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1. 发明申请

WO2010040091A1 NOVEL DNA NANOSTRUCTURES THAT PROMOTE CELL-CELL INTERACTION AND USE THEREOF 审中-公开
标题翻译：促进细胞间相互作用的新型DNA纳米结构及其应用
公开(公告)号：WO2010040091A1
公开(公告)日：2010-04-08
申请号：PCT/US2009/059432
申请日：2009-10-02
申请人： ARIZONA BOARD OF REGENTS, A BODY CORPORATE ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY , CHANG, Yung , YAN, Hao
发明人： CHANG, Yung , YAN, Hao
IPC分类号： A61K31/711 , C12N15/113
CPC分类号： C12N15/115 , A61K31/711 , B82Y5/00 , C12N15/10 , C12N15/111 , C12N2310/16 , C12N2310/51 , C12N2320/13 , Y10T428/2982
摘要： The present invention provides a ligand-nucleic acid nanostructure that promotes cell-cell interaction. Specially, the invention provides a ligand-nucleic acid nanostructure for treating tumor in a mammal. The methods of using and making the composition comprising a ligand-nucleic acid nanostructure are also provided.
摘要翻译：本发明提供了促进细胞 - 细胞相互作用的配体 - 核酸纳米结构。特别地，本发明提供了用于治疗哺乳动物肿瘤的配体 - 核酸纳米结构。还提供了使用和制备包含配体 - 核酸纳米结构的组合物的方法。

2. 发明申请

WO2019147309A9 RNA NANOSTRUCTURES AND METHODS OF MAKING AND USING RNA NANOSTRUCTURES 审中-公开
公开(公告)号：WO2019147309A9
公开(公告)日：2019-08-01
申请号：PCT/US2018/048976
申请日：2018-08-30
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , YAN, Hao , CHANG, Yung , LIU, Xiaowei , ZHANG, Fei , QI, Xiaodong
发明人： YAN, Hao , CHANG, Yung , LIU, Xiaowei , ZHANG, Fei , QI, Xiaodong
IPC分类号： C12N15/11 , B82Y5/00 , A61K31/713
摘要： Certain embodiments provide RNA nanostructure (e.g., comprising one single-stranded RNA (ssRNA) molecule, wherein the RNA nanostructure comprises at least one paranemic cohesion crossover), as well as compositions and methods of use thereof. In certain embodiments, such RNA nanostructures are immuno-modulatory (e.g., immuno-stimulatory).

3. 发明申请

WO2019147308A9 RNA NANOSTRUCTURES AND METHODS OF MAKING AND USING RNA NANOSTRUCTURES 审中-公开
公开(公告)号：WO2019147308A9
公开(公告)日：2019-08-01
申请号：PCT/US2018/048973
申请日：2018-08-30
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , YAN, Hao , CHANG, Yung , LIU, Xiaowei , ZHANG, Fei , QI, Xiaodong
发明人： YAN, Hao , CHANG, Yung , LIU, Xiaowei , ZHANG, Fei , QI, Xiaodong
摘要： Certain embodiments provide RNA nanostructure (e.g., comprising one single-stranded RNA (ssRNA) molecule, wherein the RNA nanostructure comprises at least one paranemic cohesion crossover), as well as compositions and methods of use thereof. In certain embodiments, such RNA nanostructures are immuno-modulatory (e.g., immuno-stimulatory).

4. 发明申请

WO2019147308A2 RNA NANOSTRUCTURES AND METHODS OF MAKING AND USING RNA NANOSTRUCTURES 审中-公开
公开(公告)号：WO2019147308A2
公开(公告)日：2019-08-01
申请号：PCT/US2018/048973
申请日：2018-08-30
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , YAN, Hao , CHANG, Yung , LIU, Xiaowei , ZHANG, Fei , QI, Xiaodong
发明人： YAN, Hao , CHANG, Yung , LIU, Xiaowei , ZHANG, Fei , QI, Xiaodong
摘要： Certain embodiments provide RNA nanostructure (e.g., comprising one single-stranded RNA (ssRNA) molecule, wherein the RNA nanostructure comprises at least one paranemic cohesion crossover), as well as compositions and methods of use thereof. In certain embodiments, such RNA nanostructures are immuno-modulatory (e.g., immuno-stimulatory).

