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1. 发明申请

WO2007127443A2 METHOD AND APPARATUS TO PROVIDE SAFETY CHECKS FOR NEURAL STIMULATION 审中-公开
标题翻译：提供安全检查用于神经刺激的方法和装置
公开(公告)号：WO2007127443A2
公开(公告)日：2007-11-08
申请号：PCT/US2007/010362
申请日：2007-04-27
申请人： SECOND SIGHT MEDICAL PRODUCTS, INC. , GREENBERG, Robert, Jay , MCCLURE, Kelly, Hobart , LITTLE, James, Singleton , DAI, Rongqing , ROY, Arup , CASTRO, Richard, Agustin , REINHOLD, John , TANG, Kea-Tiong , YADAV, Sumit , ZHOU, Chunhong , ZHOU, Dao, Min , MAKSY, Pishoy
发明人： GREENBERG, Robert, Jay , MCCLURE, Kelly, Hobart , LITTLE, James, Singleton , DAI, Rongqing , ROY, Arup , CASTRO, Richard, Agustin , REINHOLD, John , TANG, Kea-Tiong , YADAV, Sumit , ZHOU, Chunhong , ZHOU, Dao, Min , MAKSY, Pishoy
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/0551 , A61N1/08 , A61N1/36142 , A61N1/36185
摘要： The present application deals generally with the stimulation of neural tissue by electronic means and specifically with controlling the level of electrical stimulation in order to prevent damage to the neural tissue. Methods presented in the disclosure include detecting current leakage via electrode impedance measurement, electrode capacitance measurement, and testing the electrode response to a test current pulse. Apparatus presented in the disclosure include circuitry and systems capable of performing the methods disclosed.
摘要翻译：本申请一般涉及通过电子手段刺激神经组织，特别是控制电刺激的水平以防止对神经组织的损伤。本公开中提出的方法包括通过电极阻抗测量，电极电容测量和测试电极对测试电流脉冲的响应来检测电流泄漏。本公开中提出的装置包括能够执行所公开的方法的电路和系统。

2. 发明申请

WO2008153592A1 VIDEO PROCESSING UNIT FOR A VISUAL PROSTHETIC APPARATUS 审中-公开
标题翻译：视频预处理设备的视频处理单元
公开(公告)号：WO2008153592A1
公开(公告)日：2008-12-18
申请号：PCT/US2007/083944
申请日：2007-11-07
申请人： SECOND SIGHT MEDICAL PRODUCTS, INC. , MCCLURE, Kelly H. , ROY, Arup , CASTRO, Richard Agustin , YADAV, Sumit , DAI, Rongqing , GREENBERG, Robert J. , CHANG, Da-Yu , WU, Xiaofan , LOFTIN, Scott , MCCORD, Susan
发明人： MCCLURE, Kelly H. , ROY, Arup , CASTRO, Richard Agustin , YADAV, Sumit , DAI, Rongqing , GREENBERG, Robert J. , CHANG, Da-Yu , WU, Xiaofan , LOFTIN, Scott , MCCORD, Susan
IPC分类号： A61N1/36
CPC分类号： A61N1/36046 , A61N1/37247 , A61N1/37258
摘要： A visual prosthesis apparatus and a method for providing artificial vision are disclosed in the present disclosure. The visual prosthesis apparatus comprises a video capture device for capturing a video image, a video processing unit associated with the video capture device, the video processing unit configured to convert the video image to stimulation patterns, and a retinal stimulation system configured to stimulate neural tissue in a subject's eye based on the stimulation patterns, wherein the video processing unit is configured to be powered on after a first time interval upon activation of a power button, wherein the video processing unit is configured to be powered off after a second time interval upon activation of a power button.
摘要翻译：在本公开中公开了一种视觉假体装置和用于提供人造视觉的方法。视觉假体装置包括用于捕获视频图像的视频捕获装置，与视频捕捉装置相关联的视频处理单元，被配置为将视频图像转换成刺激模式的视频处理单元以及被配置为刺激神经组织的视网膜刺激系统基于刺激模式在受试者的眼中，其中视频处理单元被配置为在激活电源按钮之后在第一时间间隔之后通电，其中视频处理单元被配置为在第二时间间隔之后关闭电源激活电源按钮。

