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1. 发明申请

WO2006019764A3 SYSTEMS AND METHODS FOR ENHANCING OR AFFECTING NEURAL STIMULATION EFFICIENCY AND/OR EFFICACY 审中-公开
标题翻译：用于增强或影响神经刺激效率和/或功效的系统和方法
公开(公告)号：WO2006019764A3
公开(公告)日：2006-12-07
申请号：PCT/US2005024766
申请日：2005-07-15
申请人： NORTHSTAR NEUROSCIENCE INC , GLINER BRADFORD , WYLER ALLEN , FOWLER BRAD , SHEFFIELD DOUGLAS W , KUNTZ RICHARD , LEYDE KENT
发明人： GLINER BRADFORD , WYLER ALLEN , FOWLER BRAD , SHEFFIELD DOUGLAS W , KUNTZ RICHARD , LEYDE KENT
IPC分类号： A61N1/06
CPC分类号： A61N1/36135 , A61N1/0531 , A61N1/0534 , A61N1/3606 , A61N1/36064 , A61N1/36067 , A61N1/36082 , A61N1/36103 , A61N1/36146 , A61N1/37252
摘要： Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy are disclosed. In one embodiment, a system and/or method may apply electromagnetic stimulation to a patient's nervous system over a first time domain according to a first set of stimulation parameters, and over a second time domain according to a second set of stimulation parameters. The first and second time domains may be sequential, simultaneous, or nested. Stimulation parameters may vary in accordance with one or more types of duty cycle, amplitude, pulse repetition frequency, pulse width, spatiotemporal, and/or polarity variations. Stimulation may be applied at subthreshold, threshold, and/or suprathreshold levels in one or more periodic, aperiodic (e.g., chaotic), and/or pseudo-random manners. In some embodiments stimulation may comprise a burst pattern having an interburst frequency corresponding to an intrinsic brainwave frequency, and regular and/or varying intraburst stimulation parameters. Stimulation signals providing reduced power consumption with at least adequate symptomatic relief may be applied prior to moderate or significant power source depletion.
摘要翻译：公开了用于增强或影响神经刺激效率和/或功效的系统和方法。在一个实施例中，系统和/或方法可以根据第一组刺激参数在第一时域上将电磁刺激应用于患者的神经系统，并且根据第二组刺激参数在第二时域上应用电磁刺激。第一和第二时间域可以是顺序的，同时的或嵌套的。刺激参数可以根据一种或多种类型的占空比，幅度，脉冲重复频率，脉冲宽度，时空和/或极性变化而变化。刺激可以以一个或多个周期性，非周期性（例如混沌）和/或伪随机方式在亚阈值，阈值和/或超阈值水平应用。在一些实施例中，刺激可以包括具有对应于内在脑波频率的内爆频率的突发模式，以及规则和/或变化的内爆刺激参数。在适度或显着的电源耗尽之前可以应用提供至少充分症状缓解的减少功率消耗的刺激信号。

2. 发明申请

WO2004066820A3 SYSTEMS AND METHODS FOR REDUCING THE LIKELIHOOD OF INDUCING COLLATERAL NEURAL ACTIVITY DURING NEURAL STIMULATION THRESHOLD TEST PROCEDURES 审中-公开
标题翻译：在神经刺激阈值测试程序期间减少感染性神经活动的兴趣的系统和方法
公开(公告)号：WO2004066820A3
公开(公告)日：2005-07-07
申请号：PCT/US2004002251
申请日：2004-01-26
申请人： NORTHSTAR NEUROSCIENCE INC , GLINER BRADFORD EVAN , LEYDE KENT
发明人： GLINER BRADFORD EVAN , LEYDE KENT
IPC分类号： A61B20060101 , A61N1/05 , A61N1/18 , A61N1/34 , A61N1/36 , A61N1/375
CPC分类号： A61N1/0534 , A61N1/0531 , A61N1/0551 , A61N1/0553 , A61N1/36017 , A61N1/36025 , A61N1/36071 , A61N1/36082 , A61N1/36185 , A61N1/375 , A61N1/3756 , A61N1/3787
摘要： Test procedures for determining a neural stimulation threshold of a patient. In one embodiment, the procedure includes applying a test stimulation signal to the patient and monitoring the patient for a response to the test stimulation signal. The procedure can further include determining a first neural stimulation threshold and calculating a second neural stimulation threshold. The first neural stimulation threshold corresponds to the lowest intensity test stimulation signal that evokes a patient response. The second neural stimulation threshold corresponds to a treatment stimulation signal directed toward affecting a neural activity within the patient.
摘要翻译：用于确定患者的神经刺激阈值的测试程序。在一个实施例中，该过程包括将测试刺激信号应用于患者并监测患者对测试刺激信号的响应。该过程还可以包括确定第一神经刺激阈值并计算第二神经刺激阈值。第一神经刺激阈值对应于唤起患者反应的最低强度测试刺激信号。第二神经刺激阈值对应于针对影响患者内的神经活动的治疗刺激信号。

