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1. 发明申请

WO2007058804A1 DIELECTROPHORETIC TWEEZERS APPARATUS AND METHODS 审中-公开
标题翻译：电子二极管装置和方法
公开(公告)号：WO2007058804A1
公开(公告)日：2007-05-24
申请号：PCT/US2006/043137
申请日：2006-11-06
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , HUNT, Thomas , WESTERVELT, Robert , BLESZYNSKI, Ania
发明人： HUNT, Thomas , WESTERVELT, Robert , BLESZYNSKI, Ania
IPC分类号： G12B21/02 , B82B3/00 , B25J7/00 , G01N33/487 , G01N27/447 , B03C5/02 , C12N13/00 , C12M1/42 , G11B9/00
CPC分类号： B03C5/005 , B03C5/026 , B82B3/00 , C12N13/00 , G01Q80/00 , G11B9/14 , G11B9/1409 , G11B11/002
摘要： Dielectrophoretic (DEP) tweezers apparatus and methods for various applications, including particle trapping. Two electrodes are disposed on or otherwise constitute an elongated object forming a tip. A voltage is applied across these electrodes to produce a non-uniform electromagnetic field proximate to the tip thereby creating a dielectrophoretic trap. Once trapped, a particle may be moved to desired locations via manipulation of the elongated object or the medium in which the particle is located. Multiple DEP tweezers apparatus may be arranged to form arrays of tips capable of respectively generating local electromagnetic fields confined to the tips. Such DEP arrays may be employed in nanofabrication processes involving nanolithography or nano-manipulation, as well as data storage and retrieval applications.
摘要翻译：介电泳（DEP）镊子用于各种应用的设备和方法，包括颗粒捕获。两个电极设置在或以其他方式构成形成尖端的细长物体。在这些电极之间施加电压以在尖端附近产生不均匀的电磁场，从而产生介电电泳阱。一旦被捕获，颗粒可以通过操纵细长物体或颗粒所在的介质而移动到所需位置。多个DEP镊子装置可以被布置成形成能够分别产生局限于尖端的局部电磁场的尖端阵列。这种DEP阵列可以用于涉及纳米光刻或纳米操作的纳米制造工艺，以及数据存储和检索应用。

2. 发明申请

WO2007106402A3 METHODS AND APPARATUS FOR NEAR FIELD IRRADIATION 审中-公开
标题翻译：近场辐射的方法和装置
公开(公告)号：WO2007106402A3
公开(公告)日：2008-02-21
申请号：PCT/US2007006103
申请日：2007-03-09
申请人： HARVARD COLLEGE , ISSADORE DAVID , HUNT THOMAS , ADAMSON KRISTI , WESTERVELT ROBERT , ROGERS RICK
发明人： ISSADORE DAVID , HUNT THOMAS , ADAMSON KRISTI , WESTERVELT ROBERT , ROGERS RICK
IPC分类号： B01J19/12 , G01N33/53 , H05B6/72 , H05B6/80
CPC分类号： H05B6/72 , B01L3/5027 , B01L7/52 , B01L2300/0822 , B01L2300/1866 , G01N1/44
摘要： Irradiation methods and apparatus configured to deliver power, via electromagnetic fields at a variety of frequencies and power levels, in a localized fashion to a target area. In one example, an electromagnetic field generator is disposed on a substrate and configured to deliver power via electromagnetic energy to a thin region proximate to (above) a surface of the substrate, wherein electromagnetic field intensity decreases significantly beyond the thin region. Such methods and apparatus are particularly useful in a wide variety of processes involving chemical and/or physical interactions in connection with a sample of interest located in the thin region. In different aspects, irradiator apparatus may be configured as disposable devices, and/or used in combination with one or more microfluidic or sensing components, for a variety of medical / laboratory / diagnostic methods and instrumentation implementations.
摘要翻译：该照射方法和装置被配置为以局部方式通过各种频率和功率水平的电磁场向目标区域传递电力。在一个示例中，电磁场发生器设置在基板上并且被配置为经由电磁能传递电力到靠近（高于）基板表面的薄区域，其中电磁场强度显着地减小到薄区域之外。这种方法和装置在涉及与位于薄区域中的感兴趣样品相关的化学和/或物理相互作用的各种各样的方法中特别有用。在不同方面，辐射器装置可被配置为一次性装置，和/或与一个或多个微流体或感测部件组合使用，用于各种医疗/实验室/诊断方法和仪器实施。

