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1. 发明申请

WO2008005090A2 SELF FIXING ASSEMBLED BONE-TENDON-BONE GRAFT 审中-公开
标题翻译：自固定骨头骨骨折
公开(公告)号：WO2008005090A2
公开(公告)日：2008-01-10
申请号：PCT/US2007009218
申请日：2007-04-16
申请人： REGENERATION TECH INC , OLSEN RAYMOND E , LEWIS WESLEY I , BIANCHI JOHN R , KUTSAVAGE JOE , URBANIAK DANIEL J , CARR ANGELA , SANDERS BEN R
发明人： OLSEN RAYMOND E , LEWIS WESLEY I , BIANCHI JOHN R , KUTSAVAGE JOE , URBANIAK DANIEL J , CARR ANGELA , SANDERS BEN R
IPC分类号： A61F2/08
CPC分类号： A61F2/0811 , A61F2/0805 , A61F2002/0829 , A61F2002/0841 , A61F2002/0864 , A61F2002/0882
摘要： The present invention has multiple aspects relating to assembled self fixing bone-tendon-bone (BTB) grafts and BTB implants. A preferred application in which self fixing assembled bone-tendon-bone (BTB) grafts and implants of the present technology can be used is for ACL repairs in a human patient. In one embodiment, a self fixing BTB graft is characterized by the presence of threads along at least a portion of the exterior surface of one or both bone blocks. In another embodiment, a self fixing assembled bone-tendon-bone implant comprises a removable tendon tensioner which imparts a predetermined tension on the tendon of the BTB graft. In this embodiment, the tensioner can be narrower than the diameter of the bone blocks or can be threaded such that the threads are continuous with the threads of at least one of the bone blocks. The threads facilitate the simultaneous implantation of the leading and trailing bone blocks of the BTB graft in tapped (threaded) holes in the tibia and the femur of a recipient patient. The tensioner maintains the tension on the tendon and the spacing between the bone blocks until the leading bone block is fixed (threaded) in the tapped hole in the femur and the trailing bone block is fixed (threaded) into the tapped tibial bone tunnel. Once the bone blocks are substantially in their fixed positions, the tensioner is removed arthroscopically in the joint space between the tibia and the femur.
摘要翻译：本发明涉及组装的自固定骨腱骨（BTB）移植物和BTB植入物的多个方面。可以使用本技术的自固定组装骨腱骨（BTB）移植物和植入物的优选应用是在人类患者中进行ACL修复。在一个实施例中，自固定BTB移植物的特征在于沿着一个或两个骨块的外表面的至少一部分存在螺纹。在另一个实施例中，自固定组装的骨腱骨植入物包括可移动的腱张紧器，其在BTB移植物的腱上施加预定的张力。在该实施例中，张紧器可以比骨块的直径窄，或者可以是螺纹，使得螺纹与至少一个骨块的螺纹连续。这些螺纹有助于同时植入BTB移植物的前后骨块在胫骨和接受者患者的股骨的螺纹（螺纹）孔中。张紧器维持肌腱上的张力和骨块之间的间距，直到前骨块在股骨的螺纹孔中固定（螺纹），并且后骨块被固定（螺纹）到敲击的胫骨骨隧道中。一旦骨块基本处于其固定位置，张紧器在关节镜下被移除在胫骨和股骨之间的关节间隙中。

