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1. 发明申请

WO2006019764A3 SYSTEMS AND METHODS FOR ENHANCING OR AFFECTING NEURAL STIMULATION EFFICIENCY AND/OR EFFICACY 审中-公开
标题翻译：用于增强或影响神经刺激效率和/或功效的系统和方法
公开(公告)号：WO2006019764A3
公开(公告)日：2006-12-07
申请号：PCT/US2005024766
申请日：2005-07-15
申请人： NORTHSTAR NEUROSCIENCE INC , GLINER BRADFORD , WYLER ALLEN , FOWLER BRAD , SHEFFIELD DOUGLAS W , KUNTZ RICHARD , LEYDE KENT
发明人： GLINER BRADFORD , WYLER ALLEN , FOWLER BRAD , SHEFFIELD DOUGLAS W , KUNTZ RICHARD , LEYDE KENT
IPC分类号： A61N1/06
CPC分类号： A61N1/36135 , A61N1/0531 , A61N1/0534 , A61N1/3606 , A61N1/36064 , A61N1/36067 , A61N1/36082 , A61N1/36103 , A61N1/36146 , A61N1/37252
摘要： Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy are disclosed. In one embodiment, a system and/or method may apply electromagnetic stimulation to a patient's nervous system over a first time domain according to a first set of stimulation parameters, and over a second time domain according to a second set of stimulation parameters. The first and second time domains may be sequential, simultaneous, or nested. Stimulation parameters may vary in accordance with one or more types of duty cycle, amplitude, pulse repetition frequency, pulse width, spatiotemporal, and/or polarity variations. Stimulation may be applied at subthreshold, threshold, and/or suprathreshold levels in one or more periodic, aperiodic (e.g., chaotic), and/or pseudo-random manners. In some embodiments stimulation may comprise a burst pattern having an interburst frequency corresponding to an intrinsic brainwave frequency, and regular and/or varying intraburst stimulation parameters. Stimulation signals providing reduced power consumption with at least adequate symptomatic relief may be applied prior to moderate or significant power source depletion.
摘要翻译：公开了用于增强或影响神经刺激效率和/或功效的系统和方法。在一个实施例中，系统和/或方法可以根据第一组刺激参数在第一时域上将电磁刺激应用于患者的神经系统，并且根据第二组刺激参数在第二时域上应用电磁刺激。第一和第二时间域可以是顺序的，同时的或嵌套的。刺激参数可以根据一种或多种类型的占空比，幅度，脉冲重复频率，脉冲宽度，时空和/或极性变化而变化。刺激可以以一个或多个周期性，非周期性（例如混沌）和/或伪随机方式在亚阈值，阈值和/或超阈值水平应用。在一些实施例中，刺激可以包括具有对应于内在脑波频率的内爆频率的突发模式，以及规则和/或变化的内爆刺激参数。在适度或显着的电源耗尽之前可以应用提供至少充分症状缓解的减少功率消耗的刺激信号。

2. 发明申请

WO2006053143A3 ELECTRICAL TREATMENT OF MOVEMENT DISORDERS 审中-公开
标题翻译：电动治疗运动障碍
公开(公告)号：WO2006053143A3
公开(公告)日：2007-04-26
申请号：PCT/US2005040777
申请日：2005-11-10
申请人： NORTHSTAR NEUROSCIENCE INC , WYLER ALLEN , FOWLER BRAD
发明人： WYLER ALLEN , FOWLER BRAD
IPC分类号： A61N1/00
CPC分类号： A61N1/36067 , A61N1/0531 , A61N1/0534
摘要： Methods and systems for treating movement disorders are disclosed. A method in accordance with one embodiment can include determining that the movement disorder affects the patient's gait, oral functioning, and/or other functioning, and applying electrical stimulation proximate to the interhemispheric fissure, the Sylvian fissure, or between the two fissures, respectively. In another embodiment, the method can include selecting at least one neural process from among a plurality of processes sequentially carried out by a patient to cause a muscle movement in the patient (e.g., a planning process, an initiation process, and an execution process), and applying electrical stimulation to a location of the patient's brain associated with the at least one neural process.
摘要翻译：公开了用于治疗运动障碍的方法和系统。根据一个实施例的方法可以包括确定运动障碍影响患者的步态，口腔功能和/或其他功能，以及分别在大脑间裂隙，西尔维亚裂缝或两个裂缝之间施加电刺激。在另一个实施例中，该方法可以包括从由患者依次执行的多个进程中选择至少一个神经过程以引起患者的肌肉运动（例如，计划过程，发起过程和执行过程）并且将电刺激施加到与所述至少一个神经过程相关联的患者脑部的位置。

