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1. 发明申请

WO2013018083A3 ELECTROSTIMULATION IN TREATING CEREBROVASCULAR CONDITIONS 审中-公开
标题翻译：电解治疗脑血管病变
公开(公告)号：WO2013018083A3
公开(公告)日：2014-08-21
申请号：PCT/IL2012000290
申请日：2012-08-02
申请人： SAMSON NEUROSCIENCES LTD , SHALEV ALON , LEVY RONNIE , BEINART YIFTACH
发明人： SHALEV ALON , LEVY RONNIE , BEINART YIFTACH
IPC分类号： A61N1/36 , A61N1/05
CPC分类号： A61N1/36103 , A61N1/0558 , A61N1/36017 , A61N1/36025 , A61N1/36053 , A61N1/36057 , A61N1/36175 , A61N1/3787
摘要： A system for treating a medical condition in a living body, comprising two subsystems, an implant subsystem and an electrical stimulation unit subsystem. The implant subsystem comprises at least one electrostimulation module, contains at least one electrically conductive electrode and, preferably, an anchoring member. The electrical stimulation unit, adapted for producing and controlling electrical waveforms, is connected to the electrodes. The implant subsystem is implanted adjacent to at least one of the following structures: the carotid sinus nerve, aortic nerve, common carotid artery, external carotid artery, internal carotid artery, carotid artery bifurcation, carotid body, aortic body or aortic arch receptors. The electrical stimulation unit is maintained outside the patient's body and is adapted to program, generate, control and deliver the electrical waveform via a wired or a wireless connection to the implant subsystem, thereby stimulating the structure it is adjacent to and treating the medical condition.
摘要翻译：一种用于治疗生物体内的医疗状况的系统，包括两个子系统，植入子系统和电刺激单元子系统。植入子系统包括至少一个电刺激模块，其包含至少一个导电电极，并且优选地包括锚定构件。适于产生和控制电波形的电刺激单元连接到电极。植入子系统相邻于以下结构中的至少一个：颈动脉窦神经，主动脉神经，颈总动脉，颈外动脉，颈内动脉，颈动脉分叉，颈动脉体，主动脉体或主动脉弓受体。电刺激单元保持在患者身体外部，并且适于通过有线或无线连接对植入物子系统进行编程，生成，控制和传送电波形，从而刺激其与医疗状况相邻并处理的结构。

2. 发明申请

WO2014120584A3 ELECTROSTIMULATION IN TREATING CEREBROVASCULAR CONDITIONS 审中-公开
标题翻译：电解治疗脑血管病变
公开(公告)号：WO2014120584A3
公开(公告)日：2014-10-23
申请号：PCT/US2014013094
申请日：2014-01-27
申请人： SAMSON NEUROSCIENCES LTD , KLEIN DAVID
发明人： LEVY RONNIE , BEINART YIFTACH , SHALEV ALON
IPC分类号： A61N1/36 , A61N1/05 , A61N1/375
CPC分类号： A61N1/05 , A61N1/0558 , A61N1/08 , A61N1/36025 , A61N1/36053 , A61N1/36057 , A61N1/375
摘要： An electrostimulation device (10) includes an electrode shaft (12) that includes a plurality of electrodes (24). In one embodiment, a controller (28) is in electrical communication with the electrodes (24), and the controller (28) controls operating parameters associated with energization of the electrodes (24). A fixation member (60) includes a member (66) for receiving therein a portion of the electrode shaft (12) and a locking member (86) is provided for releasably affixing the electrode shaft (12) to the fixation member (60).
摘要翻译：电刺激装置（10）包括包括多个电极（24）的电极轴（12）。在一个实施例中，控制器（28）与电极（24）电连通，并且控制器（28）控制与电极（24）的通电相关联的操作参数。固定构件（60）包括用于在其中容纳电极轴（12）的一部分的构件（66），并且设置有用于将电极轴（12）可释放地固定到固定构件（60）的锁定构件（86）。