2. 发明申请

WO2006096512A3 ADJUSTABLE AND FIXED ASSEMBLED BONE-TENDON-BONE GRAFT 审中-公开
标题翻译：可调节和固定的组合骨头骨骨折
公开(公告)号：WO2006096512A3
公开(公告)日：2009-04-16
申请号：PCT/US2006007614
申请日：2006-03-03
申请人： REGENERATION TECH INC , BIANCHI JOHN R , LEWIS WESLEY I , KUTSAVAGE JOE , URBANIAK DAN , CARR ANGELA , KLEIN GLENN C , SANDERS BEN R
发明人： BIANCHI JOHN R , LEWIS WESLEY I , KUTSAVAGE JOE , URBANIAK DAN , CARR ANGELA , KLEIN GLENN C , SANDERS BEN R
IPC分类号： A61F2/08
CPC分类号： A61F2/0811 , A61F2/08 , A61F2002/0823 , A61F2002/0829 , A61F2002/0852 , A61F2002/0858 , A61F2002/0864 , A61F2002/0882 , A61F2002/2839 , A61F2002/30057 , A61F2220/0016 , A61F2220/0033 , A61F2220/0041 , A61F2230/0004 , A61F2230/0008 , A61F2230/0019 , A61F2230/0021 , A61F2230/0023 , A61F2230/0026 , A61F2230/0045 , A61F2230/0047 , A61F2230/0054 , A61F2230/0076 , A61F2250/0025 , A61F2250/0026 , A61F2250/006 , A61F2250/0062 , A61F2250/0081
摘要： The present invention has multiple aspects. In its simplest aspect, the present invention is directed to an intermediate bone block comprising a machined segment of cortical bone, cancellous bone or both, the intermediate having a face comprising one to ten compression surfaces and one to ten cavities, the compression surfaces suitable for compressing soft tissue, the cavities for receiving and holding overflow soft tissue. The cavities are preferably channels, and more preferably channels having an omega cross-sectional profile. Surprisingly, the cavities and channels, which reduced the compressed surface area between the intermediate bone block and the tendon, significantly improved tendon load at failure. In standardized tests, an intermediate bone block of this invention, when combined with high surface area bone blocks of the prior art bone blocks, unexpectedly increased their load at failure. The invention is also directed to bone block assemblies suitable for binding to a soft tissue to form an implantable graft, and to such implantable grafts. A particularly preferred graft is a bone-tendon-bone graft.
摘要翻译：本发明具有多个方面。在其最简单的方面，本发明涉及一种中间骨块，其包括皮质骨，松质骨或两者的加工部分，所述中间体具有包括1至10个压缩表面和1至10个腔的表面，所述压缩表面适于压缩软组织，用于接收和保持溢流软组织的空腔。空腔优选为通道，更优选具有Ω形横截面轮廓的通道。令人惊讶的是，减小中间骨块和腱之间的压缩表面积的腔和通道显着改善了失败时的腱负荷。在标准化测试中，当与现有技术的骨块的高表面积骨块组合时，本发明的中间骨块意外地增加了它们在失败时的负荷。本发明还涉及适于结合软组织以形成可植入移植物的骨块组合物，以及这种可植入移植物。特别优选的移植物是骨 - 肌 - 骨移植物。

3. 发明申请

WO2006096513A3 ASSEMBLED BONE-TENDON-BONE GRAFTS 审中-公开
标题翻译：组装的骨头骨骨架
公开(公告)号：WO2006096513A3
公开(公告)日：2007-10-25
申请号：PCT/US2006007615
申请日：2006-03-03
申请人： REGENERATION TECH INC , BIANCHI JOHN R , LEWIS WESLEY I , KUTSAVAGE JOE , URBANIAK DAN , CARR ANGELA , KLEIN GLENN C , SANDERS BEN R
发明人： BIANCHI JOHN R , LEWIS WESLEY I , KUTSAVAGE JOE , URBANIAK DAN , CARR ANGELA , KLEIN GLENN C , SANDERS BEN R
IPC分类号： A61F2/08 , A61F2/28
CPC分类号： A61F2/0811 , A61F2/08 , A61F2002/087 , A61F2002/2839 , A61F2002/30057
摘要： The present invention has multiple aspects. In its simplest aspect, the present invention is directed to an intermediate bone block comprising a machined segment of cortical bone, cancellous bone or both, the intermediate having a face comprising one to ten compression surfaces and one to ten cavities, the compression surfaces suitable for compressing soft tissue, the cavities for receiving and holding overflow soft tissue. The cavities are preferably channels, and more preferably channels having an omega cross-sectional profile. Surprisingly, the cavities and channels, which reduced the compressed surface area between the intermediate bone block and the tendon, significantly improved tendon load at failure. In standardized tests, an intermediate bone block of this invention, when combined with high surface area bone blocks of the prior art bone blocks, unexpectedly increased their load at failure. The invention is also directed to bone block assemblies suitable for binding to a soft tissue to form an implantable graft, and to such implantable grafts. A particularly preferred graft is a bone-tendon-bone graft.
摘要翻译：本发明具有多个方面。在其最简单的方面，本发明涉及一种中间骨块，其包括皮质骨，松质骨或两者的加工部分，所述中间体具有包括1至10个压缩表面和1至10个腔的表面，所述压缩表面适于压缩软组织，用于接收和保持溢流软组织的空腔。空腔优选为通道，更优选具有Ω形横截面轮廓的通道。令人惊讶的是，减小中间骨块和腱之间的压缩表面积的腔和通道显着改善了失败时的腱负荷。在标准化测试中，当与现有技术的骨块的高表面积骨块组合时，本发明的中间骨块意外地增加了它们在失败时的负荷。本发明还涉及适于结合软组织以形成可植入移植物的骨块组合物，以及这种可植入移植物。特别优选的移植物是骨 - 肌 - 骨移植物。

