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1. 发明申请

WO2010048610A3 COMPOSITIONS AND METHODS FOR PROMOTING BONE FORMATION 审中-公开
标题翻译：用于促进骨形成的组合物和方法
公开(公告)号：WO2010048610A3
公开(公告)日：2010-07-15
申请号：PCT/US2009062055
申请日：2009-10-26
申请人： OSTEOTECH INC , SHIMP LAWRENCE A , BEHNAM KEYVAN , WEI GUOBAO , SELIM ABDULHAFEZ A
发明人： SHIMP LAWRENCE A , BEHNAM KEYVAN , WEI GUOBAO , SELIM ABDULHAFEZ A
IPC分类号： A61K9/00 , A61K38/18 , A61L27/22
CPC分类号： A61L27/54 , A61F2/28 , A61F2002/2817 , A61F2310/00359 , A61K9/0024 , A61K31/573 , A61K33/42 , A61K35/32 , A61K38/177 , A61K38/1866 , A61K38/191 , A61K38/193 , A61K38/2006 , A61K38/202 , A61K38/29 , A61L27/12 , A61L27/3608 , A61L27/3821 , A61L2300/258 , A61L2300/412 , A61L2300/414 , A61L2300/426 , A61L2300/428 , A61L2300/43 , A61L2300/45 , A61L2400/18 , A61L2430/02 , A61K2300/00
摘要： A method for promoting bone formation is provided. More specifically, a method for promoting bone formation by promoting osteoclast formation is provided. In one embodiment, an implant comprising an implantable material and an osteoclast stimulating substance is provided.
摘要翻译：提供了促进骨形成的方法。更具体地，提供了促进破骨细胞形成促进骨形成的方法。在一个实施例中，提供包括可植入材料和破骨细胞刺激物质的植入物。

2. 发明申请

WO2010033884A2 METHOD FOR THE TREATMENT OF RADIATION-INDUCED NEUTROPENIA BY ADMINISTRATION OF A MULTI-PEGYLATED GRANULOCYTE COLONY STIMULATING FACTOR (G-CSF) VARIANT 审中-公开
标题翻译：通过施用多聚乙二醇化的粒细胞集落刺激因子（G-CSF）变体来治疗辐射诱导的中性粒细胞减少症的方法
公开(公告)号：WO2010033884A2
公开(公告)日：2010-03-25
申请号：PCT/US2009057600
申请日：2009-09-18
申请人： MAXYGEN INC , YONEHIRO GRANT , MACVITTIE THOMAS J
发明人： YONEHIRO GRANT , MACVITTIE THOMAS J
IPC分类号： A61K39/00
CPC分类号： A61K38/1816 , A61K38/00 , A61K38/18 , A61K38/196 , A61K38/202 , A61K47/60 , C07K14/535 , A61K2300/00
摘要： The invention relates to a method for treating or preventing radiation-induced neutropenia in a patient exposed to radiation by administering to the patient a multi- PEGylated granulocyte colony stimulating factor (G-CSF) variant.
摘要翻译：本发明涉及通过向患者施用多PEG化粒细胞集落刺激因子（G-CSF）变体来治疗或预防暴露于辐射的患者中的辐射诱导的嗜中性粒细胞减少症的方法。

