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1. 发明申请

WO2004043218A3 SURGICAL TOOLS AND TECHNIQUES FOR STIMULATION 审中-公开
标题翻译：手术工具和刺激技术
公开(公告)号：WO2004043218A3
公开(公告)日：2006-07-13
申请号：PCT/IL0300966
申请日：2003-11-13
申请人： BRAINSGATE LTD , LORIAN ADI , GROSS YOSSI , SHALEV ALON , BENARY RAPHAEL
发明人： GROSS YOSSI , SHALEV ALON , BENARY RAPHAEL
IPC分类号： A61N1/08 , A61B20060101 , A61B1/00 , A61N1/30 , A61N1/36
CPC分类号： A61N1/36082 , A61N1/0546 , A61N1/08 , A61N1/30
摘要： Apparatus for treating a subject is provided, the apparatus comprising (a) a stimulation device (352), adapted to be implanted in a vicinity of a site selected from the list consisting of: a sphenopalatine ganglion (SPG) (52) of the subject and a neural tract originating in or leading to the SPG; and (b) a connecting element (356), coupled to the stimulation device (352), and adapted to be passed through at least a portion of a greater palatine canal (282) of the subject. Also provided is a method for implanting a treatment stimulation device (352) in a vicinity of a site of a subject, the method comprising passing the device (352) through a greater palatine foramen (22) of the subject, and bringing the device (352) into contact with the vicinity of the site, the site selected from the list consisting of: a sphenopalatine ganglion (SPG) (52) of the subject and a neural tract originating in or leading to the SPG.
摘要翻译：提供了用于治疗受试者的装置，所述装置包括（a）刺激装置（352），其适于植入在选自以下的位置附近：所述受试者的蝶腭神经节（SPG）（52）以及源自或导致SPG的神经系统; 和（b）联接到刺激装置（352）的连接元件（356），并且适于穿过受试者的较大腭管（282）的至少一部分。还提供了一种用于在受试者的位置附近植入治疗刺激装置（352）的方法，所述方法包括使装置（352）穿过被检体的较大的腭孔（22），并使装置 352）与所述位点附近接触，所述位置选自由所述受试者的蝶腭神经节（SPG）（52）和源自或通向所述SPG的神经系统的列表。

2. 发明申请

WO2004043217A3 STIMULATION FOR TREATING EYE PATHOLOGIES 审中-公开
标题翻译：刺激眼睛病理学
公开(公告)号：WO2004043217A3
公开(公告)日：2004-08-19
申请号：PCT/IL0300965
申请日：2003-11-13
申请人： BRAINSGATE LTD , GROSS YOSSI , SHALEV ALON
发明人： GROSS YOSSI , SHALEV ALON
IPC分类号： A61B20060101 , A61N1/04 , A61N1/18
CPC分类号： A61N1/36046 , A61M5/14276 , A61M5/1723 , A61M2205/3303 , A61M2210/0618 , A61M2210/0693 , A61N1/0526 , A61N1/0546 , A61N1/0548
摘要： Apparatus is provided for treating a condition of an eye of a subject, comprising a stimulator (4) adapted to stimulate at least one site of the subject, so as to treat the eye condition, the site selected from the list consisting of: a sphenopalatine ganglion (SPG) (6) of the subject, an anterior ethmoidal nerve (404) of the subject, a posterior ethmoidal nerve (406) of the subject, a communicating branch between an anterior ethmoidal nerve (404) and a retro-orbital branch of an SPG (6) of the subject, a communicating branch between a posterior ethmoidal nerve (406) anda retro-orbital branch of an SPG (6) of the subject, a greater palatine nerve of the subject, a lesser palatine nerve of the subject, a sphenopalatine nerve of the subject, a communicating branch between a maxillary nerve and an SPG (6) of the subject, a nasopalatine nerve of the subject, a posterior nasal nerve of the subject, an infraorbital nerve of the subject, an otic ganglion of the subject, an afferent fiber going into the otic ganglion of the subject, an efferent fiber going out of the otic ganglion of the subject, a vidian nerve of the subject, a greater superficial petrosal nerve of the subject, and a lesser deep petrosal nerve of the subject.
摘要翻译：提供了用于治疗受试者的眼睛状况的装置，包括适于刺激受试者的至少一个部位的刺激器（4），以便治疗眼睛状况，选自以下的部位，所述名单包括：苯丙胺酸受试者的神经节（SPG）（6），受试者的前脑膜神经（404），受试者的后脑膜神经（406），前筛骨神经（404）和后眼眶分支的受试者的SPG（6）中，后脑膜神经（406）与受试者的SPG（6）的后视轨分支之间的连通分支，受试者的较大的腭神经，较小的腭神经受试者，受试者的蝶腭神经，受试者的上颌神经和SPG（6）之间的连通分支，受试者的鼻ine神经，受试者的后鼻神经，受试者的眶下神经，耳部神经节的主题，传入纤维goin g进入受试者的耳神经节，从受试者的耳神经节出来的传出纤维，受试者的维管神经，受试者的更浅的腹腔神经和受试者的较小的深部岩石神经。