3. 发明申请

WO2008052082A3 FREQUENCY SHIFT KEYING (FSK) MAGNETIC TELEMETRY SYSTEM FOR IMPLANTABLE MEDICAL DEVICES AND ASSOCIATED SYSTEMS AND METHODS 审中-公开
标题翻译：用于可移植医疗设备和相关系统和方法的频移键控（FSK）磁电报系统
公开(公告)号：WO2008052082A3
公开(公告)日：2008-06-19
申请号：PCT/US2007082438
申请日：2007-10-24
申请人： NORTHSTAR NEUROSCIENCE INC , LEYDE KENT , BLAND MICHAEL
发明人： LEYDE KENT , BLAND MICHAEL
IPC分类号： G11B5/00
CPC分类号： G01D21/00 , A61B5/0031
摘要： A telemetry receive unit for use in an implantable medical device or system can include a coil unit, a single-bit analog to digital converter (ADC), a finite impulse response filter (FIR) coupled to the single-bit ADC, and an accumulator coupled to one or more filter taps of the FIR filter. The accumulator, in operation, can produce one or more data recognition signals corresponding to sampled bits at least temporarily stored at the FIR filter. In several examples, the data recognition signals discriminate between frequency modulated signals that are received at the coil unit, including frequency shift keying (FSK) modulated signals.
摘要翻译：用于可植入医疗设备或系统的遥测接收单元可以包括线圈单元，单比特模数转换器（ADC），耦合到单比特ADC的有限脉冲响应滤波器（FIR）和累加器耦合到FIR滤波器的一个或多个滤波器抽头。在操作中，累加器可以产生一个或多个对应于至少临时存储在FIR滤波器的采样位的数据识别信号。在几个示例中，数据识别信号区分在线圈单元接收的频率调制信号，包括频移键控（FSK）调制信号。

4. 发明申请

WO2005002665A3 APPARATUSES AND SYSTEMS FOR APPLYING ELECTRICAL STIMULATION TO A PATIENT 审中-公开
标题翻译：将电刺激应用于患者的装置和系统
公开(公告)号：WO2005002665A3
公开(公告)日：2005-06-02
申请号：PCT/US2004020786
申请日：2004-06-28
申请人： NORTHSTAR NEUROSCIENCE INC , GENAU CHRIS , LEYDE KENT , MIAZGA JAY , STERN CORINNE J
发明人： GENAU CHRIS , LEYDE KENT , MIAZGA JAY , STERN CORINNE J
IPC分类号： A61N20060101 , A61N1/05 , A61N1/08 , A61N1/36
CPC分类号： A61N1/0531 , A61N1/0539 , A61N1/0551 , A61N1/3605 , A61N1/36082
摘要： Apparatus and systems for applying electrical stimulation to a site on a patient. In one embodiment, an implantable electrode assembly includes an electrode array carried by a flexible support member. The electrode array can include a first plurality of electrodes spaced apart from a second plurality of electrodes. The first plurality of electrodes can be connected to a first lead line, and the second plurality of electrodes can be similarly connected to a second lead line. The first and second lead lines can be housed in a cable extending away from the support member.
摘要翻译：将电刺激施加到患者的部位上的装置和系统。在一个实施例中，可植入电极组件包括由柔性支撑构件承载的电极阵列。电极阵列可以包括与第二多个电极间隔开的第一多个电极。第一多个电极可以连接到第一引线，并且第二多个电极可以类似地连接到第二引线。第一引线和第二引线可以容纳在远离支撑构件的电缆中。

