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1. 发明申请

WO2009052492A3 DEMINERALIZED BONE MATRIX COMPOSITIONS AND METHODS 审中-公开
标题翻译：脱钙骨基质组合物和方法
公开(公告)号：WO2009052492A3
公开(公告)日：2009-12-10
申请号：PCT/US2008080498
申请日：2008-10-20
申请人： OSTEOTECH INC , BEHNAM KEYVAN , WEI GUOBAO , BEISSER JAMES
发明人： BEHNAM KEYVAN , WEI GUOBAO , BEISSER JAMES
IPC分类号： A61L27/36 , A61L27/50 , A61L27/54
CPC分类号： A61L27/3608 , A61L27/3683 , A61L27/50 , A61L27/54 , A61L2300/414
摘要： Bone matrix compositions and, more specifically, demineralized bone matrix (DBM) having increased osteoinductive capacity and methods for its production are provided. Specifically, DBM derived from cortical bone from the periosteal layer of bone are provided. Compositions comprising a disproportionate amount of DBM prepared from bone derived from the periosteal and/or middle layer of bone are provided. Preparations of and methods of use of periosteal DBM compositions are disclosed.
摘要翻译：提供了具有增加的骨诱导能力的骨基质组合物，更具体地说是脱矿骨基质（DBM）及其制备方法。具体而言，提供了源自骨骨膜层的皮质骨的DBM。提供了包含由骨骨膜和/或中层骨衍生的骨制备的不成比例量的DBM的组合物。公开了骨膜DBM组合物的制备方法和使用方法。

2. 发明申请

WO2009009688A9 DELIVERY SYSTEM 审中-公开
标题翻译：输送系统
公开(公告)号：WO2009009688A9
公开(公告)日：2009-05-07
申请号：PCT/US2008069690
申请日：2008-07-10
申请人： OSTEOTECH INC , WEI GUOBAO , BEHNAM KEYVAN , FORSYTH NANETTE , WINTERBOTTOM JOHN , BEISSER JAMES , BOYCE TODD M , BERVEN SIGURD , BETZ RANDAL , O'BRIEN MICHAEL , SHELEKOV ALEXIS
发明人： WEI GUOBAO , BEHNAM KEYVAN , FORSYTH NANETTE , WINTERBOTTOM JOHN , BEISSER JAMES , BOYCE TODD M , BERVEN SIGURD , BETZ RANDAL , O'BRIEN MICHAEL , SHELEKOV ALEXIS
IPC分类号： A61L24/00 , A61L27/56
CPC分类号： A61F2/2846 , A61B17/7097 , A61B17/7098 , A61F2/0095 , A61F2/28 , A61F2/4455 , A61F2/4601 , A61F2002/2817 , A61F2002/2835 , A61F2002/2839 , A61F2002/285 , A61F2002/30588 , A61F2002/30738
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust, the release of the substance.
摘要翻译：提供了用于将物质或材料递送至手术部位的覆盖物。其中提供有物质的覆盖物可以被称为递送系统。通常，覆盖物可以是能够至少部分地保留设置在其中的物质直到覆盖物被置于手术部位处的单隔室或多隔室结构。放置后，覆盖物可以促进物质或周围物质的转移。例如，该物质可以被释放（主动或被动）到手术部位。覆盖物可以参与，控制或调整物质的释放。

3. 发明申请

WO2009082554A3 BONE MATRIX COMPOSITIONS HAVING NANOSCALE TEXTURED SURFACES 审中-公开
标题翻译：骨基质组合物具有纳米纹理表面
公开(公告)号：WO2009082554A3
公开(公告)日：2010-08-26
申请号：PCT/US2008083005
申请日：2008-11-10
申请人： OSTEOTECH INC , WEI GUOBAO , BEHNAM KEYVAN , FORSYTH NANETTE
发明人： WEI GUOBAO , BEHNAM KEYVAN , FORSYTH NANETTE
IPC分类号： A61L27/24 , A61L27/36
CPC分类号： A61L27/24 , A61L2400/12 , A61L2430/02 , A61L2430/40 , B63B35/7906
摘要： Bone matrix compositions having nanoscale textured surfaces and methods for their production are provided. In some embodiments, bone matrix is prepared for implantation and retains nanoscale textured surfaces. In other embodiments, nanostructures are imparted to bone matrix wherein collagen fibrils on the surface of the bone matrix have been compromised, thus imparting a nanoscale textured surface to the bone matrix. Generally, these methods may be applied to mineralized or demineralized bone including partially or surface demineralized bone.
摘要翻译：提供具有纳米尺度纹理表面的骨基质组合物及其生产方法。在一些实施方案中，准备骨基质用于植入并保留纳米尺度的纹理表面。在其它实施方案中，纳米结构被赋予骨基质，其中骨基质表面上的胶原原纤维已被破坏，从而赋予骨基质纳米尺度的纹理表面。通常，这些方法可以应用于包括部分或表面脱矿质骨的矿化或去矿化骨。

