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1. 发明申请

WO2006132659A2 NANOWIRE HETEROSTRUCTURES 审中-公开
公开(公告)号：WO2006132659A2
公开(公告)日：2006-12-14
申请号：PCT/US2005/034345
申请日：2005-09-21
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , LU, Wei , XIANG, Jie , TIMKO, Brian, P. , WU, Yue , YAN, Hao , LIEBER, Charles, M.
发明人： LU, Wei , XIANG, Jie , TIMKO, Brian, P. , WU, Yue , YAN, Hao , LIEBER, Charles, M.
IPC分类号： H01L29/06
CPC分类号： B82Y10/00 , G11C2213/17 , G11C2213/18 , H01L29/0665 , H01L29/0673 , H01L29/068 , H01L29/1606 , H01L29/165
摘要： The present invention generally relates to nanoscale heterostructures and, in some cases, to nanowire heterostructures exhibiting ballistic transport, and/or to metal-semiconductor junctions that that exhibit no or reduced Schottky barriers. One aspect of the invention provides a solid nanowire having a core and a shell, both of which are essentially undoped. For example, in one embodiment, the core may consist essentially of undoped germanium and the shell may consist essentially of undoped silicon. Carriers are injected into the nanowire, which can be ballistically transported through the nanowire. In other embodiments, however, the invention is not limited to solid nanowires, and other configurations, involving other nanoscale wires, are also contemplated within the scope of the present invention. Yet another aspect of the invention provides a junction between a metal and a nanoscale wire that exhibit no or reduced Schottky barriers. As a non-limiting example, a nanoscale wire having a core and a shell may be in physical contact with a metal electrode, such that the Schottky barrier to the core is reduced or eliminated. Still other aspects of the invention are directed to electronic devices exhibiting such properties, and techniques for methods of making or using such devices.
摘要翻译：本发明一般涉及纳米尺度异质结构，在某些情况下涉及显示弹道输运的纳米线异质结构，和/或涉及没有或减少的肖特基势垒的金属 - 半导体结。本发明的一个方面提供了具有核和壳的固体纳米线，两者都基本上是未掺杂的。例如，在一个实施例中，芯可以基本上由未掺杂的锗组成，并且壳可以基本上由未掺杂的硅组成。载体被注入纳米线，可以通过纳米线进行弹道传输。然而，在其它实施方案中，本发明不限于固体纳米线，并且涉及其它纳米尺寸线的其它构型也在本发明的范围内。本发明的另一方面提供了金属和纳米尺寸线之间的连接处，其不显示或减小肖特基势垒。作为非限制性实例，具有芯和壳的纳米线可以与金属电极物理接触，使得芯的肖特基势垒被减少或消除。本发明的其它方面涉及具有这种性质的电子设备，以及制造或使用这些设备的方法的技术。

2. 发明申请

WO2007044034A2 NANOSCALE WIRE-BASED DATA STORAGE 审中-公开
标题翻译：纳米线基数据存储
公开(公告)号：WO2007044034A2
公开(公告)日：2007-04-19
申请号：PCT/US2005/044212
申请日：2005-12-06
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , LIEBER, Charles, M. , WU, Yue , YAN, Hao
发明人： LIEBER, Charles, M. , WU, Yue , YAN, Hao
IPC分类号： H01R24/00
CPC分类号： H01L29/0665 , B82Y10/00 , B82Y30/00 , G11C11/22 , G11C11/223 , G11C11/54 , G11C11/56 , G11C11/5657 , G11C13/003 , G11C13/025 , G11C2213/16 , G11C2213/17 , G11C2213/18 , G11C2213/75 , G11C2213/77 , H01L29/0673 , H01L29/068 , H01L29/78391
摘要： The present invention generally relates to nanotechnology and submicroelectronic devices that can be used in circuitry and, in some cases, to nanoscale wires and other nanostructures able to encode data. One aspect of the invention provides a nanoscale wire or other nanostructure having a region that is electrically-polarizable, for example, a nanoscale wire may comprise a core and an electrically-polarizable shell. In some cases, the electrically-polarizable region is able to retain its polarization state in the absence of an external electric field. All, or only a portion, of the electricallypolarizable region may be polarized, for example, to encode one or more bits of data. In one set of embodiments, the electrically-polarizable region comprises a functional oxide or a ferroelectric oxide material, for example, BaTiO 3 , lead zirconium titanate, or the like. In some embodiments, the nanoscale wire (or other nanostructure) may further comprise other materials, for example, a separation region separating the electricallypolarizable region from other regions of the nanoscale wire. For example, in a nanoscale wire, one or more intermediate shells may separate the core from the electricallypolarizable shell.
摘要翻译：本发明一般涉及可用于电路中并且在某些情况下可用于纳米级线和其他能够编码数据的纳米结构的纳米技术和次级微电子器件。本发明的一个方面提供了具有可电极化的区域的纳米线或其他纳米结构，例如纳米线可以包括核和电极化壳。在一些情况下，电极化区域能够在没有外部电场的情况下保持其极化状态。例如，所有或只有一部分电极和可怕极化区域可以被极化，以编码一个或多个数据位。在一组实施例中，可电极化区域包括功能氧化物或铁电氧化物材料，例如BaTiO 3，钛酸铅锆等。在一些实施例中，纳米线（或其他纳米结构）可以进一步包括其他材料，例如将纳米级线的其他区域与电和可;的可极化区域分开的分离区域。例如，在纳米线中，一个或多个中间壳可以将芯与电极和可怕的极化壳分开。

