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1. 发明申请

WO2008076324A3 COMPOSITIONS AND METHODS TO TREAT MUSCULAR & CARDIOVASCULAR DISORDERS 审中-公开
标题翻译：用于治疗肌肉和心脏血管疾病的组合物和方法
公开(公告)号：WO2008076324A3
公开(公告)日：2009-04-09
申请号：PCT/US2007025535
申请日：2007-12-13
申请人： NOVARTIS AG , BEUVINK IWAN , HALL JONATHAN , WEILER JAN , SCHNELL CHRISTIAN , MUELLER MATTHIAS , SCHINKE-BRAUN MARTINA , SERLUCA FABRIZIO
发明人： BEUVINK IWAN , HALL JONATHAN , WEILER JAN , SCHNELL CHRISTIAN , MUELLER MATTHIAS , SCHINKE-BRAUN MARTINA , SERLUCA FABRIZIO
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , C12N2310/113 , C12N2310/141
摘要： The present invention relates to a novel microRNA, mir-208-2, implicated in muscular and cardiovascular disorders. The present invention also relates to oligonucleotide therapeutic agents (antisense oligonucleotides and/or double stranded oligonucleotides such as dsRNA) and their use in the treatment of muscular and cardiovascular disorders resulting from dysregulation of mir-208-2.
摘要翻译：本发明涉及涉及肌肉和心血管疾病的新型微小RNA，mir-208-2。本发明还涉及寡核苷酸治疗剂（反义寡核苷酸和/或双链寡核苷酸，例如dsRNA）及其在治疗由mir-208-2失调导致的肌肉和心血管疾病的用途。

2. 发明申请

WO2008071771A3 INHIBITION OF GPR4 审中-公开
标题翻译： GPR4的抑制
公开(公告)号：WO2008071771A3
公开(公告)日：2008-09-18
申请号：PCT/EP2007063899
申请日：2007-12-13
申请人： NOVARTIS AG , SEUWEN KLAUS , BILLY ERIC , SUPLY THOMAS , WYDER LORENZA , DAWSON KING JANET , LUDWIG MARIE-GABRIELLE , MUELLER MATTHIAS , NATH PUNEETA , JONES CAROL ELIZABETH
发明人： SEUWEN KLAUS , BILLY ERIC , SUPLY THOMAS , WYDER LORENZA , DAWSON KING JANET , LUDWIG MARIE-GABRIELLE , MUELLER MATTHIAS , NATH PUNEETA , JONES CAROL ELIZABETH
IPC分类号： A01K67/027 , A61K48/00 , C12N15/113
CPC分类号： C12N15/1138 , A01K67/0275 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C07K14/723 , C12N15/8509 , C12N2310/14 , G01N2333/726
摘要： The present invention relates to the use of a GPR4 inhibitor for the manufacture of a medicament for the inhibition of angiogenesis, for instance for the inhibition of tumour growth in the treatment of cancer. In a preferred embodiment, said inhibitor is a siRNA, preferably double-stranded. In addition, the present invention further encompasses non-human animals wherein the GPR4 has been inactivated, for instance a knock-out mouse lacking GPR4, and the use of said animals as an experimental model for angiogenesis and for screening for compounds modulating angiogenesis.
摘要翻译：本发明涉及GPR4抑制剂在制备用于抑制血管生成的药物中的用途，例如用于抑制癌症治疗中的肿瘤生长。在一个优选的实施方案中，所述抑制剂是siRNA，优选双链。此外，本发明还包括其中GPR4已失活的非人动物，例如缺乏GPR4的敲除小鼠，以及所述动物作为血管生成的实验模型和筛选调节血管生成的化合物的用途。

