会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 10. 发明申请
    • IMPROVED FORMULATIONS OF ANTI-ANGIOGENIC PEPTIDES
    • 改善抗生血管肽的制剂
    • WO2006083906A2
    • 2006-08-10
    • PCT/US2006003461
    • 2006-02-01
    • ATTENUON LLCMAZAR ANDREW PHEIATI HASHEMSCHRIER JAYLI MINGHARRIS SCOTT
    • MAZAR ANDREW PHEIATI HASHEMSCHRIER JAYLI MINGHARRIS SCOTT
    • A61K38/04
    • A61K9/0019A61K9/19A61K38/04A61K47/12A61K47/183
    • Described herein are compositions/formulations of the Cys-containing anti-angiogenic peptide Pro-His-Ser-Cys-Asn (preferably in its capped form as Ac-PHSCN-NH2) or acid addition salts thereof or analogue thereof, that comprise at least one additional compound that stabilizes the peptide or analogue against spontaneous tandem dimerization or higher oligomerization. Preferred formulations include an acidic buffer such as citrate, glycine as an excipient and bulking agent. Optional additional components of the formulation are a reducing agent, a non-thiol biocompatible anti-oxidant, a lyoprotectant (typically one or more sugars, one or more amino acids, one or more methylamine, one or more lyotropic salts, and/or one or more polyols. Also provided is an article of manufacture or kit comprising the formulation in solution or in lyophilized form. A method of inhibiting angiogenesis in a subject, comprising administering to the subject the peptide in the above formulation is also disclosed.
    • 本文描述了含有Cys的抗血管生成肽Pro-His-Ser-Cys-Asn(优选以其作为Ac-PHSCN-NH 2的封端形式)或其酸加成盐或其类似物的组合物/制剂,其至少包含 一种额外的化合物,其稳定肽或类似物以抵抗自发串联二聚化或更高级寡聚化。 优选的制剂包括酸性缓冲剂如柠檬酸盐,作为赋形剂的甘氨酸和填充剂。 制剂的任选的另外的组分是还原剂,非硫醇生物相容性抗氧化剂,冻干保护剂(通常一种或多种糖,一种或多种氨基酸,一种或多种甲胺,一种或多种溶致盐,和/或一种 还提供了一种制剂或试剂盒,其包含溶液或冻干形式的制剂。一种抑制受试者血管生成的方法,包括对受试者施用上述制剂中的肽。