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1. 发明申请

WO2007015190A2 OPTICAL IMAGING 审中-公开
标题翻译：光学成像
公开(公告)号：WO2007015190A2
公开(公告)日：2007-02-08
申请号：PCT/IB2006/052543
申请日：2006-07-25
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N. V. , NIELSEN, Tim , VAN STEVENDAAL, Udo , GLEICH, Bernhard , SCHAEFFTER, Tobias , HAAKER, Paul , MAZURKEWITZ, Peter , WEISS, Steffen
发明人： NIELSEN, Tim , VAN STEVENDAAL, Udo , GLEICH, Bernhard , SCHAEFFTER, Tobias , HAAKER, Paul , MAZURKEWITZ, Peter , WEISS, Steffen
CPC分类号： A61B5/0059 , A61B5/05
摘要： An optical imaging apparatus (100) for examination of an object of interest (101), the optical imaging apparatus (100) comprising an optical radiation source (102) adapted to emit a primary optical radiation beam onto the object of interest (101), an optical radiation detector (106) adapted to detect a secondary optical radiation beam emitted by the object of interest (101) upon absorbing the primary optical radiation beam, a magnetic field generating element (107) adapted to generate an inhomogeneous magnetic field varying along an extension of the object of interest (101), and a determination unit (108) adapted to determine information concerning the object of interest (101) based on an analysis of the detected secondary optical radiation beam in combination with an analysis of the inhomogeneous magnetic field.
摘要翻译：一种用于检查感兴趣对象（101）的光学成像设备（100），所述光学成像设备（100）包括光学辐射源（102），所述光学辐射源适于将主光学辐射束发射到所述感兴趣对象（101），适于在吸收所述主光学辐射束时检测由所述感兴趣对象（101）发射的次级光辐射束的光辐射检测器（106），磁场生成元件（107），适于产生沿感兴趣对象（101）的延伸方向变化的非均匀磁场，以及确定单元（108），适于基于组合检测到的次级光辐射束的分析来确定关于感兴趣对象（101）的信息并分析了非均匀磁场。

2. 发明申请

WO2006027738A1 COMPOUNDS AND METHODS FOR COMBINED OPTICAL-ULTRASOUND IMAGING 审中-公开
标题翻译：用于组合光学超声成像的化合物和方法
公开(公告)号：WO2006027738A1
公开(公告)日：2006-03-16
申请号：PCT/IB2005/052898
申请日：2005-09-06
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N.V. , NIELSEN, Tim , WEISS, Steffen , SCHAEFFTER, Tobias , GLEICH, Bernhard , HAAKER, Paul , VAN STEVENDAAL, Udo , MAZURKEWITZ, Peter
发明人： NIELSEN, Tim , WEISS, Steffen , SCHAEFFTER, Tobias , GLEICH, Bernhard , HAAKER, Paul , VAN STEVENDAAL, Udo , MAZURKEWITZ, Peter
IPC分类号： G01N33/58 , G01N33/542 , A61K49/00 , A61K49/22
CPC分类号： A61K49/225 , A61B5/0059 , A61K49/0091 , G01N21/1717 , G01N2021/6441
摘要： The present invention relates to novel methods and compounds for combined opticalultrasound imaging. The compounds of the present invention relate to particles comprising fluorescence donor and acceptor molecules for energy exchange via FRET. The methods of the present invention use ultrasound to modify the distance between donor and acceptor molecules present on the particles, and to consequently modify the fluorescence emitted by the donor and acceptor. The compounds and methods of the present invention are useful in medical or diagnostic imaging.
摘要翻译：本发明涉及组合光超声成像的新方法和化合物。本发明的化合物涉及通过FRET进行能量交换的包含荧光供体和受体分子的颗粒。本发明的方法使用超声波改变存在于颗粒上的供体和受体分子之间的距离，并因此改变由供体和受体发出的荧光。本发明的化合物和方法可用于医学或诊断成像。