3. 发明申请

WO2007064916A2 FITTING A NEURAL PROSTHESIS USING IMPEDANCE AND ELECTRODE HEIGHT 审中-公开
标题翻译：用阻抗和电极高度拟合神经假体
公开(公告)号：WO2007064916A2
公开(公告)日：2007-06-07
申请号：PCT/US2006/046042
申请日：2006-12-01
申请人： SECOND SIGHT MEDICAL PRODUCTS, INC. , DOHENY EYE INSTITUTE , GREENBERG, Robert, J. , ROY, Arup , MCMAHON, Matthew, J. , HUMAYUN, Mark, S. , WEILAND, James, David , HORSAGER, Alan, Matthew , ZHOU, Dao, Min , HINES, Amy , YADAV, Sumit , DAI, Rongqing , FINE, Ione
发明人： GREENBERG, Robert, J. , ROY, Arup , MCMAHON, Matthew, J. , HUMAYUN, Mark, S. , WEILAND, James, David , HORSAGER, Alan, Matthew , ZHOU, Dao, Min , HINES, Amy , YADAV, Sumit , DAI, Rongqing , FINE, Ione
CPC分类号： A61N1/0543 , A61N1/36046 , A61N1/37247
摘要： The invention is a method of automatically adjusting an electrode array to the neural characteristics of an individual subject. The response to electrical neural stimulation varies from subject to subject. Measure of impedance may be used to predict the electrode height from the neural tissue and, thereby, predict the threshold of perception. Alternatively, electrode height may be measured directly to predict the threshold of perception. Also, impedance measurement may be used to quickly identify defective electrodes and proper electrode placement.
摘要翻译：本发明是一种将电极阵列自动调整为个体对象的神经特征的方法。对电神经刺激的反应因受试者而异。阻抗测量可用于预测来自神经组织的电极高度，从而预测感知的阈值。或者，可以直接测量电极高度以预测感知的阈值。此外，阻抗测量可用于快速识别有缺陷的电极和适当的电极位置。

4. 发明申请

WO2007035743A3 DOWNLOADABLE FILTERS FOR A VISUAL PROSTHESIS 审中-公开
公开(公告)号：WO2007035743A3
公开(公告)日：2007-03-29
申请号：PCT/US2006/036501
申请日：2006-09-18
申请人： SECOND SIGHT MEDICAL PRODUCTS, INC. , MCCLURE, Kelly, H. , ROY, Arup , YADAV, Sumit , MAKSY, Pishoy , MELISTRUP, Peter
发明人： MCCLURE, Kelly, H. , ROY, Arup , YADAV, Sumit , MAKSY, Pishoy , MELISTRUP, Peter
IPC分类号： A61N1/36 , A61F9/08 , A61N1/05 , A61F2/14
摘要： The present invention is a method of neural stimulation and more specifically an improved method of providing flexible video/image possessing in a visual prosthesis by providing downloadable video filters. In a visual prosthesis, the input video image will, for the foreseeable future, be higher resolution than the output stimulation of the retina, optic nerve or visual cortex. This is due to limits of electrode array technology and the rapid advancement of video camera technology. It is therefore, advantageous to apply video processing algorithms (filters) to help provide the most useful information to the lower resolution electrode array. Different filters are more effective in different environments and for different subjects. Furthermore, filters will continue to improve over time. Examples of situation dependent filters include reverse image, contrast increasing, edge detection, segmentation using chromatic information and motion detection. Filters loaded in the video processing unit may be selected dynamically to suit the situation or the user's preference. It is therefore advantageous to provide flexibility in applying filters. However, it is also important to maintain the security necessary for a medical device. The present invention provides for an external (not implanted) video processing unit with downloadable video filters.