4. 发明申请

WO2010048610A3 COMPOSITIONS AND METHODS FOR PROMOTING BONE FORMATION 审中-公开
标题翻译：用于促进骨形成的组合物和方法
公开(公告)号：WO2010048610A3
公开(公告)日：2010-07-15
申请号：PCT/US2009062055
申请日：2009-10-26
申请人： OSTEOTECH INC , SHIMP LAWRENCE A , BEHNAM KEYVAN , WEI GUOBAO , SELIM ABDULHAFEZ A
发明人： SHIMP LAWRENCE A , BEHNAM KEYVAN , WEI GUOBAO , SELIM ABDULHAFEZ A
IPC分类号： A61K9/00 , A61K38/18 , A61L27/22
CPC分类号： A61L27/54 , A61F2/28 , A61F2002/2817 , A61F2310/00359 , A61K9/0024 , A61K31/573 , A61K33/42 , A61K35/32 , A61K38/177 , A61K38/1866 , A61K38/191 , A61K38/193 , A61K38/2006 , A61K38/202 , A61K38/29 , A61L27/12 , A61L27/3608 , A61L27/3821 , A61L2300/258 , A61L2300/412 , A61L2300/414 , A61L2300/426 , A61L2300/428 , A61L2300/43 , A61L2300/45 , A61L2400/18 , A61L2430/02 , A61K2300/00
摘要： A method for promoting bone formation is provided. More specifically, a method for promoting bone formation by promoting osteoclast formation is provided. In one embodiment, an implant comprising an implantable material and an osteoclast stimulating substance is provided.
摘要翻译：提供了促进骨形成的方法。更具体地，提供了促进破骨细胞形成促进骨形成的方法。在一个实施例中，提供包括可植入材料和破骨细胞刺激物质的植入物。

5. 发明申请

WO2011017284A3 BONE MATRIX COMPOSITIONS AND METHODS 审中-公开
标题翻译：骨基质组合物和方法
公开(公告)号：WO2011017284A3
公开(公告)日：2011-05-05
申请号：PCT/US2010044180
申请日：2010-08-03
申请人： OSTEOTECH INC , WEI GUOBAO , SHIMP LAWRENCE A , DEAN SHELDON W III , DECARO MARK , SCHWARZ CARL R , OUKO MARTIN O , BEHNAM KEYVAN
发明人： WEI GUOBAO , SHIMP LAWRENCE A , DEAN SHELDON W III , DECARO MARK , SCHWARZ CARL R , OUKO MARTIN O , BEHNAM KEYVAN
IPC分类号： A61L27/36
CPC分类号： A61L27/3608 , A61L27/3691 , A61L2430/02 , A61L2430/40
摘要： Methods for demineralizing bone are provided. In some embodiments, the methods include demineralizing the bone in a demineralization medium and separating the bone into particles during demineralization. In other embodiments, the methods include placing the bone in a demineralization medium and treating the demineralization medium while the bone is in the demineralization medium to optimize the demineralization process.
摘要翻译：提供了使骨质脱矿质的方法。在一些实施方案中，所述方法包括在脱矿质介质中使骨骼脱矿质，并在脱矿质过程中将骨分离成颗粒。在其他实施方案中，所述方法包括将骨放置在脱盐培养基中并在骨在脱盐培养基中处理脱矿质培养基以优化脱矿质过程。

