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1. 发明申请

WO2007127443A2 METHOD AND APPARATUS TO PROVIDE SAFETY CHECKS FOR NEURAL STIMULATION 审中-公开
标题翻译：提供安全检查用于神经刺激的方法和装置
公开(公告)号：WO2007127443A2
公开(公告)日：2007-11-08
申请号：PCT/US2007/010362
申请日：2007-04-27
申请人： SECOND SIGHT MEDICAL PRODUCTS, INC. , GREENBERG, Robert, Jay , MCCLURE, Kelly, Hobart , LITTLE, James, Singleton , DAI, Rongqing , ROY, Arup , CASTRO, Richard, Agustin , REINHOLD, John , TANG, Kea-Tiong , YADAV, Sumit , ZHOU, Chunhong , ZHOU, Dao, Min , MAKSY, Pishoy
发明人： GREENBERG, Robert, Jay , MCCLURE, Kelly, Hobart , LITTLE, James, Singleton , DAI, Rongqing , ROY, Arup , CASTRO, Richard, Agustin , REINHOLD, John , TANG, Kea-Tiong , YADAV, Sumit , ZHOU, Chunhong , ZHOU, Dao, Min , MAKSY, Pishoy
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/0551 , A61N1/08 , A61N1/36142 , A61N1/36185
摘要： The present application deals generally with the stimulation of neural tissue by electronic means and specifically with controlling the level of electrical stimulation in order to prevent damage to the neural tissue. Methods presented in the disclosure include detecting current leakage via electrode impedance measurement, electrode capacitance measurement, and testing the electrode response to a test current pulse. Apparatus presented in the disclosure include circuitry and systems capable of performing the methods disclosed.
摘要翻译：本申请一般涉及通过电子手段刺激神经组织，特别是控制电刺激的水平以防止对神经组织的损伤。本公开中提出的方法包括通过电极阻抗测量，电极电容测量和测试电极对测试电流脉冲的响应来检测电流泄漏。本公开中提出的装置包括能够执行所公开的方法的电路和系统。

2. 发明申请

WO2008013879A2 PROCESS FOR CATHODIC PROTECTION OF ELECTRODE MATERIALS 审中-公开
标题翻译：电极材料阴极保护工艺
公开(公告)号：WO2008013879A2
公开(公告)日：2008-01-31
申请号：PCT/US2007/016783
申请日：2007-07-26
申请人： SECOND SIGHT MEDICAL PRODUCTS, INC. , ZHOU, Dao, Min , HINES, Amy , LITTLE, James, Singleton , GREENBERG, Robert, J.
发明人： ZHOU, Dao, Min , HINES, Amy , LITTLE, James, Singleton , GREENBERG, Robert, J.
IPC分类号： C23F13/02
CPC分类号： C23F13/00 , A61N1/05 , A61N1/08 , C23F13/02
摘要： The present invention relates to a process for cathodic protection of electrode or electrode materials wherein negative bias is applied on the electrode, the negative bias is obtained by asymmetric current pulse. The asymmetric current pulse is obtained by performing negative phase with higher amplitude. The asymmetric current pulse is obtained by performing negative phase with wider pulse width than that of the anodic phase. The asymmetric current pulse is obtained by performing negative phase with higher amplitude and with wider pulse width than that of the anodic phase. The present invention further relates to a process for cathodic protection of electrode or electrode materials, wherein negative bias is applied on the electrode, wherein the negative bias is obtained by asymmetric current pulse, wherein the asymmetric current pulse is obtained by performing negative phase with wider pulse width than that of the anodic phase. The wider pulse width is obtained by pulse trains.
摘要翻译：本发明涉及一种用于对电极或电极材料进行阴极保护的方法，其中对电极施加负偏压，通过不对称电流脉冲获得负偏压。通过执行具有较高振幅的负相来获得非对称电流脉冲。通过执行具有比阳极相宽的脉冲宽度的负相来获得非对称电流脉冲。通过执行具有更高幅度和宽于脉冲宽度的阳极相的负相位获得非对称电流脉冲。本发明还涉及一种用于对电极或电极材料进行阴极保护的方法，其中在电极上施加负偏压，其中通过不对称电流脉冲获得负偏压，其中非对称电流脉冲通过执行具有更宽的负相脉冲宽度大于阳极相。通过脉冲串获得更宽的脉冲宽度。

