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1. 发明申请

WO2005099419A2 METHODS AND APPARATUS FOR MANIPULATION AND/OR DETECTION OF BIOLOGICAL SAMPLES AND OTHER OBJECTS 审中-公开
标题翻译：用于操作和/或检测生物样本和其他对象的方法和设备
公开(公告)号：WO2005099419A2
公开(公告)日：2005-10-27
申请号：PCT/US2005/012719
申请日：2005-04-13
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , HAM, Donhee , WESTERVELT, Robert , HUNT, Thomas , LIU, Yong , LEE, Hakho
发明人： HAM, Donhee , WESTERVELT, Robert , HUNT, Thomas , LIU, Yong , LEE, Hakho
IPC分类号： G01R33/30 , G01R33/465 , G01R33/56
CPC分类号： G01R33/302 , B01L3/502761 , B01L2200/0668 , B01L2200/147 , B01L2300/0816 , B01L2300/0819 , B01L2300/0877 , B01L2300/1822 , B01L2300/1827 , B01L2400/043 , G01N15/1031 , G01N24/08 , G01N24/10 , G01R33/307 , G01R33/34092 , G01R33/3415 , G01R33/465 , G01R33/4808 , G01R33/5604
摘要： Methods and apparatus for manipulation, detection, imaging, characterization, sorting and/or assembly of biological or other materials, involving an integration of CMOS or other semiconductor-based technology and microfluidics. In one implementation, various components relating to the generation of electric and/or magnetic fields are implemented on an IC chip that is fabricated using standard protocols. The generated electric and/or magnetic fields are used to manipulate and/or detect one or more dielectric and/or magnetic particles and distinguish different types of particles. A microfluidic system is fabricated either directly on top of the IC chip, or as a separate entity that is then appropriately bonded to the IC chip, to facilitate the introduction and removal of cells in a biocompatible environment, or other particles/objects of interest suspended in a fluid. The patterned electric and/or magnetic fields generated by the IC chip can trap and move biological cells or other objects inside the microfluidic system. Electric and/or magnetic field generating components also may be controlled using signals of various frequencies so as to detect one or more cells, particles or objects of interest, and even the type of particle or object of interest, by measuring resonance characteristics associated with interactions between samples and one or more of the field-generating devices. Such systems may be employed in a variety of biological and medical related applications, including cell sorting and tissue assembly.
摘要翻译：用于生物或其他材料的操纵，检测，成像，表征，分类和/或组装的方法和设备，涉及CMOS或其他基于半导体的技术与微流体的集成。在一个实施方式中，在使用标准协议制造的IC芯片上实现与产生电场和/或磁场有关的各种组件。所产生的电场和/或磁场用于操纵和/或检测一个或多个电介质和/或磁性颗粒并区分不同类型的颗粒。微流体系统直接在IC芯片的顶部制造，或作为单独的实体制造，然后适当地粘合到IC芯片，以促进引入和移除生物相容性环境中的细胞或悬浮的其他粒子/目标物体在流体中。由IC芯片产生的图案化的电场和/或磁场可以捕获和移动微流体系统内部的生物细胞或其他物体。还可以使用各种频率的信号来控制电和/或磁场生成组件，以便通过测量与相互作用相关联的共振特征来检测一个或多个细胞，感兴趣的粒子或物体，甚至感兴趣的粒子或物体的类型样品与一个或多个场生成装置之间。这样的系统可用于各种生物和医学相关应用，包括细胞分选和组织装配。

2. 发明申请

WO2007084345A1 MICROSCOPY METHODS AND APPARATUS FOR MANIPULATION AND/OR DETECTION OF BIOLOGICAL SAMPLES AND OTHER OBJECTS 审中-公开
标题翻译：用于操纵和/或检测生物样品和其他物体的微观方法和装置
公开(公告)号：WO2007084345A1
公开(公告)日：2007-07-26
申请号：PCT/US2007/000779
申请日：2007-01-12
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , HAM, Donhee , WESTERVELT, Robert , HUNT, Thomas , LIU, Yong , LEE, Hakho
发明人： HAM, Donhee , WESTERVELT, Robert , HUNT, Thomas , LIU, Yong , LEE, Hakho
IPC分类号： G02B21/32 , G01N21/00 , G01N15/00
CPC分类号： G02B21/34 , B01J2219/00653 , B01J2219/00655 , B01J2219/00659 , B01J2219/00702 , B01L3/502761 , B01L2200/0668 , B01L2300/0819 , B01L2300/0877 , B01L2300/1822 , B01L2400/0415 , B01L2400/043 , G01N15/1463 , G02B21/32
摘要： Microscopy methods and apparatus for manipulation, detection, imaging, characterization, sorting and/or assembly of biological or other materials, involving an integration of CMOS or other semiconductor-based technology and microfluidics in connection with a microscope. In one implementation, a microscope including optics and a stage is outfitted with various components relating to the generation of electric and/or magnetic fields, which are implemented on an IC chip. A microfluidic system is fabricated either directly on top of the IC chip, or as a separate entity that is then appropriately bonded to the IC chip, to facilitate the introduction and removal of cells in a biocompatible environment, or other particles/objects of interest suspended in a fluid. The patterned electric and/or magnetic fields generated by the IC chip can trap and move biological cells or other objects inside the microfluidic system to facilitate viewing via the microscope.
摘要翻译：显微镜方法和用于操纵，检测，成像，表征，分选和/或组装生物或其他材料的装置，涉及CMOS或其他基于半导体的技术和与显微镜相结合的微流体的集成。在一个实施方式中，包括光学器件和阶段的显微镜配备有与在IC芯片上实现的电场和/或磁场的产生相关的各种组件。微流体系统直接制造在IC芯片的顶部上，或者作为独立的实体，然后适当地结合到IC芯片，以便于在生物相容性环境中引入和去除细胞，或者其他悬浮的颗粒/物体在流体中。由IC芯片产生的图案化电场和/或磁场可捕获和移动微流体系统内的生物细胞或其它物体，以便于通过显微镜观察。

