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1. 发明申请

WO2013173207A3 NUCLEAR MAGNETIC RESONANCE APPARATUS, SYSTEMS, AND METHODS 审中-公开
标题翻译：核磁共振装置，系统和方法
公开(公告)号：WO2013173207A3
公开(公告)日：2014-01-09
申请号：PCT/US2013040713
申请日：2013-05-13
申请人： UNIV MICHIGAN STATE
发明人： ALOCILJA EVANGELYN , LUO YILUN
IPC分类号： G01N24/00
CPC分类号： G01N24/08 , G01R33/28 , G01R33/302 , G01R33/448
摘要： In one aspect, the disclosure relates to a nuclear magnetic resonance transceiver including: (a) a variable-frequency electromagnetic signal generator with (i) a frequency input and (ii) an EM signal output; (b) an electronic frequency controller including (i) a frequency output coupled to the frequency input of the variable-frequency EM signal generator, (ii) an intermediate frequency set-point input, and (iii) an intermediate frequency measurement input; (c) an NMR transmission probe with an EM signal input coupled to the EM signal output of the variable-frequency EM signal generator; (d) an NMR receiving probe with an EM signal output; and (e) an electronic mixer with (i) a first input coupled to the EM signal output of the NMR receiving probe, (ii) a second input coupled to the EM signal output of the variable-frequency EM signal generator, and (iii) a mixed EM signal output coupled to the frequency measurement input of the frequency controller.
摘要翻译：一方面，本公开涉及一种核磁共振收发器，包括：（a）可变频率电磁信号发生器，其具有（i）频率输入和（ii）EM信号输出; （b）电子频率控制器，包括：（i）与可变频率EM信号发生器的频率输入耦合的频率输出，（ii）中频设定点输入，和（iii）中频测量输入; （c）具有耦合到可变频率EM信号发生器的EM信号输出的EM信号输入的NMR传输探针; （d）具有EM信号输出的NMR接收探针; 和（e）电子混合器，其具有（i）耦合到NMR接收探针的EM信号输出的第一输入，（ii）耦合到可变频率EM信号发生器的EM信号输出的第二输入，和（iii ）耦合到频率控制器的频率测量输入的混合EM信号输出。

2. 发明申请

WO2014004573A1 PORTABLE DEVICE FOR NMR BASED ANALYSIS OF RHEOLOGICAL CHANGES IN LIQUID SAMPLES 审中-公开
标题翻译：用于基于NMR分析的液体样品中流变学变化的便携式装置
公开(公告)号：WO2014004573A1
公开(公告)日：2014-01-03
申请号：PCT/US2013/047703
申请日：2013-06-25
申请人： T2 BIOSYSTEMS, INC.
发明人： WELLMAN, Parris, S. , BLANCO, Matthew , PEINE, William
IPC分类号： G01V3/00
CPC分类号： G01R33/30 , B01L3/502 , B01L2200/147 , B01L2200/16 , B01L2300/0672 , B01L2300/0864 , B01L2400/0406 , B01L2400/0457 , B01L2400/0487 , B01L2400/0683 , G01N24/08 , G01R33/302
摘要： The invention features a portable device for monitoring changes in the rheological state of multiple samples by NMR based measurement. The rheological changes can be, for example, gelation occurring during limulus amoebocyte lysate (LAL) testing for endotoxins or blood coagulation. The inventive method entails organization of individual NMR tubes in a disposable cartridge where the tubes are connected through a top cover, provided with movable actuators to push the reagent in the reagent compartments of the individual chambers to the reaction chambers in a predetermined sequence.
摘要翻译：本发明的特征在于用于通过基于NMR的测量来监测多个样品的流变状态的变化的便携式装置。流变学变化可以是例如在鲎变形细胞裂解物（LAL）测试内部毒素或血液凝固时发生凝胶化。本发明的方法需要在一次性盒中组织各个NMR管，其中管通过顶盖连接，设置有可移动致动器，以将预定顺序将各个室的试剂室中的试剂推到反应室。

