专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2008059434A2 DIFFUSE OPTICAL TOMOGRAPHY WITH MARKERS CONTAINING FLUORESCENT MATERIAL 审中-公开
标题翻译：含有荧光材料标记的DIFFUSE光学图像
公开(公告)号：WO2008059434A2
公开(公告)日：2008-05-22
申请号：PCT/IB2007/054593
申请日：2007-11-12
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , ZIEGLER, Andy , KOEHLER, Thomas , NIELSEN, Tim , VAN DER MARK, Martinus, B. , VAN BEEK, Michael, C.
发明人： ZIEGLER, Andy , KOEHLER, Thomas , NIELSEN, Tim , VAN DER MARK, Martinus, B. , VAN BEEK, Michael, C.
IPC分类号： A61B5/00 , G01J3/44
CPC分类号： A61B5/4312 , A61B5/0091 , G01N21/4795 , G01N21/6456
摘要： The invention relates to a system, a medical image acquisition system, and a method for imaging an interior of a turbid medium (25). The invention also relates to a marker (60) for use in the method for imaging an interior of a turbid medium (25). The system, the medical image acquisition system, and the method may be used for obtaining an image of an interior of a turbid medium (25) by: accommodation of a turbid medium (25) inside a receiving volume (20); irradiation of the receiving volume (20) with light from a light source; detection of light emanating from the receiving volume (20) as a result of irradiating the receiving volume (20) with light from the light source through the use of a photodetector unit. The detected light is then used to reconstruct an image of an interior of the turbid medium (25). According to the invention, the system, the medical acquisition system, and the method are adapted such that during a measurement the receiving volume (20) comprises at least one marker (60) comprising a predetermined concentration of a chosen fluorescent agent. The light source is arranged for generating excitation light that causes fluorescent emission in the marker (60) and the photodetector is arranged to detect light emanating from the receiving volume (20) as a result of irradiating the receiving volume (20) with excitation light. The use of a marker (60) according to the invention enables obtaining information relating to the geometry of the turbid medium (25). If the turbid medium (25) comprises an unknown concentration of a second fluorescent agent, and the light source and the photodetector unit are arranged for causing fluorescence in the second fluorescent agent and detecting the resulting fluorescence light, respectively, the use of a marker (60) according to the invention enables calibration of the signal resulting from this fluorescence light.
摘要翻译：本发明涉及一种系统，医学图像采集系统和用于对浑浊介质（25）的内部进行成像的方法。本发明还涉及一种用于对浑浊介质（25）的内部进行成像的方法中使用的标记（60）。该系统，医学图像采集系统和该方法可以用于通过以下方式获得浑浊介质的内部的图像：通过在接收容积（20）内容纳混浊介质（25）; 用来自光源的光照射接收体积（20）; 通过使用光电检测器单元对来自光源的光照射接收体积（20）的结果来检测从接收体积（20）发出的光。然后使用检测到的光来重建混浊介质（25）的内部的图像。根据本发明，适配系统，医疗采集系统和方法，使得在测量期间，接收体积（20）包括至少一个包含预定浓度的所选荧光剂的标记物（60）。光源被布置成产生在标记（60）中引起荧光发射的激发光，并且光电检测器被布置成通过用激发光照射接收体积（20）来检测从接收体积（20）发出的光。使用根据本发明的标记（60）能够获得与混浊介质（25）的几何形状有关的信息。如果混浊介质（25）包含未知浓度的第二荧光剂，并且将光源和光检测器单元布置成在第二荧光剂中引起荧光并分别检测所得到的荧光，则使用标记物 60）根据本发明可以校准由该荧光产生的信号。