4. 发明申请

WO2006096511A3 INTERMEDIATE BONE BLOCK AND ITS USE IN BONE BLOCK ASSEMBLIES AND ASSEMBLED BONE-TENDON-BONE GRAFTS 审中-公开
标题翻译：中间骨块及其在骨块组装中的使用以及组装的骨头骨骨架
公开(公告)号：WO2006096511A3
公开(公告)日：2007-10-18
申请号：PCT/US2006007613
申请日：2006-03-03
申请人： REGENERATION TECH INC , BIANCHI JOHN R , LEWIS WESLEY I
发明人： BIANCHI JOHN R , LEWIS WESLEY I
IPC分类号： A61F2/08
CPC分类号： A61F2/0811 , A61F2/08 , A61F2002/087 , A61F2002/2839 , A61F2002/30057
摘要： The present invention is directed to an intermediate bone block comprising a machined segment of cortical bones, cancellous bone or both, the intermediate having a face comprising one to two compression surfaces and one to ten cavities, the compression surfaces suitable for compressing soft tissue, the cavities for receiving and holding overflow soft tissue. The cavities are preferably channels, and more preferably channels having an omega cross-sectional profile. The cavities and channels significantly improve tendon load at failure. The invention is also directed to bone block assemblies suitable for binding to a soft tissue to form an implantable graft, and to such implantable grafts. A particular preferred graft is a bone-tendon-bone graft.
摘要翻译：本发明涉及一种中间骨块，其包括皮质骨，松质骨或两者的加工段，所述中间体具有包括一至两个压缩表面和一至十个腔的表面，所述压缩表面适于压缩软组织，用于接收和保持溢出软组织的腔。空腔优选为通道，更优选具有Ω形横截面轮廓的通道。腔和通道显着改善失败时的肌腱负荷。本发明还涉及适于结合软组织以形成可植入移植物的骨块组合物，以及这种可植入移植物。特别优选的移植物是骨 - 腱 - 骨移植物。