3. 发明申请

WO2004010923A3 DELIVERING COMPOUNDS TO THE BRAIN BY MODIFYING PROPERTIES OF THE BBB AND CEREBRAL CIRCULATION 审中-公开
标题翻译：通过修改BBB和胚胎循环的特性将化合物传递给脑
公开(公告)号：WO2004010923A3
公开(公告)日：2004-08-19
申请号：PCT/IL0300631
申请日：2003-07-31
申请人： BRAINSGATE LTD , GROSS YOSSI , SHALITA BENNY , SHALEV ALON
发明人： GROSS YOSSI , SHALITA BENNY , SHALEV ALON
IPC分类号： A61B5/04 , A61K20060101
CPC分类号： A61N1/205 , A61K9/0043 , A61K48/0075 , A61M2210/0618 , A61M2210/0693 , A61N1/0546 , A61N1/0548 , A61N1/306 , A61N1/325 , A61N1/3605 , A61N1/36189 , A61N1/37211
摘要： A chemical agent delivery system is provided, including a chemical agent supplied to a body of a subject for delivery to a site in a central nervous system of said subject via blood of said subject; and a stimulator (4) for stimulating parasympathetic fibers associated with the sphenopalatine ganglion (6), thereby to render a blood brain barrier (BBB) of said subject permeable to said chemical agent during at least a portion of the time that said chemical agent is present in said blood.
摘要翻译：提供了一种化学试剂递送系统，包括供应给受试者的身体的化学试剂，以通过所述受试者的血液递送至所述受试者的中枢神经系统的部位; 以及刺激器（4），用于刺激与蝶腭神经节相关的副交感神经纤维（6），从而使所述受试者的血脑屏障（BBB）在所述化学药剂的至少一段时间内可渗透所述化学试剂存在于血液中。

4. 发明申请

WO2004044947A3 STIMULATION CIRCUITRY AND CONTROL OF ELECTRONIC MEDICAL DEVICE 审中-公开
标题翻译：电刺激电路与电子医疗器械的控制
公开(公告)号：WO2004044947A3
公开(公告)日：2005-07-07
申请号：PCT/IL0300967
申请日：2003-11-13
申请人： BRAINSGATE LTD , GROSS YOSSI , SHALEV ALON , KEREN AVRAHAM
发明人： GROSS YOSSI , SHALEV ALON , KEREN AVRAHAM
IPC分类号： A61B5/055 , A61N1/378 , G01R33/28 , A61H1/02
CPC分类号： A61N1/3787 , A61B5/055 , G01R33/28
摘要： Apparatus is provided for use with an implanted medical device (30) having two conductive elements (14) in contact with tissue (12) of a subject. The apparatus comprises a shunt (18), electrically coupled between the conductive elements (14), the shunt (18) adapted to be in a first state when the subject is exposed to a source of radiofrequence (RF) energy, and adapted to be in a second state when the subject is not exposed th the RF energy, the shunt (18) being characterized such that in the first state the shunt (18) has a first impedance, and in the second state the shunt (18) has a second impedance at least two times greater than the first impedance.
摘要翻译：提供了用于与具有与受试者的组织（12）接触的两个导电元件（14）的植入医疗装置（30）一起使用的装置。该装置包括电耦合在导电元件（14）之间的并联（18），当被摄体暴露于射频（RF）能量源时，分流器适于处于第一状态，并且适合于在第二状态下，当受试者不暴露RF能量时，分流器（18）的特征在于，在第一状态下，分流器（18）具有第一阻抗，并且在第二状态中，分流器（18）具有第二阻抗比第一阻抗大至少两倍。