2. 发明申请

WO2009013692A2 MULTIMODALITY MATCHING MEDIUM FOR DIFFUSE OPTICAL TOMOGRAPHY AND ULTRASOUND MEASUREMENTS 审中-公开
标题翻译：用于弥散性光学造影和超声波测量的多功能匹配介质
公开(公告)号：WO2009013692A2
公开(公告)日：2009-01-29
申请号：PCT/IB2008/052910
申请日：2008-07-21
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN DER MARK, Martinus, B , ENTREKIN, Robert, R. , VAN BEEK, Michael, C. , BAKKER, Levinus, P. , VAN DER VAART, Nijs, C.
发明人： VAN DER MARK, Martinus, B , ENTREKIN, Robert, R. , VAN BEEK, Michael, C. , BAKKER, Levinus, P. , VAN DER VAART, Nijs, C.
IPC分类号： A61B5/00 , A61B8/08 , A61K49/22 , G01N21/17 , G01N21/47 , G01N21/49 , G01N29/24 , G01N29/28
CPC分类号： A61K49/0002 , A61B5/0035 , A61B5/0091 , A61B5/4312 , A61B8/0825 , A61B8/4272 , A61B8/429 , A61B8/4416 , A61B2562/146 , A61K49/226
摘要： The invention relates to a matching medium that is used to optically couple an optically turbid medium to its surroundings during diffuse optical tomography measurements. Generally, an optical matching medium makes it hard to acoustically couple the turbid medium to its surroundings efficiently. According to the invention, this problem is solved by using a matching medium that matches both the optical and acoustic characteristics of the turbid medium to the optical and acoustic characteristics of the surroundings of the turbid medium. The invention explains how a multimodality matching medium can be obtained that both optically and acoustically couples human tissue to its surroundings.
摘要翻译：本发明涉及一种匹配介质，其用于在漫射光学层析成像测量期间将光学混浊介质光学耦合到其周围环境。通常，光学匹配介质使得难以有效地将混浊介质与其周围环境耦合。根据本发明，通过使用与混浊介质的光学和声学特性匹配的匹配介质与混浊介质周围的光学和声学特性相匹配来解决该问题。本发明解释了如何获得将人体组织光学和声学耦合到其周围环境的多模式匹配介质。

3. 发明申请

WO2008062354A1 A SYSTEM, DEVICE, METHOD, COMPUTER-READABLE MEDIUM, AND USE FOR IN VIVO IMAGING OF TISSUE IN AN ANATOMICAL STRUCTURE 审中-公开
标题翻译：系统，装置，方法，计算机可读介质和用于在解剖结构中进行组织成像的用途
公开(公告)号：WO2008062354A1
公开(公告)日：2008-05-29
申请号：PCT/IB2007/054674
申请日：2007-11-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BAKKER, Levinus, P. , VAN BEEK, Michael, C. , VAN DER MARK, Martinus, B. , VAN DEN HAM, Rene , HENDRIKS, Bernardus, H., W. , HOFFMANN, Ralf , VAN DER VAART, Nijs, C. , VAN DER VOORT, Marjolein
发明人： BAKKER, Levinus, P. , VAN BEEK, Michael, C. , VAN DER MARK, Martinus, B. , VAN DEN HAM, Rene , HENDRIKS, Bernardus, H., W. , HOFFMANN, Ralf , VAN DER VAART, Nijs, C. , VAN DER VOORT, Marjolein
IPC分类号： A61B5/00 , A61B8/12
CPC分类号： A61B5/0095 , A61B5/0035 , A61B5/0084 , A61B5/0086 , A61B8/12 , A61B8/4416
摘要： A system is provided that may be used for locating and diagnosing lesions in the human body in vivo. In some embodiments, once the exact position of a lesion is found, a biopsy may be taken from the lesion using e.g. ultra sound techniques for guidance of the biopsy needle. Use of the system drastically reduces the negative biopsy samples compared to currently used "blind sampling" techniques. This reduces patient discomfort and minimizes infections as the number of biopsy samples is reduced. A method and computer- readable medium is also provided.
摘要翻译：提供了可用于在体内定位和诊断人体损伤的系统。在一些实施例中，一旦发现病变的确切位置，可以使用例如病变从病变中取出活组织检查。超声技术用于指导活检针。与目前使用的“盲采”技术相比，使用该系统大大减少了活检样本的阴性。这减少了患者的不适，并使活检样本的数量减少了感染的最小程度。还提供了一种方法和计算机可读介质。