3. 发明申请

WO2012049264A3 METHOD FOR PRODUCING FLAME-PROOFED THERMOPLASTIC MOLDING COMPOUNDS 审中-公开
标题翻译：用于生产的阻燃热塑性模塑料
公开(公告)号：WO2012049264A3
公开(公告)日：2013-02-21
申请号：PCT/EP2011067919
申请日：2011-10-13
申请人： BASF SE , MUELLER MATTHIAS , GUENTHERBERG NORBERT
发明人： MUELLER MATTHIAS , GUENTHERBERG NORBERT
IPC分类号： B29C47/00 , B29C47/10
CPC分类号： C08J3/203 , B29C47/0004 , B29C47/0014 , B29C47/0021 , B29C47/1045 , B29C47/1081 , B29C47/38 , B29C47/6087 , B29K2105/0005 , B29K2105/0026 , B29K2995/0016 , B29K2995/0059 , C08K7/24
摘要： The invention relates to a method for producing thermoplastic molding compounds, comprising: A) 40 to 99 wt % of at least one thermoplastic polymer, B) 1 to 60 wt % of a flame-proofing agent component containing an expandable graphite, and C) 0 to 60 wt % of further additives, by melt-mixing components A), B) and C) in a screw-type extruder, wherein the screw-type extruder, along the feed direction, comprises, in the following order, at least one dosing zone, a plastifying zone, a homogenizing zone, a second dosing zone, and a discharge zone, in that the dosing takes place into the screw-type extruder having the length L, wherein the length L is defined as the section starting with the first dosing unit for adding components A, B and/or C and ending, in the feed direction, at the discharge opening, a melt is generated after adding components A, B and C in the range of 0 liter to 0.15 liter in a first method step in the presence of component B1), and in a second method step, after the addition of component B1) in the range of 0.5 liter to 0.95 liter, component B1) is mixed into said melt, wherein said method offers technical advantages.
摘要翻译：一种制备热塑性模塑组合物的方法，包括：从40 A）至99重量％的至少一种热塑性聚合物的％，B）1至60重量阻燃剂％的组分，其包括可膨胀石墨，和C）0至60重量的其它添加剂的％由组分a）的熔融混合包括的，B）和C）在螺杆挤出机，其中，沿着以该顺序输送方向的螺杆挤出机中的至少一个计量区，塑化区，均化区域，第二计量区，并通过所述剂量在放电区螺杆挤出机的长度L，其中，所述长度L被定义为距离起点从所述第一计量装置用于加入组分A，B和/或C的并在所述出口开口终了的输送方向，在加入组分A，B和C的后在不存在组分B1的第一工艺步骤）的熔体在0 L至0.15 L，未范围产生 D IN的第二工艺步骤中，除了组分B1）在0.5升〜0.95 L中的组分B1混合）的范围内后在该熔体中进行，提供了技术优势。

4. 发明申请

WO2008071392A3 APPARATUS AND METHOD FOR ENERGY RECOVERY 审中-公开
标题翻译：用于能量回收的设备和方法
公开(公告)号：WO2008071392A3
公开(公告)日：2008-10-16
申请号：PCT/EP2007010817
申请日：2007-12-11
申请人： BOSCH GMBH ROBERT , MUELLER MATTHIAS , SCHMUTTERMAIR PETER
发明人： MUELLER MATTHIAS , SCHMUTTERMAIR PETER
IPC分类号： B60T1/10 , B60T10/04
CPC分类号： B60T1/10 , B60K6/12 , B60T17/04 , Y02T10/6208 , Y02T10/92
摘要： The invention relates to an apparatus for energy recovery. The apparatus comprises a hydrostatic machine (2) and at least one hydraulic storage means (35). The hydraulic storage means (35) is connected to the hydrostatic machine (2) via a working line (3). A valve device (100) is provided for influencing the volumetric flow in the working line (3) between the hydraulic storage means (35) and the hydrostatic machine (2). The valve device (100) comprises a brake pressure regulating valve unit (13) with a valve (5) and a pilot valve unit (14) which acts on the valve (5) with a control pressure. The invention also relates to a method for controlling the apparatus for energy recovery. In order to store released energy, a required braking torque is determined by a control electronics system. The volume from the hydrostatic piston machine (2) into the working line (3) is increased and the pilot valve (14) is actuated by the control electronics system such that the valve (5) is moved towards its open position.
摘要翻译：本发明涉及一种能量回收装置。该装置包括静液压机（2）和至少一个液压蓄能器（35）。通过工作管路（3），液压蓄能器（35）连接到静液压机械（2）。用于影响工作管路（3）中的体积流量的阀装置（100）设置在液压蓄能器（35）和静液压机械（2）之间。阀装置（100）包括具有阀（5）的制动压力调节阀单元（13）和以控制压力作用于阀（5）的导阀单元（14）。此外，本发明涉及用于控制能量回收装置的方法。为了存储释放的能量，要求的制动转矩由控制电子设备确定。在工作线（3）静压活塞发动机（2）的体积增大，并且先导阀（14），以便通过所述阀（5）朝其打开位置移动的控制电子设备的控制。