3. 发明申请

WO2012054589A3 CONDUIT-CONTAINING DEVICES AND METHODS FOR ANALYTE PROCESSING AND DETECTION 审中-公开
标题翻译：包含导管的装置和用于分析物处理和检测的方法
公开(公告)号：WO2012054589A3
公开(公告)日：2012-08-02
申请号：PCT/US2011056867
申请日：2011-10-19
申请人： T2 BIOSYSTEMS INC , LOWERY THOMAS JAY JR , WELLMAN PARRIS S , MCDONOUGH JOHN , CHEPIN JAMES FRANKLIN , RITTERSHAUS CHARLES WILLIAM , DEMAS VASILIKI , SKELLEY ALISON
发明人： LOWERY THOMAS JAY JR , WELLMAN PARRIS S , MCDONOUGH JOHN , CHEPIN JAMES FRANKLIN , RITTERSHAUS CHARLES WILLIAM , DEMAS VASILIKI , SKELLEY ALISON
IPC分类号： C12M1/34
CPC分类号： G01R33/465 , G01R33/281 , G01R33/30 , G01R33/302 , G01R33/448
摘要： This invention features devices and methods for analyte processing and detection, and use of such methods, e.g., in the treatment and diagnosis of disease or determining the presence of a pathogen.
摘要翻译：本发明的特征在于用于分析物处理和检测的装置和方法，以及这些方法的使用，例如用于疾病的治疗和诊断或确定病原体的存在。

4. 发明申请

WO2012054639A2 NMR SYSTEMS AND METHODS FOR THE RAPID DETECTION OF ANALYTES 审中-公开
标题翻译：用于快速检测分析物的NMR系统和方法
公开(公告)号：WO2012054639A2
公开(公告)日：2012-04-26
申请号：PCT/US2011/056936
申请日：2011-10-19
申请人： T2 BIOSYSTEMS, INC. , LOWERY, Thomas, Jay, Jr. , AUDEH, Mark, John , BLANCO, Matthew , CHEPIN, James, Franklin , DEMAS, Vasiliki , DHANDA, Rahul , FRITZEMEIER, Marilyn, Lee , KOH, Isaac , KUMAR, Sonia , NEELY, Lori, Anne , MOZELESKI, Brian , PLOURDE, Daniella, Lynn , RITTERSHAUS, Charles, William , WELLMAN, Parris
发明人： LOWERY, Thomas, Jay, Jr. , AUDEH, Mark, John , BLANCO, Matthew , CHEPIN, James, Franklin , DEMAS, Vasiliki , DHANDA, Rahul , FRITZEMEIER, Marilyn, Lee , KOH, Isaac , KUMAR, Sonia , NEELY, Lori, Anne , MOZELESKI, Brian , PLOURDE, Daniella, Lynn , RITTERSHAUS, Charles, William , WELLMAN, Parris
IPC分类号： G01N33/553 , C12M1/34 , G01N33/566
CPC分类号： G01N33/54326 , B82Y25/00 , C12Q1/6825 , C12Q1/6827 , C12Q1/689 , C12Q1/6895 , C12Q1/70 , C12Q1/701 , G01N24/08 , G01N27/745 , G01N33/5434 , G01N33/9493 , G01R33/093 , G01R33/1269 , G01R33/281 , G01R33/302 , G01R33/448 , C12Q2563/143 , C12Q2565/633 , C12Q2563/149 , C12Q2565/113
摘要： This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.
摘要翻译：本发明的特征在于用于检测分析物的系统和方法及其在治疗和诊断疾病中的用途。

5. 发明申请

WO2012054638A2 NMR SYSTEMS AND METHODS FOR THE DETECTION OF ANALYTES 审中-公开
标题翻译：用于检测分析物的NMR系统和方法
公开(公告)号：WO2012054638A2
公开(公告)日：2012-04-26
申请号：PCT/US2011/056933
申请日：2011-10-19
申请人： T2 BIOSYSTEMS, INC. , LOWERY, Thomas, Jay , AUDEH, Mark, John , BLANCO, Matthew , CHEPIN, James, Franklin , DEMAS, Vasiliki , DHANDA, Rahul , FRITZEMEIER, Marilyn, Lee , KOH, Isaac , KUMAR, Sonia , NEELY, Lori, Anne , MOZELESKI, Brian , PLOURDE, Daniella, Lynn , RITTERSHAUS, Charles, William , WELLMAN, Parris
发明人： LOWERY, Thomas, Jay , AUDEH, Mark, John , BLANCO, Matthew , CHEPIN, James, Franklin , DEMAS, Vasiliki , DHANDA, Rahul , FRITZEMEIER, Marilyn, Lee , KOH, Isaac , KUMAR, Sonia , NEELY, Lori, Anne , MOZELESKI, Brian , PLOURDE, Daniella, Lynn , RITTERSHAUS, Charles, William , WELLMAN, Parris
IPC分类号： G01N33/553 , C12M1/34
CPC分类号： G01N33/54326 , B82Y25/00 , C12Q1/6825 , C12Q1/6827 , C12Q1/689 , C12Q1/6895 , C12Q1/70 , C12Q1/701 , G01N24/08 , G01N27/745 , G01N33/5434 , G01N33/9493 , G01R33/093 , G01R33/1269 , G01R33/281 , G01R33/302 , G01R33/448 , C12Q2563/143 , C12Q2565/633 , C12Q2563/149 , C12Q2565/113
摘要： This invention features systems and methods for the detection of analytes, and their use in the treatment and diagnosis of disease.
摘要翻译：本发明的特征在于用于检测分析物的系统和方法及其在治疗和诊断疾病中的用途。