6. 发明申请

WO2008157495A3 BONE MATRIX COMPOSITIONS AND METHODS 审中-公开
标题翻译：骨基质组合物和方法
公开(公告)号：WO2008157495A3
公开(公告)日：2009-11-26
申请号：PCT/US2008067121
申请日：2008-06-16
申请人： OSTEOTECH INC , BEHNAM KEYVAN , WEI GUOBAO , FORSYTH NANETTE , BOYCE TODD M , SHIMP LAWRENCE A
发明人： BEHNAM KEYVAN , WEI GUOBAO , FORSYTH NANETTE , BOYCE TODD M , SHIMP LAWRENCE A
IPC分类号： A61L27/36
CPC分类号： A61L27/3695 , A61F2/28 , A61F2002/30059 , A61F2310/00359 , A61K35/00 , A61K35/32 , A61L27/3604 , A61L27/3608 , A61L27/3683 , A61L27/3834 , A61L27/54 , A61L2430/02 , A61L2430/40
摘要： Osteoinductive compositions and implants having increased biological activities, and methods for their production, are provided. The biological activities that may be increased include, but are not limited to, bone forming; bone healing; osteoinductive activity, osteogenic activity, chondrogenic activity, wound healing activity, neurogenic activity, contraction-inducing activity, mitosisinducing activity, differentiation-inducing activity, chemotactic activity, angiogenic or vasculogenic activity, and exocytosis or endocytosis-inducing activity. In one embodiment, a method for producing an osteoinductive composition comprises providing partially demineralized bone, treating the partially demineralized bone to disrupt the collagen structure of the bone, and optionally providing a tissue-derived extract and adding the tissue-derived extract to the partially demineralized bone. In another embodiment, an implantable osteoinductive and osteoconductive composition comprises partially demineralized bone, wherein the collagen structure of the bone has been disrupted, and, optionally, a tissue-derived extract.
摘要翻译：提供具有增加的生物活性的骨诱导组合物和植入物及其生产方法。可能增加的生物活性包括但不限于骨形成; 骨愈合; 骨诱导活性，成骨活性，软骨形成活性，伤口愈合活性，神经源性活性，收缩诱导活性，有丝分裂诱导活性，分化诱导活性，趋化活性，血管生成或血管发生活性，以及胞吐作用或内吞诱导活性。在一个实施方案中，用于产生骨诱导性组合物的方法包括提供部分去矿物质的骨，处理所述部分去矿物质的骨以破坏所述骨的胶原结构，以及任选地提供组织衍生的提取物，并将所述组织衍生的提取物加入到部分去矿物质骨。在另一个实施方案中，可植入的骨诱导和骨传导性组合物包含部分脱矿质骨，其中所述骨的胶原结构已被破坏，并且任选地包含组织衍生的提取物。

