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1. 发明申请

WO2017014582A1 물리적 및 생물학적 특성이 개선된 바이오 잉크 조성물 审中-公开
标题翻译：具有改善的物理和生物特性的生物油墨组合物
公开(公告)号：WO2017014582A1
公开(公告)日：2017-01-26
申请号：PCT/KR2016/007962
申请日：2016-07-21
申请人： 주식회사 바이오잉크솔루션스
发明人： 황미선
IPC分类号： A61L27/36 , A61L27/22 , C09D11/00 , B29C67/02
CPC分类号： A61L27/54 , A61L27/26 , A61L27/3804 , A61L27/3808 , A61L27/3813 , A61L27/3817 , A61L27/3821 , A61L27/3826 , A61L27/383 , A61L27/3834 , A61L27/50 , A61L2300/412 , A61L2300/414 , B29C67/02 , C09D11/00 , C08L89/06 , C08L5/02 , C08L5/08
摘要： 본 발명은 물리적 및 생리학적 특성이 개선된 바이오 잉크 조성물에 관한 발명으로, 보다 상세하게는 특정 함량의 성분 조합을 통해 높은 점성, 강한 전단 감소(shear-thinning) 경향, 빠른 가교결합의 형성 및 프린팅 후 적절한 기계적 특성을 나타내는 바이오 잉크 조성물에 관한 것이다. 본 발명의 바이오 잉크 조성물은 삼차원적 바이오 프린팅된 조직 유사기관 및 체내 이식 가능한 조직 구조체를 제조하는데 매우 유용하게 사용될 수 있다.
摘要翻译：本发明涉及具有改进的物理和生物学特性的生物油墨组合物，更具体地说，涉及生物油墨组合物，其通过组分的特定含量的组合显示出高粘度，强剪切稀化倾向，形成快速交联，印刷后适当的机械性能。本发明的生物油墨组合物能够非常有用地用于三维生物印刷组织样器官和内部可移植组织结构的制备。

2. 发明申请

WO2016042572A1 A METHOD OF INDUCING BONE FORMATION BY EX-VIVO OSTEOBLAST CULTURING FOR IMPLANTATION 审中-公开
标题翻译：诱导骨形成的方法用于植入植物体外培养
公开(公告)号：WO2016042572A1
公开(公告)日：2016-03-24
申请号：PCT/IN2015/000277
申请日：2015-07-08
申请人： JASWANTRAI DOSHI, Vishal
发明人： JASWANTRAI DOSHI, Vishal
IPC分类号： C12N5/077 , A61K35/32
CPC分类号： C12N5/0654 , A61K35/32 , A61L27/02 , A61L27/3821 , A61L27/3847 , A61L27/54 , A61L2430/02 , C12N2500/00 , C12N2500/02 , C12N2506/1353
摘要： An ex-vivo culturing method of osteoblasts for implantation, comprising a culturing of adult live osteoblasts as an ex-vivo procedure. The ex-vivo culture, which leads to the formation of the active substance, further comprises the steps of isolation of osteo-progenitor cells, differentiation of osteo-progenitor cells in to osteoblasts, expansion culture, cell culture harvest and wash followed by filling and packaging. This method is instrumental in accelerating the process of bone formation.
摘要翻译：用于植入的成骨细胞的离体培养方法，包括作为离体程序培养成年活的成骨细胞。导致活性物质形成的离体培养物还包括分离骨祖细胞，将骨祖细胞分化成成骨细胞，扩增培养，细胞培养收获和洗涤，随后填充和打包。这种方法有助于加速骨形成过程。

3. 发明申请

WO2015199492A1 나노섬유매트, 이의 제조 방법, 및 이의 세포배양용 매트 또는 골유도 재생용 차폐막으로서의 응용 审中-公开
标题翻译：纳米纤维毡，其制造方法及其作为细胞培养基或引导骨再生屏蔽膜的用途
公开(公告)号：WO2015199492A1
公开(公告)日：2015-12-30
申请号：PCT/KR2015/006573
申请日：2015-06-26
申请人： 경북대학교 산학협력단
发明人： 정영훈 , 곽종영 , 김정화 , 김창근
IPC分类号： A61L27/44 , A61L27/56 , A61L27/54
CPC分类号： A61L31/125 , A61L27/18 , A61L27/3821 , A61L27/54 , A61L27/56 , A61L31/146 , A61L31/16 , A61L2400/12 , A61L2430/02 , C12M25/14 , C12N5/0068 , C12N5/0654 , C12N2533/30 , C12N2535/10 , C12N2537/00 , C08L67/04
摘要： 나노섬유매트, 이의 제조 방법, 및 이의 세포배양용 매트 또는 골유도 재생용 차폐막으로서의 응용에서, 나노섬유매트는 나노섬유층과, 나노섬유층 상에 배치되어 나노섬유층과 접합된 보강 패턴을 포함하되, 나노섬유층의 적어도 일부가 보강 패턴과 함께 용융 고화된 형태, 용해 고화된 형태 또는 보강 패턴의 일부가 나노섬유층으로 침투하여 고화된 형태로, 나노섬유층과 보강 패턴이 결합한 것을 특징으로 한다.
摘要翻译：在纳米纤维垫，其制造方法及其作为细胞培养垫或引导骨再生屏蔽膜的用途中，纳米纤维垫包括：纳米纤维层; 以及加强图案，其设置在所述纳米纤维层上并与纳米纤维层接合，其中所述纳米纤维层和所述增强图案以其中所述纳米纤维层的至少一部分与增强图案一起熔融固化，其形式是将纳米纤维层的至少一部分与加强图案一起溶解固化，或以增强图案的一部分被穿透的形式并固化成纳米纤维层。

