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1. 发明申请

WO2008109862A2 FLEXIBLE CIRCUIT ELECTRODE ARRAY 审中-公开
标题翻译：柔性电路阵列
公开(公告)号：WO2008109862A2
公开(公告)日：2008-09-12
申请号：PCT/US2008/056301
申请日：2008-03-07
申请人： SECOND SIGHT MEDICAL PRODUCTS, INC. , DOHENY EYE INSTITUTE , AGRAWAL, Rajat , GREENBERG, Robert, J. , HUMAYUN, Mark, S. , LITTLE, James, Singleton , MECH, Brian, V. , NEYSMITH, Jordan, Matthew , TALBOT, Neil, Hamilton , ZHOU, Dao, Min
发明人： AGRAWAL, Rajat , GREENBERG, Robert, J. , HUMAYUN, Mark, S. , LITTLE, James, Singleton , MECH, Brian, V. , NEYSMITH, Jordan, Matthew , TALBOT, Neil, Hamilton , ZHOU, Dao, Min
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/0541 , A61N1/0543
摘要： A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a central opening in the area of the metal traces. A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a soft polymer filling an attachment point. A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a hump to avoid a touching of the flexible electrode array and the optic nerve.
摘要翻译：一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 和金属痕迹区域的中心开口。一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 和填充附着点的软质聚合物。一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 和一个驼峰以避免触摸柔性电极阵列和视神经。

2. 发明申请

WO2008103195A2 FLEXIBLE CIRCUIT ELECTRODE ARRAY 审中-公开
标题翻译：柔性电路电极阵列
公开(公告)号：WO2008103195A2
公开(公告)日：2008-08-28
申请号：PCT/US2007/083523
申请日：2007-11-02
申请人： SECOND SIGHT MEDICAL PRODUCTS, INC. , NEYSMITH, Jordan , TALBOT, Neil, Hamilton , LITTLE, James, Singleton , MECH, Brian, V. , GREENBERG, Robert, J. , QINGFANG, Yao , ZHOU, Dao, Min
发明人： NEYSMITH, Jordan , TALBOT, Neil, Hamilton , LITTLE, James, Singleton , MECH, Brian, V. , GREENBERG, Robert, J. , QINGFANG, Yao , ZHOU, Dao, Min
CPC分类号： A61N1/0543 , A61N1/0541 , A61N1/36046 , H05K1/028 , H05K1/0353 , H05K1/09 , H05K1/111 , H05K1/115 , H05K1/118 , H05K3/0014 , H05K3/0017 , H05K3/0041 , H05K3/06 , H05K3/188 , H05K3/22 , H05K3/388 , H05K3/4644 , H05K2201/0129 , H05K2201/0133 , H05K2201/0141 , H05K2201/0154 , Y10T29/49156 , Y10T29/49158
摘要： A flexible circuit electrode array with more than one layer of metal traces comprising: a polymer base layer; more than one layer of metal traces, separated by polymer layers, deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; and a polymer top layer deposited on said polymer base layer and said metal traces. Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow.
摘要翻译：具有多于一层金属迹线的柔性电路电极阵列，其包括：聚合物基底层; 沉积在所述聚合物基层上的由聚合物层分开的多于一层的金属迹线，所述金属迹线包括适于刺激神经组织的电极; 以及沉积在所述聚合物基层和所述金属迹线上的聚合物顶层。聚合物材料可用作神经刺激的电极阵列体。它们对视网膜刺激产生人造视觉，耳蜗刺激以产生人造听力或许多目的的皮质刺激特别有用。通过电极阵列施加在视网膜或其他神经组织上的压力是至关重要的。压力太小会导致电阻增加，同时电场分散。压力过大可能会阻碍血液流动。

3. 发明申请

WO2007149465A3 ELECTRODE WITH INCREASED STABILITY AND METHOD OF MANUFACTURING THE SAME 审中-公开
公开(公告)号：WO2007149465A3
公开(公告)日：2007-12-27
申请号：PCT/US2007/014332
申请日：2007-06-19
申请人： SECOND SIGHT MEDICAL PRODUCTS, INC. , ZHOU, Dao, Min , OK, Jerry , TALBOT, Neil, Hamilton , MECH, Brian, V. , LITTLE, James , GREENBERG, Robert, J.
发明人： ZHOU, Dao, Min , OK, Jerry , TALBOT, Neil, Hamilton , MECH, Brian, V. , LITTLE, James , GREENBERG, Robert, J.
IPC分类号： A61N1/05 , A61N1/36
摘要： The present invention provides an implantable electrode with increased stability having a clustered structure wherein the surface of the electrode is covered with a material comprising openings which are filled with sticks or posts. The present invention provides an implantable electrode with increased stability wherein the surface is of the electrode comprises mesh grids which are filled with sticks which are filed with a conducting or insulating material. The present invention provides a method of manufacturing an electrode with increased stability, comprising: depositing a metal layer on an base layer; applying photoresist layer on the metal layer; patterning the photoresist layer providing openings; electroplating the openings with metal; removing the photoresist layer leaving spaces; and filling the spaces with polymer. The present invention provides a method of manufacturing an electrode with increased stability, comprising: depositing a metal layer on an base layer; applying a polymer layer on the metal layer; applying photoresist layer on the polymer layer; patterning the photoresist layer providing openings; electroplating the openings with metal; and removing the photoresist layer.