3. 发明申请

WO2009045551A1 MINIATURIZED MAGNETIC RESONANCE SYSTEMS AND METHODS 审中-公开
标题翻译：微型磁共振系统和方法
公开(公告)号：WO2009045551A1
公开(公告)日：2009-04-09
申请号：PCT/US2008/011541
申请日：2008-10-06
申请人： THE GENERAL HOSPITAL CORPORATION , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , WEISSLEDER, Ralph , LEE, Hakho , HAM, Donhee , SUN, Nan , LIU, Yong
发明人： WEISSLEDER, Ralph , LEE, Hakho , HAM, Donhee , SUN, Nan , LIU, Yong
IPC分类号： G01V3/00
CPC分类号： G01R33/302 , G01R33/307 , G01R33/34092 , G01R33/383 , G01R33/465 , G01R33/50 , G01R33/5601 , G01R33/5617 , Y10T436/24
摘要： The present application describes devices, systems, and techniques related to a chip-based, miniaturized NMR diagnostic platform for rapid, quantitative and multi- channeled detection of biological targets.
摘要翻译：本申请描述了与基于芯片的小型化NMR诊断平台相关的装置，系统和技术，用于生物靶标的快速，定量和多通道检测。

4. 发明申请

WO2003039753A1 SYSTEM AND METHOD FOR CAPTURING AND POSITIONING PARTICLES 审中-公开
标题翻译：用于捕获和定位颗粒的系统和方法
公开(公告)号：WO2003039753A1
公开(公告)日：2003-05-15
申请号：PCT/US2002/036280
申请日：2002-11-05
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , WESTERVELT, Robert, M. , LEE, Chungsok , LEE, Hakho
发明人： WESTERVELT, Robert, M. , LEE, Chungsok , LEE, Hakho
IPC分类号： B03C1/24
CPC分类号： B01L3/502761 , B01L3/502792 , B01L2200/0647 , B01L2200/0668 , B01L2300/089 , B01L2400/0415 , B01L2400/043 , B03C1/24 , B03C2201/22 , G01N15/1456
摘要： A micro-electromagnet matrix (35 of Figure 11) captures and controls the movement of particles with nanoscale resolution. The micro-electromagnet matrix (35 of Figure 11) includes multiple layers (40 and 50 of figure 11) of microconductors (41 and 51 of Figure 11), each layer of microconductors (41 of Figure 11) being orthogonal to an adjacent layer of microconductors (51 of Figure 11). The layers of microconductors (40 and 50 of Figure 11) are formed on a substrate (20 of Figure 11) and have insulating layers (45 of Figure 11) therebetween. The field patterns produced by the micro-electromagnet matrix (35 of Figure 11) enable precise manipulation of particles. The micro-electromagnet matrix (35 of Figure 11) produces single or multiple independent field peaks in the m agnetic field that are used to trap, move, or rotate the particles. The micro-electromagnet matrix (35 of Figure 11) also produces electromagnetic fields to probe and detect particles.
摘要翻译：微电磁矩阵（图11中的35）捕获并控制具有纳米尺度分辨率的颗粒的运动。微电磁体矩阵（图11中的35）包括微层（图11的41和51）的多层（图11的40和50），每层微导体（图11的41）正交于相邻层微导体（图11中的51）。微导体层（图11的40和50）形成在衬底（图11的20）上，并具有绝缘层（图11中的45）。由微电磁矩阵（图11中的35）产生的场图可以精确地操纵颗粒。微电磁体矩阵（图11中的35）在用于捕获，移动或旋转颗粒的m场中产生单个或多个独立的场峰。微电磁矩阵（图11中的35）还产生用于探测和检测颗粒的电磁场。