3. 发明申请

WO2009116047A3 SOLID DOSAGE FORM FOR TREATING HEADACHES 审中-公开
标题翻译：用于治疗头痛的固体剂型
公开(公告)号：WO2009116047A3
公开(公告)日：2010-03-11
申请号：PCT/IL2009000314
申请日：2009-03-19
申请人： PAINDURE LTD , SHALEV ALON , LAMNSDORF ITSCHAK
发明人： SHALEV ALON , LAMNSDORF ITSCHAK
IPC分类号： A61K9/22
CPC分类号： A61K9/0024 , A61K9/0043 , A61K9/0085 , A61K31/167 , A61K31/245 , A61K47/34
摘要： A retrievable, sustained release, solid dosage form is provided for implanting into cranial bony canals and for prolonged release of an anesthetic, whereby treating neurovascular conditions, such as migraine. The dosage comprises an anesthetic contained in a polymeric carrier, and a retrieval member, the anesthetic being gradually released from the carrier.
摘要翻译：提供可回收，持续释放的固体剂型用于植入颅骨通道和延长释放麻醉剂，从而治疗神经血管病症，例如偏头痛。剂量包括聚合物载体中含有的麻醉剂和回收构件，麻醉剂逐渐从载体释放。

4. 发明申请

WO2006080010A3 DEVICE AND METHOD FOR CORONARY ARTERY BYPASS PROCEDURE 审中-公开
标题翻译：冠状动脉旁路手术的装置及方法
公开(公告)号：WO2006080010A3
公开(公告)日：2008-01-24
申请号：PCT/IL2006000104
申请日：2006-01-25
申请人： NICAST LTD , SHALEV ALON
发明人： SHALEV ALON
IPC分类号： A61B17/04 , A61F2/06
CPC分类号： A61F2/06 , A61F2/07 , A61F2/24 , A61F2002/072 , A61F2250/0039 , A61F2250/006 , A61F2250/0067
摘要： A method of bypassing a coronary artery being at least partially occluded. The method comprises: using a branching graft for establishing direct fluid communication between three or more vascular locations. Specifically direct fluid communication is established between an upstream vascular location, a downstream vascular location and a distal vascular location. The distal vascular location is preferably selected on a distal artery or a distal portion of an artery to ensure that arterial blood flow in the distal artery generates sufficient pressure gradient in the branching graft to maintain the direct fluid communication.
摘要翻译：绕过冠状动脉至少部分闭塞的方法。该方法包括：使用分枝移植物来建立三个或更多个血管位置之间的直接流体连通。在上游血管位置，下游血管位置和远端血管位置之间建立直接的流体连通。优选在远端动脉或动脉的远端部分选择远端血管位置，以确保远端动脉中的动脉血流在分支移植物中产生足够的压力梯度以保持直接的流体连通。

5. 发明申请

WO2006080009A3 IMPLANTABLE BIOREACTORS AND USES THEREOF 审中-公开
标题翻译：可植入的生物反应器及其用途
公开(公告)号：WO2006080009A3
公开(公告)日：2007-01-25
申请号：PCT/IL2006000103
申请日：2006-01-25
申请人： NICAST LTD , SHALEV ALON
发明人： SHALEV ALON
IPC分类号： A61K9/22
CPC分类号： A61F2/022
摘要： An implantable bioreactor device and methods of use are provided. The device comprises a first compartment being configured capable of fluidic communication with a vasculature of a subject; and a second compartment configured for containing cells, said second compartment being separated from said first compartment by a membrane.
摘要翻译：提供可植入生物反应器装置和使用方法。该装置包括配置成能够与受试者的脉管系统流体连通的第一隔室; 以及构造成容纳细胞的第二隔室，所述第二隔室通过膜与所述第一隔室分离。

6. 发明申请

WO2006080007A3 MULTIPORT VASCULAR PROSTHESIS 审中-公开
标题翻译：多重血管造影
公开(公告)号：WO2006080007A3
公开(公告)日：2007-04-19
申请号：PCT/IL2006000101
申请日：2006-01-25
申请人： NICAST LTD , SHALEV ALON
发明人： SHALEV ALON
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61F2002/065
摘要： A vascular prosthesis (10) comprising a primary tubular structure (12) of non-woven polymer fibers and a secondary tubular structure (14) of non-woven polymer fibers is disclosed. The primary and secondary tubular structures (12,14) are in fluid communication via an anasotomosis (16) such that the primary tubular structure (12) terminates at the anastomosis (16) and the secondary tubular structure (14) continues at the anastomosis (16).
摘要翻译：公开了一种血管假体（10），其包括非织造聚合物纤维的初级管状结构（12）和非织造聚合物纤维的次级管状结构（14）。初级和次级管状结构（12,14）经由吻合器（16）流体连通，使得主管状结构（12）在吻合（16）处终止，并且次级管状结构（14）在吻合处继续 16）。