3. 发明申请

WO2007044642A2 DEVICE AND METHOD FOR COMBINED MICROFLUIDIC-MICROMAGNETIC SEPARATION OF MATERIAL IN CONTINUOUS FLOW 审中-公开
标题翻译：用于连续流动的材料的微流控 - 微生物分离的装置和方法
公开(公告)号：WO2007044642A2
公开(公告)日：2007-04-19
申请号：PCT/US2006/039344
申请日：2006-10-06
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE AND CHILDREN'S MEDICAL CENTER CORPORATION , INGBER, Donald, E. , XIA, Shannon , HUNT, Tom, P. , WESTERVELT, Robert, M.
发明人： INGBER, Donald, E. , XIA, Shannon , HUNT, Tom, P. , WESTERVELT, Robert, M.
IPC分类号： C12M3/00
CPC分类号： A61M1/3618 , A61M1/36 , A61M2205/0244 , A61M2206/11 , B01L3/502761 , B01L2200/0636 , B01L2200/0668 , B01L2300/06 , B01L2300/0864 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N15/1459 , G01N15/1463 , G01N15/1484 , G01N2015/149 , Y10T436/25375
摘要： A miniaturized, integrated, microfluidic device pulls materials bound to magnetic particles from one laminar flow path to another by applying a local magnetic field gradient. The device removes microbial and mammalian cells from flowing biological fluids without any wash steps. A microfabricated high-gradient magnetic field concentrator (HGMC) is integrated at one side of a microfluidic channel. When magnetic particles are introduced into one flow path, they remain limited to that flow path. When the HGMC is magnetized, the magnetic beads are pulled from the initial flow path into the collection stream, thereby cleansing the fluid. The microdevice allows large numbers of beads and materials to be sorted simultaneously, has no capacity limit, does not lose separation efficiency as particles are removed, and is useful for cell separations from blood and other biological fluids. This on-chip separator allows cell separations to be performed in the field outside of hospitals and laboratories.
摘要翻译：小型化，集成的微流体装置通过施加局部磁场梯度将与磁性颗粒结合的材料从一个层流路径拉到另一层。该装置在没有任何洗涤步骤的情况下除去微生物和哺乳动物细胞流动的生物微加工的高梯度磁场集中器（HGMC）集成在微流体通道的一侧。当磁性颗粒被引入一个流动路径时，它们仍然限于该流动路径。当HGMC被磁化时，将磁珠从初始流动路径拉入收集流，从而清洁流体。微型装置允许大量的珠粒和材料同时分选，没有容量限制，在颗粒被去除时不会失去分离效率，并且可用于从血液和其它生物流体中分离细胞。这种片上分离器允许在医院和实验室外的实地进行细胞分离。

