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1. 发明申请

WO2012057851A2 DIAGNOSIS AND THERAPY OF BIGEMINY AND FREQUENT PREMATURE CONTRACTIONS 审中-公开
标题翻译： BIGEMINY和FREQUEST PREMATURE合同的诊断和治疗
公开(公告)号：WO2012057851A2
公开(公告)日：2012-05-03
申请号：PCT/US2011/033577
申请日：2011-04-22
申请人： MEDTRONIC, INC. , CORBUCCI, Giorgio , BECKERS, Frank , RIEGER, Guido, H.
发明人： CORBUCCI, Giorgio , BECKERS, Frank , RIEGER, Guido, H.
IPC分类号： A61N1/365 , A61B5/0402
CPC分类号： A61B5/0468 , A61B5/0031 , A61B5/02405 , A61B5/0245 , A61N1/3622 , A61N1/3624 , A61N1/3702 , A61N1/3925 , A61N1/395 , A61N1/3962
摘要： The disclosure describes techniques for diagnosing premature contractions of a patient's heart. This system may differentiate premature atrial contractions (PACs) and premature ventricular contractions (PVCs) from atrial fibrillation by identifying changes in R-wave intervals, i.e., R-R intervals, on a Lorenz plot, measuring a coupling interval between R-waves, and analyzing a morphology of the premature contractions, e.g., the QRS complex. These techniques may also identify when severe premature contractions, or bigeminy, are present. In response to the type of premature contractions detected, the system may alert a user of the premature contractions and/or deliver cardiac pacing at an increased pacing rate to eliminate the abnormal intrinsic contractions. The system may also adjust the pacing rate and pacing rate duration for persistent premature contractions.
摘要翻译：本公开描述了用于诊断患者心脏的过早收缩的技术。该系统可以通过在Lorenz图上识别R波间隔（即RR间隔）的变化，测量R波之间的耦合间隔和分析来区分早产性心房收缩（PAC）和早产性心室收缩（PVCs）与房颤早期收缩的形态，例如QRS综合征。这些技术还可以确定何时存在严重的过早收缩或大量收缩。响应于检测到的过早收缩的类型，系统可以提醒用户过早收缩和/或以增加的起搏速率递送心脏起搏以消除异常内在收缩。该系统还可以调整持续性早产收缩的起搏速率和起搏速率持续时间。

2. 发明申请

WO2004093986A1 CARDIAC RESYNCHRONIZATION VIA LEFT VENTRICULAR PACING 审中-公开
标题翻译：通过左心室通气进行心脏再生
公开(公告)号：WO2004093986A1
公开(公告)日：2004-11-04
申请号：PCT/US2004/011244
申请日：2004-04-09
申请人： MEDTRONIC, INC. , CORBUCCI, Giorgio
发明人： CORBUCCI, Giorgio
IPC分类号： A61N1/368
CPC分类号： A61N1/368
摘要： The invention is directed to synchronizing delivery of pacing pulses to the left ventricle (22) with intrinsic right ventricular depolarizations. An interval between an atrial depolarization and an intrinsic right or left ventricular depolarization (134) is measured. A said plurality of left ventricular pacing intervals are tested and may be around said measured interval (134). One of the pacing intervals is selected (140) based on a measured characteristic of an electrogram that indicates ventricular synchrony such as QRS complex widths (116) and/or Q-T intervals (128). The implantable medical device (16) paces the left ventricle (22) based on the selected pacing interval (140).
摘要翻译：本发明涉及使具有固有右心室去极化的起搏脉冲同步到左心室（22）的递送。测量心房去极化与内在的右心室或左心室去极化之间的间隔（134）。测试所述多个左心室起搏间隔并且可以在所述测量间隔周围（134）。基于指示诸如QRS复杂宽度（116）和/或Q-T间隔（128）的心室同步的电描记图的测量特性来选择起搏间隔中的一个（140）。可植入医疗装置（16）基于所选择的起搏间隔（140）对左心室（22）进行起搏。