3. 发明申请

WO2006067692A2 ARRANGEMENT AND METHOD FOR DETERMINING THE SPATIAL DISTRIBUTION OF MAGNETIC PARTICLES 审中-公开
标题翻译：用于确定磁性颗粒的空间分布的布置和方法
公开(公告)号：WO2006067692A2
公开(公告)日：2006-06-29
申请号：PCT/IB2005/054248
申请日：2005-12-14
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N. V. , GLEICH, Bernhard , WEIZENECKER, Juergen , NIELSEN, Tim
发明人： GLEICH, Bernhard , WEIZENECKER, Juergen , NIELSEN, Tim
IPC分类号： A61B5/05
CPC分类号： A61B5/05 , A61B5/0515
摘要： The invention relates to an arrangement and a method for determining the spatial distribution of magnetic particles in an examination area. Magnetic field means are used to generate a spatially inhomogeneous gradient magnetic field with at least one region with a low field strength, in which the magnetization of the particles is in a state of non- saturation, whereas they are in a state of saturation in the remaining region. By using change means to shift the area with a low field strength within the examination area, a change in the magnetization of the magnetic particles is brought about which can be detected from outside by detection means and contains information about the spatial distribution of the magnetic particles in the examination area. The magnetic field means or the change means or the detection means or a combination of these means are arranged at least partially on a medical instrument.
摘要翻译：本发明涉及一种用于确定检查区域中磁性颗粒的空间分布的装置和方法。磁场装置用于产生具有低场强的至少一个区域的空间不均匀梯度磁场，其中颗粒的磁化处于非饱和状态，而它们处于饱和状态剩余地区。通过使用改变方法在检查区域内移动具有低场强的区域，可以通过检测装置从外部检测磁性颗粒的磁化强度的变化，并且包含关于磁性颗粒的空间分布的信息在考场。磁场装置或改变装置或检测装置或这些装置的组合至少部分地布置在医疗器械上。

4. 发明申请

WO2006064392A2 METHOD OF DETERMINING A SPATIAL DISTRIBUTION OF MAGNETIC PARTICLES 审中-公开
标题翻译：确定磁性颗粒空间分布的方法
公开(公告)号：WO2006064392A2
公开(公告)日：2006-06-22
申请号：PCT/IB2005/054042
申请日：2005-12-05
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N. V. , NIELSEN, Tim , GLEICH, Bernhard , WEIZENECKER, Jürgen
发明人： NIELSEN, Tim , GLEICH, Bernhard , WEIZENECKER, Jürgen
CPC分类号： A61B5/05 , A61B5/0515 , A61B5/7257
摘要： The invention relates to a method of determining a spatial distribution of magnetic particles in an examination area, in which a magnetic field is generated which has a first part-region having a relatively low magnetic field strength and a second part-region having a relatively high magnetic field strength. The position of the two part-regions is changed, as a result of which the magnetization in the examination area changes, and real measured values which depend on the change in magnetization are recorded. A dependence distribution which depends on a spatial distribution of magnetic particles is then determined such that a sum which comprises as summands a) the difference of the real measured values from fictitious measured values which are determined by applying a transfer function to the dependence distribution, and b) the product of a regularization parameter and of a regularization value which is determined by applying the regularization functional to the dependence distribution, is minimized. Finally, the spatial distribution of magnetic particles is determined by means of the determined dependence distribution.
摘要翻译：本发明涉及一种确定检测区域中的磁性颗粒的空间分布的方法，其中产生磁场，其具有磁场强度较低的第一部分区域和具有较高磁场强度的第二部分区域磁场强度。两部分区域的位置发生变化，其结果是检查区域的磁化改变，并且记录取决于磁化变化的实测值。然后确定依赖于磁性颗粒的空间分布的依赖性分布，使得包括作为求和的和a）通过将依赖分布应用传递函数确定的实际测量值与虚构测量值的差异，以及 b）将正则化参数和通过对依赖分布应用正则化函数确定的正则化值的乘积最小化。最后，通过确定的依赖分布来确定磁性颗粒的空间分布。