3. 发明申请

WO2008030539A2 METHODS AND COMPOSITIONS BASED ON DIPHTHERIA TOXIN-INTERLEUKIN-3 CONJUGATES 审中-公开
标题翻译：基于DIPHTHERIA TOXIN-INTERLEUKIN-3结合物的方法和组合物
公开(公告)号：WO2008030539A2
公开(公告)日：2008-03-13
申请号：PCT/US2007/019481
申请日：2007-09-07
申请人： FRANKEL, Arthur, E.
发明人： FRANKEL, Arthur, E.
IPC分类号： A61K38/20
CPC分类号： C07K14/5403 , A61K35/14 , A61K35/28 , A61K38/00 , A61K38/164 , A61K38/202 , A61K47/642 , C07K14/34 , C07K2319/55 , Y10S514/885 , A61K2300/00
摘要： The present invention provides methods for inhibiting interleukin-3 receptor- expressing cells, and, in particular, inhibiting the growth of such cells by using a diphtheria toxin-human interleukin-3 conjugate (DT-IL3) that is toxic to cells expressing the interleukin-3 receptor. In preferred embodiments, the DT-IL3 conjugate is a fusion protein comprising amino acids 1-388 of diphtheria toxin fused via a peptide linker to full-length, human interleukin-3. In certain embodiments, the methods of the present invention relate to the administration of a DT-IL3 conjugate to inhibit the growth of cancer cells and/or cancer stem cells in humans, which cells express one or more subunits of the interleukin-3 receptor. Exemplary cells include myeloid leukemia cancer stem cells. In other embodiments, the methods of the present invention relate to ex vivo purging of bone marrow or peripheral blood to remove cells that express one or more subunits of the interleukin-3 receptor such that the purged bone marrow or peripheral blood is suitable, e.g., for autologous stem cell transplantation to restore hematopoietic function.
摘要翻译：本发明提供了抑制白细胞介素-3受体表达细胞的方法，特别是通过使用对表达白细胞介素的细胞有毒性的白喉毒素 - 人白介素-3缀合物（DT-IL3）来抑制这些细胞的生长 -3受体。在优选的实施方案中，DT-IL3缀合物是包含通过肽接头融合到全长人白细胞介素-3的白喉毒素的氨基酸1-388的融合蛋白。在某些实施方案中，本发明的方法涉及施用DT-IL3缀合物以抑制人类癌细胞和/或癌干细胞的生长，所述细胞表达白细胞介素-3受体的一个或多个亚单位。示例性细胞包括骨髓性白血病癌症干细胞。在其他实施方案中，本发明的方法涉及骨髓或外周血的离体清除以去除表达白介素-3受体的一个或多个亚基的细胞，使得被清除的骨髓或外周血适合，例如，用于自体干细胞移植以恢复造血功能。

4. 发明申请

WO2004070018A3 VEGF-B AND PDGF MODULATION OF STEM CELLS 审中-公开
标题翻译： VEGF-B和PDGF调节干细胞
公开(公告)号：WO2004070018A3
公开(公告)日：2005-02-03
申请号：PCT/US2004003316
申请日：2004-02-04
申请人： LUDWIG INST CANCER RES , LICENTIA LTD , FLANDERS INTERUNIVERSITY INST , ALITALO KARI , ERIKSSON ULF , CARMELIET PETER , LI XURI , COLLEN DESIRE , YLA-HERTTUALA SEPPO , SALVEN PETRI , RAJANTIE IIRO
发明人： ALITALO KARI , ERIKSSON ULF , CARMELIET PETER , LI XURI , COLLEN DESIRE , YLA-HERTTUALA SEPPO , SALVEN PETRI , RAJANTIE IIRO
IPC分类号： A61K38/18 , A61K38/19 , A61K48/00 , A61P7/00 , A61P9/10 , C12N15/861
CPC分类号： A61K38/193 , A61K35/545 , A61K38/18 , A61K38/1858 , A61K38/1866 , A61K38/202 , A61K48/00 , A61K48/005 , C12N15/86 , C12N2710/10343 , A61K2300/00
摘要： The present invention provides materials and methods for VEGF-B AND PDGF therapy, especially therapy directed at stem cell recruitment, proliferation, and/or differentiation.
摘要翻译：本发明提供VEGF-B和PDGF治疗的材料和方法，特别是针对干细胞募集，增殖和/或分化的治疗。

5. 发明申请

WO2003030928A2 ANTITUMOR PREPARATION 审中-公开
标题翻译：抗生素制剂
公开(公告)号：WO2003030928A2
公开(公告)日：2003-04-17
申请号：PCT/EP2002/011249
申请日：2002-10-08
申请人： CIAIOLO, Carlo
发明人： CIAIOLO, Carlo
IPC分类号： A61K38/20
CPC分类号： A61K33/24 , A61K31/505 , A61K38/193 , A61K38/202 , A61K2300/00
摘要： The invention regards a combination of anticancer agents and growth factors for use in the treatment of cancer.
摘要翻译：本发明涉及用于治疗癌症的抗癌剂和生长因子的组合。