4. 发明申请

WO2014190349A3 NANOMATERIALS FOR THE INTEGRATION OF SOFT INTO HARD TISSUE 审中-公开
标题翻译：用于整合硬组织的纳米材料
公开(公告)号：WO2014190349A3
公开(公告)日：2015-04-02
申请号：PCT/US2014039577
申请日：2014-05-27
申请人： UNIV NORTHEASTERN
发明人： HICKEY DANIEL J , WEBSTER THOMAS J , ERCAN BATUR
IPC分类号： A61K35/32
CPC分类号： A61F2/0811 , A61K35/28 , A61K35/32 , A61K35/33 , A61K38/39 , A61L27/3804 , A61L27/3817 , A61L27/3821 , A61L27/3834 , A61L27/446 , A61L27/46 , A61L27/50 , A61L27/54 , A61L27/58 , A61L2300/102 , A61L2300/112 , A61L2300/222 , A61L2300/414 , A61L2300/64 , A61L2400/12 , A61L2430/10 , C08L67/04 , C08L89/06
摘要： Nanocomposite materials are provided for attaching soft tissue to hard tissue of a mammalian subject. The materials include a biodegradable polymer network suffused with mineral nanoparticles. The nanocomposite materials have a surface structure that promotes the infiltration, adhesion and proliferation of cells such as osteoblasts and fibroblasts, and are useful to reconstruct enthesis tissue, such as a tendon bone insertion. Devices containing the nanocomposites and methods for implantation of the devices at a tendon-bone interface or ligament-bone interface are provided for reconstructive surgery.
摘要翻译：提供纳米复合材料用于将软组织附着到哺乳动物受试者的硬组织。这些材料包括充满矿物纳米颗粒的可生物降解的聚合物网络。纳米复合材料具有促进细胞如成骨细胞和成纤维细胞的浸润，粘附和增殖的表面结构，并且可用于重建假体组织，例如腱骨插入。包含纳米复合材料的装置和用于在腱 - 骨界面或韧带 - 骨界面处植入装置的方法被提供用于重建手术。

5. 发明申请

WO2015038789A1 METHODS, DEVICES AND SYSTEMS FOR VIBRATION INDUCED TISSUE ENGINEERING 审中-公开
标题翻译：振动诱导组织工程的方法，装置和系统
公开(公告)号：WO2015038789A1
公开(公告)日：2015-03-19
申请号：PCT/US2014/055219
申请日：2014-09-11
申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
发明人： DENNIS, Robert, G. , VAN AALST, John, A.
IPC分类号： C12N5/0775 , C12M3/00 , C12M1/42
CPC分类号： C12M21/08 , A61F2/02 , A61L27/3691 , A61L27/3817 , A61L27/3821 , A61L27/3895 , A61L2430/02 , A61L2430/06 , C12M25/14 , C12M35/02 , C12M35/04 , C12M41/46 , C12M41/48 , C12N5/0654 , C12N5/0655 , C12N5/0665 , C12N2506/1369 , C12N2527/00
摘要： Methods, devices and systems are disclosed for vibration induced tissue engineering. Apparatuses, devices, systems and methods are provided for engineering a tissue from stem cells using vibratory signals. A tissue engineering apparatus, device, or system can include a transmitter configured to transmit a signal to a receiver, a receiver configured to receive a signal from a transmitter, a holding structure configured to hold one or more mesenchymal stem cells (MSC), and a vibratory actuator in communication with the receiver and configured to generate a vibratory signal that is applied to the MSC.
摘要翻译：公开了用于振动诱导组织工程的方法，装置和系统。提供装置，装置，系统和方法，用于使用振动信号从干细胞组织培养。组织工程设备，设备或系统可以包括被配置为向接收机发送信号的发射机，被配置为从发射机接收信号的接收机，被配置为保持一个或多个间充质干细胞（MSC）的保持结构，以及与所述接收器通信并被配置为产生施加到所述MSC的振动信号的振动致动器。