5. 发明申请

WO2008109126A1 PERMANENT MAGNET SYSTEM 审中-公开
标题翻译：永磁系统
公开(公告)号：WO2008109126A1
公开(公告)日：2008-09-12
申请号：PCT/US2008/002983
申请日：2008-03-06
申请人： HARVARD UNIVERSITY OTD (OFFICE OF TECHNOLOGY DEVELOPMENT) , WETSERVELT, Robert , HAM, Donhee , ILIC, Ognjen , LEE, Hakho , WEISSLEDER, Ralph
发明人： WETSERVELT, Robert , HAM, Donhee , ILIC, Ognjen , LEE, Hakho , WEISSLEDER, Ralph
IPC分类号： H01F7/00
CPC分类号： H01F7/0284 , G01R33/3806 , G01R33/383 , G01R33/387
摘要： A magnet system for generating a static magnetic field for NMR analysis includes a first permanent magnet, and a second permanent magnet disposed below the first permanent magnet element and substantially parallel thereto. An upper metallic disc is disposed above the first permanent magnet and a lower metallic disc is disposed below the second permanent magnet. A hollow outer metallic shield encloses the first and second permanent magnets and the upper and lower metallic discs. The upper and lower metallic discs are movable relative to the first and second permanent magnets, respectively, in such a way that the distances between the metallic discs and the respective permanent magnets are optimized so as to render the gradient of a static magnetic field generated by the magnet system sufficiently uniform for use in the NMR analysis.
摘要翻译：用于产生用于NMR分析的静磁场的磁体系统包括第一永久磁体和设置在第一永久磁铁元件下方并与其基本平行的第二永磁体。上金属盘设置在第一永磁体上方，下金属盘设置在第二永久磁铁的下方。中空的外金属屏蔽罩包围第一和第二永磁体以及上金属盘和下金属盘。上金属盘和下金属盘分别相对于第一和第二永磁体可移动，使得金属盘和相应的永久磁铁之间的距离被最优化，以便使静电磁场的梯度由磁体系统足够均匀，用于NMR分析。

6. 发明申请

WO2011150212A2 MAGNETIC NANOPARTICLES 审中-公开
标题翻译：磁性纳米粒子
公开(公告)号：WO2011150212A2
公开(公告)日：2011-12-01
申请号：PCT/US2011/038143
申请日：2011-05-26
申请人： THE GENERAL HOSPITAL CORPORATION , WEISSLEDER, Ralph , LEE, Hakho , YOON, Tae-Jong
发明人： WEISSLEDER, Ralph , LEE, Hakho , YOON, Tae-Jong
IPC分类号： A61K9/14 , A61K9/16 , A61K49/08 , A61K49/06 , A61K33/26 , A61K47/48
CPC分类号： A61K49/1824 , A61K9/5094 , A61K9/5115 , A61K33/24 , A61K33/26 , A61K33/30 , A61K41/0052 , A61K49/08 , A61K49/10 , A61K49/126 , A61K49/1827 , A61K49/183 , A61K49/1836 , A61K2800/47 , A61N2/02 , B22F1/025 , A61K2300/00
摘要： A magnetic nanoparticle includes a magnetic core and a superparamagnetic outer shell, in which the outer shell enhances magnetic properties of the nanoparticle. The enhanced magnetic properties of the magnetic nanoparticle allow for highly sensitive detection as well as diminished non-specific aggregation of nanoparticles.
摘要翻译：磁性纳米颗粒包括磁芯和超顺磁性外壳，其中外壳增强纳米颗粒的磁性能。磁性纳米颗粒的增强的磁性能允许高度敏感的检测以及纳米颗粒的非特异性聚集减少。

7. 发明申请

WO2012047653A2 SELF-ASSEMBLED MAGNETIC ARRAYS 审中-公开
标题翻译：自组装磁性阵列
公开(公告)号：WO2012047653A2
公开(公告)日：2012-04-12
申请号：PCT/US2011/053466
申请日：2011-09-27
申请人： THE GENERAL HOSPITAL CORPORATION , WEISSLEDER, Ralph , LEE, Hakho , ISSADORE, David
发明人： WEISSLEDER, Ralph , LEE, Hakho , ISSADORE, David
IPC分类号： H01F7/00 , A61B5/05 , G01N27/72
CPC分类号： G01N1/4077 , A61B5/055 , B03C1/0332 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N33/4833 , G01N2001/4088 , G01N2610/00 , G01R33/383 , H01F1/009 , H01F1/047 , H01F1/068 , H01F10/007
摘要： A magnetic device includes a substrate and an array including a plurality of magnetic particles, in which a magnetic dipole moment direction of each magnetic particle in a majority of the magnetic particles in the array alternates with respect to a magnetic dipole direction of a directly adjacent magnetic particle or directly adjacent magnetic particles in the array.
摘要翻译：磁性装置包括基板和包括多个磁性颗粒的阵列，其中阵列中大部分磁性颗粒中的每个磁性颗粒的磁偶极矩方向相对于直接相邻的磁体的磁偶极方向交替颗粒或直接相邻的磁性颗粒。

