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1. 发明申请

WO2013058879A2 MICRONEEDLE ARRAYS FOR BIOSENSING AND DRUG DELIVERY 审中-公开
标题翻译：用于生物传感和药物输送的MICRONEEDLE阵列
公开(公告)号：WO2013058879A2
公开(公告)日：2013-04-25
申请号：PCT/US2012053544
申请日：2012-08-31
申请人： UNIV CALIFORNIA , WANG JOSEPH , WINDMILLER JOSHUA RAY , NARAYAN ROGER , POLSKY RONEN
发明人： WANG JOSEPH , WINDMILLER JOSHUA RAY , NARAYAN ROGER , POLSKY RONEN
IPC分类号： A61M37/00 , A61M5/158 , G01N33/48 , G01N33/50
CPC分类号： A61B5/1473 , A61B5/14514 , A61B5/14532 , A61B5/14546 , A61B5/14865 , A61B5/150984 , A61B5/157 , A61B5/4845 , A61B5/6833 , A61B5/685 , A61B5/7282 , A61B10/0045 , A61B2010/008 , A61B2562/028 , A61B2562/046 , A61M5/158 , A61M5/1723 , A61M2005/1726 , A61M2037/0023 , A61M2037/003 , G01N33/48785
摘要： Methods, structures, and systems are disclosed for biosensing and drug delivery techniques. In one aspect, a^ device for detecting an analyte and/or releasing a biochemical into a biological fluid can include an array of hollowed needles, in which each needle includes a protruded needle structure including an exterior wall forming a hollow interior and an opening at a terminal end of the protruded needle structure that exposes the hollow interior, and a probe inside the exterior wall to interact with one or more chemical or biological substances that come in contact with the probe via the opening to produce a probe sensing signal, and an array of wires that are coupled to probes of the array of hollowed needles, respectively, each wire being electrically conductive to transmit the probe sensing signal produced by a respective probe.
摘要翻译：公开了用于生物传感和药物递送技术的方法，结构和系统。在一个方面，用于检测分析物和/或将生物化学物质释放到生物流体中的装置可以包括中空针阵列，其中每个针包括突出的针结构，所述突出的针结构包括形成中空的内部的外壁和在所述突出针结构的终端暴露所述中空内部，以及位于所述外壁内的探针，以与经由所述开口与所述探针接触的一种或多种化学或生物物质相互作用以产生探针感测信号，以及分别连接到中空针阵列的探针的导线阵列，每根线都是导电的，以传输由相应探针产生的探针感测信号。

2. 发明申请

WO2011156095A3 TEXTILE-BASED PRINTABLE ELECTRODES FOR ELECTROCHEMICAL SENSING 审中-公开
标题翻译：用于电化学感测的基于纺织品的可印刷电极
公开(公告)号：WO2011156095A3
公开(公告)日：2012-04-19
申请号：PCT/US2011037068
申请日：2011-05-18
申请人： UNIV CALIFORNIA , WANG JOSEPH , WINDMILLER JOSHUA RAY
发明人： WANG JOSEPH , WINDMILLER JOSHUA RAY
IPC分类号： G01N27/26 , A41D13/12 , A61B5/04 , G01N33/22
CPC分类号： A61B5/6804 , A41D1/002 , A61B5/0002 , A61B5/0205 , A61B5/021 , A61B5/02444 , A61B5/0245 , A61B5/14517 , A61B5/14532 , A61B5/14546 , A61B5/1477 , A61B5/1486 , A61B5/4266 , A61B5/4845 , A61B5/4884 , A61B5/6802 , A61B5/6807 , A61B5/6808 , A61B5/6831 , A61B5/742 , A61B2560/0214 , C12Q1/001 , G01N27/308 , G01N27/3271 , G01N33/0057 , G01N33/22 , H05K1/038 , H05K3/1216
摘要： Techniques and systems are disclosed for implementing textile-based screen-printed amperometric or potentiometric sensors. The chemical sensor can include carbon based electrodes to detect at least one of NADH, hydrogen peroxide, potassium ferrocyanide, TNT or DNT, in liquid or vapor phase. In one application, underwater presence of chemicals such as heavy metals and explosives is detected using the textile-based sensors.
摘要翻译：公开了用于实施基于织物的丝网印刷安培计或电位传感器的技术和系统。化学传感器可以包括碳基电极，用于检测液相或汽相中的NADH，过氧化氢，亚铁氰化钾，TNT或DNT中的至少一种。在一个应用中，使用基于纺织品的传感器检测水中存在的诸如重金属和爆炸物的化学物质。

