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    • 4. 发明申请
    • METHOD FOR RECONSTRUCTING AN IMAGE OF AN INTERIOR OF A TURBID MEDIUM AND DEVICE FOR IMAGING THE INTERIOR OF TURBID MEDIA
    • 用于重新构建涡轮介质内部的图像的方法和用于成像涡轮介质的内部的装置
    • WO2009077953A1
    • 2009-06-25
    • PCT/IB2008/055248
    • 2008-12-12
    • KONINKLIJKE PHILIPS ELECTRONICS N.V.PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBHKOEHLER, ThomasNIELSEN, Tim
    • KOEHLER, ThomasNIELSEN, Tim
    • G01N21/39G01N21/47A61B5/00
    • G01N21/4795A61B5/0091A61B5/1455A61B5/4312G01N21/274G01N21/39G01N2021/3148
    • A method for reconstructing an image of an interior of a turbid medium (1) is provided. The method comprises the steps: performing a first measurement on a turbid medium (1) to be examined by subsequently irradiating the turbid medium with light having a first wavelength (λi) from a plurality of different source positions and detecting light emanating from the turbid medium (1) in a plurality of different detection positions for each source position; performing a second measurement on the turbid medium (1) to be examined by subsequently irradiating the turbid medium with light having a second wavelength (λ2) from a plurality of different source positions and detecting light emanating from the turbid medium in a plurality of different detection positions for each source position. The second wavelength (λ2) differs slightly from the first wavelength (λi) and an image of the interior of the turbid medium (1) is reconstructed by using the ratio of the measurement results, wherein the first measurement is used as a reference measurement and the second measurement is used to determine deviations from the reference measurement.
    • 提供了一种用于重建浑浊介质(1)内部的图像的方法。 该方法包括以下步骤:通过随后用来自多个不同源位置的具有第一波长(λi)的光照射混浊介质并检测来自混浊的光的浑浊介质(1)进行第一次测量 介质(1)在每个源位置的多个不同检测位置中; 通过随后用来自多个不同源位置的具有第二波长(λ2)的光照射混浊介质,并在多个不同的源位置中检测从混浊介质发出的光,对待检查的混浊介质(1)进行第二测量 每个源位置的检测位置。 第二波长(λ2)与第一波长(λi)略微不同,并且通过使用测量结果的比率来重构混浊介质(1)的内部图像,其中第一测量用作参考 测量和第二次测量用于确定与参考测量的偏差。
    • 6. 发明申请
    • METHOD FOR CALIBRATING A DEVICE FOR IMAGING THE INTERIOR OF TURBID MEDIA AND METHOD FOR CORRECTING MEASURED INTENSITIES IN SUCH A DEVICE
    • 用于校准用于成像涡轮介质的内部的装置的方法和用于校正这种装置中的测量强度的方法
    • WO2009060383A2
    • 2009-05-14
    • PCT/IB2008/054583
    • 2008-11-04
    • KONINKLIJKE PHILIPS ELECTRONICS N.V.,PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBHKOEHLER, ThomasNIELSEN, TimBAKKER, Levinus, P.
    • KOEHLER, ThomasNIELSEN, TimBAKKER, Levinus, P.
    • G01N21/47A61B5/00A61B6/00
    • G01N21/4795A61B5/0091A61B5/4312A61B2560/0233
    • A method for calibrating a device for imaging the interior of turbid media is provided. The device for imaging the interior of turbid media uses a fluorescent contrast agent emitting fluorescence light and comprises a receptacle (2) for receiving a turbid medium during examination; at least one light source (6) optically connected to the receptacle (2) for irradiating the interior of the receptacle with light of a predetermined wavelength (λ^); at least one detector (7) optically connected to the receptacle (2) for detecting light emanating from the interior of the receptacle; and at least one filter (11) introducible in the detection light path from the receptacle (2) to the at least one detector (7). The method for calibrating comprises the steps: - performing a first reference measurement with the receptacle (2) filled with an optically matching medium (4); - performing a second reference measurement with the receptacle (2) filled with a mixture (10) of the optically matching medium and a fluorescent contrast agent; - calibrating the device based on the results of the first reference measurement and the second reference measurement.
    • 提供了一种用于校准用于对浑浊介质内部进行成像的装置的方法。 用于对浑浊介质内部进行成像的装置使用发射荧光的荧光对比剂,并且包括用于在检查期间接收混浊介质的容器(2) 至少一个光源(6),其光学连接到所述容器(2),用于用预定波长(λ^)的光照射所述容器的内部; 至少一个检测器(7),其光学连接到所述容器(2),用于检测从所述容器的内部发出的光; 以及至少一个过滤器(11),其被引入到从所述容器(2)到所述至少一个检测器(7)的检测光路中。 用于校准的方法包括以下步骤: - 用填充有光学匹配介质(4)的容器(2)执行第一参考测量; - 用所述光学匹配介质的混合物(10)填充的所述容器(2)和荧光造影剂进行第二参考测量; - 根据第一个参考测量结果和第二个参考测量结果校准设备。
    • 7. 发明申请
    • DIFFUSE OPTICAL TOMOGRAPHY WITH MARKERS CONTAINING FLUORESCENT MATERIAL
    • 含有荧光材料标记的DIFFUSE光学图像
    • WO2008059434A2
    • 2008-05-22
    • PCT/IB2007/054593
    • 2007-11-12
    • KONINKLIJKE PHILIPS ELECTRONICS N.V.PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBHZIEGLER, AndyKOEHLER, ThomasNIELSEN, TimVAN DER MARK, Martinus, B.VAN BEEK, Michael, C.
