39/06
CPC分类号： A61M39/0613 , A61M39/06 , A61M39/0693 , A61M2039/0633 , A61M2039/064 , A61M2039/0686 , A61M2207/00
摘要： Hemostasis valves and methods for making and using hemostasis valves are disclosed. An example hemostasis valve may include a main body having a distal end region and a proximal end region. A first seal member may be disposed within the proximal end region of the main body. A cartridge may be at least partially disposed within the proximal end region of the main body. The cartridge may include a second seal member. A plunger may be coupled to the proximal end region of the main body. A rotation limiting member may be positioned adjacent to the proximal end region of the main body. A tab member may be positioned adjacent to the proximal end region of the main body. The tab member may be designed to rotate relative to the proximal end region of the main body until the tab member engages the rotation limiting member.

5. 发明申请

WO2018011253A1 AN INJECTION NEEDLE ASSEMBLY 审中-公开
标题翻译：注射针头组件
公开(公告)号：WO2018011253A1
公开(公告)日：2018-01-18
申请号：PCT/EP2017/067507
申请日：2017-07-12
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH
发明人： HELMER, Michael , RAU, Matthias , HUTHMACHER, Winfried
IPC分类号： A61M5/24 , A61M5/50 , A61M5/32 , A61B5/15 , A61M5/158 , A61M5/162 , A61M39/10
CPC分类号： A61M5/3245 , A61M5/2466 , A61M5/3202 , A61M5/3213 , A61M5/3243 , A61M5/50 , A61M5/5086 , A61M39/04 , A61M2005/247 , A61M2005/3254 , A61M2039/0205 , A61M2039/1072 , A61M2205/0216 , A61M2207/00
摘要： The present invention relates to an injection needle assembly (16, 116, 216, 316, 416) for use in a medicament delivery device (10). The injection needle assembly comprises an injection needle holder (27), an injection needle (17) fixed to said injection needle holder (27), the injection needle (17) having a proximal end (18) and a distal end (19), and a sealing assembly (25) for sealing the distal end (19) of the injection needle (17). The sealing assembly (25) comprises a spacer element (31) surrounding the distal end (19) of the injection needle (17) and a sealing membrane (32) for sealing the distal end (19) of the injection needle (17).
摘要翻译：本发明涉及一种用于药物输送装置（10）的注射针组件（16,116,216,316,416）。注射针组件包括注射针保持器27，固定到所述注射针保持器27的注射针17，注射针17具有近端18和远端19，和用于密封注射针（17）的远端（19）的密封组件（25）。密封组件（25）包括围绕注射针（17）的远端（19）的隔离元件（31）和用于密封注射针（17）的远端（19）的密封膜（32）。

6. 发明申请

WO2018004842A1 DRUG DELIVERY DEVICE HAVING MINIMIZED RISK OF COMPONENT FRACTURE UPON IMPACT EVENTS 审中-公开
标题翻译：药物递送装置在冲击事件之前具有组分断裂的最小风险
公开(公告)号：WO2018004842A1
公开(公告)日：2018-01-04
申请号：PCT/US2017/032605
申请日：2017-05-15
申请人： AMGEN INC.
发明人： FITZGIBBON, Sean , JAZAYERI, Julian
IPC分类号： A61M5/20 , A61M5/315 , A61M5/32
CPC分类号： A61M5/31513 , A61M5/1454 , A61M5/2033 , A61M5/31511 , A61M5/322 , A61M2207/00
摘要： Components of drug delivery devices can experience large impact forces by a spring- loaded drive mechanism causing a drug reservoir of the delivery device to fracture. For an autoinjector having a reservoir, a plunger rod, a drive mechanism, and a carrier that experiences two impact events when the autoinjector is activated, the mass of the carrier and the mass of the rod is increased by a mass multiplier to reduce the impact pressure at both first and second impacts. The internal pressure of the device decreases in relation to a mass of the impact system 110 to force ratio, where the force is the drive force of the drive mechanism. To reduce the impact pressure from the first event, the mass of the plunger rod may be increased within a range such that the ratio of plunger rod mass to drive force is within a range of approximately a value greater than 0 kg/kgf to approximately 0.05 kg/kgf. To reduce the pressure of the second impact event, the mass of the carrier may be increased so that the ratio of the combined mass of the reservoir, plunger, plunger rod, and carrier to drive force is within a range of approximately a value greater than 0 kg/kgf to approximately 0.15 kg/kgf.
摘要翻译：药物输送装置的部件可通过弹簧加载的驱动机构经历大的冲击力，从而导致输送装置的药物储存器断裂。对于具有储存器，柱塞杆，驱动机构和载体的自动注射器，当自动注射器被激活时经历两次冲击事件，载体的质量和杆的质量增加质量倍数以减小冲击在第一次和第二次撞击时的压力。装置的内部压力相对于冲击系统110的力比减小，其中力是驱动机构的驱动力。为了减少来自第一事件的冲击压力，柱塞杆的质量可以在使得柱塞杆质量与驱动力的比率在大约大于0kg / kgf至大约0.05的值的范围内的范围内增加千克/千克力。为了减小第二碰撞事件的压力，载体的质量可以增加，使得储存器，柱塞，柱塞杆和载体的组合质量与驱动力的比率在大约大于 0千克/千克力至约0.15千克力/千克力。