4. 发明申请

WO2008064269A2 METHOD OF IMPROVING ELECTRODE TISSUE INTERFACE 审中-公开
标题翻译：改善电极组织界面的方法
公开(公告)号：WO2008064269A2
公开(公告)日：2008-05-29
申请号：PCT/US2007/085306
申请日：2007-11-20
申请人： SECOND SIGHT MEDICAL PRODUCTS, INC. , DOHENY EYE INSTITUTE , SHAH, Samip , HINES, Amy Chu, Peishuan , ZHOU, Dao, Min , GREENBERG, Robert, J. , HUMAYUN, Mark, S. , WEILAND, James, D.
发明人： SHAH, Samip , HINES, Amy Chu, Peishuan , ZHOU, Dao, Min , GREENBERG, Robert, J. , HUMAYUN, Mark, S. , WEILAND, James, D.
CPC分类号： A61N1/0543
摘要： A critical element of a retinal prosthesis is the stimulating electrode array, which is placed in close proximity to the retina. It is via this interface that a retinal prosthesis electrically stimulates nerve cells to produce the perception of light. The impedance load seen by the current driver consists of the tissue resistance and the complex electrode impedance. The results show that the tissue resistance of the retina is significantly greater than that of the vitreous humor in the eye. Circuit models of the electrode-retina interface are used to parameterize the different contributors to the overall impedance.
摘要翻译：视网膜假体的关键元件是刺激电极阵列，其被放置在靠近视网膜的位置。通过该界面，视网膜假体电刺激神经细胞产生光的感知。电流驱动器所看到的阻抗由组织电阻和复合电极阻抗组成。结果表明，视网膜的组织电阻显着大于眼玻璃体液的组织电阻。电极 - 视网膜界面的电路模型用于参数化整个阻抗的不同贡献者。

5. 发明申请

WO2007064916A2 FITTING A NEURAL PROSTHESIS USING IMPEDANCE AND ELECTRODE HEIGHT 审中-公开
标题翻译：用阻抗和电极高度拟合神经假体
公开(公告)号：WO2007064916A2
公开(公告)日：2007-06-07
申请号：PCT/US2006/046042
申请日：2006-12-01
申请人： SECOND SIGHT MEDICAL PRODUCTS, INC. , DOHENY EYE INSTITUTE , GREENBERG, Robert, J. , ROY, Arup , MCMAHON, Matthew, J. , HUMAYUN, Mark, S. , WEILAND, James, David , HORSAGER, Alan, Matthew , ZHOU, Dao, Min , HINES, Amy , YADAV, Sumit , DAI, Rongqing , FINE, Ione
发明人： GREENBERG, Robert, J. , ROY, Arup , MCMAHON, Matthew, J. , HUMAYUN, Mark, S. , WEILAND, James, David , HORSAGER, Alan, Matthew , ZHOU, Dao, Min , HINES, Amy , YADAV, Sumit , DAI, Rongqing , FINE, Ione
CPC分类号： A61N1/0543 , A61N1/36046 , A61N1/37247
摘要： The invention is a method of automatically adjusting an electrode array to the neural characteristics of an individual subject. The response to electrical neural stimulation varies from subject to subject. Measure of impedance may be used to predict the electrode height from the neural tissue and, thereby, predict the threshold of perception. Alternatively, electrode height may be measured directly to predict the threshold of perception. Also, impedance measurement may be used to quickly identify defective electrodes and proper electrode placement.
摘要翻译：本发明是一种将电极阵列自动调整为个体对象的神经特征的方法。对电神经刺激的反应因受试者而异。阻抗测量可用于预测来自神经组织的电极高度，从而预测感知的阈值。或者，可以直接测量电极高度以预测感知的阈值。此外，阻抗测量可用于快速识别有缺陷的电极和适当的电极位置。