    • ZIEGLER, AndyKOEHLER, ThomasNIELSEN, TimVAN DER MARK, Martinus, B.VAN BEEK, Michael, C.
    • A61B5/00G01J3/44
    • A61B5/4312A61B5/0091G01N21/4795G01N21/6456
    • The invention relates to a system, a medical image acquisition system, and a method for imaging an interior of a turbid medium (25). The invention also relates to a marker (60) for use in the method for imaging an interior of a turbid medium (25). The system, the medical image acquisition system, and the method may be used for obtaining an image of an interior of a turbid medium (25) by: accommodation of a turbid medium (25) inside a receiving volume (20); irradiation of the receiving volume (20) with light from a light source; detection of light emanating from the receiving volume (20) as a result of irradiating the receiving volume (20) with light from the light source through the use of a photodetector unit. The detected light is then used to reconstruct an image of an interior of the turbid medium (25). According to the invention, the system, the medical acquisition system, and the method are adapted such that during a measurement the receiving volume (20) comprises at least one marker (60) comprising a predetermined concentration of a chosen fluorescent agent. The light source is arranged for generating excitation light that causes fluorescent emission in the marker (60) and the photodetector is arranged to detect light emanating from the receiving volume (20) as a result of irradiating the receiving volume (20) with excitation light. The use of a marker (60) according to the invention enables obtaining information relating to the geometry of the turbid medium (25). If the turbid medium (25) comprises an unknown concentration of a second fluorescent agent, and the light source and the photodetector unit are arranged for causing fluorescence in the second fluorescent agent and detecting the resulting fluorescence light, respectively, the use of a marker (60) according to the invention enables calibration of the signal resulting from this fluorescence light.
    • 本发明涉及一种系统,医学图像采集系统和用于对浑浊介质(25)的内部进行成像的方法。 本发明还涉及一种用于对浑浊介质(25)的内部进行成像的方法中使用的标记(60)。 该系统,医学图像采集系统和该方法可以用于通过以下方式获得浑浊介质的内部的图像:通过在接收容积(20)内容纳混浊介质(25); 用来自光源的光照射接收体积(20); 通过使用光电检测器单元对来自光源的光照射接收体积(20)的结果来检测从接收体积(20)发出的光。 然后使用检测到的光来重建混浊介质(25)的内部的图像。 根据本发明,适配系统,医疗采集系统和方法,使得在测量期间,接收体积(20)包括至少一个包含预定浓度的所选荧光剂的标记物(60)。 光源被布置成产生在标记(60)中引起荧光发射的激发光,并且光电检测器被布置成通过用激发光照射接收体积(20)来检测从接收体积(20)发出的光。 使用根据本发明的标记(60)能够获得与混浊介质(25)的几何形状有关的信息。 如果混浊介质(25)包含未知浓度的第二荧光剂,并且将光源和光检测器单元布置成在第二荧光剂中引起荧光并分别检测所得到的荧光,则使用标记物 60)根据本发明可以校准由该荧光产生的信号。
    • 10. 发明申请
    • OPTICAL FLUORESCENCE TOMOGRAPHY CALIBRATION
    • WO2007144830A3
    • 2007-12-21
    • PCT/IB2007/052230
    • 2007-06-13
    • KONINKLIJKE PHILIPS ELECTRONICS N.V.PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBHNIELSEN, TimKOEHLER, Thomas
    • NIELSEN, TimKOEHLER, Thomas
    • G02B6/26
    • The invention relates to a device for imaging an interior of a turbid medium and a medical image acquisition device comprising: a) a measurement volume (15) for accommodating the turbid medium (45); b) a light source (5 ) for irradiating the turbid medium (45); c) a photodetector unit 10 for detecting light emanating from the measurement volume (15). The device for imaging an interior of the turbid medium and the medical image acquisition device are adapted such that the devices further comprise a calibration device (55, 60) arranged to be optically coupled to the measurement volume (15) and comprising a calibration light source (65) arranged to simultaneously generate the excitation light and further light corresponding to the fluorescence light. The invention also relates to a calibration device (60) arranged to be inserted into a receptacle (20) that comprises a measurement volume (15) for receiving a turbid medium (45) in a device for imaging an interior of a turbid medium (45), having a contact part (70) comprising a contact surface (75) that fits at least a part of the surface of the receptacle (20) facing the measurement volume (15), and having a calibration light source (65) arranged to simultaneously generate light that causes fluorescent emission in a fluorescent agent present in the turbid medium and further light corresponding to the fluorescence light. The contact part (70) may be removable.