3. 发明申请

WO2009131865A1 A SYSTEM TO MONITOR EJECTION TIME AND QT INTERVAL TO ALERT PATIENTS BEFORE SYNCOPAL EVENTS 审中-公开
标题翻译：监测病人出院时间和间隔时间间隔的系统
公开(公告)号：WO2009131865A1
公开(公告)日：2009-10-29
申请号：PCT/US2009/040414
申请日：2009-04-14
申请人： MEDTRONIC, INC. , CORBUCCI, Giorgio , BOUTE, Willem , SCHOLTEN, Patrick , SMIT, Josephus
发明人： CORBUCCI, Giorgio , BOUTE, Willem , SCHOLTEN, Patrick , SMIT, Josephus
IPC分类号： A61N1/365 , A61B5/0452
CPC分类号： A61N1/365 , A61B5/0452 , A61N1/36535 , A61N1/36542 , A61N1/36585
摘要： An implantable medical device predicts syncope based on detecting a change in ejection time. A physiological signal is sensed that is responsive to mechanical changes associated with the cardiac ejection phase. A time interval corresponding to cardiac ejection time is detected from the physiological signal. A sudden change in the time interval is used as a predictor of syncope and causes a patient alert to be generated in response to the detected change.
摘要翻译：可植入医疗装置基于检测喷射时间的变化来预测晕厥。感测到响应于与心脏喷射阶段相关的机械变化的生理信号。从生理信号检测与心脏喷射时间对应的时间间隔。使用时间间隔的突然变化作为晕厥的预测因子，并且响应于检测到的变化而产生患者警报。

4. 发明申请

WO2007038767A1 TELEMETRY OF COMBINED ENDOCAVITARY ATRIAL AND VENTRICULAR SIGNALS 审中-公开
标题翻译：联合腔内心房和心室信号的解读
公开(公告)号：WO2007038767A1
公开(公告)日：2007-04-05
申请号：PCT/US2006/038210
申请日：2006-09-28
申请人： MEDTRONIC, INC. , CORBUCCI, Giorgio
发明人： CORBUCCI, Giorgio
IPC分类号： A61N1/362 , A61N1/372 , A61B5/0245
CPC分类号： A61B5/0031 , A61B5/0006 , A61N1/37
摘要： A method for use in an implantable medical device system, comprising: selecting a first sensing electrode operatively disposed in a first heart chamber; setting a first sensing window corresponding to cardiac electrical events occurring in a second heart chamber; enabling a first sense amplifier coupled to the first sensing electrode during the first sensing window; sensing a first signal corresponding to cardiac electrical events occurring in the second heart chamber during the first sensing window using the first sensing electrode; and transmitting the first signal from an implantable medical device to an external monitor.
摘要翻译：一种用于可植入医疗设备系统的方法，包括：选择可操作地设置在第一心脏腔室中的第一感测电极; 设置对应于在第二心脏腔室中发生的心脏电活动的第一感测窗口; 启用在所述第一感测窗期间耦合到所述第一感测电极的第一感测放大器; 使用所述第一感测电极感测对应于在所述第一感测窗期间在所述第二心脏腔室中发生的心脏电活动的第一信号; 并将第一信号从植入式医疗设备传输到外部监视器。

5. 发明申请

WO2009131879A1 IMPLANTABLE DEVICE AND METHOD FOR MONITORING VENOUS DIAMETER 审中-公开
标题翻译：用于监测直径的可植入装置和方法
公开(公告)号：WO2009131879A1
公开(公告)日：2009-10-29
申请号：PCT/US2009/040633
申请日：2009-04-15
申请人： MEDTRONIC, INC. , CORBUCCI, Giorgio , SMIT, Josephus , VAN DER VEEN, Johannes, S. , VAN LEMBERGEN, Geert , VERSCHELLING, Marinus, C., j.
发明人： CORBUCCI, Giorgio , SMIT, Josephus , VAN DER VEEN, Johannes, S. , VAN LEMBERGEN, Geert , VERSCHELLING, Marinus, C., j.
IPC分类号： A61B5/0215 , A61B5/107
CPC分类号： A61B5/1076 , A61B5/02007 , A61B5/02028 , A61B5/0205 , A61B5/02152 , A61B5/02158 , A61B5/0538 , A61B5/0816 , A61B5/7275 , A61B5/7278 , A61B5/7282 , A61B8/0891 , A61B8/12
摘要： An implantable medical device system receives a signal from an implantable sensor operatively positioned relative to a vein, the signal being responsive to changes in a diameter of the vein. A diameter of the vein is determined in response to the sensor signal and used in estimating central venous pressure (CVP).
摘要翻译：植入式医疗装置系统从相对于静脉可操作地定位的可植入传感器接收信号，所述信号响应于静脉直径的变化。根据传感器信号确定静脉的直径，并用于估计中心静脉压（CVP）。