3. 发明申请

WO2010040091A1 NOVEL DNA NANOSTRUCTURES THAT PROMOTE CELL-CELL INTERACTION AND USE THEREOF 审中-公开
标题翻译：促进细胞间相互作用的新型DNA纳米结构及其应用
公开(公告)号：WO2010040091A1
公开(公告)日：2010-04-08
申请号：PCT/US2009/059432
申请日：2009-10-02
申请人： ARIZONA BOARD OF REGENTS, A BODY CORPORATE ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY , CHANG, Yung , YAN, Hao
发明人： CHANG, Yung , YAN, Hao
IPC分类号： A61K31/711 , C12N15/113
CPC分类号： C12N15/115 , A61K31/711 , B82Y5/00 , C12N15/10 , C12N15/111 , C12N2310/16 , C12N2310/51 , C12N2320/13 , Y10T428/2982
摘要： The present invention provides a ligand-nucleic acid nanostructure that promotes cell-cell interaction. Specially, the invention provides a ligand-nucleic acid nanostructure for treating tumor in a mammal. The methods of using and making the composition comprising a ligand-nucleic acid nanostructure are also provided.
摘要翻译：本发明提供了促进细胞 - 细胞相互作用的配体 - 核酸纳米结构。特别地，本发明提供了用于治疗哺乳动物肿瘤的配体 - 核酸纳米结构。还提供了使用和制备包含配体 - 核酸纳米结构的组合物的方法。

4. 发明申请

WO2019147309A9 RNA NANOSTRUCTURES AND METHODS OF MAKING AND USING RNA NANOSTRUCTURES 审中-公开
公开(公告)号：WO2019147309A9
公开(公告)日：2019-08-01
申请号：PCT/US2018/048976
申请日：2018-08-30
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , YAN, Hao , CHANG, Yung , LIU, Xiaowei , ZHANG, Fei , QI, Xiaodong
发明人： YAN, Hao , CHANG, Yung , LIU, Xiaowei , ZHANG, Fei , QI, Xiaodong
IPC分类号： C12N15/11 , B82Y5/00 , A61K31/713
摘要： Certain embodiments provide RNA nanostructure (e.g., comprising one single-stranded RNA (ssRNA) molecule, wherein the RNA nanostructure comprises at least one paranemic cohesion crossover), as well as compositions and methods of use thereof. In certain embodiments, such RNA nanostructures are immuno-modulatory (e.g., immuno-stimulatory).

5. 发明申请

WO2019147309A2 RNA NANOSTRUCTURES AND METHODS OF MAKING AND USING RNA NANOSTRUCTURES 审中-公开
公开(公告)号：WO2019147309A2
公开(公告)日：2019-08-01
申请号：PCT/US2018/048976
申请日：2018-08-30
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , YAN, Hao , CHANG, Yung , LIU, Xiaowei , ZHANG, Fei , QI, Xiaodong
发明人： YAN, Hao , CHANG, Yung , LIU, Xiaowei , ZHANG, Fei , QI, Xiaodong
摘要： Certain embodiments provide RNA nanostructure (e.g., comprising one single-stranded RNA (ssRNA) molecule, wherein the RNA nanostructure comprises at least one paranemic cohesion crossover), as well as compositions and methods of use thereof. In certain embodiments, such RNA nanostructures are immuno-modulatory (e.g., immuno-stimulatory).

6. 发明申请

WO2019147308A3 RNA NANOSTRUCTURES AND METHODS OF MAKING AND USING RNA NANOSTRUCTURES 审中-公开
公开(公告)号：WO2019147308A3
公开(公告)日：2019-08-01
申请号：PCT/US2018/048973
申请日：2018-08-30
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , YAN, Hao , CHANG, Yung , LIU, Xiaowei , ZHANG, Fei , QI, Xiaodong
发明人： YAN, Hao , CHANG, Yung , LIU, Xiaowei , ZHANG, Fei , QI, Xiaodong
IPC分类号： C12N15/117 , B82Y5/00 , A61K31/713 , A61K39/39
摘要： Certain embodiments provide RNA nanostructure (e.g., comprising one single-stranded RNA (ssRNA) molecule, wherein the RNA nanostructure comprises at least one paranemic cohesion crossover), as well as compositions and methods of use thereof. In certain embodiments, such RNA nanostructures are immuno-modulatory (e.g., immuno-stimulatory).