3. 发明申请

WO2011116151A3 ENZYME-LOGIC BIOSENSING 审中-公开
标题翻译： ENZYME-LOGIC生物传感
公开(公告)号：WO2011116151A3
公开(公告)日：2012-01-19
申请号：PCT/US2011028747
申请日：2011-03-16
申请人： UNIV CALIFORNIA , UNIV CLARKSON , WANG JOSEPH , WINDMILLER JOSHUA RAY , SANTHOSH PADMANABHAN , CHUANG MIN-CHIEH , KATZ EVGENY , HALAMEK JAN , BOCHAROVA VERA , PITA MARCOS , PRIVMAN VLADIMIR
发明人： WANG JOSEPH , WINDMILLER JOSHUA RAY , SANTHOSH PADMANABHAN , CHUANG MIN-CHIEH , KATZ EVGENY , HALAMEK JAN , BOCHAROVA VERA , PITA MARCOS , PRIVMAN VLADIMIR
IPC分类号： C12Q1/26 , C12Q1/48 , G01N33/15 , G01N33/50
CPC分类号： G01N27/327 , C12Q1/001 , C12Q1/005 , C12Q1/006 , G01N21/31 , G01N27/27 , G01N2333/902 , G01N2333/90241 , G01N2333/904 , G01N2333/908 , G01N2333/91188 , G01N2333/91205 , G01N2333/988 , G06N3/002
摘要： Techniques, apparatus and systems are disclosed for implementing enzyme-logic based diagnosis that uses patterns of multiple markers and biochemical processing of the signal information for reliably identifying cardiac abnormalities and providing a final digital binary answer. In one aspect, a biochemical logic sensing system includes a network of enzyme- biocatalyzed logic gates adapted to receive biomarker input signals and perform an enzyme- biocatalyzed reaction resembling a Boolean logic operation using the received biomarker input signals to generate an output signal of the enzyme-biocatalyzed reaction. A signal processing unit is connected to the network of enzyme-biocatalyzed logic gates. The signal processing unit processes the generated output signal of the enzyme-biocatalyzed reaction and generates a digital binary output having a value of zero or one. The generated digital binary output indicates a type of an injury.
摘要翻译：公开了技术，装置和系统，用于实现基于酶 - 逻辑的诊断，其使用多个标记的模式和用于可靠地识别心脏异常并提供最终数字二进制答案的信号信息的生化处理。一方面，生物化学逻辑感测系统包括适于接收生物标志物输入信号的酶 - 生物催化逻辑门网络，并且使用所接收的生物标志物输入信号进行类似于布尔逻辑运算的酶 - 生物催化反应以产生酶的输出信号 - 催化反应。信号处理单元连接到酶 - 生物催化逻辑门的网络。信号处理单元处理所生成的酶 - 生物催化反应的输出信号，并生成值为零或1的数字二进制输出。生成的数字二进制输出表示伤害类型。

4. 发明申请

WO2004027377A3 ELECTROACTIVE MICROSPHERES AND METHODS 审中-公开
标题翻译：电活性微球和方法
公开(公告)号：WO2004027377A3
公开(公告)日：2004-09-23
申请号：PCT/US0329029
申请日：2003-09-19
申请人： UNIV NEW MEXICO STATE TECH TRA , WANG JOSEPH , POLSKY RONEN , TURNER KATHRYN L
发明人： WANG JOSEPH , POLSKY RONEN , TURNER KATHRYN L
IPC分类号： G01N33/543 , G01N33/553 , G01N33/53 , G01N21/00 , G01N21/76 , G01N33/533 , G01N33/536 , G01N33/538
CPC分类号： G01N33/54346 , C12Q1/6825 , G01N33/54326 , G01N33/553 , Y10S436/801 , Y10S436/805 , Y10S436/81 , Y10S436/815 , C12Q2537/125 , C12Q2563/116 , C12Q2563/149
摘要： Methods and devices for electrochemical detection of a specific binding pair member utilizing a microsphere with an incorporated electroactive marker, wherein a member of the specific binding pair to be detected is bound, directly or through one or more intermediates, to the microsphere. Multiple specific binding pair members may be detected by use of electrochemically distinguishable electroactive markers. Microspheres with incorporated electroactive markers may include one or more functional groups for binding members of specific binding pairs, and are preferably insoluble in aqueous solvents but soluble in selected organic solvents.
摘要翻译：使用具有引入的电活性标记的微球体特异性结合对成员的电化学检测的方法和装置，其中要检测的特异性结合对的成员直接或通过一个或多个中间体结合到微球体。可以通过使用电化学上可区分的电活性标记来检测多个特异性结合对成员。具有引入的电活性标记的微球可以包括用于结合特异性结合对成员的一个或多个官能团，并且优选不溶于水性溶剂，但可溶于选定的有机溶剂。