3. 发明申请

WO2008103195A2 FLEXIBLE CIRCUIT ELECTRODE ARRAY 审中-公开
标题翻译：柔性电路电极阵列
公开(公告)号：WO2008103195A2
公开(公告)日：2008-08-28
申请号：PCT/US2007/083523
申请日：2007-11-02
申请人： SECOND SIGHT MEDICAL PRODUCTS, INC. , NEYSMITH, Jordan , TALBOT, Neil, Hamilton , LITTLE, James, Singleton , MECH, Brian, V. , GREENBERG, Robert, J. , QINGFANG, Yao , ZHOU, Dao, Min
发明人： NEYSMITH, Jordan , TALBOT, Neil, Hamilton , LITTLE, James, Singleton , MECH, Brian, V. , GREENBERG, Robert, J. , QINGFANG, Yao , ZHOU, Dao, Min
CPC分类号： A61N1/0543 , A61N1/0541 , A61N1/36046 , H05K1/028 , H05K1/0353 , H05K1/09 , H05K1/111 , H05K1/115 , H05K1/118 , H05K3/0014 , H05K3/0017 , H05K3/0041 , H05K3/06 , H05K3/188 , H05K3/22 , H05K3/388 , H05K3/4644 , H05K2201/0129 , H05K2201/0133 , H05K2201/0141 , H05K2201/0154 , Y10T29/49156 , Y10T29/49158
摘要： A flexible circuit electrode array with more than one layer of metal traces comprising: a polymer base layer; more than one layer of metal traces, separated by polymer layers, deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; and a polymer top layer deposited on said polymer base layer and said metal traces. Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, or cortical stimulation many purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow.
摘要翻译：具有多于一层金属迹线的柔性电路电极阵列，其包括：聚合物基底层; 沉积在所述聚合物基层上的由聚合物层分开的多于一层的金属迹线，所述金属迹线包括适于刺激神经组织的电极; 以及沉积在所述聚合物基层和所述金属迹线上的聚合物顶层。聚合物材料可用作神经刺激的电极阵列体。它们对视网膜刺激产生人造视觉，耳蜗刺激以产生人造听力或许多目的的皮质刺激特别有用。通过电极阵列施加在视网膜或其他神经组织上的压力是至关重要的。压力太小会导致电阻增加，同时电场分散。压力过大可能会阻碍血液流动。

4. 发明申请

WO2008109862A2 FLEXIBLE CIRCUIT ELECTRODE ARRAY 审中-公开
标题翻译：柔性电路阵列
公开(公告)号：WO2008109862A2
公开(公告)日：2008-09-12
申请号：PCT/US2008/056301
申请日：2008-03-07
申请人： SECOND SIGHT MEDICAL PRODUCTS, INC. , DOHENY EYE INSTITUTE , AGRAWAL, Rajat , GREENBERG, Robert, J. , HUMAYUN, Mark, S. , LITTLE, James, Singleton , MECH, Brian, V. , NEYSMITH, Jordan, Matthew , TALBOT, Neil, Hamilton , ZHOU, Dao, Min
发明人： AGRAWAL, Rajat , GREENBERG, Robert, J. , HUMAYUN, Mark, S. , LITTLE, James, Singleton , MECH, Brian, V. , NEYSMITH, Jordan, Matthew , TALBOT, Neil, Hamilton , ZHOU, Dao, Min
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/0541 , A61N1/0543
摘要： A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a central opening in the area of the metal traces. A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a soft polymer filling an attachment point. A flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a hump to avoid a touching of the flexible electrode array and the optic nerve.
摘要翻译：一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 和金属痕迹区域的中心开口。一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 和填充附着点的软质聚合物。一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 和一个驼峰以避免触摸柔性电极阵列和视神经。