4. 发明申请

WO2009005680A1 METHODS AND APPARATUS FOR MANIPULATION OF FLUIDIC SPECIES 审中-公开
标题翻译：用于操作流体物种的方法和装置
公开(公告)号：WO2009005680A1
公开(公告)日：2009-01-08
申请号：PCT/US2008/007941
申请日：2008-06-26
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , HUNT, Thomas , ISSADORE, David , WESTERVELT, Robert
发明人： HUNT, Thomas , ISSADORE, David , WESTERVELT, Robert
IPC分类号： B01L3/00
CPC分类号： B01L3/502792 , B01L3/502761 , B01L2200/0626 , B01L2200/0647 , B01L2200/0652 , B01L2200/0673 , B01L2300/0819 , B01L2300/089 , B01L2400/0415 , B01L2400/043
摘要： The present disclosure relates generally to methods and apparatus for manipulating, detecting, imaging, and/or identifying particles, fluids, or other objects via electromagnetic fields, including methods and apparatus for identifying, sorting, splitting, coalescing, and/or reacting such particles, fluids, or other objects. Certain aspects of the invention are generally directed to methods and devices for producing electric or magnetic fields, e.g., from one or more field-generating components (200) (for example, arranged in an array), to control or manipulate a particle, fluid, or other object. For example, a fluidic droplet may be identified, sorted, separated, split, fused or coalesced, mixed, charged, sensed, determined, etc., using various systems and methods as described herein. In some cases, a particle, a fluidic species (e.g., a droplet), or another object may be contained or constrained by one or more layers of fluid. Other aspects of the invention are directed to methods of making such devices, methods of promoting the making or use of such devices, or the like.
摘要翻译：本公开总体上涉及用于通过电磁场操纵，检测，成像和/或识别颗粒，流体或其它物体的方法和装置，包括用于识别，分选，聚结和/或反应这种颗粒的方法和装置，流体或其他物体。本发明的某些方面通常涉及用于产生电场或磁场的方法和装置，例如，从一个或多个场产生部件（200）（例如，排列成阵列），以控制或操纵颗粒流体，或其他对象。例如，使用本文所述的各种系统和方法，可以识别，分类，分离，分离，融合或聚结，混合，充电，感测，确定等流体液滴。在一些情况下，颗粒，流体物质（例如，液滴）或另一物体可以被一层或多层流体包含或约束。本发明的其它方面涉及制造这种装置的方法，促进制造或使用这种装置的方法等。

5. 发明申请

WO2007127239A3 TRAPPING METHOD FOR DIGITAL COLOR PRINTING 审中-公开
公开(公告)号：WO2007127239A3
公开(公告)日：2007-11-08
申请号：PCT/US2007/010004
申请日：2007-04-25
申请人： PEERLESS SYSTEMS CORPORATION , GANDHI, Lakhbir , WESTERVELT, Robert , SCHMIDT, Kenneth, A. , SU, Dongpei , ABKARIAN, Alfred , RALEY, Mark
发明人： GANDHI, Lakhbir , WESTERVELT, Robert , SCHMIDT, Kenneth, A. , SU, Dongpei , ABKARIAN, Alfred , RALEY, Mark
IPC分类号： H04N1/387 , H04N1/56 , H04N1/58
摘要： A system and method for trapping in electrophotographic color printing and related technologies for printing or display in which the final image is an overlay of multiple components subject to alignment errors. Trapping is based on the cyan (C), magenta (M), and black (K) planes. There are four steps as follows: detect object edges on each of the four color planes; detect coincident and opposing edge transitions on each pair of planes (CM, CK, and KM); determine which plane to trap, i.e., to extend object across edge; and generate trap on that plane using a simple trap generation rule and a single trap generation rule.

6. 发明申请

WO2007127239A2 TRAPPING METHOD FOR DIGITAL COLOR PRINTING 审中-公开
标题翻译：数字彩印打印方法
公开(公告)号：WO2007127239A2
公开(公告)日：2007-11-08
申请号：PCT/US2007010004
申请日：2007-04-25
申请人： PEERLESS SYSTEMS CORP , GANDHI LAKHBIR , WESTERVELT ROBERT , SCHMIDT KENNETH A , SU DONGPEI , ABKARIAN ALFRED , RALEY MARK
发明人： GANDHI LAKHBIR , WESTERVELT ROBERT , SCHMIDT KENNETH A , SU DONGPEI , ABKARIAN ALFRED , RALEY MARK
IPC分类号： G06T7/40
CPC分类号： H04N1/58
摘要： A system and method for trapping in electrophotographic color printing and related technologies for printing or display in which the final image is an overlay of multiple components subject to alignment errors. Trapping is based on the cyan (C), magenta (M), and black (K) planes. There are four steps as follows: detect object edges on each of the four color planes; detect coincident and opposing edge transitions on each pair of planes (CM, CK, and KM); determine which plane to trap, i.e., to extend object across edge; and generate trap on that plane using a simple trap generation rule and a single trap generation rule.
摘要翻译：用于捕获电子照相彩色打印的系统和方法以及用于打印或显示的相关技术，其中最终图像是受到对准误差的多个部件的覆盖。捕获是基于青色（C），品红色（M）和黑色（K）面。有四个步骤如下：检测四个颜色平面中的每一个上的物体边缘; 检测每对平面（CM，CK和KM）上的重合和相对的边缘转换; 确定要捕获的平面，即，跨越边缘延伸物体; 并使用简单的陷阱生成规则和单个陷阱生成规则在该平面上生成陷阱。