6. 发明申请

WO2008013879A2 PROCESS FOR CATHODIC PROTECTION OF ELECTRODE MATERIALS 审中-公开
标题翻译：电极材料阴极保护工艺
公开(公告)号：WO2008013879A2
公开(公告)日：2008-01-31
申请号：PCT/US2007/016783
申请日：2007-07-26
申请人： SECOND SIGHT MEDICAL PRODUCTS, INC. , ZHOU, Dao, Min , HINES, Amy , LITTLE, James, Singleton , GREENBERG, Robert, J.
发明人： ZHOU, Dao, Min , HINES, Amy , LITTLE, James, Singleton , GREENBERG, Robert, J.
IPC分类号： C23F13/02
CPC分类号： C23F13/00 , A61N1/05 , A61N1/08 , C23F13/02
摘要： The present invention relates to a process for cathodic protection of electrode or electrode materials wherein negative bias is applied on the electrode, the negative bias is obtained by asymmetric current pulse. The asymmetric current pulse is obtained by performing negative phase with higher amplitude. The asymmetric current pulse is obtained by performing negative phase with wider pulse width than that of the anodic phase. The asymmetric current pulse is obtained by performing negative phase with higher amplitude and with wider pulse width than that of the anodic phase. The present invention further relates to a process for cathodic protection of electrode or electrode materials, wherein negative bias is applied on the electrode, wherein the negative bias is obtained by asymmetric current pulse, wherein the asymmetric current pulse is obtained by performing negative phase with wider pulse width than that of the anodic phase. The wider pulse width is obtained by pulse trains.
摘要翻译：本发明涉及一种用于对电极或电极材料进行阴极保护的方法，其中对电极施加负偏压，通过不对称电流脉冲获得负偏压。通过执行具有较高振幅的负相来获得非对称电流脉冲。通过执行具有比阳极相宽的脉冲宽度的负相来获得非对称电流脉冲。通过执行具有更高幅度和宽于脉冲宽度的阳极相的负相位获得非对称电流脉冲。本发明还涉及一种用于对电极或电极材料进行阴极保护的方法，其中在电极上施加负偏压，其中通过不对称电流脉冲获得负偏压，其中非对称电流脉冲通过执行具有更宽的负相脉冲宽度大于阳极相。通过脉冲串获得更宽的脉冲宽度。

7. 发明申请

WO2007127443A2 METHOD AND APPARATUS TO PROVIDE SAFETY CHECKS FOR NEURAL STIMULATION 审中-公开
标题翻译：提供安全检查用于神经刺激的方法和装置
公开(公告)号：WO2007127443A2
公开(公告)日：2007-11-08
申请号：PCT/US2007/010362
申请日：2007-04-27
申请人： SECOND SIGHT MEDICAL PRODUCTS, INC. , GREENBERG, Robert, Jay , MCCLURE, Kelly, Hobart , LITTLE, James, Singleton , DAI, Rongqing , ROY, Arup , CASTRO, Richard, Agustin , REINHOLD, John , TANG, Kea-Tiong , YADAV, Sumit , ZHOU, Chunhong , ZHOU, Dao, Min , MAKSY, Pishoy
发明人： GREENBERG, Robert, Jay , MCCLURE, Kelly, Hobart , LITTLE, James, Singleton , DAI, Rongqing , ROY, Arup , CASTRO, Richard, Agustin , REINHOLD, John , TANG, Kea-Tiong , YADAV, Sumit , ZHOU, Chunhong , ZHOU, Dao, Min , MAKSY, Pishoy
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/0551 , A61N1/08 , A61N1/36142 , A61N1/36185
摘要： The present application deals generally with the stimulation of neural tissue by electronic means and specifically with controlling the level of electrical stimulation in order to prevent damage to the neural tissue. Methods presented in the disclosure include detecting current leakage via electrode impedance measurement, electrode capacitance measurement, and testing the electrode response to a test current pulse. Apparatus presented in the disclosure include circuitry and systems capable of performing the methods disclosed.
摘要翻译：本申请一般涉及通过电子手段刺激神经组织，特别是控制电刺激的水平以防止对神经组织的损伤。本公开中提出的方法包括通过电极阻抗测量，电极电容测量和测试电极对测试电流脉冲的响应来检测电流泄漏。本公开中提出的装置包括能够执行所公开的方法的电路和系统。