5. 发明申请

WO2006096514A3 BONE BLOCK ASSEMBLIES AND THEIR USE IN ASSEMBLED BONE-TENDON-BONE GRAFTS 审中-公开
标题翻译：骨块组装及其在组装的骨头骨骨骼中的使用
公开(公告)号：WO2006096514A3
公开(公告)日：2007-09-13
申请号：PCT/US2006007616
申请日：2006-03-03
申请人： REGENERATION TECH INC , BIANCHI JOHN R , LEWIS WESLEY I
发明人： BIANCHI JOHN R , LEWIS WESLEY I
IPC分类号： A61F2/08 , A61F2/28
CPC分类号： A61F2/0811 , A61F2002/0829 , A61F2002/0864 , A61F2002/087 , A61F2002/0882 , A61F2002/2839 , A61F2002/30057
摘要： The present invention has multiple aspects. In its simplest aspect, the present invention is directed to an intermediate bone block comprising a machined segment of cortical bone, cancellous bone or both, the intermediate having a face comprising one to ten compression surfaces and one to ten cavities, the compression surfaces suitable for compressing soft tissue, the cavities for receiving and holding overflow soft tissue. The cavities are preferably channels, and more preferably channels having an omega cross-sectional profile. Surprisingly, the cavities and channels, which reduced the compressed surface area between the intermediate bone block and the tendon, significantly improved tendon load at failure. In standardized tests, an intermediate bone block of this invention, when combined with high surface area bone blocks of the prior art bone blocks, unexpectedly increased their load at failure. The invention is also directed to bone block assemblies suitable for binding to a soft tissue to form an implantable graft, and to such implantable grafts. A particularly preferred graft is a bone-tendon-bone graft.
摘要翻译：本发明具有多个方面。在其最简单的方面，本发明涉及一种中间骨块，其包括皮质骨，松质骨或两者的加工段，所述中间体具有包含1至10个压缩表面和1至10个空腔的表面，所述压缩表面适于压缩软组织，用于接收和保持溢出软组织的空腔。空腔优选为通道，更优选具有Ω形横截面轮廓的通道。令人惊奇的是，减少中间骨块和腱之间的压缩表面积的空腔和通道显着改善了失败时的腱负荷。在标准化测试中，当与现有技术的骨块的高表面积骨块组合时，本发明的中间骨块意外地增加了它们在失败时的负荷。本发明还涉及适于结合软组织以形成可植入移植物的骨块组合物，以及这种可植入移植物。特别优选的移植物是骨 - 腱骨移植物。

6. 发明申请

WO0029037A9 TISSUE POOLING PROCESS 审中-公开
标题翻译：组织集中过程
公开(公告)号：WO0029037A9
公开(公告)日：2001-11-01
申请号：PCT/US9926407
申请日：1999-11-08
申请人： REGENERATION TECH INC , MILLS C RANDAL , WIRONEN JOHN F , HANSTKE SEAN
发明人： DONDA RUSSELL S , GROOMS JAMIE M , BIANCHI JOHN R , MILLS C RANDAL , WIRONEN JOHN F , HANSTKE SEAN
IPC分类号： A61L2/18 , A61F2/00 , A61F2/02 , A61F2/04 , A61F2/06 , A61F2/08 , A61F2/24 , A61F2/28 , A61F2/30 , A61F2/44 , A61F2/46 , A61L2/00 , A61L2/02 , A61L2/025 , A61L2/08 , A61L2/20 , A61L2/24 , A61L27/00
CPC分类号： A61F2/28 , A61F2/08 , A61F2/0811 , A61F2/3094 , A61F2/442 , A61F2/446 , A61F2/447 , A61F2/4644 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/30057 , A61F2002/30059 , A61F2002/30062 , A61F2002/30113 , A61F2002/30153 , A61F2002/30179 , A61F2002/30224 , A61F2002/30225 , A61F2002/30235 , A61F2002/30261 , A61F2002/30266 , A61F2002/3028 , A61F2002/30329 , A61F2002/30354 , A61F2002/30383 , A61F2002/30387 , A61F2002/30448 , A61F2002/30492 , A61F2002/30563 , A61F2002/30599 , A61F2002/30677 , A61F2002/30785 , A61F2002/30795 , A61F2002/3085 , A61F2002/30904 , A61F2002/30957 , A61F2002/30975 , A61F2002/4649 , A61F2210/0004 , A61F2220/0025 , A61F2220/0033 , A61F2220/005 , A61F2230/0006 , A61F2230/0019 , A61F2230/0058 , A61F2230/0063 , A61F2230/0069 , A61F2230/0082 , A61F2250/0063 , A61F2310/00365 , A61F2310/00383 , A61F2310/0097 , A61F2310/00976 , A61L2/0088 , A61L2/025
摘要： This invention includes a novel method for safely, effectively and efficiently pooling of tissues for treatment prior to implantation into a recipient in need thereof. In one embodiment, the method includes perfusion of a porous implant which achieves efficient interpenetration of desired factors into and removal of undesirable factors from the pores of the implant, cleaning of the implant, efficient passivation of the implant (inactivation of pathogens, microorganisms, cells, viruses and the like and reduction in antigenicity thereof), and the novel implant produced by such treatment. The process presents a system wherein the rate of pressure cycling, the fact of pressure cycling, and the amplitude of pressure cycling, results in highly cleaned tissues and other implants for implantation. Target decontamination goals for this process include between about a one (1) to twelve (12) log reduction in bacterial contamination, between about a one (1) to fifteen (15) log reduction in enveloped virus contamination, up to about a five (5) log reduction in non-enveloped virus contamination, between about a two (2) to ten (10) fold reduction in endotoxin, maintenance of implant or graft biologic and biomechanical properties, absence of tissue toxicity due to cleaning solutions used, and reduced implant antigenicity.
摘要翻译：本发明包括一种新的方法，用于在植入有需要的接受者之前安全，有效和高效地将组织汇集起来进行治疗。在一个实施方案中，所述方法包括灌注多孔植入物，其实现所需因子与植入物的孔隙中的不期望因子的有效渗透和去除，植入物的清洁，植入物的有效钝化（病原体，微生物，细胞的灭活，病毒等以及其抗原性降低）以及通过这种治疗产生的新型植入物。该方法提出了一种系统，其中压力循环的速率，压力循环的事实和压力循环的幅度导致用于植入的高度清洁的组织和其他植入物。该过程的目标净化目标包括细菌污染降低约一（1）至十二（12）个对数，包膜病毒污染降低约一（1）至十五（15）个对数，最多约五（ 5）无包膜病毒污染的对数减少，内毒素减少约二（2）至十（10）倍，植入物或移植物生物学和生物力学特性的维持，由于使用的清洁溶液导致的组织毒性的减少和减少植入抗原性。