7. 发明申请

WO2007084345A1 MICROSCOPY METHODS AND APPARATUS FOR MANIPULATION AND/OR DETECTION OF BIOLOGICAL SAMPLES AND OTHER OBJECTS 审中-公开
标题翻译：用于操纵和/或检测生物样品和其他物体的微观方法和装置
公开(公告)号：WO2007084345A1
公开(公告)日：2007-07-26
申请号：PCT/US2007/000779
申请日：2007-01-12
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , HAM, Donhee , WESTERVELT, Robert , HUNT, Thomas , LIU, Yong , LEE, Hakho
发明人： HAM, Donhee , WESTERVELT, Robert , HUNT, Thomas , LIU, Yong , LEE, Hakho
IPC分类号： G02B21/32 , G01N21/00 , G01N15/00
CPC分类号： G02B21/34 , B01J2219/00653 , B01J2219/00655 , B01J2219/00659 , B01J2219/00702 , B01L3/502761 , B01L2200/0668 , B01L2300/0819 , B01L2300/0877 , B01L2300/1822 , B01L2400/0415 , B01L2400/043 , G01N15/1463 , G02B21/32
摘要： Microscopy methods and apparatus for manipulation, detection, imaging, characterization, sorting and/or assembly of biological or other materials, involving an integration of CMOS or other semiconductor-based technology and microfluidics in connection with a microscope. In one implementation, a microscope including optics and a stage is outfitted with various components relating to the generation of electric and/or magnetic fields, which are implemented on an IC chip. A microfluidic system is fabricated either directly on top of the IC chip, or as a separate entity that is then appropriately bonded to the IC chip, to facilitate the introduction and removal of cells in a biocompatible environment, or other particles/objects of interest suspended in a fluid. The patterned electric and/or magnetic fields generated by the IC chip can trap and move biological cells or other objects inside the microfluidic system to facilitate viewing via the microscope.
摘要翻译：显微镜方法和用于操纵，检测，成像，表征，分选和/或组装生物或其他材料的装置，涉及CMOS或其他基于半导体的技术和与显微镜相结合的微流体的集成。在一个实施方式中，包括光学器件和阶段的显微镜配备有与在IC芯片上实现的电场和/或磁场的产生相关的各种组件。微流体系统直接制造在IC芯片的顶部上，或者作为独立的实体，然后适当地结合到IC芯片，以便于在生物相容性环境中引入和去除细胞，或者其他悬浮的颗粒/物体在流体中。由IC芯片产生的图案化电场和/或磁场可捕获和移动微流体系统内的生物细胞或其它物体，以便于通过显微镜观察。

