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1. 发明申请

WO2008157497A2 METHOD OF TREATING TISSUE 审中-公开
标题翻译：治疗组织的方法
公开(公告)号：WO2008157497A2
公开(公告)日：2008-12-24
申请号：PCT/US2008067123
申请日：2008-06-16
申请人： OSTEOTECH INC , SHIMP LAWRENCE A , WEI GUOBAO
发明人： SHIMP LAWRENCE A , WEI GUOBAO
IPC分类号： A61L27/36 , A61F2/28
CPC分类号： A61L27/3691 , A61F2/4644 , A61F2002/4646 , A61L27/30 , A61L27/34 , A61L27/3604 , A61L27/3847 , A61L27/48 , A61L27/50 , A61L2430/40 , C08L67/04
摘要： In one embodiment, the method comprises providing tissue, preparing the tissue, and treating the tissue to improve remodeling characteristics of the tissue. The tissue may be, for example, cortical bone. Treating the tissue to improve remodeling characteristics may comprise heating the tissue, treating the tissue with a chemical, or other. Heating the tissue may be done in the absence of oxygen and may comprise heating the tissue in a vacuum, heating the tissue in an inert atmosphere, heating the tissue in a reducing atmosphere, coating the tissue with a protective coating and heating the tissue, or other. Further embodiments comprise treating the tissue in supercritical fluids, for example, to dry or virally inactivate the tissue.
摘要翻译：在一个实施方案中，该方法包括提供组织，制备组织和处理组织以改善组织的重塑特征。组织可以是例如皮质骨。处理组织以改善重塑特征可以包括加热组织，用化学品或其它物质处理组织。加热组织可以在没有氧的情况下进行，并且可以包括在真空中加热组织，在惰性气氛中加热组织，在还原气氛中加热组织，用保护涂层涂覆组织并加热组织，或其他。另外的实施方案包括处理超临界流体中的组织，例如干燥或病毒灭活组织。

2. 发明申请

WO2010093950A9 DELIVERY SYSTEM CARTRIDGE 审中-公开
标题翻译：交货系统碳粉盒
公开(公告)号：WO2010093950A9
公开(公告)日：2010-12-02
申请号：PCT/US2010024134
申请日：2010-02-12
申请人： OSTEOTECH INC , WEI GUOBAO , BOYCE TODD M , SHIMP LAWRENCE A
发明人： WEI GUOBAO , BOYCE TODD M , SHIMP LAWRENCE A
IPC分类号： A61F2/28 , A61F2/44 , A61L27/36 , A61L27/54
CPC分类号： A61B17/8819 , A61B17/823 , A61B17/8825 , A61B2017/8813 , A61F2/30 , A61F2/4603 , A61F2002/0086 , A61F2002/2825 , A61F2002/2835 , A61F2002/30059 , A61F2002/30064 , A61F2002/3007 , A61F2002/30072 , A61F2002/30588 , A61F2002/30677 , A61F2002/3068 , A61F2002/3093 , A61F2002/30971 , A61F2002/4623 , A61F2002/4627 , A61F2250/0068 , A61F2310/00592 , A61F2310/00958 , A61F2310/0097
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. In some embodiments, the covering may be configured and sized for receipt by an implant device. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust the release of the substance.
摘要翻译：提供了用于将物质或材料递送至手术部位的覆盖物。其中提供有物质的覆盖物可以被称为递送系统。通常，覆盖物可以是能够至少部分地保留设置在其中的物质直到覆盖物被置于手术部位处的单隔室或多隔室结构。在一些实施例中，覆盖物可以被配置和定尺寸为由植入装置接收。放置后，覆盖物可以促进物质或周围物质的转移。例如，该物质可以被释放（主动或被动）到手术部位。覆盖物可以参与，控制或调整物质的释放。

