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    • 1. 发明申请
    • NANO-OTOLOGIC PROTECTIVE EQUIPMENT FOR IMPACT NOISE TOXICITY AND/OR BLAST OVERPRESSURE EXPOSURE
    • 影响噪声和/或爆发过度暴露的纳米生物防护设备
    • WO2007082241A2
    • 2007-07-19
    • PCT/US2007/060346
    • 2007-01-10
    • PRESIDENT AND FELLOWS OF HARVARD COLLEGEROGERS, RichardCLIFFORD, BrendanWESTERVELT, RobertHUTCHINSON, JohnSTONE, HowardOLDMIXON, Eben
    • ROGERS, RichardCLIFFORD, BrendanWESTERVELT, RobertHUTCHINSON, JohnSTONE, HowardOLDMIXON, Eben
    • A61F13/00
    • A61F11/08A61N1/36036
    • An apparatus for preventing hearing loss having a body made of a soft compliant material having first and second ends and a channel extending therethrough, an acoustically limp material adjacent one of the ends of the body with the acoustically limp material having a hole therein aligned with the channel extending through the body, and a component film, disc or other structure covering or sealing the opening in the acoustically limp material. The film or disc may be formed of a high-strength polymer material and may be less than 10 micrometers in thickness. Rather than having a single channel extending through the body, a plurality of channels may extend therethrough and a plurality of corresponding holes may be provided in the acoustically limp material. The film, disc or other structure covers or seals the plurality of holes in the acoustically limp material. The film, disc or other structure may be attached in such a fashion as to behave like a flap whose operation is to close in response to high energy sound waves. The flap is pressed shut from the high intensity shock wave itself. The body may cylindrical in shape or may have another shape to fit snugly in a human ear canal.
    • 一种用于防止听力损失的装置,具有由具有第一和第二端的柔性柔性材料制成的主体和延伸穿过其中的通道,与身体的一个端部相邻的声学瑕疵材料,其中具有孔的声lim材料与 通道延伸穿过本体,以及覆盖或密封声学柔软材料中的开口的部件膜,盘或其他结构。 膜或盘可以由高强度聚合物材料形成,并且厚度可以小于10微米。 不是具有延伸穿过主体的单个通道,而是可以在多个通道中延伸通过,并且可以在声学柔软的材料中设置多个对应的孔。 胶片,碟片或其他结构覆盖或密封声lim材料中的多个孔。 胶片,碟片或其他结构可以以与其操作以响应于高能量声波而关闭的片状的方式附接。 从高强度冲击波本身关闭襟翼。 身体可以是圆柱形的或者可以具有另一形状以适合贴合在人耳道中。
    • 4. 发明申请
    • METHODS AND APPARATUS FOR MANIPULATION AND/OR DETECTION OF BIOLOGICAL SAMPLES AND OTHER OBJECTS
    • 用于操作和/或检测生物样本和其他对象的方法和设备
    • WO2005099419A2
    • 2005-10-27
    • PCT/US2005/012719
    • 2005-04-13
    • PRESIDENT AND FELLOWS OF HARVARD COLLEGEHAM, DonheeWESTERVELT, RobertHUNT, ThomasLIU, YongLEE, Hakho
    • HAM, DonheeWESTERVELT, RobertHUNT, ThomasLIU, YongLEE, Hakho
    • G01R33/30G01R33/465G01R33/56
    • G01R33/302B01L3/502761B01L2200/0668B01L2200/147B01L2300/0816B01L2300/0819B01L2300/0877B01L2300/1822B01L2300/1827B01L2400/043G01N15/1031G01N24/08G01N24/10G01R33/307G01R33/34092G01R33/3415G01R33/465G01R33/4808G01R33/5604
    • Methods and apparatus for manipulation, detection, imaging, characterization, sorting and/or assembly of biological or other materials, involving an integration of CMOS or other semiconductor-based technology and microfluidics. In one implementation, various components relating to the generation of electric and/or magnetic fields are implemented on an IC chip that is fabricated using standard protocols. The generated electric and/or magnetic fields are used to manipulate and/or detect one or more dielectric and/or magnetic particles and distinguish different types of particles. A microfluidic system is fabricated either directly on top of the IC chip, or as a separate entity that is then appropriately bonded to the IC chip, to facilitate the introduction and removal of cells in a biocompatible environment, or other particles/objects of interest suspended in a fluid. The patterned electric and/or magnetic fields generated by the IC chip can trap and move biological cells or other objects inside the microfluidic system. Electric and/or magnetic field generating components also may be controlled using signals of various frequencies so as to detect one or more cells, particles or objects of interest, and even the type of particle or object of interest, by measuring resonance characteristics associated with interactions between samples and one or more of the field-generating devices. Such systems may be employed in a variety of biological and medical related applications, including cell sorting and tissue assembly.