5. 发明申请

WO03026734A3 METHOD AND APPARATUS FOR SECURING AND/OR IDENTIFYING A LINK TO A PERCUTANEOUS PROBE 审中-公开
标题翻译：用于保护和/或识别与胰腺探针的连接的方法和装置
公开(公告)号：WO03026734A3
公开(公告)日：2003-08-14
申请号：PCT/US0231169
申请日：2002-09-27
申请人： VERTIS NEUROSCIENCE INC , LEYDE KENT , HARRIS JOHN F , LEONARD PAUL C , GLINER BRADFORD EVAN
发明人： LEYDE KENT , HARRIS JOHN F , LEONARD PAUL C , GLINER BRADFORD EVAN
IPC分类号： A61B5/05 , A61H39/00 , A61H39/08 , A61N20060101 , A61N1/00 , A61N1/05 , A61N1/08 , A61N1/18 , A61N1/36
CPC分类号： A61N1/08 , A61N1/0551 , A61N1/36114
摘要： A method and apparatus for administering percutaneous electrical therapy to a recipient. The apparatus can include an electrical coupler having a coupling member configured to be removably positioned at least proximate to a percutaneous probe. The coupling member canbe coupleable to a source of therapeutic electrical signals via a therapeutic signal transmission link to transmit the therapeutic electrical signals to the recipient. The apparatus can further include a status signal transmission link at least proximate to the therapeutic signal transmission link and coupleable to a status signal emitter. The status signal transmission link can be at leasttamper-resistant and/or tamper-evident, and can be configured to transmit a status signal having a first characteristic value when the status signal transmission link is in a first condition and asecond characteristic value when the status signal transmission link has been altered from a first condition to a second condition.
摘要翻译：一种用于向接受者施用经皮电疗法的方法和装置。该装置可以包括具有耦合构件的电耦合器，该耦合构件构造成可移除地定位成至少靠近经皮探针。耦合构件可以通过治疗信号传输链路耦合到治疗电信号源，以将治疗电信号传送到接收者。该装置还可以包括至少靠近治疗信号传输链路并可耦合到状态信号发射器的状态信号传输链路。状态信号传输链路可以是至少防篡改和/或防篡改的，并且可以被配置为当状态信号传输链路处于第一状态时发送具有第一特征值的状态信号，并且当状态信号传输链路的状态信号传输链路已经从第一状态改变到第二状态。

6. 发明申请

WO03026735A3 METHOD AND APPARATUS FOR CONTROLLING PERCUTANEOUS ELECTRICAL SIGNALS 审中-公开
标题翻译：用于控制经皮电信号的方法和设备
公开(公告)号：WO03026735A3
公开(公告)日：2003-08-21
申请号：PCT/US0231176
申请日：2002-09-27
申请人： VERTIS NEUROSCIENCE INC , LEYDE KENT , BISHAY JON M , HARRIS JOHN F
发明人： LEYDE KENT , BISHAY JON M , HARRIS JOHN F
IPC分类号： A61H39/04 , A61N1/08 , A61N1/32 , A61N1/34
CPC分类号： A61N1/36021 , A61N1/08 , A61N1/37247
摘要： Methods and apparatuses for controlling percutaneous electrical signals. In one embodiment,the method can include a computer-implemented method for displaying characteristics of an electrical therapy signal, which can include receiving a first value for a characteristic of an electrical therapy signal and directing transmission of a first electrical therapy signal with the first value. The method can further include directing a digital display device to display a first graph representing the first value, receiving a second value for the characteristic, directing transmission of a second electrical therapy signal with the second value, and directing the digital display device to display a second graph concurrent with a display of the first graph. The apparatus can simultaneously control signal levels directed to multiple channels, and can automatically set the signal levels to zero when a therapy session is ended or paused.
摘要翻译：用于控制经皮电信号的方法和设备。在一个实施例中，该方法可以包括用于显示电疗信号的特性的计算机实现的方法，该方法可以包括：接收电疗信号的特性的第一值并且指示第一电疗信号的发送具有第一值。该方法可以进一步包括引导数字显示设备显示表示第一值的第一图形，接收该特征的第二值，引导具有第二值的第二电疗信号的传输，并且引导数字显示设备显示第二图与第一图的显示同时发生。该装置可以同时控制针对多个通道的信号水平，并且可以在治疗期结束或暂停时自动将信号水平设置为零。

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