7. 发明申请

WO2017195146A1 PROCESS FOR THE REALIZATION OF A DILDO, DILDO THUS OBTAINED AND KIT FOR ITS COMMERCIALIZATION 审中-公开
标题翻译：实现DILDO，DILDO由此获得的工具以及用于其商业化的工具
公开(公告)号：WO2017195146A1
公开(公告)日：2017-11-16
申请号：PCT/IB2017/052769
申请日：2017-05-11
申请人： AMBESI, Cristian
发明人： AMBESI, Cristian
IPC分类号： A61H19/00 , B29C41/08 , B29C41/14
CPC分类号： A61H19/44 , A61H2201/0161 , A61M2207/00 , B29C41/08 , B29C41/14
摘要： The process for the realization of a dildo comprises: - a coating step (A) of a support body (11) with plastic material (12) for the formation of a coated body (13) comprising a contact layer (14) enveloping the support body (11); a heat treatment step (B) of the coated body (13) for the stabilization of the contact layer (14); - a separation step (C) of the contact layer (14) from the support body (11) to obtain a contact portion (2) of a dildo (1); a closing step of the contact portion (2) for the realization of the dildo (1).
摘要翻译：用于实现假阴茎的方法包括： - 用塑料材料（12）形成涂覆体（13）的支撑体（11）的涂覆步骤（A）包括包围支撑体（11）的接触层（14）; 用于稳定接触层（14）的涂覆体（13）的热处理步骤（B）; - 接触层（14）与支撑体（11）的分离步骤（C），以获得阴茎假体（1）的接触部分（2）; 实现假阴茎（1）的接触部分（2）的闭合步骤。

8. 发明申请

WO2017194933A1 PERCUTANEOUS ACCESS APPARATUS 审中-公开
标题翻译：按需访问设备
公开(公告)号：WO2017194933A1
公开(公告)日：2017-11-16
申请号：PCT/GB2017/051293
申请日：2017-05-10
申请人： RENISHAW PLC
发明人： LEWIS, Trefor Owen , STEWART, Patricia Grace
IPC分类号： A61M39/02 , A61M39/04 , A61M39/10
CPC分类号： A61M39/0247 , A61M39/04 , A61M39/105 , A61M2039/0081 , A61M2039/0205 , A61M2039/025 , A61M2039/0261 , A61M2039/0264 , A61M2039/027 , A61M2039/0276 , A61M2039/0282 , A61M2039/0288 , A61M2039/082 , A61M2205/12 , A61M2207/00 , A61M2210/0687 , A61M2210/0693
摘要： A percutaneous fluid access apparatus includes a percutaneous fluid access device. The percutaneous fluid access device has a base portion including a subcutaneous portion and at least one port for connection to one or more fluid conduits within a body of a patient. A housing has at least one fluid channel and at least one seal for sealing the at least one fluid channel, and the housing is removably attachable to the base portion. The at least one fluid channel is in fluid communication with the at least one port when the housing is attached to the base portion.
摘要翻译：经皮流体通路装置包括经皮流体通路装置。经皮液体进入装置具有包括皮下部分的基部和用于连接到患者身体内的一个或多个流体导管的至少一个端口。壳体具有至少一个流体通道和至少一个用于密封至少一个流体通道的密封件，并且壳体可拆卸地连接到基部。当壳体连接到基部时，至少一个流体通道与至少一个端口流体连通。