5. 发明申请

WO2011049750A1 MULTIFUNCTIONAL APTAMER-NUCLEIC ACID NANOSTRUCTURES FOR TUMOR-TARGETED KILLING 审中-公开
标题翻译：用于肿瘤靶向杀伤的多功能APTAMER-NUCOICACID NANOSTRUCTURES
公开(公告)号：WO2011049750A1
公开(公告)日：2011-04-28
申请号：PCT/US2010/051751
申请日：2010-10-07
申请人： ARIZONA BOARD OF REGENTS, a body corporate of the State Of Arizona acting for and on behalf of Arizona State University , CHANG, Yung , YAN, Hao
发明人： CHANG, Yung , YAN, Hao
IPC分类号： C12N15/115
CPC分类号： C12N15/115 , C12N15/10 , C12N2310/16 , C12N2310/3519
摘要： The present invention provides compositions comprising a ligand-nucleic acid nanostructure that promote tumor cell-specific killing and methods of using the compositions. Specially, the invention provides aptamer-nucleic acid nanostructures for treating tumors in a mammal. The methods of making the compositions are also provided.
摘要翻译：本发明提供了包含促进肿瘤细胞特异性杀伤的配体 - 核酸纳米结构的组合物和使用该组合物的方法。特别地，本发明提供用于治疗哺乳动物肿瘤的适体 - 核酸纳米结构。还提供了制备组合物的方法。

6. 发明申请

WO2010060030A1 TLR LIGAND-NUCLEIC ACID NANOSTRUCTURE AS A NOVEL IMMUNE MODULATORY AGENT AND METHOD OF USING THE SAME 审中-公开
标题翻译：作为新型免疫调节剂的TLR配糖核酸纳结构及其使用方法
公开(公告)号：WO2010060030A1
公开(公告)日：2010-05-27
申请号：PCT/US2009/065508
申请日：2009-11-23
申请人： ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA , CHANG, Yung , YAN, Hao
发明人： CHANG, Yung , YAN, Hao
IPC分类号： C12N15/117 , C12N15/115 , A61K31/7088 , A61P37/02 , C40B40/06
CPC分类号： C12N15/115 , B82Y5/00 , C12N15/10 , C12N15/117 , C12N2310/16 , C12N2310/17 , C12N2310/351 , C12N2310/3519 , C12N2310/51
摘要： The present invention provides a composition comprising at least one TLR ligand bound to a nucleic acid nanostructure and methods of use thereof. The methods of making the composition comprising a TLR ligand bound to a nucleic acid nanostructure are also provided.
摘要翻译：本发明提供包含至少一种与核酸纳米结构结合的TLR配体及其使用方法的组合物。还提供了制备包含与核酸纳米结构结合的TLR配体的组合物的方法。

7. 发明申请

WO2013119676A1 NOVEL DNA-ORIGAMI NANOVACCINES 审中-公开
标题翻译：新型DNA-ORIGAMI纳米微粒
公开(公告)号：WO2013119676A1
公开(公告)日：2013-08-15
申请号：PCT/US2013/024945
申请日：2013-02-06
申请人： ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA ACTING FOR AND ON BEHALF OF ARIZONA STATE UNIVERSITY , CHANG, Yung , YAN, Hao , GHIRLANDA, Giovanna
发明人： CHANG, Yung , YAN, Hao , GHIRLANDA, Giovanna
IPC分类号： C07H21/04
CPC分类号： A61K47/4823 , A61K31/7088 , A61K39/12 , A61K39/21 , A61K39/39 , A61K47/61 , A61K47/66 , A61K47/6891 , A61K2039/53 , A61K2039/55555 , A61K2039/55561 , C07K16/1063 , C07K16/14 , C12N15/117 , C12N2310/17 , C12N2310/351 , C12N2310/3519 , C12N2310/52 , C12N2320/32 , C12N2740/16034
摘要： The present invention provides compositions comprising a DNA-nanostructure and at least one targeting moiety, wherein the at least one targeting moiety is linked to the DNA-nanostructure; and wherein the at least one targeting moiety is selected from the group consisting of antigens, aptamers, shRNAs and combinations thereof, and methods of use thereof.
摘要翻译：本发明提供了包含DNA-纳米结构和至少一个靶向部分的组合物，其中所述至少一个靶向部分连接到所述DNA-纳米结构; 并且其中所述至少一个靶向部分选自抗原，适体，shRNA及其组合，及其使用方法。

8. 发明申请

WO2019147309A2 RNA NANOSTRUCTURES AND METHODS OF MAKING AND USING RNA NANOSTRUCTURES 审中-公开
公开(公告)号：WO2019147309A2
公开(公告)日：2019-08-01
申请号：PCT/US2018/048976
申请日：2018-08-30
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , YAN, Hao , CHANG, Yung , LIU, Xiaowei , ZHANG, Fei , QI, Xiaodong
发明人： YAN, Hao , CHANG, Yung , LIU, Xiaowei , ZHANG, Fei , QI, Xiaodong
摘要： Certain embodiments provide RNA nanostructure (e.g., comprising one single-stranded RNA (ssRNA) molecule, wherein the RNA nanostructure comprises at least one paranemic cohesion crossover), as well as compositions and methods of use thereof. In certain embodiments, such RNA nanostructures are immuno-modulatory (e.g., immuno-stimulatory).