7. 发明申请

WO2014200933A1 OBTAINING INFORMATION FROM SINGLE CELLS WITHIN POPULATIONS USING DNA ORIGAMI NANOSTRUCTURES 审中-公开
标题翻译：使用DNA ORIGAMI NANOSTRUCTURES从人群中获取单细胞信息
公开(公告)号：WO2014200933A1
公开(公告)日：2014-12-18
申请号：PCT/US2014/041581
申请日：2014-06-09
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , BLATTMAN, Joseph , YAN, Hao , SCHOETTLE, Louis , WEI, Xixi
发明人： BLATTMAN, Joseph , YAN, Hao , SCHOETTLE, Louis , WEI, Xixi
IPC分类号： C12N15/87 , C07H21/04 , B82Y5/00
CPC分类号： C12N15/1062 , B82Y5/00 , B82Y15/00 , C12Q1/6806 , C12Q1/6816 , C12Q1/6881 , C12Q2600/16 , C12Q2563/155
摘要： Methods for construction of DNA origami nanostructures, as well as for binding, isolation, linking, and deep sequencing information, such as both of TCR alpha and beta CDR3 mRNA, from individual cells within a mixed population of cells without the need for single cell sorting.
摘要翻译：用于构建DNA折纸纳米结构的方法，以及结合，分离，连接和深度测序信息（例如TCRα和βCD3mRNA两者），来自混合细胞群体内的各个细胞，而不需要单细胞分选。

8. 发明申请

WO2008048970A2 SYNTHETIC ANTIBODIES 审中-公开
标题翻译：合成抗体
公开(公告)号：WO2008048970A2
公开(公告)日：2008-04-24
申请号：PCT/US2007/081536
申请日：2007-10-16
申请人： THE ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA acting for and on behalf of A RIZONA STATE UNIVERSITY , JOHNSTON, Stephen, Albert , WOODBURY, Neal , CHAPUT, John, C. , DIEHNELT, Chris, W. , YAN, Hao
发明人： JOHNSTON, Stephen, Albert , WOODBURY, Neal , CHAPUT, John, C. , DIEHNELT, Chris, W. , YAN, Hao
IPC分类号： A61K39/395
CPC分类号： G01N33/54306 , C07K16/00 , C07K16/14 , C07K16/2881 , C07K2317/31 , C40B40/10
摘要： The present invention provides methods for synthetic antibodies, methods for making synthetic antibodies, methods for identifying ligands, and related methods and reagents.
摘要翻译：本发明提供合成抗体的方法，制备合成抗体的方法，鉴定配体的方法以及相关的方法和试剂。

9. 发明申请

WO2008033848A2 SELF-ASSEMBLED COMBINATORIAL ENCODING NANOARRAYS FOR MULTIPLEXED BIOSENSING 审中-公开
标题翻译：自组装编码纳米复合生物多样性的组合
公开(公告)号：WO2008033848A2
公开(公告)日：2008-03-20
申请号：PCT/US2007/078174
申请日：2007-09-11
申请人： THE ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY , YAN, Hao , LIN, Chenxiang , KATILIUS, Evaldas , LIU, Yan
发明人： YAN, Hao , LIN, Chenxiang , KATILIUS, Evaldas , LIU, Yan
IPC分类号： C40B40/08
CPC分类号： C12N15/10 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00599 , B01J2219/00605 , B01J2219/00626 , B01J2219/00659 , B01J2219/00677 , B01J2219/00709 , B01J2219/00722 , B82Y30/00 , C40B50/14 , C40B50/16
摘要： The present invention provides combinatorial encoding nucleic acid tiling arrays and methods for their use and synthesis.
摘要翻译：本发明提供组合编码核酸贴片阵列及其使用和合成方法。

10. 发明申请

WO2019147308A9 RNA NANOSTRUCTURES AND METHODS OF MAKING AND USING RNA NANOSTRUCTURES 审中-公开
公开(公告)号：WO2019147308A9
公开(公告)日：2019-08-01
申请号：PCT/US2018/048973
申请日：2018-08-30
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , YAN, Hao , CHANG, Yung , LIU, Xiaowei , ZHANG, Fei , QI, Xiaodong
发明人： YAN, Hao , CHANG, Yung , LIU, Xiaowei , ZHANG, Fei , QI, Xiaodong
摘要： Certain embodiments provide RNA nanostructure (e.g., comprising one single-stranded RNA (ssRNA) molecule, wherein the RNA nanostructure comprises at least one paranemic cohesion crossover), as well as compositions and methods of use thereof. In certain embodiments, such RNA nanostructures are immuno-modulatory (e.g., immuno-stimulatory).

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