5. 发明申请

WO2011120048A3 NANOMOTORS AND MOTION-BASED DETECTION OF BIOMOLECULAR INTERACTIONS 审中-公开
标题翻译： NANOMOTORS和基于运动的生物分子相互作用的检测
公开(公告)号：WO2011120048A3
公开(公告)日：2012-02-23
申请号：PCT/US2011030211
申请日：2011-03-28
申请人： UNIV CALIFORNIA , WANG JOSEPH , WU JIE , BALASUBRAMANIAN SHANKAR , KAGAN DANIEL , MANESH KAKAYIL MANIAN
发明人： WANG JOSEPH , WU JIE , BALASUBRAMANIAN SHANKAR , KAGAN DANIEL , MANESH KAKAYIL MANIAN
IPC分类号： G01N33/53 , C12Q1/68 , G01N33/58
CPC分类号： C12Q1/6886 , B82Y15/00 , C07K17/14 , C12N15/115 , C12Q1/6816 , G01N33/557 , G01N33/558 , G01N33/587 , Y10S977/726 , Y10S977/773 , Y10S977/92 , C12Q2563/113 , C12Q2563/155
摘要： Techniques and systems are disclosed for detecting biomolecular interactions based on the motion of nanomotors. In one aspect, a method of detecting biomolecular interactions based on a motion of a nanomachine includes functionalizing a nanomachine with a capture probe adapted to interact with biological targets; and detecting a presence of the biological targets in an environment based on a motion of the nanomachine.
摘要翻译：公开了用于基于纳米电动机的运动来检测生物分子相互作用的技术和系统。在一个方面，基于纳米机械的运动来检测生物分子相互作用的方法包括用适于与生物靶相互作用的捕获探针对纳米机械进行功能化; 以及基于所述纳米机械的运动在环境中检测所述生物学目标的存在。

6. 发明申请

WO2012166215A3 MEMBRANE TEMPLATE SYNTHESIS OF MICROTUBE ENGINES 审中-公开
标题翻译：微波发生器的膜模板合成
公开(公告)号：WO2012166215A3
公开(公告)日：2013-03-14
申请号：PCT/US2012000269
申请日：2012-06-04
申请人： UNIV CALIFORNIA , WANG JOSEPH , GAO WEI , SATTAYASAMITSATHIT SIRILAK
发明人： WANG JOSEPH , GAO WEI , SATTAYASAMITSATHIT SIRILAK
IPC分类号： G01N35/08 , B81B1/00 , B82B1/00 , G01N33/48
CPC分类号： C25D1/02 , A61K9/70 , A61K47/02 , A61K47/34 , B01J20/22 , B01J23/42 , B01J23/8906 , B01J23/8913 , B01J23/892 , B01J31/06 , B01J35/0006 , B01J35/0033 , B01J35/02 , B01J37/0215 , B01J37/0244 , B01J2231/005 , B01J2531/005 , B82Y15/00 , B82Y30/00 , C25D1/006 , C25D1/20 , C25D3/12 , F03H99/00 , G01N33/48707
摘要： Methods, structures, devices and systems are disclosed for fabrication of microtube engines using membrane template electrodeposition. Such nanomotors operate based on bubble- induced propulsion in biological fluids and salt-rich environments. In one aspect, fabricating microengines includes depositing a polymer layer on a membrane template, depositing a conductive metal layer on the polymer layer, and dissolving the membrane template to release the multilayer microtubes.
摘要翻译：公开了使用膜模板电沉积制造微管引擎的方法，结构，装置和系统。这种纳米电动机基于生物流体和富含盐的环境中的气泡诱导推进而运行。一方面，制造微引线包括在膜模板上沉积聚合物层，在聚合物层上沉积导电金属层，以及溶解膜模板以释放多层微管。