7. 发明申请

WO2004043218A3 SURGICAL TOOLS AND TECHNIQUES FOR STIMULATION 审中-公开
标题翻译：手术工具和刺激技术
公开(公告)号：WO2004043218A3
公开(公告)日：2006-07-13
申请号：PCT/IL0300966
申请日：2003-11-13
申请人： BRAINSGATE LTD , LORIAN ADI , GROSS YOSSI , SHALEV ALON , BENARY RAPHAEL
发明人： GROSS YOSSI , SHALEV ALON , BENARY RAPHAEL
IPC分类号： A61N1/08 , A61B20060101 , A61B1/00 , A61N1/30 , A61N1/36
CPC分类号： A61N1/36082 , A61N1/0546 , A61N1/08 , A61N1/30
摘要： Apparatus for treating a subject is provided, the apparatus comprising (a) a stimulation device (352), adapted to be implanted in a vicinity of a site selected from the list consisting of: a sphenopalatine ganglion (SPG) (52) of the subject and a neural tract originating in or leading to the SPG; and (b) a connecting element (356), coupled to the stimulation device (352), and adapted to be passed through at least a portion of a greater palatine canal (282) of the subject. Also provided is a method for implanting a treatment stimulation device (352) in a vicinity of a site of a subject, the method comprising passing the device (352) through a greater palatine foramen (22) of the subject, and bringing the device (352) into contact with the vicinity of the site, the site selected from the list consisting of: a sphenopalatine ganglion (SPG) (52) of the subject and a neural tract originating in or leading to the SPG.
摘要翻译：提供了用于治疗受试者的装置，所述装置包括（a）刺激装置（352），其适于植入在选自以下的位置附近：所述受试者的蝶腭神经节（SPG）（52）以及源自或导致SPG的神经系统; 和（b）联接到刺激装置（352）的连接元件（356），并且适于穿过受试者的较大腭管（282）的至少一部分。还提供了一种用于在受试者的位置附近植入治疗刺激装置（352）的方法，所述方法包括使装置（352）穿过被检体的较大的腭孔（22），并使装置 352）与所述位点附近接触，所述位置选自由所述受试者的蝶腭神经节（SPG）（52）和源自或通向所述SPG的神经系统的列表。

8. 发明申请

WO2005002467A3 STIMULATION ARENA 审中-公开
标题翻译：刺激ARENA
公开(公告)号：WO2005002467A3
公开(公告)日：2005-04-07
申请号：PCT/IL2004000611
申请日：2004-07-07
申请人： BRAINSGATE LTD , SHALEV ALON
发明人： SHALEV ALON
IPC分类号： A61F20060101 , A61N20060101 , A61N1/05 , A61N1/36
CPC分类号： A61N1/3605 , A61N1/0546 , A61N1/0548 , A61N1/36017
摘要： Apparatus (300) is provided for use with a non-human animal (312), the animal (312) having implanted therein (a) an implanted coil (318) and, electrically coupled to the coil (318), (b) an electrode (320) in contact with target tissue in a head of the animal (312). The apparatus (300) includes a cage (311) to contain the animal (312); a cage coil (322), surrounding at least a portion of the cage (311); and a coil current driver (324), which drives cage coil current through the cage coil (322) thereby inductively driving induced current through the implanted coil (318), into the electrode (320), and into the target tissue.
摘要翻译：提供用于与非人类动物（312）一起使用的装置（300），所述动物（312）在其中植入了（a）植入线圈（318）并且电耦合到所述线圈（318），（b）电极（320）与动物（312）的头部中的目标组织接触。该设备（300）包括笼子（311）以容纳动物（312）; 笼圈（322），其围绕所述笼（311）的至少一部分; 以及线圈电流驱动器（324），其通过笼线圈（322）驱动笼线圈电流，从而感应地驱动感应电流通过植入线圈（318），进入电极（320）并进入目标组织。