3. 发明申请

WO2007047854A2 METHODS AND SYSTEMS FOR ESTABLISHING PARAMETERS FOR NEURAL STIMULATION 审中-公开
标题翻译：用于建立神经刺激参数的方法和系统
公开(公告)号：WO2007047854A2
公开(公告)日：2007-04-26
申请号：PCT/US2006040910
申请日：2006-10-18
申请人： NORTHSTAR NEUROSCIENCE INC , WYLER ALLEN , GLINER BRADFORD EVAN , SLOAN LEIF R
发明人： WYLER ALLEN , GLINER BRADFORD EVAN , SLOAN LEIF R
IPC分类号： A61N1/18
CPC分类号： A61N1/36082 , A61N1/0531 , A61N1/0534 , A61N1/0539
摘要： Methods and systems for establishing parameters for neural stimulation are disclosed. A method in accordance with one embodiment includes applying a first stimulus to a first neural population associated with a first neural function, using a first set of stimulation parameters. The method can further include detecting a response to the first stimulus at least proximate to the patient's central nervous system and, based at least in part on the response to the first stimulus and on the first set of stimulation parameters, applying a second stimulus to a second neural population. The second neural population can be associated with a second neural function different than the first neural function and can be stimulated using a second set of stimulation parameters. In a further embodiment, evidence of a neural activity can be detected at the patient's central nervous system, and electromagnetic stimulation of a target neural population at the patient's central nervous system can be automatically triggered, based at least in part on the detected evidence.
摘要翻译：公开了建立神经刺激参数的方法和系统。根据一个实施例的方法包括使用第一组刺激参数将第一刺激应用于与第一神经功能相关联的第一神经群体。该方法还可以包括至少接近患者的中枢神经系统检测对第一刺激的响应，并且至少部分地基于对第一刺激的响应和第一组刺激参数，对第一刺激施加第二刺激第二神经人群。第二神经群体可以与不同于第一神经功能的第二神经功能相关联，并且可以使用第二组刺激参数来刺激。在另一实施例中，可以在患者的中枢神经系统处检测到神经活动的证据，并且至少部分地基于检测到的证据，可以自动触发患者中枢神经系统上的目标神经群体的电磁刺激。

4. 发明申请

WO2007047853A2 METHODS AND SYSTEMS FOR IMPROVING NEURAL FUNCTIONING, INCLUDING COGNITIVE FUNCTIONING AND NEGLECT DISORDERS 审中-公开
标题翻译：用于改善神经功能的方法和系统，包括认知功能和忽视病症
公开(公告)号：WO2007047853A2
公开(公告)日：2007-04-26
申请号：PCT/US2006040909
申请日：2006-10-18
申请人： NORTHSTAR NEUROSCIENCE INC , WYLER ALLEN , GLINER BRAFORD EVAN
发明人： WYLER ALLEN , GLINER BRAFORD EVAN
IPC分类号： A61N1/39
CPC分类号： A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/36082
摘要： Methods and systems for improving neural functioning, including cognitive functioning and neglect disorders, are disclosed. A method for treating a patient in accordance with one embodiment of the invention includes applying electrical stimulation beneath a patient's skull to improve neuropsychological functioning of the patient, and, after applying the electrical stimulation, evaluating the functioning of the patient. The method can further include a process based at least in part on results of the evaluation, with the process including maintaining and/or changing at least one parameter in accordance with which the electrical stimulation is applied, and/or ceasing to apply the electrical stimulation. Accordingly, aspects of the foregoing methods can be used to improve functioning in normal patients and/or patients suffering from disorders such as cognitive disorders.
摘要翻译：公开了用于改善神经功能的方法和系统，包括认知功能和忽视障碍。根据本发明的一个实施例的用于治疗患者的方法包括在患者颅骨下施加电刺激以改善患者的神经心理功能，并且在施加电刺激之后评估患者的功能。该方法可以进一步包括至少部分基于评估结果的过程，其中该过程包括维持和/或改变至少一个参数，根据该参数施加电刺激，和/或停止施加电刺激。因此，前述方法的各方面可用于改善正常患者和/或患有诸如认知障碍之类的疾病的患者的功能。

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