3. 发明申请

WO2010093959A3 DELIVERY SYSTEMS, TOOLS, AND METHODS OF USE 审中-公开
标题翻译：交付系统，工具和使用方法
公开(公告)号：WO2010093959A3
公开(公告)日：2010-10-21
申请号：PCT/US2010024144
申请日：2010-02-12
申请人： OSTEOTECH INC , BETZ RANDAL R , BODEN SCOTT , GUPTA MUNISH CHANDRA , O'BRIEN MICHAEL F , SANDHU HARVINDER , SHELOKOV ALEXIS , SYBERT DARYL R , VACCARO ALEXANDER , WEI GUOBAO , BOYCE TODD M , COHEN ROBERT , RICHARDS CRISTY , SHIMP LAWRENCE A
发明人： BETZ RANDAL R , BODEN SCOTT , GUPTA MUNISH CHANDRA , O'BRIEN MICHAEL F , SANDHU HARVINDER , SHELOKOV ALEXIS , SYBERT DARYL R , VACCARO ALEXANDER , WEI GUOBAO , BOYCE TODD M , COHEN ROBERT , RICHARDS CRISTY , SHIMP LAWRENCE A
IPC分类号： A61F2/28 , A61F2/44 , A61F2/46 , A61L2/02 , A61L2/03 , A61L2/04 , A61L2/08 , A61L2/14 , A61L27/36 , A61L27/54
CPC分类号： A61B17/8819 , A61B17/823 , A61B17/8825 , A61B2017/8813 , A61F2/30 , A61F2/4603 , A61F2002/0086 , A61F2002/2825 , A61F2002/2835 , A61F2002/30059 , A61F2002/30064 , A61F2002/3007 , A61F2002/30072 , A61F2002/30588 , A61F2002/30677 , A61F2002/3068 , A61F2002/3093 , A61F2002/30971 , A61F2002/4623 , A61F2002/4627 , A61F2250/0068 , A61F2310/00592 , A61F2310/00958 , A61F2310/0097
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust the release of the substance. In various embodiments, the covering is suitable for a variety of procedure specific uses. Implantation tools may be provided for placing the covering at a surgical site. Kits may be provided including variously sized or shaped coverings and one or more tools for use in placing the covering.
摘要翻译：提供了用于将物质或材料递送至手术部位的覆盖物。其中提供有物质的覆盖物可以被称为递送系统。通常，覆盖物可以是能够至少部分地保留设置在其中的物质直到覆盖物被置于手术部位处的单隔室或多隔室结构。放置后，覆盖物可以促进物质或周围物质的转移。例如，该物质可以被释放（主动或被动）到手术部位。覆盖物可以参与，控制或调整物质的释放。在各种实施例中，覆盖物适用于各种程序特定用途。可以提供植入工具用于将覆盖物放置在手术部位。可以提供包括各种尺寸或形状的覆盖物和用于放置覆盖物的一个或多个工具的套件。

4. 发明申请

WO2010048610A3 COMPOSITIONS AND METHODS FOR PROMOTING BONE FORMATION 审中-公开
标题翻译：用于促进骨形成的组合物和方法
公开(公告)号：WO2010048610A3
公开(公告)日：2010-07-15
申请号：PCT/US2009062055
申请日：2009-10-26
申请人： OSTEOTECH INC , SHIMP LAWRENCE A , BEHNAM KEYVAN , WEI GUOBAO , SELIM ABDULHAFEZ A
发明人： SHIMP LAWRENCE A , BEHNAM KEYVAN , WEI GUOBAO , SELIM ABDULHAFEZ A
IPC分类号： A61K9/00 , A61K38/18 , A61L27/22
CPC分类号： A61L27/54 , A61F2/28 , A61F2002/2817 , A61F2310/00359 , A61K9/0024 , A61K31/573 , A61K33/42 , A61K35/32 , A61K38/177 , A61K38/1866 , A61K38/191 , A61K38/193 , A61K38/2006 , A61K38/202 , A61K38/29 , A61L27/12 , A61L27/3608 , A61L27/3821 , A61L2300/258 , A61L2300/412 , A61L2300/414 , A61L2300/426 , A61L2300/428 , A61L2300/43 , A61L2300/45 , A61L2400/18 , A61L2430/02 , A61K2300/00
摘要： A method for promoting bone formation is provided. More specifically, a method for promoting bone formation by promoting osteoclast formation is provided. In one embodiment, an implant comprising an implantable material and an osteoclast stimulating substance is provided.
摘要翻译：提供了促进骨形成的方法。更具体地，提供了促进破骨细胞形成促进骨形成的方法。在一个实施例中，提供包括可植入材料和破骨细胞刺激物质的植入物。