5. 发明申请

WO2008013937A2 VISUAL PROSTHESIS 审中-公开
标题翻译：视觉假体
公开(公告)号：WO2008013937A2
公开(公告)日：2008-01-31
申请号：PCT/US2007/016897
申请日：2007-07-27
申请人： SECOND SIGHT MEDICAL PRODUCTS, INC. , MCCLURE, Kelly, H. , ROY, Arup , YADAV, Sumit , CASTRO, Richard, Agustin , MCCORD, Susan
发明人： MCCLURE, Kelly, H. , ROY, Arup , YADAV, Sumit , CASTRO, Richard, Agustin , MCCORD, Susan
IPC分类号： A61N1/36
CPC分类号： A61N1/36046 , A61N1/0543 , A61N1/3787
摘要： A visual prosthesis apparatus and a method for providing artificial vision are disclosed in the present disclosure. The visual prosthesis apparatus comprises a camera for capturing a video image, a video processing unit configured to convert the video image to stimulation patterns, and a retinal stimulation system configured stimulate neural tissue in a subjects eye based on the stimulation patterns. An artificial vision may be provided by capturing a video image, converting the video image to stimulation patterns, and stimulating neural tissue in a subjects eye based on the stimulation patterns.
摘要翻译：在本公开中公开了一种用于提供人造视觉的视觉假体装置和方法。视觉假体装置包括用于捕获视频图像的相机，配置成将视频图像转换为刺激图案的视频处理单元，以及配置的视网膜刺激系统基于刺激图案刺激对象眼睛中的神经组织。可以通过捕获视频图像，将视频图像转换成刺激图案，并基于刺激图案刺激对象眼睛中的神经组织来提供人工视觉。

6. 发明申请

WO2023034182A1 NON-OPIOID METHODS FOR TREATING PAIN 审中-公开
公开(公告)号：WO2023034182A1
公开(公告)日：2023-03-09
申请号：PCT/US2022/041820
申请日：2022-08-29
申请人： UNIVERSITY OF CONNECTICUT , SCHMIDT, Tannin , YADAV, Sumit , FENG, Bin , EMADI, Sharareh
发明人： SCHMIDT, Tannin , YADAV, Sumit , FENG, Bin , EMADI, Sharareh
IPC分类号： A61K38/17 , A61P19/04 , A61P25/02 , A61K47/00
摘要： The present disclosure relates to administration of pharmaceutically acceptable composition as a means to reduce acute and chronic pain and treat other conditions. Pharmaceutical acceptable composition comprising a pharmaceutically effective amount of a full length recombinant human PRG4 (rhPRG4) or a fragment thereof and a pharmaceutically acceptable carrier or diluent.

7. 发明申请

WO2008124065A2 COMPUTER METHOD AND SYSTEM FOR EQUITY FINANCING BY RETAIL INVESTORS WITH COLLECTIVE DUE DILIGENCE FUNDING 审中-公开
标题翻译：零售投资者与集体借款资金进行股权融资的计算机方法与制度
公开(公告)号：WO2008124065A2
公开(公告)日：2008-10-16
申请号：PCT/US2008/004407
申请日：2008-04-04
申请人： PHISTREAM, INC. , SINHA, Vaibhav , ABBAS, Misam , YADAV, Sumit
发明人： SINHA, Vaibhav , ABBAS, Misam , YADAV, Sumit
CPC分类号： G06Q40/06 , G06Q40/00
摘要： The present invention provides a business facilitation system enabling retail investors to acquire equity in business entities that are seeking equity financing. The fund seeker electronically posts a proposal seeking funds. Through electronic communication means investors commit to buying the private equity at the rate fixed or indicate interest in getting due diligence conducted. If the funds sought are not met by unconditional commitments then investors who had indicated interest in due diligence can make conditional commitments based on the results of the due diligence for which they are willing to pool in funds. If a certain percentage of the funds sought are committed or met though conditional commitments whose conditions are satisfied within a fixed time period, then the fund seeker honors the proposal. Otherwise the fund seeker can revise, extend, honor or withdraw the proposal.
摘要翻译：本发明提供了一种商业便利化系统，使得零售投资者能够收购正在寻求股权融资的商业实体的股权。基金寻求者以电子方式发布寻求资金的提案。通过电子交易，投资者决定以固定利率购买私募股权，或表示进行尽职调查的兴趣。如果所要求的资金不能通过无条件承诺实现，那么表示有意尽职调查的投资者可以根据愿意汇款的尽职调查结果，作出有条件的承诺。如果所要求资金的一定百分比是通过有条件的承诺在一段固定的时间内得到满足的，那么基金追求者就会对该提案表示荣誉。否则，基金寻求者可以修改，延期，兑现或撤回提案。

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