5. 发明申请

WO2008021524A3 PACKAGE FOR AN IMPLANTABLE NEURAL STIMULATION DEVICE 审中-公开
公开(公告)号：WO2008021524A3
公开(公告)日：2008-02-21
申请号：PCT/US2007/018315
申请日：2007-08-18
申请人： SECOND SIGHT MEDICAL PRODUCTS, INC. , OK, Jerry , GREENBERG, Robert, J. , TALBOT, Neil, Hamilton , LITTLE, James, Singleton , DAI, Rongqing , NEYSMITH, Jordan, Matthew , MCCLURE, Kelly, H.
发明人： OK, Jerry , GREENBERG, Robert, J. , TALBOT, Neil, Hamilton , LITTLE, James, Singleton , DAI, Rongqing , NEYSMITH, Jordan, Matthew , MCCLURE, Kelly, H.
IPC分类号： A61N1/00
摘要： The present invention is an improved hermetic package for implantation in the human body. The implantable device comprises an electrically non-conductive substrate; a plurality of electrically conductive vias through said electrically non-conductive substrate; a flip-chip circuit attached to said electrically non-conductive substrate using conductive bumps and electrically connected to a first subset of said plurality of electrically conductive vias, wherein said flip-chip circuit contains one or more stacks or a folded stack; a wire bonded circuit attached to said electrically non-conductive substrate and electrically connected to a second subset of said electrically conductive vias; and a cover bonded to said electrically non-conductive substrate, said cover, said electrically non-conductive substrate and said electrically conductive vias forming a hermetic package.

6. 发明申请

WO2011137298A3 IMPROVED BIOCOMPATIBLE BONDING METHOD 审中-公开
公开(公告)号：WO2011137298A3
公开(公告)日：2011-11-03
申请号：PCT/US2011/034471
申请日：2011-04-29
申请人： SECOND SIGHT MEDICAL PRODUCTS,INC. , FARAJI, Boozarjomehr , ZHOU, David, Daomin , GREENBERG, Robert, J. , OK, Jerry , TALBOT, Neil, Hamilton , LITTLE, James, Singleton
发明人： FARAJI, Boozarjomehr , ZHOU, David, Daomin , GREENBERG, Robert, J. , OK, Jerry , TALBOT, Neil, Hamilton , LITTLE, James, Singleton
IPC分类号： A61N1/36 , A61N1/375 , H01L21/60 , H01L21/56 , A61B5/04
摘要： The invention is a device and method for connecting a hermetic package to a flexible circuit such as for an electrode array in an implantable device. Attaching metal pads on a flexible circuit to metal pads on a hermetic device by conductive adhesive is known. A smooth metal, such as platinum, does not bond well to conductive epoxy. The invention provides a roughened surface, such as by etching or by applying high surface area platinum gray, to improve adhesion to platinum or other metal pads.

7. 发明申请

WO2007035774A1 RETINAL PROSTHESIS WITH A NEW CONFIGURATION 审中-公开
标题翻译：用新的配置进行RETINAL PROSTHISIS
公开(公告)号：WO2007035774A1
公开(公告)日：2007-03-29
申请号：PCT/US2006/036549
申请日：2006-09-19
申请人： SECOND SIGHT MEDICAL PRODUCTS, INC. , GREENBERG, Robert, J. , MCMAHON, Matthew, J. , LITTLE, James, Singleton , MCCLURE, Kelly, H. , MECH, Brian, V. , TALBOT, Neil, Hamiton , NEYSMITH, Jordan, M.
发明人： GREENBERG, Robert, J. , MCMAHON, Matthew, J. , LITTLE, James, Singleton , MCCLURE, Kelly, H. , MECH, Brian, V. , TALBOT, Neil, Hamiton , NEYSMITH, Jordan, M.
IPC分类号： A61N1/36
CPC分类号： A61N1/0543 , A61N1/025 , A61N1/36046 , A61N1/37229 , H05K1/028 , H05K1/0281 , H05K1/118 , H05K3/0014 , H05K3/28 , H05K2201/0133 , H05K2201/09018 , H05K2201/09909 , H05K2203/1105 , H05K2203/1476 , H05K2203/302
摘要： Polymer materials are useful as electrode array bodies for neural stimulation. They are particularly useful for retinal stimulation to create artificial vision, cochlear stimulation to create artificial hearing, and cortical stimulation, and many related purposes. The pressure applied against the retina, or other neural tissue, by an electrode array is critical. Too little pressure causes increased electrical resistance, along with electric field dispersion. Too much pressure may block blood flow. Common flexible circuit fabrication techniques generally require that a flexible circuit electrode array be made flat. Since neural tissue is almost never flat, a flat array will necessarily apply uneven pressure. Further, the edges of a flexible circuit polymer array may be sharp and cut the delicate neural tissue. By applying the right amount of heat to a completed array, a curve can be induced. With a thermoplastic polymer it may be further advantageous to repeatedly heat the flexible circuit in multiple molds, each with a decreasing radius. Further, it is advantageous to add material along the edges. It is further advantageous to provide a fold or twist in the flexible circuit array. Additional material may be added inside and outside the fold to promote a good seal with tissue.
摘要翻译：聚合物材料可用作神经刺激的电极阵列体。它们特别适用于视网膜刺激以产生人造视觉，耳蜗刺激以产生人造听觉和皮质刺激以及许多相关目的。通过电极阵列对视网膜或其他神经组织施加的压力是至关重要的。太小的压力会导致电阻增加以及电场分散。太大的压力可能会阻止血液流动。通常的柔性电路制造技术通常需要使柔性电路电极阵列平坦。由于神经组织几乎从不平坦，平面阵列必然会施加不均匀的压力。此外，柔性电路聚合物阵列的边缘可以是尖锐的并切割精细的神经组织。通过将适量的热应用于完整的阵列，可以引起曲线。对于热塑性聚合物，可以进一步有利的是在多个模具中反复加热柔性电路，每个模具具有减小的半径。此外，沿着边缘添加材料是有利的。在柔性电路阵列中提供折叠或扭曲是更有利的。可以在折叠内部和外部添加附加材料以促进与组织的良好密封。