6. 发明申请

WO02099081A3 METHODS OF USING COLONY STIMULATING FACTORS IN THE TREATMENT OF TISSUE DAMAGE AND ISCHEMIA 审中-公开
标题翻译：使用组织刺激因子治疗组织损伤和异位症的方法
公开(公告)号：WO02099081A3
公开(公告)日：2003-02-27
申请号：PCT/US0218237
申请日：2002-06-07
申请人： QUARK BIOTECH INC , CHAJUT AYELET
发明人： CHAJUT AYELET
IPC分类号： A61K38/18 , A61K38/19 , A61K38/20 , A61K38/22
CPC分类号： A61K38/204 , A61K38/18 , A61K38/193 , A61K38/202
摘要： The present invention relates to novel uses of growth factors, particularly colony stimulating factors (CSFs), that stimulate migration and differentiation of stem cells in order to promote and enhance recovery from tissue trauma and ischemic events, including ischemia of the central nervous system, as well as for use in preventing or alleviating chronic degenerative processes, including neuronal degeneration.
摘要翻译：本发明涉及刺激干细胞迁移和分化的生长因子，特别是集落刺激因子（CSF）的新用途，以促进和增强组织创伤和缺血事件（包括中枢神经系统缺血）的恢复，如以及用于预防或缓解慢性退行性过程，包括神经元变性。

7. 发明申请

WO00040240A1 METHODS AND COMPOSITIONS FOR TOPICAL TREATMENT OF DAMAGED TISSUE USING REACTIVE OXYGEN METABOLITE PRODUCTION OR RELEASE INHIBITORS 审中-公开
标题翻译：使用反应性氧化代谢物生产或释放抑制剂对损伤组织进行局部治疗的方法和组合物
公开(公告)号：WO00040240A1
公开(公告)日：2000-07-13
申请号：PCT/US2000/000317
申请日：2000-01-07
IPC分类号： A61K31/00 , A61K31/203 , A61K31/4045 , A61K31/417 , A61K38/20 , A61K31/415 , A61K31/20 , A61K31/40
CPC分类号： A61K38/202 , A61K8/4946 , A61K9/0014 , A61K9/0034 , A61K9/0048 , A61K9/0056 , A61K9/006 , A61K9/122 , A61K31/00 , A61K31/203 , A61K31/4045 , A61K31/417 , A61L15/44 , A61L2300/204 , A61L2300/426 , A61L2300/428 , A61Q11/00 , A61Q17/04
摘要： The invention disclosed herein relates to compositions and methods for treating cell damage caused by reactive oxygen species in relation to a variety of skin disorders. More specifically, the invention disclosed herein relates to the treatment of skin disorders through the topical delivery of reactive oxygen metabolite production or release inhibiting compounds.
摘要翻译：本文公开的本发明涉及用于治疗与各种皮肤疾病相关的由活性氧引起的细胞损伤的组合物和方法。更具体地，本文公开的本发明涉及通过局部递送活性氧代谢产物或释放抑制化合物来治疗皮肤病症。

8. 发明申请

WO9712598A2 DERMATOLOGICAL AND COSMETIC COMPOSITIONS SUITABLE FOR TOPICAL APPLICATION, HAVING MODULATING EFFECT ON THE ENDOGENOUS CERAMIDE OF THE SKIN 审中-公开
标题翻译：适用于局部应用的皮肤和化妆组合物，对皮肤的内源性乙酰胺具有调节作用
公开(公告)号：WO9712598A2
公开(公告)日：1997-04-10
申请号：PCT/IT9600184
申请日：1996-10-03
申请人： MENDES SRL , PREX SRL , SIMONE CLAUDIO DE
发明人： DE SIMONE CLAUDIO
IPC分类号： A61K8/64 , A61K38/19 , A61K38/20 , A61Q19/00 , A61K7/48
CPC分类号： A61K8/64 , A61K38/193 , A61K38/202 , A61K45/06 , A61Q19/00
摘要： The use of growth factors such as granulocyte-monocyte colony stimulating factor and macrophage colony stimulating factors is disclosed for producing dermatological and cosmetic compositions suitable for topical application, endowed with a modulating effect on the endogenous ceramides of the skin.
摘要翻译：公开了使用生长因子例如粒细胞 - 单核细胞集落刺激因子和巨噬细胞集落刺激因子来生产适用于局部施用的皮肤病学和化妆品组合物，其赋予对皮肤内源性神经酰胺的调节作用。