4. 发明申请

WO2009060370A3 METHOD AND DEVICE FOR IMAGING AN INTERIOR OF AN OPTICALLY TURBID MEDIUM 审中-公开
公开(公告)号：WO2009060370A3
公开(公告)日：2009-05-14
申请号：PCT/IB2008/054559
申请日：2008-11-03
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BAKKER, Levinus, P. , VAN BEEK, Michael, C. , VAN DER MARK, Martinus, B.
发明人： BAKKER, Levinus, P. , VAN BEEK, Michael, C. , VAN DER MARK, Martinus, B.
IPC分类号： A61B5/00 , G01N21/64
摘要： The invention relates to a method and a device (30, 125) for imaging an interior of an optically turbid medium (40). Light from a light source (35) is coupled into the turbid medium (40). Detection light emanating from the turbid medium (40) as a result of coupling (5) light from the light source (35) into the turbid medium (40) is collected. A first characteristic and a second characteristic of collected detection light are measured simultaneously. Next, the ratio of a first linear combination of the measured characteristics and a second linear combination of the measured characteristics is taken based on the recognition that the noise in both linear combinations is correlated.

5. 发明申请

WO2007060602A2 A METHOD AND DEVICE FOR IMAGING AN INTERIOR OF A TURBID MEDIUM 审中-公开
标题翻译：一种用于成像涡轮介质内部的方法和装置
公开(公告)号：WO2007060602A2
公开(公告)日：2007-05-31
申请号：PCT/IB2006/054349
申请日：2006-11-21
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BAKKER, Levinus, P. , 'T HOOFT, Gert , VAN DER MARK, Martinus, B. , VAN BEEK, Michael, C.
发明人： BAKKER, Levinus, P. , 'T HOOFT, Gert , VAN DER MARK, Martinus, B. , VAN BEEK, Michael, C.
IPC分类号： A61B5/00
CPC分类号： A61B5/4312 , A61B5/0091
摘要： The invention relates to a method and device (1) for imaging an interior of a turbid medium (55). A turbid medium (55) inside a measurement volume (15) is irradiated from a plurality of source positions (25a) with light from a light source (5), and light emanating from the measurement volume (15) is detected from a plurality of detection positions (25b). An image of the interior of the turbid medium (55) is reconstructed from the detected light. In both the method and the device (1), detector signals can be amplified for each source position-detection position pair by a multi-gain amplification unit comprising an amplifier circuit (60). The amplification factor is selected from a number of possible amplification factors based on detected signal strength in the prior art. According to the invention, however, the method and device are adapted such that the amplification factor is selected for at least one source position-detection position pair on the basis of an estimate of expected electrical signal strength.
摘要翻译：本发明涉及一种用于对混浊介质（55）的内部进行成像的方法和设备（1）。利用来自光源（5）的光从多个源位置（25a）照射测量体积（15）内的混浊介质（55），并且从多个测量体积（15）中检测从测量体积（15）发出的光检测位置（25b）。从检测到的光重建混浊介质（55）的内部的图像。在该方法和装置（1）中，可以通过包括放大器电路（60）的多增益放大单元为每个源位置检测位置对放大检测器信号。基于现有技术中的检测信号强度，从许多可能的放大因子中选择放大因子。然而，根据本发明，该方法和装置被调整为使得基于预期电信号强度的估计为至少一个源位置检测位置对选择放大因子。