9. 发明申请

WO2019147308A3 RNA NANOSTRUCTURES AND METHODS OF MAKING AND USING RNA NANOSTRUCTURES 审中-公开
公开(公告)号：WO2019147308A3
公开(公告)日：2019-08-01
申请号：PCT/US2018/048973
申请日：2018-08-30
申请人： ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY , YAN, Hao , CHANG, Yung , LIU, Xiaowei , ZHANG, Fei , QI, Xiaodong
发明人： YAN, Hao , CHANG, Yung , LIU, Xiaowei , ZHANG, Fei , QI, Xiaodong
IPC分类号： C12N15/117 , B82Y5/00 , A61K31/713 , A61K39/39
摘要： Certain embodiments provide RNA nanostructure (e.g., comprising one single-stranded RNA (ssRNA) molecule, wherein the RNA nanostructure comprises at least one paranemic cohesion crossover), as well as compositions and methods of use thereof. In certain embodiments, such RNA nanostructures are immuno-modulatory (e.g., immuno-stimulatory).

10. 发明申请

WO2006132659A2 NANOWIRE HETEROSTRUCTURES 审中-公开
公开(公告)号：WO2006132659A2
公开(公告)日：2006-12-14
申请号：PCT/US2005/034345
申请日：2005-09-21
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , LU, Wei , XIANG, Jie , TIMKO, Brian, P. , WU, Yue , YAN, Hao , LIEBER, Charles, M.
发明人： LU, Wei , XIANG, Jie , TIMKO, Brian, P. , WU, Yue , YAN, Hao , LIEBER, Charles, M.
IPC分类号： H01L29/06
CPC分类号： B82Y10/00 , G11C2213/17 , G11C2213/18 , H01L29/0665 , H01L29/0673 , H01L29/068 , H01L29/1606 , H01L29/165
摘要： The present invention generally relates to nanoscale heterostructures and, in some cases, to nanowire heterostructures exhibiting ballistic transport, and/or to metal-semiconductor junctions that that exhibit no or reduced Schottky barriers. One aspect of the invention provides a solid nanowire having a core and a shell, both of which are essentially undoped. For example, in one embodiment, the core may consist essentially of undoped germanium and the shell may consist essentially of undoped silicon. Carriers are injected into the nanowire, which can be ballistically transported through the nanowire. In other embodiments, however, the invention is not limited to solid nanowires, and other configurations, involving other nanoscale wires, are also contemplated within the scope of the present invention. Yet another aspect of the invention provides a junction between a metal and a nanoscale wire that exhibit no or reduced Schottky barriers. As a non-limiting example, a nanoscale wire having a core and a shell may be in physical contact with a metal electrode, such that the Schottky barrier to the core is reduced or eliminated. Still other aspects of the invention are directed to electronic devices exhibiting such properties, and techniques for methods of making or using such devices.
摘要翻译：本发明一般涉及纳米尺度异质结构，在某些情况下涉及显示弹道输运的纳米线异质结构，和/或涉及没有或减少的肖特基势垒的金属 - 半导体结。本发明的一个方面提供了具有核和壳的固体纳米线，两者都基本上是未掺杂的。例如，在一个实施例中，芯可以基本上由未掺杂的锗组成，并且壳可以基本上由未掺杂的硅组成。载体被注入纳米线，可以通过纳米线进行弹道传输。然而，在其它实施方案中，本发明不限于固体纳米线，并且涉及其它纳米尺寸线的其它构型也在本发明的范围内。本发明的另一方面提供了金属和纳米尺寸线之间的连接处，其不显示或减小肖特基势垒。作为非限制性实例，具有芯和壳的纳米线可以与金属电极物理接触，使得芯的肖特基势垒被减少或消除。本发明的其它方面涉及具有这种性质的电子设备，以及制造或使用这些设备的方法的技术。

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