5. 发明申请

WO2004045242A2 STIMULATION FOR TREATING EAR PATHOLOGIES 审中-公开
标题翻译：刺激治疗耳道病理
公开(公告)号：WO2004045242A2
公开(公告)日：2004-05-27
申请号：PCT/IL0300963
申请日：2003-11-13
申请人： BRAINSGATE LTD , SHALEV ALON , GROSS YOSSI
发明人： SHALEV ALON , GROSS YOSSI
IPC分类号： A61H23/02 , A61N1/36 , H04R
CPC分类号： A61N1/36036 , A61H23/02 , A61H2205/027
摘要： Apparatus is provided for treating a condition of an ear of a subject, comprising a stimulator (4) adapted to stimulate at least one site of the subject at a level sufficient to treat the ear condition, the site selected from the list consisting of: an otic ganglion (9) of the subject, an afferent fiber going into the otic ganglion (9) of the subject, an efferent fiber going out of the otic ganglion (9) of the subject, a sphenopalatine ganglion (SPG) (6) of the subject, an anterior ethmoidal nerve of the subject, a posterior ethmoidal nerve of the subject, a communicating branch between an anterior ethmoidal nerve and a retro-orbital branch of an SPG (6) of the subject, a communicating branch between a posterior ethmoidal nerve and a retro-orbital branch of an SPG (6) of the subject, a greater palatine nerve of the subject, a lesser palatine nerve of the subject, a sphenopalatine nerve of the subject, a communicating branch between a maxillary nerve and an SPG (6) of the subject, a nasopalatine nerve of the subject, a posterior nasal nerve of the subject, an infraorbital nerve of the subject, a vidian nerve of the subject, a greater superficial petrosal nerve of the subject, and a lesser deep petrosal nerve of the subject.
摘要翻译：提供了用于治疗受试者的耳朵状况的装置，该装置包括刺激器（4），该刺激器适于以足以治疗耳朵状况的水平刺激受试者的至少一个部位，所述部位选自：（9）的神经节神经节（9），进入受试者的耳神经节（9）的传入纤维，从受试者的耳神经节（9）出来的传出纤维，蝶形神经节（SPG）（6）所述受试者，所述受试者的前筛前神经，所述受试者的后筛前神经，所述受试者的SPG（6）的前筛前神经和眶后分支之间的连通分支，后筛筛神经和该对象的SPG（6）的眶后分支，该对象的较大腭神经，该对象的较小腭神经，该对象的蝶腭神经，上颌神经与SPG之间的连通分支（6）的主题，一个nas 受试者的乳糜泻神经，受试者的后鼻神经，受试者的眶下神经，受试者的腓肠神经，受试者的更大的表面岩肌神经和受试者的较小深部岩肌神经。

6. 发明申请

WO0185094A3 METHOD AND APPARATUS FOR STIMULATING THE SPHENOPALATINE GANGLION TO MODIFY PROPERTIES OF THE BBB AND CEREBRAL BLOOD FLOW 审中-公开
标题翻译：刺激血管紧张素转换酶修饰BBB和脑血流量特性的方法和装置
公开(公告)号：WO0185094A3
公开(公告)日：2002-03-28
申请号：PCT/IL0100402
申请日：2001-05-07
申请人： BRAINSGATE LTD , SHALEV ALON , GROSS YOSSI
发明人： SHALEV ALON , GROSS YOSSI
IPC分类号： A61B5/01 , A61B5/022 , A61B5/026 , A61B5/0295 , A61B5/0476 , A61B8/06 , A61N1/05 , A61N1/32 , A61N1/36 , A61P9/10 , A61B10/00
CPC分类号： A61N1/36082 , A61B5/026 , A61B5/4076 , A61N1/0546 , A61N1/326
摘要： Apparatus for modifying a property of a brain of a patient is provided, including one or more electrodes (7), adapted to be applied to a site selected from a group of sites consisting of: a sphenopalatine ganglion (SPG) (6) of the patient and a neural tract originating in or leading to the SPG. A control unit (8) is adapted to drive the one or more electrodes to apply a current to the site capable of inducing (a) an increase in permeability of a blood-brain barrier (BBB) of the patient, (b) a change in cerebral blood flow of the patient, and/or (c) an inhibition of parasympathetic activity of the SPG.
摘要翻译：提供了用于改变患者的脑的性质的装置，包括一个或多个电极（7），其适于施加到选自下列部位的部位：由以下组成的一组部位：蝶腭神经节（SPG）（6）患者和源自或通过SPG的神经系统。控制单元（8）适于驱动一个或多个电极以向能够诱导（a）增加患者血脑屏障（BBB）的渗透性的部位施加电流，（b）改变在患者的脑血流中，和/或（c）抑制SPG的副交感活性。