5. 发明申请

WO2006064405A1 METHOD OF DETERMINING A SPATIAL DISTRIBUTION OF MAGNETIC PARTICLES 审中-公开
标题翻译：确定磁性颗粒空间分布的方法
公开(公告)号：WO2006064405A1
公开(公告)日：2006-06-22
申请号：PCT/IB2005/054073
申请日：2005-12-06
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N. V. , GLEICH, Bernhard , WEIZENECKER, Jürgen , NIELSEN, Tim
发明人： GLEICH, Bernhard , WEIZENECKER, Jürgen , NIELSEN, Tim
IPC分类号： A61B5/05
CPC分类号： A61B5/0515 , A61B5/05 , A61B5/7257
摘要： The invention relates to a method of determining a spatial distribution of magnetic particles in an examination zone, in which a magnetic field is generated that has a first sub-zone of lower magnetic field strength and a second sub-zone of higher magnetic field strength. The positions of the two sub-zones are changed, as a result of which the magnetization in the examination zone changes. Measured values that depend on the change in magnetization are acquired. A reference response function by means of which measured values can be determined mathematically from a spatial distribution of magnetic particles is then determined by means of at least extensive magnetic specimen distribution. Finally, the spatial distribution of magnetic particles is reconstructed from the measured values by means of the reference response function.
摘要翻译：本发明涉及一种确定检测区中的磁性颗粒的空间分布的方法，其中产生具有较低磁场强度的第一子区和较高磁场强度的第二子区的磁场。两个子区域的位置改变，结果是检查区域的磁化改变。取决于磁化变化的测量值。然后可以借助于至少广泛的磁性样本分布来确定参考响应函数，通过该参考响应函数可以从磁性粒子的空间分布以数学方式确定测量值。最后，通过参考响应函数从测量值重建磁性粒子的空间分布。

6. 发明申请

WO2007031911A2 SPATIALLY RESOLVED OXYMETRY 审中-公开
标题翻译：空间分解氧化
公开(公告)号：WO2007031911A2
公开(公告)日：2007-03-22
申请号：PCT/IB2006/053144
申请日：2006-09-07
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N. V. , NIELSEN, Tim , KOEHLER, Thomas
发明人： NIELSEN, Tim , KOEHLER, Thomas
IPC分类号： A61B5/00
CPC分类号： A61B5/0073 , A61B5/14551 , A61B5/1495
摘要： In optical tomography, a calibration of the data may be necessary for image reconstruction. According to an exemplary embodiment of the present invention, the object of interest is used for calibration, wherein the image data is acquired during a highly oxygenated phase of the object of interest and wherein the calibration data is acquired during a low oxygenated phase of the object of interest. This may provide for an improved calibration, resulting in improved image quality.
摘要翻译：在光学层析成像中，图像重构可能需要校准数据。根据本发明的示例性实施例，感兴趣的对象被用于校准，其中在感兴趣对象的高度充氧阶段期间获取图像数据，并且其中在对象的低氧合期期间获取校准数据出于兴趣。这可以提供改进的校准，导致改善的图像质量。

7. 发明申请

WO2007031899A2 EFFICIENT ITERATIVE FOUR-DIMENSIONAL CARDIAC CONE-BEAM CT RECONSTRUCTION 审中-公开
标题翻译：高效的四维心脏重建CT重建
公开(公告)号：WO2007031899A2
公开(公告)日：2007-03-22
申请号：PCT/IB2006/053055
申请日：2006-09-01
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N. V. , GRASS, Michael , ZIEGLER, Andy , NIELSEN, Tim
发明人： GRASS, Michael , ZIEGLER, Andy , NIELSEN, Tim
CPC分类号： A61B6/032 , A61B6/027 , A61B6/541 , G06T11/006 , G06T2211/412 , G06T2211/424
摘要： The increasing cone angle of current high-end and future CT systems leads to a decrease in image quality if approximate cone-beam reconstruction methods are used. According to an exemplary embodiment of the present invention, an iterative four-dimensional cardiac CT reconstruction is provided, in which phase volumes are selected from the four-dimensional data set, each having the same spatial volume at different phase points. Corresponding voxels inside these phase volumes are then forward projected onto the same projection. After calculation of a different projection, these voxels are updated. This may provide for an efficient implementation of an iterative four-dimensional cardiac cone-beam CT reconstruction.
摘要翻译：目前的高端和未来CT系统的锥角越来越大，如果使用近似锥束重建方法，则会导致图像质量下降。根据本发明的示例性实施例，提供了一种迭代的四维心脏CT重建，其中从四维数据集中选择相位体积，每个四维数据集在不同相位处具有相同的空间体积。然后将这些相位体积内的相应体素向前投影到相同的投影上。在计算了不同的投影之后，这些体素被更新。这可以提供迭代四维心脏锥束CT重建的有效实施。