6. 发明申请

WO2007060571A1 A DEVICE FOR IMAGING AN INTERIOR OF A TURBID MEDIUM 审中-公开
标题翻译：用于形成涡轮介质内部的装置
公开(公告)号：WO2007060571A1
公开(公告)日：2007-05-31
申请号：PCT/IB2006/054226
申请日：2006-11-13
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , BAKKER, Levinus, P. , VAN BEEK, Michael, C. , VAN DER MARK, Martinus, B.
发明人： BAKKER, Levinus, P. , VAN BEEK, Michael, C. , VAN DER MARK, Martinus, B.
IPC分类号： A61B5/00 , G01N21/64
CPC分类号： G01N21/4795 , A61B5/0091 , G01N21/6456 , G01N2021/1787 , G01N2021/6421
摘要： The invention relates to a device (1) for imaging an interior of a turbid medium (25). The device (1) may be used to accommodate a turbid medium (25) inside a measurement volume (20) and irradiate the turbid medium (25) with light from a light source (5), after which light emanating from the measurement volume (20) is detected and used to determine an image of the interior of the turbid medium (25). The device (1) is adapted such that additional means are introduced for irradiating the turbid medium (25) with light causing fluorescent emission in a contrast agent present in the turbid medium (25), for detecting the fluorescent emission in at least two spectral regions, and for calculating an image reconstruction for the at least two spectral regions detected. By detecting the fluorescent emission spectroscopically, that is as a function of wavelength, information can be obtained from which the concentration of a predetermined component present inside the turbid medium can be determined.
摘要翻译：本发明涉及一种用于对浑浊介质（25）的内部进行成像的装置（1）。装置（1）可用于容纳测量体积（20）内部的混浊介质（25），并用来自光源（5）的光照射混浊介质（25），之后从测量体积 20）被检测并用于确定混浊介质（25）的内部的图像。装置（1）适于使得附加装置被引入以用在浑浊介质（25）中存在的造影剂中引起荧光发射的光照射混浊介质，以检测至少两个光谱区域中的荧光发射并且用于计算所检测的至少两个光谱区域的图像重建。通过检测荧光发射光谱，即作为波长的函数，可以获得可以确定存在于混浊介质内的预定成分的浓度的信息。

7. 发明申请

WO2009019653A3 IMAGING SYSTEM COMPRISING AN OPTICAL TWO-WAY SWITCH 审中-公开
公开(公告)号：WO2009019653A3
公开(公告)日：2009-02-12
申请号：PCT/IB2008/053143
申请日：2008-08-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN BEEK, Michael, C. , VAN DER MARK, Martinus, B. , BAKKER, Levinus, P. , VAN DER VOORT, Marjolein
发明人： VAN BEEK, Michael, C. , VAN DER MARK, Martinus, B. , BAKKER, Levinus, P. , VAN DER VOORT, Marjolein
IPC分类号： G02B6/35 , A61B5/00
摘要： The invention relates to an optical imaging method for imaging an object comprising the following steps: - coupling light from a light source to an illumination position for illuminating the object, with the illumination position being selected from a plurality of illumination positions for illuminating the object using an optical switch, with the optical switch being optically coupled to the light source and to the plurality of illumination positions; - collecting light emanating from the object at least one collection position, with the light emanating from the object as a result of coupling light from the light source to the selected illumination position for illuminating the object. According to the invention the method is amended in that the method further comprises the following step: - coupling light collected at a collection position through the optical switch. The method allows to couple the process of receiving light from the object to be imaged to the process of coupling light from the light source to the object to be imaged. The invention also relates to an optical switch for use in the method.

8. 发明申请

WO2008062346A1 A SYSTEM, METHOD, COMPUTER-READABLE MEDIUM AND USE FOR IMAGING OF TISSUE IN AN ANATOMICAL STRUCTURE 审中-公开
标题翻译：系统，方法，计算机可读介质和用于在解剖结构中形成组织的用途
公开(公告)号：WO2008062346A1
公开(公告)日：2008-05-29
申请号：PCT/IB2007/054626
申请日：2007-11-14
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN BEEK, Michael, C. , VAN DER MARK, Martinus, B. , BAKKER, Levinus, P. , VAN DEN HAM, René , HENDRIKS, Bernardus, H., W. , HOFFMANN, Ralf , VAN DER VAART, Nijs, C. , VAN DER VOORT, Marjolein
发明人： VAN BEEK, Michael, C. , VAN DER MARK, Martinus, B. , BAKKER, Levinus, P. , VAN DEN HAM, René , HENDRIKS, Bernardus, H., W. , HOFFMANN, Ralf , VAN DER VAART, Nijs, C. , VAN DER VOORT, Marjolein
IPC分类号： A61B5/00
CPC分类号： A61B5/4381 , A61B5/0073 , A61B5/0084 , A61B5/0086 , A61B8/12
摘要： A system for imaging of prostate cancer in a prostate in vivo is provided. The system utilizes Diffuse Optical Tomography (DOT) for creating a 3D image for the detection of suspicious prostate tissue. The DOT image may be used to guide the biopsy, thereby reducing the number of false negatives. A method, computer-readable medium and use are also provided.
摘要翻译：提供了一种用于前列腺体内前列腺癌成像的系统。该系统利用漫射光学层析成像（DOT）创建用于检测可疑前列腺组织的3D图像。 DOT图像可用于指导活组织检查，从而减少假阴性的数量。还提供了一种方法，计算机可读介质和使用。