8. 发明申请

WO2009003182A1 FLEXIBLE CIRCUIT ELECTRODE ARRAY 审中-公开
标题翻译：柔性电路阵列
公开(公告)号：WO2009003182A1
公开(公告)日：2008-12-31
申请号：PCT/US2008/068640
申请日：2008-06-27
申请人： SECOND SIGHT MEDICAL PRODUCTS, INC. , ZHOU, David, Daomin , GREENBERG, Robert, J. , NEYSMITH, Jordan, Matthew , NG, Boon-Khai , LITTLE, James, Singleton
发明人： ZHOU, David, Daomin , GREENBERG, Robert, J. , NEYSMITH, Jordan, Matthew , NG, Boon-Khai , LITTLE, James, Singleton
IPC分类号： A61N1/05
CPC分类号： A61N1/0543 , A61N1/0541 , H05K1/036 , H05K1/0393 , H05K1/118 , H05K3/28 , H05K2201/0133 , H05K2201/0195 , Y10T156/1002
摘要： A flexible circuit electrode array, which comprises: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a partial or entire coating of the base and top layer by a soft polymer. A method of preparing a flexible circuit electrode array, comprising: (a) providing a first soft polymer layer; (b) depositing a first a base layer on the first soft polymer layer; (c) providing a metal thin film on the base layer; (d) depositing a top polymer layer on the metal thin film; (e) providing holes in the top polymer layer; (f) depositing a second soft polymer layer on the top polymer layer; (g) providing holes in the second soft polymer layer for bond pads and electrodes; and (h) preparing electrodes in the provided holes. A method of preparing a flexible circuit electrode array, comprising: (a) providing a first soft polymer layer; (b) depositing a first a base layer on the first soft polymer layer; (c) providing a metal thin film on the base layer; (d) depositing a top polymer layer on the metal thin film; (e) depositing a second soft polymer layer on the top polymer layer; (f) providing holes in the second soft polymer layer and in the top polymer layer for bond pads and electrodes; and (g) preparing electrodes in the provided holes.
摘要翻译：一种柔性电路电极阵列，包括：聚合物基层; 沉积在所述聚合物基层上的金属痕迹，包括适于刺激神经组织的电极; 沉积在所述聚合物基底层和所述金属迹线上的聚合物顶层; 以及通过软聚合物的基底和顶层的部分或全部涂层。一种制备柔性电路电极阵列的方法，包括：（a）提供第一软聚合物层; （b）在第一软聚合物层上沉积第一基底层; （c）在基层上提供金属薄膜; （d）在金属薄膜上沉积顶部聚合物层; （e）在顶部聚合物层中提供孔; （f）在顶部聚合物层上沉积第二软聚合物层; （g）在第二软聚合物层中为接合焊盘和电极提供孔; 和（h）在所提供的孔中制备电极。一种制备柔性电路电极阵列的方法，包括：（a）提供第一软聚合物层; （b）在第一软聚合物层上沉积第一基底层; （c）在基层上提供金属薄膜; （d）在金属薄膜上沉积顶部聚合物层; （e）在顶部聚合物层上沉积第二软聚合物层; （f）在第二软聚合物层和顶部聚合物层中提供用于接合焊盘和电极的孔; 和（g）在所提供的孔中制备电极。