6. 发明申请

WO2012054589A2 CONDUIT-CONTAINING DEVICES AND METHODS FOR ANALYTE PROCESSING AND DETECTION 审中-公开
公开(公告)号：WO2012054589A2
公开(公告)日：2012-04-26
申请号：PCT/US2011/056867
申请日：2011-10-19
申请人： T2 BIOSYSTEMS, INC. , LOWERY, Thomas, Jay, Jr. , WELLMAN, Parris, S. , MCDONOUGH, John , CHEPIN, James, Franklin , RITTERSHAUS, Charles, William , DEMAS, Vasiliki , SKELLEY, Alison
发明人： LOWERY, Thomas, Jay, Jr. , WELLMAN, Parris, S. , MCDONOUGH, John , CHEPIN, James, Franklin , RITTERSHAUS, Charles, William , DEMAS, Vasiliki , SKELLEY, Alison
IPC分类号： G01R33/46
CPC分类号： G01R33/465 , G01R33/281 , G01R33/30 , G01R33/302 , G01R33/448
摘要： This invention features devices and methods for analyte processing and detection, and use of such methods, e.g., in the treatment and diagnosis of disease or determining the presence of a pathogen.

7. 发明申请

WO2011014696A2 DUAL-USE NMR PROBE 审中-公开
标题翻译：双重核磁共振探针
公开(公告)号：WO2011014696A2
公开(公告)日：2011-02-03
申请号：PCT/US2010/043775
申请日：2010-07-29
申请人： VARIAN, INC , ZENS, Abert, P.
发明人： ZENS, Abert, P.
IPC分类号： G01N24/08 , G01R33/32
CPC分类号： G01R33/34092 , G01R33/302 , G01R33/34007 , G01R33/3628 , G01R33/422
摘要： An NMR probe comprising an RF resonator 48 serves in a first mode for conventional sensitivity optimized studies of abundant samples at frequency ω 0 , and in a second mode for independent sensitivity optimized studies of micro sample quantities at frequency ω 0 through use of a removeably insertable self-resonant micro-coil 50 within the RF resonator 48 and closely surrounding a micro sample, that is preferably independently removeably insertable within the micro-coil. The NMR probe exhibits an enhanced tuning range to resonate in its first mode and in the second mode to inductively couple to the self-resonant micro-coil 50 to induce self-resonance of the micro-coil 50 at ω 0 .
摘要翻译：包括RF谐振器48的NMR探针以第一模式用于在频率ω0处的丰富样本的常规灵敏度优化研究，并且在第二模式中用于独立灵敏度优化通过在RF谐振器48内使用可移除地插入的自谐振微型线圈50并紧密围绕微型样本来研究在频率ω0处的微量样本量，微型样本优选地独立地可移除地插入微型 - 线圈。 NMR探针表现出增强的调谐范围，以在其第一模式和第二模式下共振，以感应耦合到自谐振微型线圈50，以在ω0 0处引起微型线圈50的自谐振。子>