    • 用于生物或其他材料的操纵,检测,成像,表征,分类和/或组装的方法和设备,涉及CMOS或其他基于半导体的技术与微流体的集成。 在一个实施方式中,在使用标准协议制造的IC芯片上实现与产生电场和/或磁场有关的各种组件。 所产生的电场和/或磁场用于操纵和/或检测一个或多个电介质和/或磁性颗粒并区分不同类型的颗粒。 微流体系统直接在IC芯片的顶部制造,或作为单独的实体制造,然后适当地粘合到IC芯片,以促进引入和移除生物相容性环境中的细胞或悬浮的其他粒子/目标物体 在流体中。 由IC芯片产生的图案化的电场和/或磁场可以捕获和移动微流体系统内部的生物细胞或其他物体。 还可以使用各种频率的信号来控制电和/或磁场生成组件,以便通过测量与相互作用相关联的共振特征来检测一个或多个细胞,感兴趣的粒子或物体,甚至感兴趣的粒子或物体的类型 样品与一个或多个场生成装置之间。 这样的系统可用于各种生物和医学相关应用,包括细胞分选和组织装配。
    • 6. 发明申请
    • METHODS AND APPARATUS FOR MANIPULATION OF FLUIDIC SPECIES
    • 用于操作流体物种的方法和装置
    • WO2009005680A1
    • 2009-01-08
    • PCT/US2008/007941
    • 2008-06-26
    • PRESIDENT AND FELLOWS OF HARVARD COLLEGEHUNT, ThomasISSADORE, DavidWESTERVELT, Robert
    • HUNT, ThomasISSADORE, DavidWESTERVELT, Robert
    • B01L3/00
    • B01L3/502792B01L3/502761B01L2200/0626B01L2200/0647B01L2200/0652B01L2200/0673B01L2300/0819B01L2300/089B01L2400/0415B01L2400/043
    • The present disclosure relates generally to methods and apparatus for manipulating, detecting, imaging, and/or identifying particles, fluids, or other objects via electromagnetic fields, including methods and apparatus for identifying, sorting, splitting, coalescing, and/or reacting such particles, fluids, or other objects. Certain aspects of the invention are generally directed to methods and devices for producing electric or magnetic fields, e.g., from one or more field-generating components (200) (for example, arranged in an array), to control or manipulate a particle, fluid, or other object. For example, a fluidic droplet may be identified, sorted, separated, split, fused or coalesced, mixed, charged, sensed, determined, etc., using various systems and methods as described herein. In some cases, a particle, a fluidic species (e.g., a droplet), or another object may be contained or constrained by one or more layers of fluid. Other aspects of the invention are directed to methods of making such devices, methods of promoting the making or use of such devices, or the like.
    • 本公开总体上涉及用于通过电磁场操纵,检测,成像和/或识别颗粒,流体或其它物体的方法和装置,包括用于识别,分选,聚结和/或反应这种颗粒的方法和装置 ,流体或其他物体。 本发明的某些方面通常涉及用于产生电场或磁场的方法和装置,例如,从一个或多个场产生部件(200)(例如,排列成阵列),以控制或操纵颗粒流体 ,或其他对象。 例如,使用本文所述的各种系统和方法,可以识别,分类,分离,分离,融合或聚结,混合,充电,感测,确定等流体液滴。 在一些情况下,颗粒,流体物质(例如,液滴)或另一物体可以被一层或多层流体包含或约束。 本发明的其它方面涉及制造这种装置的方法,促进制造或使用这种装置的方法等。