7. 发明申请

WO0106933A3 SUTURE ANCHOR 审中-公开
公开(公告)号：WO0106933A3
公开(公告)日：2001-06-21
申请号：PCT/US0020293
申请日：2000-07-26
申请人： REGENERATION TECH INC
发明人： BIANCHI JOHN R , CARTER KEVIN C , SANDER TOM , MILLS C RANDAL , DONDA RUSSELL S , SPENCER RANDAL , ESCH MICHAEL , BERNHARDT ANDY , LEE DANIEL R , WEBECK ILSA
IPC分类号： A61B17/04 , A61B17/86 , A61F2/00 , A61F2/08 , A61F2/28
CPC分类号： A61F2/0811 , A61B17/0401 , A61B17/8625 , A61B17/864 , A61B2017/0409 , A61B2017/0412 , A61B2017/0414 , A61B2017/0427 , A61B2017/044 , A61F2/0805 , A61F2002/0888 , A61F2002/2839 , A61F2002/30059
摘要： A substantially cylindrical or wedge-shaped cortical bone implant (10) wherein one end of the cylinder (30) or wedge tapers to a sharp point (21) and which comprises one or more through-channel(s) (40) for receipt of suture(s), is disclosed for fixation of tissues to bone or other tissues of sufficient strength to provide solid fixation of tissue to which the implant is affixed (10). The implant (10) optionally has a circumferential, longitudinal or angled barbs to enhance structural and retention characteristics of the implant. Certain embodiments of the invention include portions of the implant in a partially or fully demineralized state, such that added flexibility is imparted to the demineralized or partially demineralized segment. Additionally, embodiments of this invention optionally include threaded portions (410), fluted portions or slotted portions (610), depending on the desired implantation means and retention characteristics. The implant is optimally configured for a single step impaction implantation, although other forms of implantation are also contemplated.
摘要翻译：一种基本上圆柱形或楔形的皮质骨植入物（10），其中所述圆柱体（30）或楔形物的一端渐缩到尖点（21）并且包括一个或多个通道（40），用于接收缝合线被公开用于将组织固定到具有足够强度的骨或其他组织，以提供固定植入物的组织的固体固定（10）。植入物（10）任选地具有周向的，纵向的或倾斜的倒钩，以增强植入物的结构和保持特性。本发明的某些实施方案包括部分或完全脱矿质状态的植入物部分，从而赋予软化矿物质或部分去矿物质部分增加的灵活性。另外，根据所需的注入装置和保持特性，本发明的实施例可选地包括螺纹部分（410），槽纹部分或开槽部分（610）。植入物被最佳地构造成用于单步冲击植入，尽管也考虑了其他形式的植入。

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