6. 发明申请

WO2014099652A1 COMPOSITIONS AND METHODS FOR TEMPLATING THREE-DIMENSIONAL MINERALIZATION 审中-公开
标题翻译：用于三维矿化的组合物和方法
公开(公告)号：WO2014099652A1
公开(公告)日：2014-06-26
申请号：PCT/US2013/074950
申请日：2013-12-13
申请人： UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL
发明人： SONG, Jie , LIU, Pingsheng
IPC分类号： A61L27/44 , A61L27/38 , A61L27/58 , A61F2/08 , A61F2/28 , A61C13/00
CPC分类号： A61L27/46 , A61C8/0016 , A61L27/3821 , A61L27/427 , A61L27/58 , A61L2430/02 , A61L2430/06 , A61L2430/12 , C08L33/12
摘要： The invention provides novel compositions and methods for three-dimensional mineralization templated by synthetic scaffolds having zwitterionic mediators. The invention enables 3-D mineralization nucleation and growth of minerals in a well-controlled and defined manner. The composite materials prepared by the disclosed methods are cytocompatible and/or biodegradable and are suitable for use as medical implants in a variety of applications in skeletal tissue repair and regeneration. For example, cytocompatible zwitterionic sulfobetaine ligands are employed to facilitate 3-D mineralization of HA across covalently crosslinked hydrogels. The overall charge- neutral zwitterionic hydrogel effectively recruited oppositely charged precursor ions while overcame excessive swelling exhibited by anionic and cationic hydrogels under physiological conditions, resulting in denser and structurally well-integrated mineralized composite materials.
摘要翻译：本发明提供了由具有两性离子介体的合成支架模板化的三维矿化的新型组合物和方法。本发明能够以良好控制和限定的方式实现三维矿化成核和矿物生长。通过公开的方法制备的复合材料是细胞相容性和/或可生物降解的，并且适合用作骨骼组织修复和再生中各种应用中的医学植入物。例如，使用细胞相容的两性离子磺基甜菜碱配体来促进HA通过共价交联的水凝胶的3-D矿化。整个电荷 - 中性的两性离子水凝胶在生理条件下有效地招募了带相反电荷的前体离子，同时克服阴离子和阳离子水凝胶表现出的过度溶胀，导致更致密和结构完全一体化的矿化复合材料。

7. 发明申请

WO2014070796A1 METHODS OF TRANSPLANTING CHONDROCYTES 审中-公开
标题翻译：转运途径的方法
公开(公告)号：WO2014070796A1
公开(公告)日：2014-05-08
申请号：PCT/US2013/067349
申请日：2013-10-29
申请人： SCRIPPS HEALTH
发明人： D'LIMA, Darryl, D. , OLEE, Tsaiwei , COLWELL, Clifford, W.
IPC分类号： A61L27/24 , A61L27/20 , A61L27/56 , A61L27/38
CPC分类号： A61L27/44 , A61L27/26 , A61L27/3817 , A61L27/3821 , A61L27/54 , A61L2300/412 , A61L2300/64 , A61L2430/02 , A61L2430/06 , C08L5/08 , C08L89/06
摘要： Provided are tri-component matrices having collagen, hyaluronan, and chondroitin sulfate. Also provided are processes for producing a tri-component matrix. Additionally, provided are processes for providing cells capable of producing cartilage to a bone or cartilage defects.
摘要翻译：提供具有胶原，透明质酸和硫酸软骨素的三组分基质。还提供了用于生产三组分基质的方法。另外，提供了提供能够产生软骨到骨骼或软骨缺陷的细胞的方法。

8. 发明申请

WO2014033325A1 CELL-BASED ACTIVATION OF DEVITALIZED ENGINEERED GRAFTS FOR TISSUE REPAIR 审中-公开
标题翻译：用于组织修复的基于细胞的工程化植物的活化
公开(公告)号：WO2014033325A1
公开(公告)日：2014-03-06
申请号：PCT/EP2013/068194
申请日：2013-09-03
申请人： UNIVERSITÄTSSPITAL BASEL RECHTSDIENST
发明人： PAPADIMITROPOULOS, Adam , MARTIN, Ivan , TODOROV, Atanas
IPC分类号： A61L27/36 , A61L27/38
CPC分类号： A61L27/3612 , A61L27/3654 , A61L27/3687 , A61L27/3691 , A61L27/3821 , A61L27/3895 , A61L2430/02
摘要： The invention relates to a method for production of a graft for use in a method of connective tissue repair or connective tissue regeneration or connective tissue replacement, characterized by (a) providing a hypertrophic cartilaginous template (HCT), (b) providing a preparation of osteoclast precursor cells, (c) seeding said preparation onto said HCT under conditions of cell culture in the presence of MCSF and RANKL, yielding seeded HCT, and (d) maintaining said seeded HCT under conditions of cell culture for a period of at least 12 hrs. The invention further relates to grafts provided by the method of the invention for repair, regeneration and replacement of connective tissue, particularly bone.
摘要翻译：本发明涉及一种生产用于结缔组织修复或结缔组织再生或结缔组织置换方法的移植物的方法，其特征在于（a）提供增生性软骨模板（HCT），（b）提供破骨细胞前体细胞，（c）在MCSF和RANKL存在下，在细胞培养条件下将所述制剂接种到所述HCT上，产生接种的HCT，和（d）将所述接种的HCT在细胞培养条件下保持至少12 小时。本发明还涉及通过本发明的方法提供的用于修复，再生和替换结缔组织，特别是骨的移植物。