9. 发明申请

WO2017180529A1 DOUBLE DISK TRANSDERMAL PROCESS 审中-公开
标题翻译：双盘传输过程
公开(公告)号：WO2017180529A1
公开(公告)日：2017-10-19
申请号：PCT/US2017/026850
申请日：2017-04-10
申请人： MYLAN INC.
发明人： TOLIA, Gaurav, Thakersi , PLACHTA, Malachi , HENDERSON, Grant , BARNETT, Brad
IPC分类号： A61K9/70 , B32B37/12
CPC分类号： A61K9/7084 , A61M2207/00 , B29L2031/753 , B32B37/00 , B32B37/12 , B32B2037/1276
摘要： A double disk dermal device for administration of one or more active agents to the skin or mucosa of a host, in particular a patch is described including: a) active reservoir film layer; b) a backing overlay adjacent to the active reservoir film layer extending beyond the perimeter of the reservoir layer in all directions; c) second overlay backing layer with a coating of pressure sensitive adhesive which is adjacent to the first backing overlay extending beyond the perimeter of the first backing overlay in all directions; and d) a removable release liner. A method of making the device is also provided.
摘要翻译：描述了用于将一种或多种活性剂施用于宿主的皮肤或粘膜，特别是贴剂的双盘皮肤装置，其包括：a）活性储库膜层; b）靠近在所有方向上延伸超出储层的周边的有源储层薄膜层的背衬覆盖层; c）具有压敏粘合剂涂层的第二覆盖背衬层，所述压敏粘合剂涂层与所述第一背衬覆盖层相邻地延伸超过所述第一背衬覆盖层的周边，沿所有方向延伸; 和d）可移除的释放衬里。还提供了制造该设备的方法。

10. 发明申请

WO2017145188A1 OPENING AND SUPPLYING SYSTEM FOR PRE-FILLED CONTAINERS, RESPECTIVE FILLED CONTAINERS, AND METHODS FOR THEIR REALIZATION 审中-公开
标题翻译：预充式容器的开放和供应系统，各种填充容器及其实现方法
公开(公告)号：WO2017145188A1
公开(公告)日：2017-08-31
申请号：PCT/IT2017/000034
申请日：2017-02-23
申请人： BREVETTI ANGELA S.R.L.
发明人： CONSOLARO Roberto , CONSOLARO, Angelo , KABBUR, Rajeev
IPC分类号： A61M5/24 , A61J1/20 , A61M5/34 , A61M39/10
CPC分类号： A61M5/288 , A61M5/24 , A61M5/282 , A61M5/34 , A61M5/345 , A61M5/346 , A61M39/10 , A61M2005/2444 , A61M2207/00 , B29C49/04
摘要： The present invention relates to an opening and liquid supplying system (100) for pre-filled containers (10, 30) equipped with a supplying end, comprising a coupling element (20), connecting means (6) movable from a first position to a second position, and movable protection means (9); the coupling element (20) has an end (27) closed and suitable for being punched, and first guiding means (21) for guiding the movement of the connecting means (6) movable from the first position, close to the closed end (27), to the second position, apart from such end, and vice versa; the connecting means (6) have engaging means (7) for engaging with the protection means (9) so as to move integrally along a second degree of freedom, different than the first degree of freedom, and first matches (1 1) for the first guiding means (21). The invention relates also to a respective pre-filled container equipped with such system and the method for realize them.
摘要翻译：本发明涉及一种用于预装填容器（10,30）的开口和液体供应系统（100），其配备有供应端，该供应端包括耦合元件（20），连接装置）可从第一位置移动到第二位置，以及可移动保护装置（9）; 所述联接元件（20）具有一个封闭的端部（27）并且适于冲压，并且第一引导装置（21）用于引导所述连接装置（6）的运动从所述第一位置移动，靠近所述封闭端）到第二个位置，除此之外，反之亦然; 所述连接装置（6）具有用于与所述保护装置（9）接合以便沿着与所述第一自由度不同的第二自由度一体地移动的接合装置（7），并且所述第一匹配装置（11）第一引导装置（21）。本发明还涉及配备有这种系统的相应的预装容器以及实现它们的方法。

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