5. 发明申请

WO2011017284A3 BONE MATRIX COMPOSITIONS AND METHODS 审中-公开
标题翻译：骨基质组合物和方法
公开(公告)号：WO2011017284A3
公开(公告)日：2011-05-05
申请号：PCT/US2010044180
申请日：2010-08-03
申请人： OSTEOTECH INC , WEI GUOBAO , SHIMP LAWRENCE A , DEAN SHELDON W III , DECARO MARK , SCHWARZ CARL R , OUKO MARTIN O , BEHNAM KEYVAN
发明人： WEI GUOBAO , SHIMP LAWRENCE A , DEAN SHELDON W III , DECARO MARK , SCHWARZ CARL R , OUKO MARTIN O , BEHNAM KEYVAN
IPC分类号： A61L27/36
CPC分类号： A61L27/3608 , A61L27/3691 , A61L2430/02 , A61L2430/40
摘要： Methods for demineralizing bone are provided. In some embodiments, the methods include demineralizing the bone in a demineralization medium and separating the bone into particles during demineralization. In other embodiments, the methods include placing the bone in a demineralization medium and treating the demineralization medium while the bone is in the demineralization medium to optimize the demineralization process.
摘要翻译：提供了使骨质脱矿质的方法。在一些实施方案中，所述方法包括在脱矿质介质中使骨骼脱矿质，并在脱矿质过程中将骨分离成颗粒。在其他实施方案中，所述方法包括将骨放置在脱盐培养基中并在骨在脱盐培养基中处理脱矿质培养基以优化脱矿质过程。

6. 发明申请

WO2010093955A1 SEGMENTED DELIVERY SYSTEM 审中-公开
标题翻译：分段送货系统
公开(公告)号：WO2010093955A1
公开(公告)日：2010-08-19
申请号：PCT/US2010024140
申请日：2010-02-12
申请人： OSTEOTECH INC , WEI GUOBAO , BOYCE TODD M , COHEN ROBERT , RICHARDS CRISTY , SHIMP LAWRENCE A
发明人： WEI GUOBAO , BOYCE TODD M , COHEN ROBERT , RICHARDS CRISTY , SHIMP LAWRENCE A
IPC分类号： A61F2/28 , A61F2/44 , A61F2/46 , A61L2/02 , A61L2/03 , A61L2/08 , A61L2/14 , A61L27/36 , A61L27/54
CPC分类号： A61B17/8819 , A61B17/823 , A61B17/8825 , A61B2017/8813 , A61F2/30 , A61F2/4603 , A61F2002/0086 , A61F2002/2825 , A61F2002/2835 , A61F2002/30059 , A61F2002/30064 , A61F2002/3007 , A61F2002/30072 , A61F2002/30588 , A61F2002/30677 , A61F2002/3068 , A61F2002/3093 , A61F2002/30971 , A61F2002/4623 , A61F2002/4627 , A61F2250/0068 , A61F2310/00592 , A61F2310/00958 , A61F2310/0097
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust the release of the substance. In various embodiments, the covering may be formed of a collagen material and is suitable for a variety of procedure specific uses.
摘要翻译：提供了用于将物质或材料递送至手术部位的覆盖物。其中提供有物质的覆盖物可以被称为递送系统。通常，覆盖物可以是能够至少部分地保留设置在其中的物质直到覆盖物被置于手术部位处的单隔室或多隔室结构。放置后，覆盖物可以促进物质或周围物质的转移。例如，该物质可以被释放（主动或被动）到手术部位。覆盖物可以参与，控制或调整物质的释放。在各种实施例中，覆盖物可以由胶原蛋白材料形成并且适用于各种程序特定用途。