8. 发明申请

WO2003039753A1 SYSTEM AND METHOD FOR CAPTURING AND POSITIONING PARTICLES 审中-公开
标题翻译：用于捕获和定位颗粒的系统和方法
公开(公告)号：WO2003039753A1
公开(公告)日：2003-05-15
申请号：PCT/US2002/036280
申请日：2002-11-05
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , WESTERVELT, Robert, M. , LEE, Chungsok , LEE, Hakho
发明人： WESTERVELT, Robert, M. , LEE, Chungsok , LEE, Hakho
IPC分类号： B03C1/24
CPC分类号： B01L3/502761 , B01L3/502792 , B01L2200/0647 , B01L2200/0668 , B01L2300/089 , B01L2400/0415 , B01L2400/043 , B03C1/24 , B03C2201/22 , G01N15/1456
摘要： A micro-electromagnet matrix (35 of Figure 11) captures and controls the movement of particles with nanoscale resolution. The micro-electromagnet matrix (35 of Figure 11) includes multiple layers (40 and 50 of figure 11) of microconductors (41 and 51 of Figure 11), each layer of microconductors (41 of Figure 11) being orthogonal to an adjacent layer of microconductors (51 of Figure 11). The layers of microconductors (40 and 50 of Figure 11) are formed on a substrate (20 of Figure 11) and have insulating layers (45 of Figure 11) therebetween. The field patterns produced by the micro-electromagnet matrix (35 of Figure 11) enable precise manipulation of particles. The micro-electromagnet matrix (35 of Figure 11) produces single or multiple independent field peaks in the m agnetic field that are used to trap, move, or rotate the particles. The micro-electromagnet matrix (35 of Figure 11) also produces electromagnetic fields to probe and detect particles.
摘要翻译：微电磁矩阵（图11中的35）捕获并控制具有纳米尺度分辨率的颗粒的运动。微电磁体矩阵（图11中的35）包括微层（图11的41和51）的多层（图11的40和50），每层微导体（图11的41）正交于相邻层微导体（图11中的51）。微导体层（图11的40和50）形成在衬底（图11的20）上，并具有绝缘层（图11中的45）。由微电磁矩阵（图11中的35）产生的场图可以精确地操纵颗粒。微电磁体矩阵（图11中的35）在用于捕获，移动或旋转颗粒的m场中产生单个或多个独立的场峰。微电磁矩阵（图11中的35）还产生用于探测和检测颗粒的电磁场。

9. 发明申请

WO2012030977A1 SWALLOWABLE WIRELESS BIOSENSOR FOR REAL-TIME DETECTION OF GASTROINTESTINAL BLEEDING 审中-公开
标题翻译：易于使用的无线生物传感器用于实时检测胃肠道出血
公开(公告)号：WO2012030977A1
公开(公告)日：2012-03-08
申请号：PCT/US2011/049992
申请日：2011-08-31
申请人： ENDOLUMINA INC. , BARKER, Nicholas , THOMPSON, Christopher C. , WESTERVELT, Robert , NEMIROSKI, Alex , OBSTEIN, Keith L.
发明人： BARKER, Nicholas , THOMPSON, Christopher C. , WESTERVELT, Robert , NEMIROSKI, Alex , OBSTEIN, Keith L.
IPC分类号： A61B5/145
CPC分类号： A61B5/4216 , A61B5/073
摘要： A swallowable device for monitoring physical and chemical parameter of a patient may include a casing with a sensor coupled to the casing. The sensor can be configured to detect a physical or chemical parameter of the patient-such as gastrointestinal bleeding. The device includes a wireless transmitter for transmitting a signal to an external receiver, with the signal encoding the physical and chemical parameters of the patient detected by the sensor.
摘要翻译：用于监测患者的物理和化学参数的吞咽装置可以包括具有耦合到壳体的传感器的壳体。传感器可被配置为检测患者的物理或化学参数 - 例如胃肠道出血。该装置包括用于将信号发送到外部接收器的无线发射器，其中信号编码由传感器检测到的患者的物理和化学参数。

10. 发明申请

WO2011066431A3 SYSTEM AND METHOD FOR WIRELESS BIOSENSOR MONITORING 审中-公开
公开(公告)号：WO2011066431A3
公开(公告)日：2011-06-03
申请号：PCT/US2010/058061
申请日：2010-11-24
申请人： BRIGHAM AND WOMEN'S HOSPITAL, INC. , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , THOMPSON, Christopher, C. , WESTERVELT, Robert , NEMIROSKI, Alex , OBSTEIN, Keith, L.
发明人： THOMPSON, Christopher, C. , WESTERVELT, Robert , NEMIROSKI, Alex , OBSTEIN, Keith, L.
IPC分类号： A61B1/00 , A61B5/0215 , A61B5/027
摘要： A system and method for monitoring a physical parameter of a subject is provided. The system may include a casing with a sensor coupled to the casing. The sensor may be configured to detect a physical parameter of the subject. The physical parameter may include a chemical parameter of the subject. The system includes an endoscopic clip coupled to the casing and may include a wireless transmitter for transmitting a signal via a wireless medium. The signal encodes the physical parameter of the subject detected by the sensor and the wireless transmitter is electronically connected to the endoscopic clip. The system may further include a monitor configured to communicate with the wireless transmitter for receiving the signal encoding the physical parameter of the subject.

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