9. 发明申请

WO2004043217A3 STIMULATION FOR TREATING EYE PATHOLOGIES 审中-公开
标题翻译：刺激眼睛病理学
公开(公告)号：WO2004043217A3
公开(公告)日：2004-08-19
申请号：PCT/IL0300965
申请日：2003-11-13
申请人： BRAINSGATE LTD , GROSS YOSSI , SHALEV ALON
发明人： GROSS YOSSI , SHALEV ALON
IPC分类号： A61B20060101 , A61N1/04 , A61N1/18
CPC分类号： A61N1/36046 , A61M5/14276 , A61M5/1723 , A61M2205/3303 , A61M2210/0618 , A61M2210/0693 , A61N1/0526 , A61N1/0546 , A61N1/0548
摘要： Apparatus is provided for treating a condition of an eye of a subject, comprising a stimulator (4) adapted to stimulate at least one site of the subject, so as to treat the eye condition, the site selected from the list consisting of: a sphenopalatine ganglion (SPG) (6) of the subject, an anterior ethmoidal nerve (404) of the subject, a posterior ethmoidal nerve (406) of the subject, a communicating branch between an anterior ethmoidal nerve (404) and a retro-orbital branch of an SPG (6) of the subject, a communicating branch between a posterior ethmoidal nerve (406) anda retro-orbital branch of an SPG (6) of the subject, a greater palatine nerve of the subject, a lesser palatine nerve of the subject, a sphenopalatine nerve of the subject, a communicating branch between a maxillary nerve and an SPG (6) of the subject, a nasopalatine nerve of the subject, a posterior nasal nerve of the subject, an infraorbital nerve of the subject, an otic ganglion of the subject, an afferent fiber going into the otic ganglion of the subject, an efferent fiber going out of the otic ganglion of the subject, a vidian nerve of the subject, a greater superficial petrosal nerve of the subject, and a lesser deep petrosal nerve of the subject.
摘要翻译：提供了用于治疗受试者的眼睛状况的装置，包括适于刺激受试者的至少一个部位的刺激器（4），以便治疗眼睛状况，选自以下的部位，所述名单包括：苯丙胺酸受试者的神经节（SPG）（6），受试者的前脑膜神经（404），受试者的后脑膜神经（406），前筛骨神经（404）和后眼眶分支的受试者的SPG（6）中，后脑膜神经（406）与受试者的SPG（6）的后视轨分支之间的连通分支，受试者的较大的腭神经，较小的腭神经受试者，受试者的蝶腭神经，受试者的上颌神经和SPG（6）之间的连通分支，受试者的鼻ine神经，受试者的后鼻神经，受试者的眶下神经，耳部神经节的主题，传入纤维goin g进入受试者的耳神经节，从受试者的耳神经节出来的传出纤维，受试者的维管神经，受试者的更浅的腹腔神经和受试者的较小的深部岩石神经。

10. 发明申请

WO2004010923A3 DELIVERING COMPOUNDS TO THE BRAIN BY MODIFYING PROPERTIES OF THE BBB AND CEREBRAL CIRCULATION 审中-公开
标题翻译：通过修改BBB和胚胎循环的特性将化合物传递给脑
公开(公告)号：WO2004010923A3
公开(公告)日：2004-08-19
申请号：PCT/IL0300631
申请日：2003-07-31
申请人： BRAINSGATE LTD , GROSS YOSSI , SHALITA BENNY , SHALEV ALON
发明人： GROSS YOSSI , SHALITA BENNY , SHALEV ALON
IPC分类号： A61B5/04 , A61K20060101
CPC分类号： A61N1/205 , A61K9/0043 , A61K48/0075 , A61M2210/0618 , A61M2210/0693 , A61N1/0546 , A61N1/0548 , A61N1/306 , A61N1/325 , A61N1/3605 , A61N1/36189 , A61N1/37211
摘要： A chemical agent delivery system is provided, including a chemical agent supplied to a body of a subject for delivery to a site in a central nervous system of said subject via blood of said subject; and a stimulator (4) for stimulating parasympathetic fibers associated with the sphenopalatine ganglion (6), thereby to render a blood brain barrier (BBB) of said subject permeable to said chemical agent during at least a portion of the time that said chemical agent is present in said blood.
摘要翻译：提供了一种化学试剂递送系统，包括供应给受试者的身体的化学试剂，以通过所述受试者的血液递送至所述受试者的中枢神经系统的部位; 以及刺激器（4），用于刺激与蝶腭神经节相关的副交感神经纤维（6），从而使所述受试者的血脑屏障（BBB）在所述化学药剂的至少一段时间内可渗透所述化学试剂存在于血液中。

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