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1. 发明申请

WO2022020814A1 ON-SITE RAPID QUANTIFICATION OF TETRAHYDROCANNABINOL 审中-公开
公开(公告)号：WO2022020814A1
公开(公告)日：2022-01-27
申请号：PCT/US2021/043234
申请日：2021-07-26
申请人： THE GENERAL HOSPITAL CORPORATION , INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY , LEE, Hakho , WEISSLEDER, Ralph , YU, Hojeong , CHEON, Jinwoo
发明人： LEE, Hakho , WEISSLEDER, Ralph , YU, Hojeong , CHEON, Jinwoo
IPC分类号： A61B10/00 , B01L3/00 , G01N1/00 , G01N33/487
摘要： Aspects of the present disclosure provide devices and methods for rapid, quantitative, on-site detection of controlled substances. Devices include a sample processing module and a sensor cartridge, and optionally a detection cradle.

2. 发明申请

WO2007084345A1 MICROSCOPY METHODS AND APPARATUS FOR MANIPULATION AND/OR DETECTION OF BIOLOGICAL SAMPLES AND OTHER OBJECTS 审中-公开
标题翻译：用于操纵和/或检测生物样品和其他物体的微观方法和装置
公开(公告)号：WO2007084345A1
公开(公告)日：2007-07-26
申请号：PCT/US2007/000779
申请日：2007-01-12
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , HAM, Donhee , WESTERVELT, Robert , HUNT, Thomas , LIU, Yong , LEE, Hakho
发明人： HAM, Donhee , WESTERVELT, Robert , HUNT, Thomas , LIU, Yong , LEE, Hakho
IPC分类号： G02B21/32 , G01N21/00 , G01N15/00
CPC分类号： G02B21/34 , B01J2219/00653 , B01J2219/00655 , B01J2219/00659 , B01J2219/00702 , B01L3/502761 , B01L2200/0668 , B01L2300/0819 , B01L2300/0877 , B01L2300/1822 , B01L2400/0415 , B01L2400/043 , G01N15/1463 , G02B21/32
摘要： Microscopy methods and apparatus for manipulation, detection, imaging, characterization, sorting and/or assembly of biological or other materials, involving an integration of CMOS or other semiconductor-based technology and microfluidics in connection with a microscope. In one implementation, a microscope including optics and a stage is outfitted with various components relating to the generation of electric and/or magnetic fields, which are implemented on an IC chip. A microfluidic system is fabricated either directly on top of the IC chip, or as a separate entity that is then appropriately bonded to the IC chip, to facilitate the introduction and removal of cells in a biocompatible environment, or other particles/objects of interest suspended in a fluid. The patterned electric and/or magnetic fields generated by the IC chip can trap and move biological cells or other objects inside the microfluidic system to facilitate viewing via the microscope.
摘要翻译：显微镜方法和用于操纵，检测，成像，表征，分选和/或组装生物或其他材料的装置，涉及CMOS或其他基于半导体的技术和与显微镜相结合的微流体的集成。在一个实施方式中，包括光学器件和阶段的显微镜配备有与在IC芯片上实现的电场和/或磁场的产生相关的各种组件。微流体系统直接制造在IC芯片的顶部上，或者作为独立的实体，然后适当地结合到IC芯片，以便于在生物相容性环境中引入和去除细胞，或者其他悬浮的颗粒/物体在流体中。由IC芯片产生的图案化电场和/或磁场可捕获和移动微流体系统内的生物细胞或其它物体，以便于通过显微镜观察。