9. 发明申请

WO2008101225A3 FLEXIBLE CIRCUIT ELECTRODE ARRAY WITH WIRE OR FILM SUPPORT 审中-公开
公开(公告)号：WO2008101225A3
公开(公告)日：2008-08-21
申请号：PCT/US2008/054181
申请日：2008-02-15
申请人： SECOND SIGHT MEDICAL PRODUCTS, INC. , DOHENY EYE INSTITUTE , GREENBERG, Robert, J. , DE JUAN, Eugene , HUMAYUN, Mark, S. , MCCLURE, Kelly, H. , TALBOT, Neil, Hamilton , NEYSMITH, Jordan, Matthew , MECH, Brian, V. , LITTLE, James, Singleton , KHALDI, Mohamed
发明人： GREENBERG, Robert, J. , DE JUAN, Eugene , HUMAYUN, Mark, S. , MCCLURE, Kelly, H. , TALBOT, Neil, Hamilton , NEYSMITH, Jordan, Matthew , MECH, Brian, V. , LITTLE, James, Singleton , KHALDI, Mohamed
IPC分类号： A61N1/05
摘要： The disclosure relates to a flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and at least one support embedded in said array. The disclosure further relates to a flexible circuit electrode array comprising: a polymer base layer; metal traces deposited on said polymer base layer, including electrodes suitable to stimulate neural tissue; a polymer top layer deposited on said polymer base layer and said metal traces; and a folded flexible circuit cable connecting the electrode array with an interconnection pad. The disclosure further relates to a method of making a flexible circuit electrode array comprising: depositing a polymer base layer; depositing metal on said polymer base layer; patterning said metal to form metal traces; depositing a polymer top layer on said polymer base layer and said metal traces; heating said flexible circuit electrode array in a mold to form a three dimensional shape in said flexible circuit electrode array, embedding a support at least in the base layer, top layer or between the base and top layer, and/or folding a flexible circuit cable at least once connecting the electrode array with an interconnection pad the array.

10. 发明申请

WO2009062114A2 COCHLEAR STIMULATION DEVICE 审中-公开
标题翻译： COCHLEAR刺激装置
公开(公告)号：WO2009062114A2
公开(公告)日：2009-05-14
申请号：PCT/US2008/082904
申请日：2008-11-07
申请人： SECOND SIGHT MEDICAL PRODUCTS, INC. , GREENBERG, Robert, J. , ZHOU, David, Daomin , NEYSMITH, Jordan, Matthew , MCCLURE, Kelly , WEI, Jianing , TALBOT, Neil, Hamilton , LITTLE, James, Singleton
发明人： GREENBERG, Robert, J. , ZHOU, David, Daomin , NEYSMITH, Jordan, Matthew , MCCLURE, Kelly , WEI, Jianing , TALBOT, Neil, Hamilton , LITTLE, James, Singleton
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/0541 , A61N1/0472
摘要： A cochlear stimulation device comprising an electrode array designed to provide enhanced charge injection capacity necessary for neural stimulation. The electrode array comprises electrodes with high surface area or a fractal geometry and correspondingly high electrode capacitance and low electrical impedance. The resultant electrodes have a robust surface and sufficient mechanical strength to withstand physical stress vital for long term stability. The device further comprises wire traces having a multilayer structure which provides a reduced width for the conducting part of the electrode array. The cochlear prosthesis is attached by a grommet to the cochleostomy that is made from a single piece of biocompatible polymer. The device, designed to achieve optimum neural stimulation by appropriate electrode design, is a significant improvement over commercially available hand-built devices.
摘要翻译：耳蜗刺激装置包括设计成提供神经刺激所需的增强的电荷注入能力的电极阵列。电极阵列包括具有高表面积或分形几何形状的电极以及相当高的电极电容和低的电阻抗。所得电极具有坚固的表面和足够的机械强度以抵抗对于长期稳定性至关重要的物理应力。该装置还包括具有多层结构的导线迹线，其为电极阵列的导电部分提供减小的宽度。耳蜗假体通过索环连接到由单一生物相容性聚合物制成的耳蜗切开术。该设备旨在通过适当的电极设计实现最佳的神经刺激，是相对于市售的手工设备的显着改进。

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