7. 发明申请

WO2008157495A3 BONE MATRIX COMPOSITIONS AND METHODS 审中-公开
标题翻译：骨基质组合物和方法
公开(公告)号：WO2008157495A3
公开(公告)日：2009-11-26
申请号：PCT/US2008067121
申请日：2008-06-16
申请人： OSTEOTECH INC , BEHNAM KEYVAN , WEI GUOBAO , FORSYTH NANETTE , BOYCE TODD M , SHIMP LAWRENCE A
发明人： BEHNAM KEYVAN , WEI GUOBAO , FORSYTH NANETTE , BOYCE TODD M , SHIMP LAWRENCE A
IPC分类号： A61L27/36
CPC分类号： A61L27/3695 , A61F2/28 , A61F2002/30059 , A61F2310/00359 , A61K35/00 , A61K35/32 , A61L27/3604 , A61L27/3608 , A61L27/3683 , A61L27/3834 , A61L27/54 , A61L2430/02 , A61L2430/40
摘要： Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosisinducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone, and optionally providing a tissue-derived extract and adding the tissue-derived extract to the partially demineralized bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized bone, wherein the collagen structure of the bone has been disrupted, and, optionally, a tissue-derived extract.
摘要翻译：提供具有增加的生物活性的骨诱导组合物和植入物及其生产方法。可能增加的生物活性包括但不限于骨形成; 骨愈合; 骨诱导活性，成骨活性，软骨形成活性，伤口愈合活性，神经源性活性，收缩诱导活性，有丝分裂诱导活性，分化诱导活性，趋化活性，血管生成或血管发生活性，以及胞吐作用或内吞诱导活性。在一个实施方案中，用于产生骨诱导性组合物的方法包括提供部分去矿物质的骨，处理所述部分去矿物质的骨以破坏所述骨的胶原结构，以及任选地提供组织衍生的提取物，并将所述组织衍生的提取物加入到部分去矿物质骨。在另一个实施方案中，可植入的骨诱导和骨传导性组合物包含部分脱矿质骨，其中所述骨的胶原结构已被破坏，并且任选地包含组织衍生的提取物。

8. 发明申请

WO2009082554A3 BONE MATRIX COMPOSITIONS HAVING NANOSCALE TEXTURED SURFACES 审中-公开
标题翻译：骨基质组合物具有纳米纹理表面
公开(公告)号：WO2009082554A3
公开(公告)日：2010-08-26
申请号：PCT/US2008083005
申请日：2008-11-10
申请人： OSTEOTECH INC , WEI GUOBAO , BEHNAM KEYVAN , FORSYTH NANETTE
发明人： WEI GUOBAO , BEHNAM KEYVAN , FORSYTH NANETTE
IPC分类号： A61L27/24 , A61L27/36
CPC分类号： A61L27/24 , A61L2400/12 , A61L2430/02 , A61L2430/40 , B63B35/7906
摘要： Bone matrix compositions having nanoscale textured surfaces and methods for their production are provided. In some embodiments, bone matrix is prepared for implantation and retains nanoscale textured surfaces. In other embodiments, nanostructures are imparted to bone matrix wherein collagen fibrils on the surface of the bone matrix have been compromised, thus imparting a nanoscale textured surface to the bone matrix. Generally, these methods may be applied to mineralized or demineralized bone including partially or surface demineralized bone.
摘要翻译：提供具有纳米尺度纹理表面的骨基质组合物及其生产方法。在一些实施方案中，准备骨基质用于植入并保留纳米尺度的纹理表面。在其它实施方案中，纳米结构被赋予骨基质，其中骨基质表面上的胶原原纤维已被破坏，从而赋予骨基质纳米尺度的纹理表面。通常，这些方法可以应用于包括部分或表面脱矿质骨的矿化或去矿化骨。