3. 发明申请

WO2003039753A1 SYSTEM AND METHOD FOR CAPTURING AND POSITIONING PARTICLES 审中-公开
标题翻译：用于捕获和定位颗粒的系统和方法
公开(公告)号：WO2003039753A1
公开(公告)日：2003-05-15
申请号：PCT/US2002/036280
申请日：2002-11-05
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , WESTERVELT, Robert, M. , LEE, Chungsok , LEE, Hakho
发明人： WESTERVELT, Robert, M. , LEE, Chungsok , LEE, Hakho
IPC分类号： B03C1/24
CPC分类号： B01L3/502761 , B01L3/502792 , B01L2200/0647 , B01L2200/0668 , B01L2300/089 , B01L2400/0415 , B01L2400/043 , B03C1/24 , B03C2201/22 , G01N15/1456
摘要： A micro-electromagnet matrix (35 of Figure 11) captures and controls the movement of particles with nanoscale resolution. The micro-electromagnet matrix (35 of Figure 11) includes multiple layers (40 and 50 of figure 11) of microconductors (41 and 51 of Figure 11), each layer of microconductors (41 of Figure 11) being orthogonal to an adjacent layer of microconductors (51 of Figure 11). The layers of microconductors (40 and 50 of Figure 11) are formed on a substrate (20 of Figure 11) and have insulating layers (45 of Figure 11) therebetween. The field patterns produced by the micro-electromagnet matrix (35 of Figure 11) enable precise manipulation of particles. The micro-electromagnet matrix (35 of Figure 11) produces single or multiple independent field peaks in the m agnetic field that are used to trap, move, or rotate the particles. The micro-electromagnet matrix (35 of Figure 11) also produces electromagnetic fields to probe and detect particles.
摘要翻译：微电磁矩阵（图11中的35）捕获并控制具有纳米尺度分辨率的颗粒的运动。微电磁体矩阵（图11中的35）包括微层（图11的41和51）的多层（图11的40和50），每层微导体（图11的41）正交于相邻层微导体（图11中的51）。微导体层（图11的40和50）形成在衬底（图11的20）上，并具有绝缘层（图11中的45）。由微电磁矩阵（图11中的35）产生的场图可以精确地操纵颗粒。微电磁体矩阵（图11中的35）在用于捕获，移动或旋转颗粒的m场中产生单个或多个独立的场峰。微电磁矩阵（图11中的35）还产生用于探测和检测颗粒的电磁场。

4. 发明申请

WO2012047653A2 SELF-ASSEMBLED MAGNETIC ARRAYS 审中-公开
标题翻译：自组装磁性阵列
公开(公告)号：WO2012047653A2
公开(公告)日：2012-04-12
申请号：PCT/US2011/053466
申请日：2011-09-27
申请人： THE GENERAL HOSPITAL CORPORATION , WEISSLEDER, Ralph , LEE, Hakho , ISSADORE, David
发明人： WEISSLEDER, Ralph , LEE, Hakho , ISSADORE, David
IPC分类号： H01F7/00 , A61B5/05 , G01N27/72
CPC分类号： G01N1/4077 , A61B5/055 , B03C1/0332 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N33/4833 , G01N2001/4088 , G01N2610/00 , G01R33/383 , H01F1/009 , H01F1/047 , H01F1/068 , H01F10/007
摘要： A magnetic device includes a substrate and an array including a plurality of magnetic particles, in which a magnetic dipole moment direction of each magnetic particle in a majority of the magnetic particles in the array alternates with respect to a magnetic dipole direction of a directly adjacent magnetic particle or directly adjacent magnetic particles in the array.
摘要翻译：磁性装置包括基板和包括多个磁性颗粒的阵列，其中阵列中大部分磁性颗粒中的每个磁性颗粒的磁偶极矩方向相对于直接相邻的磁体的磁偶极方向交替颗粒或直接相邻的磁性颗粒。