9. 发明申请

WO1995009005A1 METHODS FOR STIMULATING INTERLEUKIN-6 SYNTHESIS AND INDUCING THROMBOCYTOPOIESIS USING ONCOSTATIN M 审中-公开
标题翻译：刺激白细胞介素-6合成和使用辛伐他汀M诱导血栓形成的方法
公开(公告)号：WO1995009005A1
公开(公告)日：1995-04-06
申请号：PCT/US1994010923
申请日：1994-09-27
申请人： BRISTOL-MYERS SQUIBB COMPANY
发明人： BRISTOL-MYERS SQUIBB COMPANY , WALLACE, Philip, M. , BROWN, Thomas, J.
IPC分类号： A61K38/19
CPC分类号： A61K38/204 , A61K38/1816 , A61K38/193 , A61K38/196 , A61K38/202 , A61K47/642 , A61K47/6813 , A61K2300/00
摘要： The present invention relates to methods of using oncostatin M (OM). In particular, it relates to the use of OM to stimulate interleukin 6 (IL-6) synthesis in target cells, especially human endothelial cells. The resultant IL-6, in turn, may perform a variety of functions such as cell growth regulation, leukocyte differentiation, and tumor inhibition. Furthermore, the present invention also relates to the use of OM to treat cytopenias, including anemia and thrombocytopoiesis, and to increase tolerance to irradiation and cytotoxic drugs. Therefore, the methods of the invention may have a wide range of applications, including, but not limited to, the inhibition of tumor growth, the treatment of cytopenias, and to increase the tolerance to radio- and chemotherapy. OM may be used in combination with various cytokines, including erythropoietin, colony-stimulating factors, interleukin-3 or thrombopoietin.
摘要翻译：本发明涉及使用制瘤素M（OM）的方法。特别地，它涉及使用OM来刺激靶细胞，特别是人内皮细胞中的白细胞介素6（IL-6）合成。所得到的IL-6又可以进行各种功能，例如细胞生长调节，白细胞分化和肿瘤抑制。此外，本发明还涉及OM用于治疗血细胞减少症（包括贫血和血小板生成）并增加对照射和细胞毒性药物的耐受性的用途。因此，本发明的方法可以具有广泛的应用，包括但不限于抑制肿瘤生长，治疗血细胞减少以及增加对放射和化学疗法的耐受性。 OM可以与各种细胞因子，包括促红细胞生成素，集落刺激因子，白介素-3或血小板生成素组合使用。

10. 发明申请

WO1993015754A1 HEPATIC GROWTH FACTOR RECEPTOR 审中-公开
标题翻译： HEPATIC生长因子受体
公开(公告)号：WO1993015754A1
公开(公告)日：1993-08-19
申请号：PCT/US1993000824
申请日：1993-02-05
申请人： UNITED STATES OF AMERICA, as represented by the ...
发明人： UNITED STATES OF AMERICA, as represented by the ... , KMIECIK, Thomas, E. , VANDE WOUDE, George, F.
IPC分类号： A61K37/02
CPC分类号： C07K14/71 , A61K38/00 , A61K38/193 , A61K38/202 , C07K14/4753 , C07K14/82 , C07K16/22 , C07K16/32 , C12Q1/6813 , C12Q1/6886 , C12Q2600/158 , G01N33/57446 , G01N33/6872 , A61K2300/00
摘要： The present invention relates to a complex comprising hepatocyte growth factor (HGF) and met proto-oncogene protein. The present invention also relates to methods for detecting the presence of HGF ligand, met proto-oncogene receptor and methods for isolating either the ligand or receptor or complex comprising both. The present invention further relates to methods of diagnostic proliferative disorders and diseases such as hepatitis or hepatocarcinogenesis by detecting these ligand-receptor pairs.
摘要翻译：本发明涉及包含肝细胞生长因子（HGF）和met原癌基因蛋白的复合物。本发明还涉及用于检测HGF配体，met原癌基因受体的存在的方法和用于分离包含两者的配体或受体或复合物的方法。本发明还涉及通过检测这些配体 - 受体对来诊断增殖性疾病和诸如肝炎或肝癌发生的疾病的方法。

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