9. 发明申请

WO2013136089A1 POLYMER-GLASS COMPOSITE MATERIAL 审中-公开
标题翻译：聚合物玻璃复合材料
公开(公告)号：WO2013136089A1
公开(公告)日：2013-09-19
申请号：PCT/GB2013/050663
申请日：2013-03-15
申请人： THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH
发明人： BRADLEY, Mark , RABANI, Gouher
IPC分类号： A61L27/38 , A61L27/44 , A61L27/56
CPC分类号： A61L27/56 , A61L27/3817 , A61L27/3821 , A61L27/446 , A61L2430/02 , A61L2430/06 , A61L2430/24 , C08L67/04
摘要： Disclosed is a porous polymer-glass composite material comprising at least 80wt% of a biodegradable polymeric material; and water soluble glass. The polymer-glass composite material may be prepared by porogen leaching, which provides for control over the size and size distributions of the pores. The mechanical properties and biocompatibility of the polymer-glass composite material enables its use as a tissue scaffold, to promote tissue regrowth.
摘要翻译：公开了一种多孔聚合物玻璃复合材料，其包含至少80重量％的可生物降解的聚合物材料; 和水溶性玻璃。聚合物 - 玻璃复合材料可以通过致孔剂浸出来制备，其提供对孔的尺寸和尺寸分布的控制。聚合物 - 玻璃复合材料的机械性能和生物相容性使其能够用作组织支架，以促进组织再生长。

10. 发明申请

WO2012103881A3 IMPLANTABLE BIOLOGICAL JOINT REPLACEMENT 审中-公开
标题翻译：生物可植入联合补充
公开(公告)号：WO2012103881A3
公开(公告)日：2013-02-28
申请号：PCT/DE2012000415
申请日：2012-04-17
申请人： HILDEBRANDT BERNHARD
发明人： HILDEBRANDT BERNHARD
IPC分类号： A61F2/30 , A61F2/34 , A61F2/36 , A61F2/46 , C12M3/00
CPC分类号： A61F2/30756 , A61F2/30749 , A61F2/3094 , A61F2/34 , A61F2/3603 , A61F2/4609 , A61F2002/30448 , A61F2002/30762 , A61F2002/30766 , A61F2002/30878 , A61F2002/3092 , A61F2002/30971 , A61F2002/3401 , A61F2002/4628 , A61F2002/4685 , A61F2002/485 , A61F2002/487 , A61F2310/00011 , A61F2310/00293 , A61F2310/00371 , A61F2310/00982 , A61L27/3612 , A61L27/3817 , A61L27/3821 , A61L27/3843 , A61L27/3891 , A61L2430/24
摘要： The present invention overcomes the problems of conventional mechanical endoprostheses and the drawbacks of current methods of cartilage replacement by making provisions for the production of a complete biological joint replacement. In order to produce a biological joint replacement having hyaline cartilage, which can cope with heavy loads, devices are used for the shaping, the promotion of diffusion and in particular the compression of the joint replacement that is to be produced, i.e. a compression with alternating pressures and eventually a sliding movement of the walker on the surface of the joint replacement. The invention also relates to substances and methods for promoting the formation of hyaline cartilage tissue. The biological joint replacement is currently preferably suited for implantation in the shoulder and the hip, but can also be applied to other joints by using multi-dimensional milling techniques.
摘要翻译：通过提供生产完整的生物关节置换物，本发明克服了传统机械内置假体的问题和以前的软骨置换方法的局限性。为了生产具有透明软骨的可靠的生物关节替代物，使用了提供成形，扩散促进以及尤其是要生产的关节替代物的弯曲的装置，交替施加压力并且步行者可能在关节置换物的表面上滑动。还设想了促进透明软骨组织形成的物质和程序。生物关节置换目前优选用于植入肩和髋，但也可以通过使用多维铣削技术用于其他关节。

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