5. 发明申请

WO2005099419A3 MANIPULATION AND/OR DETECTION OF BIOLOGICAL SAMPLES OR OTHER OBJECTS 审中-公开
标题翻译：操纵和/或检测生物样本或其他物体
公开(公告)号：WO2005099419A3
公开(公告)日：2007-11-22
申请号：PCT/US2005012719
申请日：2005-04-13
申请人： HARVARD COLLEGE , HAM DONHEE , WESTERVELT ROBERT , HUNT THOMAS , LIU YONG , LEE HAKHO
发明人： HAM DONHEE , WESTERVELT ROBERT , HUNT THOMAS , LIU YONG , LEE HAKHO
IPC分类号： G01N27/00 , G01N33/53 , G01R33/30 , G01R33/465 , G01R33/56
CPC分类号： G01R33/302 , B01L3/502761 , B01L2200/0668 , B01L2200/147 , B01L2300/0816 , B01L2300/0819 , B01L2300/0877 , B01L2300/1822 , B01L2300/1827 , B01L2400/043 , G01N15/1031 , G01N24/08 , G01N24/10 , G01R33/307 , G01R33/34092 , G01R33/3415 , G01R33/465 , G01R33/4808 , G01R33/5604
摘要： Methods and apparatus for manipulation, detection, imaging, characterization, sorting or assembly of biological or other matenals, involving an integration of CMOS or other semiconductor-based technology and microfluidics are disclosed In one implementation, vapous components relating to the generation of electric or magnetic fields, implemented on an IC chip, are used to manipulate or detect one or more dielectpc or magnetic particles and to distinguish different types of particles A microfluidic system integrated with the IC chip facilitates the introduction and removal of cells or other particles of interest suspended in a fluid Patterned electpc or magnetic fields generated by the IC chip can trap and move biological cells or other objects inside the microfluidic system Field generating components may also be applied to generate signals of vapous frequencies to measure resonance charactepstics of objects of interest
摘要翻译：公开了涉及CMOS或其他基于半导体的技术和微流体的集成的生物或其它成像的操作，检测，成像，表征，分选或装配的方法和装置。在一个实施方案中，涉及电或磁在IC芯片上实现的场用于操纵或检测一个或多个介质或磁性颗粒并区分不同类型的颗粒与IC芯片集成的微流体系统有助于引入和去除悬浮在由IC芯片产生的流体图案化的电场或磁场可以捕获并移动微流体系统内的生物细胞或其他物体。场产生组件也可以应用于产生不同频率的信号以测量感兴趣对象的共振特征

6. 发明申请

WO2005099419A2 METHODS AND APPARATUS FOR MANIPULATION AND/OR DETECTION OF BIOLOGICAL SAMPLES AND OTHER OBJECTS 审中-公开
标题翻译：用于操作和/或检测生物样本和其他对象的方法和设备
公开(公告)号：WO2005099419A2
公开(公告)日：2005-10-27
申请号：PCT/US2005/012719
申请日：2005-04-13
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , HAM, Donhee , WESTERVELT, Robert , HUNT, Thomas , LIU, Yong , LEE, Hakho
发明人： HAM, Donhee , WESTERVELT, Robert , HUNT, Thomas , LIU, Yong , LEE, Hakho
IPC分类号： G01R33/30 , G01R33/465 , G01R33/56
CPC分类号： G01R33/302 , B01L3/502761 , B01L2200/0668 , B01L2200/147 , B01L2300/0816 , B01L2300/0819 , B01L2300/0877 , B01L2300/1822 , B01L2300/1827 , B01L2400/043 , G01N15/1031 , G01N24/08 , G01N24/10 , G01R33/307 , G01R33/34092 , G01R33/3415 , G01R33/465 , G01R33/4808 , G01R33/5604
摘要： Methods and apparatus for manipulation, detection, imaging, characterization, sorting and/or assembly of biological or other materials, involving an integration of CMOS or other semiconductor-based technology and microfluidics. In one implementation, various components relating to the generation of electric and/or magnetic fields are implemented on an IC chip that is fabricated using standard protocols. The generated electric and/or magnetic fields are used to manipulate and/or detect one or more dielectric and/or magnetic particles and distinguish different types of particles. A microfluidic system is fabricated either directly on top of the IC chip, or as a separate entity that is then appropriately bonded to the IC chip, to facilitate the introduction and removal of cells in a biocompatible environment, or other particles/objects of interest suspended in a fluid. The patterned electric and/or magnetic fields generated by the IC chip can trap and move biological cells or other objects inside the microfluidic system. Electric and/or magnetic field generating components also may be controlled using signals of various frequencies so as to detect one or more cells, particles or objects of interest, and even the type of particle or object of interest, by measuring resonance characteristics associated with interactions between samples and one or more of the field-generating devices. Such systems may be employed in a variety of biological and medical related applications, including cell sorting and tissue assembly.
摘要翻译：用于生物或其他材料的操纵，检测，成像，表征，分类和/或组装的方法和设备，涉及CMOS或其他基于半导体的技术与微流体的集成。在一个实施方式中，在使用标准协议制造的IC芯片上实现与产生电场和/或磁场有关的各种组件。所产生的电场和/或磁场用于操纵和/或检测一个或多个电介质和/或磁性颗粒并区分不同类型的颗粒。微流体系统直接在IC芯片的顶部制造，或作为单独的实体制造，然后适当地粘合到IC芯片，以促进引入和移除生物相容性环境中的细胞或悬浮的其他粒子/目标物体在流体中。由IC芯片产生的图案化的电场和/或磁场可以捕获和移动微流体系统内部的生物细胞或其他物体。还可以使用各种频率的信号来控制电和/或磁场生成组件，以便通过测量与相互作用相关联的共振特征来检测一个或多个细胞，感兴趣的粒子或物体，甚至感兴趣的粒子或物体的类型样品与一个或多个场生成装置之间。这样的系统可用于各种生物和医学相关应用，包括细胞分选和组织装配。