7. 发明申请

WO2011141918A3 REFLECTANCE-FACILITATED ULTRASOUND TREATMENT AND MONITORING 审中-公开
标题翻译：反射辅助超声治疗和监测
公开(公告)号：WO2011141918A3
公开(公告)日：2012-01-19
申请号：PCT/IL2011000382
申请日：2011-05-12
申请人： TSOREF LIAT , GROSS YOSSI , KARDOSH MICHAEL
发明人： TSOREF LIAT , GROSS YOSSI , KARDOSH MICHAEL
IPC分类号： A61B18/04
CPC分类号： A61B34/20 , A61B8/0841 , A61B8/0883 , A61B8/12 , A61B8/445 , A61B8/481 , A61B8/5223 , A61B17/320016 , A61B17/320092 , A61B19/5244 , A61B2017/00026 , A61B2017/00084 , A61B2017/00106 , A61B2017/00243 , A61B2017/320052 , A61B2018/00285 , A61B2034/2063 , A61B2090/3784 , A61N7/022 , A61N2007/0052 , A61N2007/0056 , A61N2007/0069 , A61N2007/0091
摘要： Apparatus comprising an ultrasound ablation system (10), which comprises a reflection-facilitation element (12), configured to be placed at an extramyocardial site of a subject, and to provide an extramyocardial reflective region; and an ultrasound tool (20), which comprises at least one ultrasound transducer (40) configured to be positioned within a heart chamber of the subject. The ultrasound transducer (40) is configured to ablate myocardial tissue by applying ultrasound energy to the myocardial tissue such that at least a portion of the transmitted energy is reflected by the reflective region onto the myocardial tissue. Other embodiments are also described.
摘要翻译：包括超声消融系统（10）的装置，其包括被配置为放置在受试者的心肌外部位置处的反射促进元件（12），并且提供心外膜反射区域; 和超声波工具（20），其包括构造成定位在受试者的心室内的至少一个超声换能器（40）。超声换能器（40）被配置为通过向心肌组织施加超声能量来消融心肌组织，使得至少一部分透射能量被反射区域反射到心肌组织上。还描述了其它实施例。

8. 发明申请

WO2009095918A3 PERISTALTIC PUMP FOR TREATMENT OF ERECTILE DYSFUNCTION 审中-公开
标题翻译：用于治疗溃疡性功能障碍的尿液泵
公开(公告)号：WO2009095918A3
公开(公告)日：2010-03-11
申请号：PCT/IL2009000115
申请日：2009-01-29
申请人： RAINBOW MEDICAL LTD , GROSS YOSSI
发明人： GROSS YOSSI
IPC分类号： A61F5/00
CPC分类号： A61F2/26 , A61N1/0408 , A61N1/0476 , A61N1/0492 , A61N1/05 , A61N1/321 , A61N1/36007
摘要： In some embodiments of the present invention, apparatus is provided for treating erectile dysfunction of a subject. The apparatus includes one or more electrodes (22) configured to be coupled to a vicinity of a blood vessel (50) that carries blood into or out of a penis (52) of the subject, and a control unit (24) configured to facilitate erection of the penis by peristaltically pumping blood in the blood vessel by stimulating nitric oxide (NO) production in the vicinity, by driving the electrodes to drive a current into the vicinity. Additional embodiments are also described.
摘要翻译：在本发明的一些实施方案中，提供了用于治疗受试者勃起功能障碍的装置。该装置包括一个或多个电极（22），其被配置为耦合到携带血液进入或离开受试者的阴茎（52）的血管（50）附近;以及控制单元（24），其被配置为便于通过驱动电极驱动电流进入附近，通过刺激附近的一氧化氮（NO）生成，通过蠕动地抽血血液来竖立阴茎。还描述了另外的实施例。