5. 发明申请

WO2007102845A3 METHOD OF SIMULATING DYNAMIC OBJECTS USING POSITION BASED DYNAMICS 审中-公开
标题翻译：利用位置动力学模拟动态目标的方法
公开(公告)号：WO2007102845A3
公开(公告)日：2007-11-01
申请号：PCT/US2006036514
申请日：2006-09-19
申请人： AGEIA TECHNOLOGIES INC , MUELLER MATTHIAS , HEIDELBERGER BRUNO , HENNIX MARCUS
发明人： MUELLER MATTHIAS , HEIDELBERGER BRUNO , HENNIX MARCUS
IPC分类号： G06T13/00
CPC分类号： G06T13/00
摘要： Disclosed is a method of simulating a dynamic object comprising a plurality of vertices. The method comprises defining a current position and a current velocity for a vertex "v" among the plurality of vertices, generating an estimated next position for vertex "v" based on the current position and current velocity, updating the estimated next position based on a plurality of constraints, and after updating the estimated next position, computing a next position and a next velocity for vertex "v" based on the current position and estimated next position.
摘要翻译：公开了一种模拟包括多个顶点的动态对象的方法。该方法包括定义多个顶点中的顶点“v”的当前位置和当前速度，基于当前位置和当前速度生成顶点“v”的估计下一个位置，基于多个约束，并且在更新估计的下一个位置之后，基于当前位置和估计的下一个位置计算顶点“v”的下一个位置和下一个速度。

6. 发明申请

WO2008049635A3 HYDROSTATIC DRIVE WITH BRAKING ENERGY RECOVERY FEATURE 审中-公开
标题翻译：带有制动能量回收静液压传动装置
公开(公告)号：WO2008049635A3
公开(公告)日：2008-06-12
申请号：PCT/EP2007009327
申请日：2007-10-26
申请人： BOSCH GMBH ROBERT , MUELLER MATTHIAS
发明人： MUELLER MATTHIAS
IPC分类号： B60K6/12
CPC分类号： B60K6/12 , F16H61/4017 , F16H61/4096 , F16H61/4148 , F16H61/4157 , Y02T10/6208
摘要： The invention relates to a hydrostatic drive (1) in an open circuit. The hydrostatic drive (1) comprises a hydraulic pump (2) and a hydraulic motor (3). The hydraulic pump (2) and the hydraulic motor (3) are connected to one another via a feed line (4). In addition, the hydrostatic drive (1) comprises a storage element (18) for storing pressure energy. A first valve device (17) which is arranged downstream of the hydraulic motor (3) alternately connects the downstream connection (9) of the hydraulic motor (3) to a tank volume (15) or to the storage element (18).
摘要翻译：本发明涉及一种在开路的静液压驱动器（1）。静液压传动装置（1）包括液压泵（2）和液压马达（3）。液压泵（2）和经由进料管线的液压马达（3）（4）彼此连接。此外，静液压传动装置（1）包括用于存储压力能量存储元件（18）。装置设置在所述液压马达的下游（3）第一阀装置（17），液压马达（3）的下游端（9）交替地连接到罐的容积（15）或存储器元件（18）。

7. 发明申请

WO2006111358A3 SECURITY ELEMENT HAVING A SPATIALLY RESOLVED MAGNETIC CODING, METHOD AND DEVICE FOR PRODUCING THE SAME AND THE USE THEREOF 审中-公开
标题翻译：具有空间释放磁性编码的安全元件，其制造方法和装置及其使用
公开(公告)号：WO2006111358A3
公开(公告)日：2006-12-07
申请号：PCT/EP2006003544
申请日：2006-04-19
申请人： HUECK FOLIEN GMBH , ZOISTER STEFAN , MUELLER MATTHIAS , BERGSMANN MARTIN
发明人： ZOISTER STEFAN , MUELLER MATTHIAS , BERGSMANN MARTIN
IPC分类号： B42D15/10
CPC分类号： B42D25/369 , B42D25/00 , B42D25/24 , B42D25/29 , B42D25/47 , B42D2033/16 , G06K19/06196
摘要： The invention relates to a security element or film materials for data carriers, valuable documents, packings and the like, which comprises a magnetic coding that is produced in situ. The invention also relates to a method and a device for producing the magnetic coding in situ.
摘要翻译：本发明涉及用于数据载体，有价文件，包装等的安全元件或膜材料，其具有原位产生的磁性编码。还描述了用于现场生产磁性编码的方法和设备。