7. 发明申请

WO2012047653A3 SELF-ASSEMBLED MAGNETIC ARRAYS 审中-公开
标题翻译：自组装的磁阵列
公开(公告)号：WO2012047653A3
公开(公告)日：2012-07-05
申请号：PCT/US2011053466
申请日：2011-09-27
申请人： GEN HOSPITAL CORP , WEISSLEDER RALPH , LEE HAKHO , ISSADORE DAVID
发明人： WEISSLEDER RALPH , LEE HAKHO , ISSADORE DAVID
IPC分类号： H01F7/00 , A61B5/05 , G01N27/72
CPC分类号： G01N1/4077 , A61B5/055 , B03C1/0332 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N33/4833 , G01N2001/4088 , G01N2610/00 , G01R33/383 , H01F1/009 , H01F1/047 , H01F1/068 , H01F10/007
摘要： A magnetic device includes a substrate and an array including a plurality of magnetic particles, in which a magnetic dipole moment direction of each magnetic particle in a majority of the magnetic particles in the array alternates with respect to a magnetic dipole direction of a directly adjacent magnetic particle or directly adjacent magnetic particles in the array.
摘要翻译：一种磁性装置，包括基板和包括多个磁性颗粒的阵列，其中，阵列中的大部分磁性颗粒中的每个磁性颗粒的磁偶极矩方向相对于直接相邻的磁性的磁偶极方向颗粒或阵列中直接相邻的磁性颗粒。

8. 发明申请

WO2011150212A3 MAGNETIC NANOPARTICLES 审中-公开
标题翻译：磁性纳米粒子
公开(公告)号：WO2011150212A3
公开(公告)日：2012-03-15
申请号：PCT/US2011038143
申请日：2011-05-26
申请人： GEN HOSPITAL CORP , WEISSLEDER RALPH , LEE HAKHO , YOON TAE-JONG
发明人： WEISSLEDER RALPH , LEE HAKHO , YOON TAE-JONG
IPC分类号： A61K9/14 , A61K9/16 , A61K33/26 , A61K47/48 , A61K49/06 , A61K49/08
CPC分类号： A61K49/1824 , A61K9/5094 , A61K9/5115 , A61K33/24 , A61K33/26 , A61K33/30 , A61K41/0052 , A61K49/08 , A61K49/10 , A61K49/126 , A61K49/1827 , A61K49/183 , A61K49/1836 , A61K2800/47 , A61N2/02 , B22F1/025 , A61K2300/00
摘要： A magnetic nanoparticle includes a magnetic core and a superparamagnetic outer shell, in which the outer shell enhances magnetic properties of the nanoparticle. The enhanced magnetic properties of the magnetic nanoparticle allow for highly sensitive detection as well as diminished non-specific aggregation of nanoparticles.
摘要翻译：磁性纳米颗粒包括磁芯和超顺磁性外壳，其中外壳增强纳米颗粒的磁性能。磁性纳米颗粒的增强的磁性能允许高度敏感的检测以及纳米颗粒的非特异性聚集减少。