8. 发明申请

WO2009046350A1 DETECTION OF MAGNETIC RESONANCE SIGNALS USING A MAGNETORESISTIVE SENSOR 审中-公开
标题翻译：使用磁传感器检测磁共振信号
公开(公告)号：WO2009046350A1
公开(公告)日：2009-04-09
申请号：PCT/US2008/078820
申请日：2008-10-03
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , BUDKER, Dmitry , PINES, Alexander , XU, Shoujun , HILTY, Christian, B. , LEDBETTER, Micah, P. , BOUCHARD, Louis, S.
发明人： BUDKER, Dmitry , PINES, Alexander , XU, Shoujun , HILTY, Christian, B. , LEDBETTER, Micah, P. , BOUCHARD, Louis, S.
IPC分类号： B03C1/00 , G01N33/553
CPC分类号： G01R33/093 , B82Y25/00 , E03F3/046 , G01N24/08 , G01R33/302 , G01R33/307 , G01R33/323 , G01R33/36 , G01R33/44 , G01R33/50 , G01R33/5602 , G01R33/56375
摘要： A method and apparatus are described wherein a micro sample of a fluidic material may be assayed without sample contamination using NMR techniques, in combination with magnetoresistive sensors. The fluidic material to be assayed is first subject to pre-polarization, in one embodiment, by passage through a magnetic field. The magnetization of the fluidic material is then subject to an encoding process, in one embodiment an rf-induced inversion by passage through an adiabatic fast-passage module. Thereafter, the changes in magnetization are detected by a pair of solid-state magnetoresistive sensors arranged in gradiometer mode. Miniaturization is afforded by the close spacing of the various modules.
摘要翻译：描述了一种方法和装置，其中可以使用NMR技术结合磁阻传感器来测定流体材料的微样品而不使用样品污染。要测定的流体物质首先经过预极化，在一个实施方案中，通过磁场。流体材料的磁化然后进行编码过程，在一个实施方案中，通过通过绝热快速通道模块的rf诱导的反转。此后，通过以梯度计模式布置的一对固态磁阻传感器来检测磁化的变化。通过各种模块的紧密间隔提供小型化。

9. 发明申请

WO2008119054A1 SYSTEM AND METHOD FOR DETECTING LABELED ENTITIES USING MICROCOIL MAGNETIC MRI 审中-公开
标题翻译：用微核磁共振技术检测标签实体的系统和方法
公开(公告)号：WO2008119054A1
公开(公告)日：2008-10-02
申请号：PCT/US2008/058518
申请日：2008-03-27
申请人： ABQMR, INC. , MCDOWELL, Andrew, F.
发明人： MCDOWELL, Andrew, F.
IPC分类号： G01R33/30 , G01R33/56 , G01R33/465
CPC分类号： G01R33/302 , G01R33/307 , G01R33/3415 , G01R33/465 , G01R33/5604
摘要： The present invention provides microcoil-based detectors for detection of an analyte in a fluid, and methods for their use. In particular, the detectors contain a permanent magnet (206) and a gradient magnetic field generator.
摘要翻译：本发明提供了用于检测流体中的分析物的基于微线圈的检测器及其使用方法。特别地，检测器包含永磁体（206）和梯度磁场发生器。

10. 发明申请

WO2007130516A3 DOWNHOLE MICRO MAGNETIC RESONANCE ANALYZER 审中-公开
标题翻译：卧式微磁共振分析仪
公开(公告)号：WO2007130516A3
公开(公告)日：2008-03-06
申请号：PCT/US2007010737
申请日：2007-05-02
申请人： SCHLUMBERGER CA LTD , SCHLUMBERGER TECHNOLOGY BV , PRAD RES & DEV NV , SCHLUMBERGER SERVICES PETROL , SCHLUMBERGER HOLDINGS , TAHERIAN REZA , GANESAN KRISHNAMURTHY , FREEDMAN ROBERT
发明人： TAHERIAN REZA , GANESAN KRISHNAMURTHY , FREEDMAN ROBERT
IPC分类号： G01R33/44 , G01R33/34
CPC分类号： G01R33/302 , G01N24/081 , G01R33/34053 , G01R33/34061 , G01R33/3456
摘要： A downhole micro MR analyzer for use in a wellbore, having a micro sample tube, a micro RF coil (14) in close proximity to the micro sample tube (16), and one or more magnets (12) disposed about the micro sample tube (16) is disclosed. The micro MR analyzer can be used for nuclear magnetic resonance or electron spin resonance experiments to ascertain formation properties and chemical compositions.
摘要翻译：一种用于井眼的井下微型MR分析仪，其具有微量样品管，紧邻微量样品管（16）的微型RF线圈（14）以及围绕微量样品管设置的一个或多个磁体（12）（16）。微型MR分析仪可用于核磁共振或电子自旋共振实验，以确定地层性质和化学成分。

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