7. 发明申请

WO2005065396A3 IMPROVED BONE MATRIX COMPOSITIONS AND METHODS 审中-公开
标题翻译：改进的骨基质组合物和方法
公开(公告)号：WO2005065396A3
公开(公告)日：2005-10-20
申请号：PCT/US2004043999
申请日：2004-12-31
申请人： OSTEOTECH INC , BEHNAM KEYVAN
发明人： BEHNAM KEYVAN
IPC分类号： A61K35/32 , A61L27/22 , A61L27/36 , A61L27/54
CPC分类号： A61K38/01 , A61L27/227 , A61L27/3608 , A61L27/365 , A61L27/3654 , A61L27/3683 , A61L27/3687 , A61L27/3847 , A61L27/3852 , A61L27/54 , A61L2300/254 , A61L2300/412 , A61L2300/432 , A61L2430/02 , A61L2430/06 , Y10S623/901
摘要： The present invention provides methods of improving the osteogenic and/or chondrogenic activity of a bone matrix, e.g., a dermineralized bone matrix (DBM), by exposing the bone matrix to one or more treatments or conditions. In preferred embodiments the bone matrix is derived from human bone. The treatment or condition may alter the structure of the bone matrix and/or cleave one or more specific proteins. Cleavage may generate peptides or protein fragments that have osteoinductive, osteogenic, or chondrogenic activity. Preferred treatments include collagenase and various other proteases. The invention further provides improved bone and cartilage matrix compositions that have been prepared according to the inventive methods and methods of treatment using the compositions. The invention further provides methods of preparing, testing, and using the improved bone matrix compositions. Ona assay comprises exposing relatively undifferentiated mesenchymal cells to a bone matrix composition and measuring expression of a marker characteristic of osteoblast or chondrocyte lineage(s). Increased expression of the marker relative to the level of the marker in cells that have been exposed to a control matrix (e.g., an inactivated or untreated matrix) indicates that the treatment or condition increased the osteogenic and/or chondrogenic activity of the bone matrix. Suitable cells include C2C12 cells. A suitable marker is alkaline phosphatase. The inventive methods increase the osteogenic and/or chondrogenic activity of human DBM when tested using this assay system.
摘要翻译：本发明提供了通过将骨基质暴露于一种或多种治疗或条件来改善骨基质（例如，矿化骨基质（DBM））的成骨和/或软骨形成活性的方法。在优选的实施方案中，骨基质来源于人骨。治疗或病症可以改变骨基质的结构和/或切割一种或多种特定蛋白质。切割可产生具有骨诱导，成骨或软骨形成活性的肽或蛋白质片段。优选的治疗包括胶原酶和各种其他蛋白酶。本发明进一步提供了根据本发明的方法和使用该组合物进行治疗的方法制备的改进的骨和软骨基质组合物。本发明进一步提供了制备，测试和使用改进的骨基质组合物的方法。 Ona测定包括将相对未分化的间充质细胞暴露于骨基质组合物并测量成骨细胞或软骨细胞谱系特征性标志物的表达。相对于已经暴露于对照基质（例如失活或未处理的基质）的细胞中标记水平的标记表达增加表明治疗或病症增加了骨基质的成骨和/或软骨形成活性。合适的细胞包括C2C12细胞。合适的标记是碱性磷酸酶。当使用该测定系统进行测试时，本发明方法增加人DBM的成骨和/或软骨形成活性。

8. 发明申请

WO2008157492A2 OSTEOINDUCTIVE DEMINERALIZED CANCELLOUS BONE 审中-公开
公开(公告)号：WO2008157492A2
公开(公告)日：2008-12-24
申请号：PCT/US2008067117
申请日：2008-06-16
申请人： OSTEOTECH INC , BEHNAM KEYVAN , FORSYTH NANETTE , RUSSELL JAMES , WINTERBOTTOM JOHN M , BOYCE TODD M
发明人： BEHNAM KEYVAN , FORSYTH NANETTE , RUSSELL JAMES , WINTERBOTTOM JOHN M , BOYCE TODD M
IPC分类号： A61L27/36
CPC分类号： A61K35/32 , A61F2/28 , A61F2002/2817 , A61F2002/30059 , A61F2310/00359 , A61L27/3608 , A61L27/3641 , A61L27/3645 , A61L27/3683 , A61L27/3687 , A61L27/3691 , A61L27/3695 , A61L27/3878 , A61L2430/02
摘要： An osteoinductive demineralized bone matrix, corresponding osteoimplants, and methods for making the osteoinductive demineralized bone matrix are disclosed. The osteoinductive demineralized bone matrix may be prepared by providing demineralized bone and altering the collagenous structure of the bone. The osteoinductive demineralized bone matrix may also be prepared by providing demineralized bone and compacting the bone, for example via mechanical compaction, grinding into a particulate, or treatment with a chemical. Additives such as growth factors or bioactive agents may be added to the osteoinductive demineralized bone matrix. The osteoinductive demineralized bone matrix may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, may induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation. The osteoinductive demineralized bone matrix may also be used as a delivery device to administer bioactive agents.
摘要翻译：公开了一种骨诱导的软骨骨架，相应的骨关节植入物以及用于制造骨诱导性软骨骨架的方法。可以通过提供软化骨和改变骨的胶原结构来制备骨诱导的软骨骨架。还可以通过提供脱矿质骨和压实骨，例如通过机械压实，研磨成颗粒或用化学品处理来制备骨诱导的软化骨基质。添加剂如生长因子或生物活性剂可以加入到骨诱导的软化骨基质中。骨诱导的骨质疏松骨质可形成成骨植骨。当植入植入哺乳动物体内的植骨植入物可能在植入物的位置诱导软骨内骨形成的完全发育级联，包括血管形成，矿化和骨髓分化。骨诱导的软化骨基质也可以用作施用生物活性剂的递送装置。