9. 发明申请

WO2007060598A2 A METHOD OF, SYSTEM FOR, AND MEDICAL IMAGE ACQUISITION SYSTEM FOR IMAGING AN INTERIOR OF A TURBID MEDIUM TAKING INTO ACCOUNT THE GEOMETRY OF THE TURBID MEDIUM 审中-公开
标题翻译：用于形成涡轮介质的内部的系统和用于摄像机的医疗图像采集系统的方法，用于涡轮介质的几何
公开(公告)号：WO2007060598A2
公开(公告)日：2007-05-31
申请号：PCT/IB2006/054341
申请日：2006-11-20
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN DER MARK, Martinus, B. , VAN BEEK, Michael, C. , BAKKER, Levinus, P.
发明人： VAN DER MARK, Martinus, B. , VAN BEEK, Michael, C. , BAKKER, Levinus, P.
CPC分类号： G01N21/4795 , G01N2021/1787 , G01N2021/4766 , G01N2021/6439
摘要： The invention relates to a method of imaging an interior of a turbid medium comprising the following steps: accommodation of the turbid medium inside a receiving volume; coupling transmission input light from a transmission light source into the receiving volume, with said transmission input light being chosen such that it is capable of propagating through the turbid medium; detection of transmission output light emanating from the receiving volume as a result of coupling transmission input light from the light source into the receiving volume through use of a transmission photodetector unit. The invention also relates to a system for imaging an interior of a turbid medium and to a medical image acquisition system both using the method. The method, system, and medical image acquisition system are adapted such that an improved way of obtaining data relating to the exterior of the turbid medium is realized. The object of the invention is realized in that the method further comprises the following steps: - coupling geometry input light from a geometry light source into the receiving volume, with the receiving volume comprising the turbid medium and with the combination of the geometry input light and the interface being chosen for creating a contrast between the turbid medium and its surroundings; detection of the contrast between the turbid medium and its surroundings through use of a contrast photodetector unit; reconstructing an image of an interior of the turbid medium using a the detected contrast. The system for imaging an interior of a turbid medium and the medical image acquisition device are adapted to further comprise a geometry light source and a contrast photodetector unit.
摘要翻译：本发明涉及一种对浑浊介质内部进行成像的方法，包括以下步骤：在接收体积内容纳混浊介质; 将来自传输光源的传输输入光耦合到接收体积中，所述传输输入光被选择为使得其能够传播通过混浊介质; 通过使用传输光电检测器单元将从光源的输入光耦合到接收体积中的结果，检测从接收体积发出的透射输出光。本发明还涉及一种用于使浑浊介质的内部成像和使用该方法的医学图像采集系统的成像系统。调整方法，系统和医学图像采集系统，从而实现获得与混浊介质的外部相关的数据的改进方式。本发明的目的是通过该方法进一步包括以下步骤： - 将来自几何光源的几何输入光耦合到接收体积中，其中接收体积包括混浊介质，并与几何输入光和选择该界面以在混浊介质及其周围环境之间产生对比度; 通过使用对比度光电检测器单元检测混浊介质及其周围环境之间的对比度; 使用检测到的对比度重建混浊介质的内部的图像。用于对混浊介质的内部进行成像的系统和医学图像采集装置适于进一步包括几何光源和对比度光电检测器单元。