8. 发明申请

WO2006097800A2 METHOD AND DEVICE FOR DETERMINING MATERIAL PROPERTIES 审中-公开
标题翻译：用于确定材料性质的方法和装置
公开(公告)号：WO2006097800A2
公开(公告)日：2006-09-21
申请号：PCT/IB2006000274
申请日：2006-02-10
申请人： UNIV KARLSRUHE TH FORSCHUNGSUN , SCHIMMEL THOMAS , MUELLER MATTHIAS
发明人： SCHIMMEL THOMAS , MUELLER MATTHIAS
IPC分类号： G01Q10/00 , G01Q60/24 , G01Q60/26 , G01Q60/28
CPC分类号： G01Q60/26 , G01Q60/28
摘要： A method of determining material properties of a contact formed between a measurement tip (3) of a microscopic probe (2) and a sample surface (7) of a sample material (6). According to the method, a distance modulation (DM) is applied for modulating a distance (d) between a support (4) of the microscopic probe (2) end the sample surface (7) in a direction (z) essentially normal to the sample surface (7) and wherein a normal force signal indicative of a normal force is measured and demodulated. In said method it is proposed that said material properties be determined using measurement data comprised in the demodulated normal force signal and related to a (concave) buckling deformation of the microscopic probe (2) relative to and away from the sample surface (7).
摘要翻译：确定在微观探针（2）的测量端（3）和样品材料（6）的样品表面（7）之间形成的接触材料性质的方法。根据该方法，施加距离调制（DM）以在基本上垂直于样品表面（7）的方向（z）处调制位于样品表面（7）的微观探针（2）的支撑体（4）之间的距离（d）样品表面（7），并且其中测量和解调表示法向力的法向力信号。在所述方法中，建议使用包含在解调的法向力信号中并与微观探针（2）相对于和远离样品表面（7）的（凹））屈曲变形相关的测量数据来确定所述材料特性。

9. 发明申请

WO2005021192A8 DIE CONSISTING OF PCBN OR A CBN COMPOSITE MATERIAL COMPRISING A CLAMPING DEPRESSION 审中-公开
标题翻译：切板或AN PCBN复合CBN使用SPAN公路
公开(公告)号：WO2005021192A8
公开(公告)日：2006-08-31
申请号：PCT/EP2004009411
申请日：2004-08-23
申请人： CERAMTEC AG , HAFNER ANDREAS , WEBER WERNER , MUELLER MATTHIAS
发明人： HAFNER ANDREAS , WEBER WERNER , MUELLER MATTHIAS
IPC分类号： B23B27/16 , B23B27/14 , B23C5/22
CPC分类号： B23B27/145 , B23B2200/088 , B23B2226/125 , Y10T428/24479
摘要： The invention relates to a die consisting of PCBN or a CBN composite material. To fix the die in a tool holder, said die comprises a clamping depression. The die is suitable for machining metals.
摘要翻译：本发明涉及从PCBN或CBN复合材料制成的切割板。对于在夹紧夹具切割板的牢固的附接被克服-，所述切割板具有夹紧槽。所述插入件适合于金属材料的加工。

10. 发明申请

WO2006030030A2 SYSTEM FOR THE SEQUENTIAL, TRANSDERMAL ADMINISTRATION OF SYSTEMICALLY ACTIVE SUBSTANCES 审中-公开
标题翻译：系统对于顺序，全身活性物质透皮给药
公开(公告)号：WO2006030030A2
公开(公告)日：2006-03-23
申请号：PCT/EP2005054634
申请日：2005-09-16
申请人： GRUENENTHAL GMBH , MUELLER MATTHIAS , KRAUS ALEXANDER , PAQUES ERIC-PAUL
发明人： MUELLER MATTHIAS , KRAUS ALEXANDER , PAQUES ERIC-PAUL
IPC分类号： A61K9/70
CPC分类号： A61K9/7023
摘要： The invention relates to a system for the sequential, transdermal administration of systemically active substances. Said system comprises at least one sub-unit, from which a therapeutic dose of a systemically active substance can be released and at least one sub-unit, from which a maximum three-quarters of said dose of a systemically active substance can be released. The invention also relates to a therapy scheme for the transdermal administration of systemically active substances, in particular, analgesics.
摘要翻译：本发明涉及一种用于连续的系统中，包括至少一个子单元，从其中全身性活性物质的治疗剂量可以被释放，并且至少一个子单元可释放的从最大的全身性活性物质的这些治疗剂量的四分之三全身活性物质的经皮给药是，以及用于全身性活性物质，尤其是止痛药的经皮给药的治疗方案。

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