8. 发明申请

WO2008042278A2 METHOD FOR MEASURING STABLE AND REPRODUCIBLE ELECTRODE-TISSUE IMPEDANCE 审中-公开
标题翻译：测量稳定和可再生的电极 - 组织阻抗的方法
公开(公告)号：WO2008042278A2
公开(公告)日：2008-04-10
申请号：PCT/US2007/020977
申请日：2007-09-28
申请人： SECOND SIGHT MEDICAL PRODUCTS, INC. , HINES, Amy, P. , ZHOU, Dao, Min , ROY, Arup , DAI, Rongqing , GREENBERG, Robert, J.
发明人： HINES, Amy, P. , ZHOU, Dao, Min , ROY, Arup , DAI, Rongqing , GREENBERG, Robert, J.
IPC分类号： A61B5/00
CPC分类号： A61N1/36046 , A61N1/0543
摘要： The present invention is a method for measuring stable and reproducible electrode-tissue impedance, comprising preconditioning an electrode-tissue interface. Further aspect of the invention is a stimulation system for a visual prosthesis generating a stimulation signal to precondition the electrode-tissue interface, comprising a computer; software, loaded in the computer, adapted to perform a stimulating method for a visual prosthesis having a plurality of electrodes; a video processing unit; and an implanted neuron-stimulator.
摘要翻译：本发明是一种用于测量稳定且可再现的电极 - 组织阻抗的方法，包括预处理电极 - 组织界面。本发明的另一方面是一种用于视觉假体的刺激系统，所述视觉假体生成刺激信号以预处理所述电极 - 组织界面，所述刺激系统包括计算机; 装载在计算机中的软件，适于执行具有多个电极的视觉假体的刺激方法; 一个视频处理单元; 和植入的神经元刺激器。

9. 发明申请

WO2007050280A2 A CATALYST AND A METHOD FOR MANUFACTURING THE SAME 审中-公开
标题翻译：催化剂及其制造方法
公开(公告)号：WO2007050280A2
公开(公告)日：2007-05-03
申请号：PCT/US2006/039572
申请日：2006-10-10
申请人： SECOND SIGHT MEDICAL PRODUCTS, INC. , ZHOU, Dao, Min , GREENBERG, Robert, J.
发明人： ZHOU, Dao, Min , GREENBERG, Robert, J.
IPC分类号： C25D3/50 , H01M4/92
CPC分类号： H01M4/8853 , B01D53/945 , B01D2255/1021 , B01J23/08 , B01J23/40 , B01J23/42 , B01J23/44 , B01J23/468 , B01J35/002 , B01J37/0215 , B01J37/348 , C25D3/50 , C25D5/16 , C25D21/12 , H01M4/8807 , H01M4/90 , H01M4/92 , H01M4/921 , H01M4/94 , H01M8/00 , H01M8/1007 , Y02P70/56 , Y02T10/22
摘要： An improved platinum and method for manufacturing the improved platinum wherein the platinum having a fractal surface coating of platinum, platinum gray, with a increase in surface area of at least 5 times when compared to shiny platinum of the same geometry and also having improved resistance to physical stress when compared to platinum black having the same surface area. The process of electroplating the surface coating of platinum gray comprising plating at a moderate rate, for example at a rate that is faster than the rate necessary to produce shiny platinum and that is less than the rate necessary to produce platinum black. Platinum gray is applied to manufacture a fuel cell and a catalyst.
摘要翻译：一种改进的铂和用于制造改进的铂的方法，其中具有铂的分形表面涂层的铂，白金灰，与相同几何形状的闪亮铂相比，表面积增加至少5倍，并且还具有改善的耐与具有相同表面积的铂黑相比，物理应力。电镀铂灰的表面涂层的过程包括以适中的速率镀覆，例如以比产生闪亮铂所需的速率快的速度并且小于生产铂黑所需的速率的速率。铂灰应用于制造燃料电池和催化剂。

10. 发明申请

WO2008042054A2 EXTERNAL COIL ASSEMBLY FOR IMPLANTABLE MEDICAL PROSTHESES 审中-公开
标题翻译：外部线圈组件用于可植入医疗器械
公开(公告)号：WO2008042054A2
公开(公告)日：2008-04-10
申请号：PCT/US2007/018078
申请日：2007-08-15
申请人： SECOND SIGHT MEDICAL PRODUCTS, INC. , DAI, Rongqing , ZHOU, Dao, Min , GREENBERG, Robert, J. , GORD, John
发明人： DAI, Rongqing , ZHOU, Dao, Min , GREENBERG, Robert, J. , GORD, John
IPC分类号： A61N1/372 , A61N1/378 , A61N1/36
CPC分类号： A61N1/37229 , A61N1/36046 , A61N1/3787
摘要： Methods and devices for inductively coupled implants on the human or animal body are disclosed. An external coil assembly to be used with the implant has a transmitting coil and one or more receiving coils. The number of the receiving coils, their distance from the transmitting coil and their shape is chosen to reduce the influence of a noise signal received by the external coil assembly.
摘要翻译：公开了用于人或动物体上的电感耦合植入物的方法和装置。与植入物一起使用的外部线圈组件具有发射线圈和一个或多个接收线圈。选择接收线圈的数量，它们与发射线圈的距离及其形状，以减少由外部线圈组件接收的噪声信号的影响。

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