9. 发明申请

WO2007053850A2 BONE MATRIX COMPOSITIONS AND METHODS 审中-公开
标题翻译：骨基质组合物和方法
公开(公告)号：WO2007053850A2
公开(公告)日：2007-05-10
申请号：PCT/US2006060452
申请日：2006-11-01
申请人： OSTEOTECH INC , BEHNAM KEYVAN
发明人： BEHNAM KEYVAN
IPC分类号： A61L27/22 , A61K35/32 , A61L27/36 , A61L27/46 , A61L27/54 , A61L27/58 , C07K14/51
CPC分类号： A61L27/3608 , A61F2/28 , A61F2002/2817 , A61F2002/2835 , A61F2002/30677 , A61F2310/00359 , A61K35/32 , A61K38/012 , A61K38/1875 , A61L27/12 , A61L27/365 , A61L27/3683 , A61L27/3687 , A61L27/425 , A61L27/48 , A61L27/54 , A61L2300/252 , A61L2300/414 , A61L2300/802 , A61L2430/02 , A61L2430/40 , C07K14/51
摘要： An osteoinductive composition, corresponding osteoimplants, and methods for making the osteoinductive composition are disclosed. The osteoinductive composition comprises osteoinductive factors, such as may be extracted from demineralized bone, and a carrier. The osteoinductive composition is prepared by providing demineralized bone, extracting osteoinductive factors from the demineralized bone, and adding the extracted osteoinductive factors to a carrier. Further additives such as bioactive agents may be added to the osteoinductive composition. The carrier and osteoinductive factors may form an osteogenic osteoimplant. The osteoimplant, when implanted in a mammalian body, can induce at the locus of the implant the full developmental cascade of endochondral bone formation including vascularization, mineralization, and bone marrow differentiation. Also, in some embodiments, the osteoinductive composition can be used as a delivery device to administer bioactive agents.
摘要翻译：公开了骨诱导组合物，相应的骨移植物和制备骨诱导组合物的方法。骨诱导组合物包含骨诱导因子，如可从脱矿骨提取的骨诱导因子和载体。骨诱导组合物通过提供脱矿骨，从脱矿骨提取骨诱导因子，并将提取的骨诱导因子添加至载体来制备。其他添加剂如生物活性剂可以添加到骨诱导组合物中。载体和骨诱导因子可以形成成骨性骨移植物。当骨植入物植入哺乳动物体内时，骨植入物可在植入物的位点诱导软骨内骨形成的完整发育级联，包括血管化，矿化和骨髓分化。而且，在一些实施方案中，骨诱导组合物可以用作递送装置以施用生物活性剂。

10. 发明申请

WO2005072403A2 BONE MORPHOGENIC PROTEIN BINDING PEPTIDE 审中-公开
标题翻译：骨形态蛋白结合肽
公开(公告)号：WO2005072403A2
公开(公告)日：2005-08-11
申请号：PCT/US2005002722
申请日：2005-01-28
申请人： UNIV CALIFORNIA , US DEPT VETERANS AFFAIRS , MURRAY SAMUEL S , BEHNAM KEYVAN , MURRAY ELSA J BROCHMANN
发明人： MURRAY SAMUEL S , BEHNAM KEYVAN , MURRAY ELSA J BROCHMANN
IPC分类号： C07K14/51
CPC分类号： A61K38/1875 , A61K35/32 , A61K38/10 , A61K38/1709 , A61K38/1841 , C07K7/08 , C07K14/47 , C07K14/51 , A61K2300/00
摘要： A cyclized peptide designated BMP Binding Peptide (BBP) is a synthetic peptide that avidly binds rhBMP-2. BBP increases the over-all osteogenic activity of rgBMP-2, increases the rate at which rhBMP-2 induces bone formation, and BBP induces calcification alone. Compositions and substrates including BBP, and methods of using BBP are useful in therapeutic, diagnostic and clinical applications requiring calcification and osteogenesis.
摘要翻译：称为BMP结合肽（BBP）的环化肽是一种合适的肽，其能够强烈地结合rhBMP-2。 BBP增加rgBMP-2的整体成骨活性，增加rhBMP-2诱导骨形成的速率，BBP单独诱导钙化。包括BBP的组合物和底物以及使用BBP的方法可用于需要钙化和成骨的治疗，诊断和临床应用。

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