9. 发明申请

WO2011150212A2 MAGNETIC NANOPARTICLES 审中-公开
标题翻译：磁性纳米粒子
公开(公告)号：WO2011150212A2
公开(公告)日：2011-12-01
申请号：PCT/US2011/038143
申请日：2011-05-26
申请人： THE GENERAL HOSPITAL CORPORATION , WEISSLEDER, Ralph , LEE, Hakho , YOON, Tae-Jong
发明人： WEISSLEDER, Ralph , LEE, Hakho , YOON, Tae-Jong
IPC分类号： A61K9/14 , A61K9/16 , A61K49/08 , A61K49/06 , A61K33/26 , A61K47/48
CPC分类号： A61K49/1824 , A61K9/5094 , A61K9/5115 , A61K33/24 , A61K33/26 , A61K33/30 , A61K41/0052 , A61K49/08 , A61K49/10 , A61K49/126 , A61K49/1827 , A61K49/183 , A61K49/1836 , A61K2800/47 , A61N2/02 , B22F1/025 , A61K2300/00
摘要： A magnetic nanoparticle includes a magnetic core and a superparamagnetic outer shell, in which the outer shell enhances magnetic properties of the nanoparticle. The enhanced magnetic properties of the magnetic nanoparticle allow for highly sensitive detection as well as diminished non-specific aggregation of nanoparticles.
摘要翻译：磁性纳米颗粒包括磁芯和超顺磁性外壳，其中外壳增强纳米颗粒的磁性能。磁性纳米颗粒的增强的磁性能允许高度敏感的检测以及纳米颗粒的非特异性聚集减少。

10. 发明申请

WO2012129281A3 DETECTION OF TARGETS USING MAGNETIC RESONANCE 审中-公开
标题翻译：使用磁共振检测目标
公开(公告)号：WO2012129281A3
公开(公告)日：2012-12-27
申请号：PCT/US2012029912
申请日：2012-03-21
申请人： GEN HOSPITAL CORP , WEISSLEDER RALPH , LEE HAKHO , ISSADORE DAVID
发明人： WEISSLEDER RALPH , LEE HAKHO , ISSADORE DAVID
IPC分类号： A61B5/055 , G01R33/44 , G06F19/00
CPC分类号： G01N33/574 , G01N21/6428 , G01N24/088 , G01N33/54326 , G01N33/57484 , G01N33/57492 , G01N33/587 , G01N2333/4725 , G01N2333/485 , G01N2333/70596 , G01N2333/71 , G01R33/1269
摘要： A portable magnetic resonance system includes a permanent magnet, a nuclear magnetic resonance probe, and control electronics. The control electronics are configured to transmit to the probe a magnetic resonance excitation signal having an excitation frequency f, receive from the probe a magnetic resonance measurement signal, detect in the magnetic resonance measurement signal a magnetic resonance frequency f0, and automatically adjust the excitation frequency f until the difference between the excitation frequency and the magnetic resonance frequency is approximately equal to a target offset.
摘要翻译：便携式磁共振系统包括永磁体，核磁共振探针和控制电子装置。控制电子设备被配置为向探头发送具有激励频率f的磁共振激励信号，从探头接收磁共振测量信号，在磁共振测量信号中检测磁共振频率f0，并自动调节激励频率直到激励频率和磁共振频率之间的差近似等于目标偏移。

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