7. 发明申请

WO2012148516A3 BIOAFFINITY SENSORS BASED ON SURFACE MONOLAYERS 审中-公开
标题翻译：基于表面单层的生物传感器
公开(公告)号：WO2012148516A3
公开(公告)日：2013-01-10
申请号：PCT/US2012023039
申请日：2012-01-27
申请人： UNIV CALIFORNIA , WANG JOSEPH , CAMPUZANO-RUIZ SUSANA
发明人： WANG JOSEPH , CAMPUZANO-RUIZ SUSANA
IPC分类号： G01N33/53 , C12Q1/68 , G01N27/26 , G01N33/553
CPC分类号： G01N33/54386 , C12Q1/689 , G01N27/30 , G01N27/327 , G01N27/3277
摘要： Methods, systems, devices and materials are disclosed for implementing a bioaffinity sensor having a self-assembled monolayer interface for detection of a target molecule. In one aspect, a sensor device for detecting a target molecule includes a surface capable of attaching a thiol and a molecular monolayer formed on the surface that includes a molecular capture probe having a thiol region, a linear alkanethiol molecule having one thiol region, and a linear alkanedithiol molecule having two thiol regions, in which the molecular capture probe includes a region for receiving a target substance having a complimentary region that couples with the region of the molecular capture probe to generate a detectable signal.
摘要翻译：公开了用于实现具有用于检测靶分子的自组装单层界面的生物亲和传感器的方法，系统，装置和材料。一方面，用于检测靶分子的传感器装置包括能够附着硫醇的表面和在表面上形成的分子单层，所述表面包含具有硫醇区的分子捕获探针，具有一个硫醇区的直链烷硫醇分子和具有两个硫醇区域的直链烷二硫醇分子，其中分子捕获探针包括用于接收具有与分子捕获探针的区域耦合以产生可检测信号的互补区的靶物质的区域。

8. 发明申请

WO2012106384A3 NANO/MICROSCALE VEHICLES FOR CAPTURE AND ISOLATION OF TARGET BIOMOLECULES AND LIVING ORGANISMS 审中-公开
标题翻译：用于捕获和分离靶生物分子和生命体的纳米/微米级车辆
公开(公告)号：WO2012106384A3
公开(公告)日：2012-11-08
申请号：PCT/US2012023410
申请日：2012-01-31
申请人： UNIV CALIFORNIA , WANG JOSEPH , BALASUBRAMANIAN SHANKAR , KAGAN DANIEL , CAMPUZANO-RUIZ SUSANA
发明人： WANG JOSEPH , BALASUBRAMANIAN SHANKAR , KAGAN DANIEL , CAMPUZANO-RUIZ SUSANA
IPC分类号： G01N33/53 , C12Q1/68 , G01N33/543
CPC分类号： C12Q1/6806 , B01D15/3885 , B01J20/22 , B01J20/32 , B01J2220/4812 , C12M1/268 , C12Q1/6834 , G01N1/10 , G01N33/54313 , G01N33/5436 , G01N33/54393 , G01N33/544
摘要： Techniques, systems, devices and materials are disclosed for capturing, isolating and transporting target biomolecules and living organisms. In one aspect, a device includes a tube structured to include a large opening and a small opening that are on opposite ends of the tube, and a tube body connecting the openings and having a cross section spatially reducing in size from the large opening to the small opening, in which the tube includes a layered wall including an inner layer having a catalyst material that is reactive with a fuel fluid to produce bubbles exiting the tube from the large opening to propel the tube to move in the fuel fluid and an external layer formed of a material capable of being functionalized, and a molecular layer functionalized onto the external layer of the tube and structured to attach to a targeted molecule in the fuel fluid.
摘要翻译：公开了捕获，分离和运输目标生物分子和活生物体的技术，系统，装置和材料。在一个方面，一种装置包括管，所述管构造成包括在所述管的相对端部上的大开口和小开口以及连接所述开口并且具有从所述大开口到所述大开口在空间上尺寸减小的横截面的管体小开口，其中管包括分层壁，所述分层壁包括具有催化剂材料的内层，所述催化剂材料与燃料流体反应以产生从所述大开口离开所述管的气泡以推动所述管在所述燃料流体中移动，并且外层由能够官能化的材料形成，以及分子层功能化到管的外层上并构造成附着到燃料流体中的目标分子。