9. 发明申请

WO2009052492A3 DEMINERALIZED BONE MATRIX COMPOSITIONS AND METHODS 审中-公开
标题翻译：脱钙骨基质组合物和方法
公开(公告)号：WO2009052492A3
公开(公告)日：2009-12-10
申请号：PCT/US2008080498
申请日：2008-10-20
申请人： OSTEOTECH INC , BEHNAM KEYVAN , WEI GUOBAO , BEISSER JAMES
发明人： BEHNAM KEYVAN , WEI GUOBAO , BEISSER JAMES
IPC分类号： A61L27/36 , A61L27/50 , A61L27/54
CPC分类号： A61L27/3608 , A61L27/3683 , A61L27/50 , A61L27/54 , A61L2300/414
摘要： Bone matrix compositions and, more specifically, demineralized bone matrix (DBM) having increased osteoinductive capacity and methods for its production are provided. Specifically, DBM derived from cortical bone from the periosteal layer of bone are provided. Compositions comprising a disproportionate amount of DBM prepared from bone derived from the periosteal and/or middle layer of bone are provided. Preparations of and methods of use of periosteal DBM compositions are disclosed.
摘要翻译：提供了具有增加的骨诱导能力的骨基质组合物，更具体地说是脱矿骨基质（DBM）及其制备方法。具体而言，提供了源自骨骨膜层的皮质骨的DBM。提供了包含由骨骨膜和/或中层骨衍生的骨制备的不成比例量的DBM的组合物。公开了骨膜DBM组合物的制备方法和使用方法。

10. 发明申请

WO2010093959A2 DELIVERY SYSTEMS, TOOLS, AND METHODS OF USE 审中-公开
标题翻译：交付系统，工具和使用方法
公开(公告)号：WO2010093959A2
公开(公告)日：2010-08-19
申请号：PCT/US2010024144
申请日：2010-02-12
申请人： OSTEOTECH INC , BETZ RANDAL R , BODEN SCOTT , GUPTA MUNISH CHANDRA , O'BRIEN MICHAEL F , SANDHU HARVINDER , SHELOKOV ALEXIS , SYBERT DARYL R , VACCARO ALEXANDER , WEI GUOBAO , BOYCE TODD M , COHEN ROBERT , RICHARDS CRISTY , SHIMP LAWRENCE P
发明人： BETZ RANDAL R , BODEN SCOTT , GUPTA MUNISH CHANDRA , O'BRIEN MICHAEL F , SANDHU HARVINDER , SHELOKOV ALEXIS , SYBERT DARYL R , VACCARO ALEXANDER , WEI GUOBAO , BOYCE TODD M , COHEN ROBERT , RICHARDS CRISTY , SHIMP LAWRENCE P
IPC分类号： A61F2/28 , A61F2/44 , A61F2/46 , A61L2/02 , A61L2/03 , A61L2/04 , A61L2/08 , A61L2/14 , A61L27/36 , A61L27/54
CPC分类号： A61B17/8819 , A61B17/823 , A61B17/8825 , A61B2017/8813 , A61F2/30 , A61F2/4603 , A61F2002/0086 , A61F2002/2825 , A61F2002/2835 , A61F2002/30059 , A61F2002/30064 , A61F2002/3007 , A61F2002/30072 , A61F2002/30588 , A61F2002/30677 , A61F2002/3068 , A61F2002/3093 , A61F2002/30971 , A61F2002/4623 , A61F2002/4627 , A61F2250/0068 , A61F2310/00592 , A61F2310/00958 , A61F2310/0097
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust the release of the substance. In various embodiments, the covering is suitable for a variety of procedure specific uses. Implantation tools may be provided for placing the covering at a surgical site. Kits may be provided including variously sized or shaped coverings and one or more tools for use in placing the covering.
摘要翻译：提供用于将物质或材料递送到外科手术部位的覆盖物。其中提供的物质的覆盖物可以被称为递送系统。通常，覆盖物可以是能够至少部分地保留其中提供的物质的单室或多室结构，直到覆盖物被放置在手术部位。放置时，覆盖物可以促进物质或周围材料的转移。例如，物质可以被释放（主动地或被动地）到手术部位。覆盖物可以参与，控制或以其他方式调节物质的释放。在各种实施方案中，覆盖物适用于各种程序特定用途。可以提供植入工具用于将覆盖物放置在手术部位。可以提供套件，包括各种尺寸或形状的覆盖物和用于放置覆盖物的一个或多个工具。

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