9. 发明申请

WO2009050719A3 IMPLOSION TECHNIQUES FOR ULTRASOUND 审中-公开
标题翻译：超声波腐蚀技术
公开(公告)号：WO2009050719A3
公开(公告)日：2010-03-11
申请号：PCT/IL2008001390
申请日：2008-10-22
申请人： SLENDER MEDICAL LTD , AZHARI HAIM , TSOREF LIAT , GROSS YOSSI , BENARIE JACOB
发明人： AZHARI HAIM , TSOREF LIAT , GROSS YOSSI , BENARIE JACOB
IPC分类号： A61B17/20
CPC分类号： A61N7/02 , A61B2017/22008 , A61B2017/22024 , A61B2017/308 , A61B2090/378 , A61N2007/0008 , A61N2007/0078
摘要： A housing (50) is placed on skin of a subject, and draws at least a portion of the skin within at least a part of the housing. The housing includes at least first and second support structures (34), placed in contact with a surface of skin surrounding the portion of the skin, the first support structure having a first concave surface (153) and the second support structure having a second concave surface (153) that faces the first concave surface. The apparatus includes one or more first ultrasound transducers (160) coupled to the first support structure and one or more second ultrasound transducers coupled to the second support structure. The apparatus also includes a control unit which drives the first and second ultrasound transducers to induce an implosion wave in a target region of the skin. Other embodiments are also described.
摘要翻译：将壳体（50）放置在受试者的皮肤上，并且在壳体的至少一部分内吸取皮肤的至少一部分。壳体包括至少第一和第二支撑结构（34），放置成与围绕皮肤部分的皮肤表面接触，第一支撑结构具有第一凹面（153），第二支撑结构具有第二凹面面（153）面向第一凹面。该装置包括耦合到第一支撑结构的一个或多个第一超声换能器（160）和耦合到第二支撑结构的一个或多个第二超声换能器。该装置还包括控制单元，其驱动第一和第二超声换能器以在皮肤的目标区域中引起内爆波。还描述了其它实施例。

10. 发明申请

WO2007110867A8 IMPLANTABLE SENSOR 审中-公开
标题翻译：可植入传感器
公开(公告)号：WO2007110867A8
公开(公告)日：2009-07-23
申请号：PCT/IL2007000399
申请日：2007-03-28
申请人： GLUSENSE LTD , GROSS YOSSI , HYMAN TEHILA
发明人： GROSS YOSSI , HYMAN TEHILA
IPC分类号： A61K49/00 , A01N1/00 , A01N63/00 , A61B5/00 , A61F13/00 , C12N5/00
CPC分类号： A61B5/14532 , A61B5/14556 , A61B5/1459 , C07K14/43595 , C07K2319/60
摘要： Apparatus is provided for detecting a concentration of an analyte in a subject. The apparatus includes a housing (20) adapted to be implanted in the subject. The housing (20) comprising an optical detector (30) adapted to detect a level of fluorescence resonance energy transfer (FRET). The apparatus also comprises live cells (26) genetically engineered to produce, in a patient's body, a sensor protein comprising a fluorescent protein donor, a fluorescent protein acceptor, and a binding protein for the analyte. Other embodiments are also described. 2
摘要翻译：提供了用于检测受试者中分析物浓度的装置。该装置包括适于植入受试者的壳体（20）。壳体（20）包括适于检测荧光共振能量转移（FRET）的水平的光学检测器（30）。该装置还包括基因工程改造以在患者体内产生包含荧光蛋白供体，荧光蛋白受体和用于分析物的结合蛋白的传感器蛋白的活细胞（26）。还描述了其它实施例。 2

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