8. 发明申请

WO2007054846A2 ABSORPTION AND SCATTERING MAP RECONSTRUCTION FOR OPTICAL FLUORESCENCE TOMOGRAPHY 审中-公开
标题翻译：吸收和散射图重建光学荧光测量
公开(公告)号：WO2007054846A2
公开(公告)日：2007-05-18
申请号：PCT/IB2006/053908
申请日：2006-10-24
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N. V. , KÖHLER, Thomas , NIELSEN, Tim
发明人： KÖHLER, Thomas , NIELSEN, Tim
IPC分类号： A61B5/00
CPC分类号： A61B5/0073
摘要： Optical fluorescence tomography is a highly sensitive method to image contrast agents in the body. However, current reconstruction methods suffer from a high complexity or even instability. According to an exemplary embodiment of the present invention, a method for absorption/scattering map reconstruction for optical fluorescence tomography may be provided, which uses a spectral model. This may provide for a subsequent fluorescence reconstruction with improved image quality.
摘要翻译：光学荧光层析成像是对身体中造影剂进行成像的高灵敏度方法。然而，目前的重建方法具有高复杂性甚至不稳定性。根据本发明的示例性实施例，可以提供使用光谱模型的用于光学荧光层析成像的吸收/散射地图重建的方法。这可以提供随后的改进的图像质量的荧光重建。

9. 发明申请

WO2006131859A2 LASER OPTICAL FEEDBACK TOMOGRAPHY SENSOR AND METHOD 审中-公开
标题翻译：激光光学反射测量传感器和方法
公开(公告)号：WO2006131859A2
公开(公告)日：2006-12-14
申请号：PCT/IB2006/051759
申请日：2006-06-01
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N. V. , KRÜGER, Sascha , NIELSEN, Tim
发明人： KRÜGER, Sascha , NIELSEN, Tim
IPC分类号： A61B5/026
CPC分类号： A61B5/0261
摘要： The invention relates to a modified Laser Optical Feedback Tomography sensor (10) which comprises an evaluator (16) for the determination of an object velocity (vz) relative to the sensor (10). The primary optical frequency (f o ) of light emitted by a laser (11) is shifted by a first frequency shift F in a frequency shifter (13) and focused into an investigation region (3). A moving object (2) in said region produces an additional Doppler frequency shift ΔF in the light sent back from the investigation region (3) which is re-injected into the laser (11). Resulting intensity oscillations of the laser (11), which critically depend on the shifted frequency of the re-injected light, are detected by a detector (15). Finally, the evaluator (16) coupled to the detector (15) determines from the observed oscillations the Doppler frequency shift ΔF and therefrom the moving velocity (V z ) of the object (2).
摘要翻译：本发明涉及一种修改的激光光学反馈层析成像传感器（10），其包括用于确定相对于传感器（10）的物体速度（vz）的评估器（16）。由激光器（11）发射的光的主要光学频率（f

10. 发明申请

WO2005059840A1 IMAGING METHOD WITH FILTERED BACK PROJECTION 审中-公开
标题翻译：具有过滤背投影的成像方法
公开(公告)号：WO2005059840A1
公开(公告)日：2005-06-30
申请号：PCT/IB2004/052665
申请日：2004-12-06
申请人： PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , KONINKLIJKE PHILIPS ELECTRONICS N. V. , NIELSEN, Tim , PROKSA, Roland
发明人： NIELSEN, Tim , PROKSA, Roland
IPC分类号： G06T11/00
CPC分类号： G06T11/006 , A61B6/037 , G06T2211/421 , Y10S378/901
摘要： The invention relates to an imaging method, in which a projection data record of an examination area to be reconstructed is generated by acquiring projections from different projection directions, in particular with the aid of a computer tomograph. For each projection direction, a filter operator is determined that is optimally adapted to a projection geometry allocated to the respective projection direction. An image of the examination area is reconstructed from the projection data record by filtering the projections with the filter operators determined and by back projection of these filtered projections.
摘要翻译：本发明涉及一种成像方法，其中特别是借助于计算机断层摄影机，通过从不同的投影方向获取投影来产生待重建的检查区域的投影数据记录。对于每个投影方向，确定最佳地适应于分配给相应投影方向的投影几何的过滤器操作器。通过用确定的滤波器运算和通过这些滤波的投影的反投影过滤投影来从投影数据记录重建检查区域的图像。

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