9. 发明申请

WO2012050928A2 FUEL-FREE NANOWIRE MOTORS 审中-公开
标题翻译：无油NANOWIRE电机
公开(公告)号：WO2012050928A2
公开(公告)日：2012-04-19
申请号：PCT/US2011053783
申请日：2011-09-28
申请人： UNIV CALIFORNIA , WANG JOSEPH
发明人： WANG JOSEPH
IPC分类号： B82B1/00 , B82B3/00
CPC分类号： H02N11/006 , B82B1/00 , B82B1/002 , B82B3/00 , B82Y10/00 , B82Y30/00 , B82Y40/00 , H01L29/872 , H01L43/12 , H02K35/00
摘要： Techniques and systems are disclosed for locomoting fuel-free nanomotors in a fluid. In one aspect of the disclosed technology, a system for locomoting fuel-free nanomotors can include an electrically-driven nanowire diode formed of two or more segments of different electrically conducting materials, a fluid container, and a mechanism that produces an electric field to drive the nanowire diode to locomote in the fluid. In another aspect, a system for locomoting fuel-free nanomotors can include a magnetically-propelled multi-segment nanowire motor formed of a magnetic segment and a flexible joint segment, a fluid container, and a mechanism that generates and controls a magnetic field to drive the multi-segment nanowire motor to locomote in the fluid. The disclosed fuel-free nanomotors can obviate fuel requirements and can be implemented for practical in vitro and in vivo biomedical applications.
摘要翻译：公开了用于在流体中移动无燃料纳米电动机的技术和系统。在所公开的技术的一个方面，用于移动无燃料纳米电动机的系统可以包括由不同导电材料的两个或多个部分形成的电驱动纳米线二极管，流体容器和产生电场驱动的机构纳米线二极管在液体中移动。在另一方面，一种用于移动无燃料纳米电动机的系统可以包括由磁性段和柔性接头段形成的磁力推进的多段纳米线马达，流体容器和产生并控制磁场驱动的机构多段纳米线马达流入液体中。所公开的无燃料纳米电动机可以消除燃料需求并且可以实现用于实际的体外和体内生物医学应用。

10. 发明申请

WO2011031463A3 NANOMOTOR-BASED PATTERNING OF SURFACE MICROSTRUCTURES 审中-公开
标题翻译：基于纳米电极的表面微结构的图案
公开(公告)号：WO2011031463A3
公开(公告)日：2011-08-04
申请号：PCT/US2010046558
申请日：2010-08-24
申请人： UNIV CALIFORNIA , WANG JOSEPH , MANESH KALAYIL MANIAN , BALASUBRAMANIAN SHANKAR
发明人： WANG JOSEPH , MANESH KALAYIL MANIAN , BALASUBRAMANIAN SHANKAR
IPC分类号： B82B3/00 , B82B1/00
CPC分类号： B82B3/00 , B05D1/18 , B05D3/10 , B05D3/107 , B05D5/00 , B05D2202/00 , B05D2350/60 , B05D2401/00 , B82Y30/00 , B82Y40/00
摘要： Among other things, methods, systems and apparatus are described for implementing nanomotor-based micro- and nanofabrication. In one aspect, a method of fabricating nanoobjects comprises functionalizing a nanomotor with a reagent. The method also includes controlling a movement of the functionalized nanomotor in a solution containing material to react with the reagent to induce a localized deposition or precipitation of a product onto a surface of a substrate or etching of the substrate.
摘要翻译：其中，描述了用于实现基于纳米电机的微和纳米制造的方法，系统和装置。在一个方面，制造纳米对象的方法包括用试剂官能化纳米电动机。该方法还包括控制官能化纳米电动机在含有材料的溶液中与所述试剂反应以使产物局部沉积或沉淀到衬底的表面上或蚀刻衬底的运动。

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