8. 发明申请

WO2022020814A1 ON-SITE RAPID QUANTIFICATION OF TETRAHYDROCANNABINOL 审中-公开
公开(公告)号：WO2022020814A1
公开(公告)日：2022-01-27
申请号：PCT/US2021/043234
申请日：2021-07-26
申请人： THE GENERAL HOSPITAL CORPORATION , INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY , LEE, Hakho , WEISSLEDER, Ralph , YU, Hojeong , CHEON, Jinwoo
发明人： LEE, Hakho , WEISSLEDER, Ralph , YU, Hojeong , CHEON, Jinwoo
IPC分类号： A61B10/00 , B01L3/00 , G01N1/00 , G01N33/487
摘要： Aspects of the present disclosure provide devices and methods for rapid, quantitative, on-site detection of controlled substances. Devices include a sample processing module and a sensor cartridge, and optionally a detection cradle.

9. 发明申请

WO2012129325A1 MOLECULAR ANALYSIS OF TUMOR SAMPLES 审中-公开
标题翻译：肿瘤样品的分子分析
公开(公告)号：WO2012129325A1
公开(公告)日：2012-09-27
申请号：PCT/US2012/029976
申请日：2012-03-21
申请人： THE GENERAL HOSPITAL CORPORATION , WEISSLEDER, Ralph , LEE, Hakho , CASTRO, Cesar
发明人： WEISSLEDER, Ralph , LEE, Hakho , CASTRO, Cesar
IPC分类号： G01N33/574 , G01N33/96 , G01N33/53 , G01N33/58
CPC分类号： G01N33/574 , G01N21/6428 , G01N24/088 , G01N33/54326 , G01N33/57484 , G01N33/57492 , G01N33/587 , G01N2333/4725 , G01N2333/485 , G01N2333/70596 , G01N2333/71 , G01R33/1269
摘要： This invention relates to methods for diagnosing cancer, e.g., cancer of epithelial origin, by detecting the presence of tumor cells in a sample, based (at least in some embodiments) on the quantification of levels of four biomarkers, MUC1, EGFR, EpCAM, and HER2. In some embodiments, the methods are performed using diagnostic magnetic resonance (DMR), e.g., with a portable relaxometer or MR imager.
摘要翻译：本发明涉及通过基于（至少在一些实施方案中）基于四种生物标志物MUC1，EGFR，EpCAM等级的量化来检测样品中肿瘤细胞的存在来检测癌症的方法，例如上皮起源的癌症。和HER2。在一些实施例中，使用诊断磁共振（DMR），例如使用便携式放大器或MR成像仪来执行所述方法。

10. 发明申请

WO2012129281A2 DETECTION OF TARGETS USING MAGNETIC RESONANCE 审中-公开
标题翻译：利用磁共振检测目标
公开(公告)号：WO2012129281A2
公开(公告)日：2012-09-27
申请号：PCT/US2012/029912
申请日：2012-03-21
申请人： THE GENERAL HOSPITAL CORPORATION , WEISSLEDER, Ralph , LEE, Hakho , ISSADORE, David
发明人： WEISSLEDER, Ralph , LEE, Hakho , ISSADORE, David
CPC分类号： G01N33/574 , G01N21/6428 , G01N24/088 , G01N33/54326 , G01N33/57484 , G01N33/57492 , G01N33/587 , G01N2333/4725 , G01N2333/485 , G01N2333/70596 , G01N2333/71 , G01R33/1269
摘要： A portable magnetic resonance system includes a permanent magnet, a nuclear magnetic resonance probe, and control electronics. The control electronics are configured to transmit to the probe a magnetic resonance excitation signal having an excitation frequency f, receive from the probe a magnetic resonance measurement signal, detect in the magnetic resonance measurement signal a magnetic resonance frequency f0, and automatically adjust the excitation frequency f until the difference between the excitation frequency and the magnetic resonance frequency is approximately equal to a target offset.
摘要翻译：便携式磁共振系统包括永磁体，核磁共振探头和控制电子器件。控制电子器件被配置为将具有激励频率f的磁共振激励信号传输到探针，从探针接收磁共振测量信号，在磁共振测量信号中检测磁共振频率f0，并自动调整激励频率直到激励频率和磁共振频率之间的差值近似等于目标偏移量为止。

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