10. 发明申请

WO2007060596A2 A METHOD OF, SYSTEM FOR, AND MEDICAL IMAGE ACQUISITION SYSTEM FOR IMAGING AN INTERIOR OF A TURBID MEDIUM TAKING INTO ACCOUNT THE GEOMETRY OF THE TURBID MEDIUM 审中-公开
标题翻译：一种用于形成涡轮介质内部进入帐户的涡轮介质的几何的系统和医学图像采集系统的方法
公开(公告)号：WO2007060596A2
公开(公告)日：2007-05-31
申请号：PCT/IB2006/054339
申请日：2006-11-20
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , VAN DER MARK, Martinus, B. , VAN BEEK, Michael, C. , BAKKER, Levinus, P.
发明人： VAN DER MARK, Martinus, B. , VAN BEEK, Michael, C. , BAKKER, Levinus, P.
CPC分类号： G01N21/4795 , G01N2021/1787 , G01N2021/4766 , G01N2021/6439
摘要： The invention relates to a method of imaging an interior of a turbid medium comprising the following steps: accommodation of the turbid medium inside a receiving volume; coupling transmission input light from a transmission light source into the receiving volume, with said transmission input light being chosen such that it is capable of propagating through the turbid medium and with at least a part of said transmission input light passing through a matching medium in the receiving volume, said matching medium being chosen to reduce optical boundary effects at an interface between the turbid medium and its surroundings; - detection of transmission output light emanating from the receiving volume as a result of coupling transmission input light from the transmission light source into the receiving volume through use of a transmission photodetector unit. The invention also relates to a system for imaging an interior of a turbid medium and a medical image acquisition system both using the method. According to the invention, the method, system for imaging an interior of a turbid medium, and medical image acquisition system are adapted such that data relating to the exterior of the turbid medium can be obtained. This object is realized in that the method further comprises the following additional steps: coupling geometry input light from a geometry light source into the receiving volume, with the receiving volume comprising the turbid medium, with the receiving volume further comprising a geometry medium for surrounding the turbid medium during coupling of geometry input light into the receiving volume, and with the combination of the geometry input light, the geometry medium, and the interface being chosen for creating a contrast between the turbid medium and its surroundings; - detection of the contrast between the turbid medium and its surroundings; reconstructing an image of an interior of the turbid medium using the detected contrast. The system for imaging an interior of a turbid medium and the medical image acquisition system are adapted to comprise a geometry light source, a geometry medium, and a contrast photodetector unit for detecting the contrast.
摘要翻译：本发明涉及一种对浑浊介质内部进行成像的方法，包括以下步骤：在接收体积内容纳混浊介质; 将来自传输光源的传输输入光耦合到接收体积中，其中所述传输输入光被选择为使得其能够传播通过混浊介质，并且所述传输输入光的至少一部分通过匹配介质选择所述匹配介质以减少在混浊介质及其周围环境之间的界面处的光学边界效应; - 通过使用传输光电检测器单元将从传输光源传输输入光耦合到接收体积中的结果，检测从接收体积发出的传输输出光。本发明还涉及一种用于使浑浊介质的内部成像的系统和使用该方法的医学图像采集系统。根据本发明，用于对混浊介质的内部进行成像的方法，以及医学图像采集系统适于使得能够获得与混浊介质的外部有关的数据。该目的的实现是，该方法还包括以下附加步骤：将来自几何光源的几何输入光耦合到接收体积中，接收体积包括混浊介质，接收体积还包括几何介质，用于围绕将几何输入光耦合到接收体积中，以及几何输入光，几何介质和界面的组合被选择用于在混浊介质及其周围环境之间形成对比度的混浊介质; - 检测混浊介质及其周围环境之间的对比度; 使用检测到的对比度重建混浊介质的内部的图像。用于对混浊介质的内部进行成像的系统和医学图像采集系统适于包括几何光源，几何介质和用于检测对比度的对比度光电检测器单元。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式