6. 发明申请

WO2009017986A1 CARDIAC RESYNCHRONIZATION THERAPY FOR PATIENTS WITH RIGHT BUNDLE BRANCH BLOCK 审中-公开
标题翻译：对于具有右手臂支架块的患者的心脏康复治疗
公开(公告)号：WO2009017986A1
公开(公告)日：2009-02-05
申请号：PCT/US2008/070437
申请日：2008-07-18
申请人： MEDTRONIC, INC. , CORBUCCI, Giorgio
发明人： CORBUCCI, Giorgio
IPC分类号： A61N1/365 , A61N1/368 , A61B7/02
CPC分类号： A61N1/36514 , A61B7/023 , A61N1/36578 , A61N1/3682 , A61N1/3684
摘要： An implantable medical device and associated method deliver cardiac resynchronization therapy in a patient having right bundle branch block by measuring an interval between a right atrial depolarization and a first heart sound and selecting a right atrial-ventricular (AV) pacing interval in response to the measured interval. Pacing pulses are delivered to the right ventricle of a patient's heart at the selected right AV pacing interval to synchronize the right ventricle with an intrinsic left ventricle depolarization.
摘要翻译：可植入医疗装置和相关方法通过测量右心房去极化和第一心脏声音之间的间隔并响应于测量的心房起搏间隔选择右心房（AV）起搏间隔，在具有右束支传导阻滞的患者中提供心脏再同步治疗间隔。起搏脉冲以选定的右AV起搏间隔输送到患者心脏的右心室，以使右心室与固有的左心室去极化同步。

7. 发明申请

WO2012057866A1 POSTURE-INDUCED CHANGES TO PHYSIOLOGICAL PARAMETERS 审中-公开
标题翻译：对生理参数的诱导变化
公开(公告)号：WO2012057866A1
公开(公告)日：2012-05-03
申请号：PCT/US2011/034479
申请日：2011-04-29
申请人： MEDTRONIC, INC. , CORBUCCI, Giorgio , LEE, Brian, B.
发明人： CORBUCCI, Giorgio , LEE, Brian, B.
IPC分类号： A61B5/024 , A61B5/029
CPC分类号： A61B5/0205 , A61B5/02028 , A61B5/024 , A61B5/02438 , A61B5/029 , A61B5/1116 , A61B5/686 , A61B5/7246 , A61B5/7282 , A61N1/3627 , A61N1/36535 , A61N1/36585 , A61N1/3702 , A61N1/37247 , G06F19/00
摘要： Methods and devices for analyzing posture-induced changes to physiological parameters of a patient (e.g., ejection time, heart rate, etc.) to provide an assessment of one or more conditions of the patient.
摘要翻译：用于分析姿势引起的对患者的生理参数的变化的方法和装置（例如，射血时间，心率等）以提供对患者的一个或多个状况的评估。

8. 发明申请

WO2007038588A1 TELEMETRY OF COMBINED ENDOCAVITARY ATRIAL AND VENTRICULAR SIGNALS 审中-公开
标题翻译：组合内分泌性心脏病和心脏信号的电传
公开(公告)号：WO2007038588A1
公开(公告)日：2007-04-05
申请号：PCT/US2006/037661
申请日：2006-09-27
申请人： MEDTRONIC, INC. , CORBUCCI, Giorgio
发明人： CORBUCCI, Giorgio
IPC分类号： A61N1/362 , A61B5/0245 , A61N1/372
CPC分类号： A61B5/0031 , A61B5/0006 , A61N1/37
摘要： A method for use in an implantable medical device system, comprising: selecting a first sensing electrode operatively disposed in a first heart chamber; setting a first sensing window corresponding to cardiac electrical events occurring in a second heart chamber; enabling a first sense amplifier coupled to the first sensing electrode during the first sensing window; sensing a first signal corresponding to cardiac electrical events occurring in the second heart chamber during the first sensing window using the first sensing electrode; and transmitting the first signal from an implantable medical device to an external monitor.
摘要翻译：一种用于可植入医疗装置系统的方法，包括：选择可操作地设置在第一心室中的第一感测电极; 设置对应于在第二心室中发生的心脏电气事件的第一感测窗口; 使得能够在第一感测窗口期间耦合到第一感测电极的第一读出放大器; 在第一感测窗口期间使用第一感测电极感测对应于在第二心室中发生的心脏电气事件的第一信号; 以及将第一信号从可植入医疗装置发送到外部监视器。

9. 发明申请

WO2004093976A2 ADDRESSING PACEMAKER SYNDOME 审中-公开
标题翻译：解决PACEMAKER SYNDOME
公开(公告)号：WO2004093976A2
公开(公告)日：2004-11-04
申请号：PCT/US2004/011743
申请日：2004-04-16
申请人： MEDTRONIC, INC. , CORBUCCI, Giorgio
发明人： CORBUCCI, Giorgio
IPC分类号： A61N1/00
CPC分类号： A61N1/368
摘要： In general, the invention is directed to techniques for detecting and addressing pacemaker syndrome. When a pacemaker detects a risk of pacemaker syndrome, the pacemaker paces one or more chambers of the heart to reduce the risk of pacemaker syndrome. One pacing technique is to apply ventricular paces, thereby reducing the delay between the atrial activation and the ventricular activation. Another technique, available to a patient who receives atrial pacing, is to decrease the atrial pacing rate.
摘要翻译：通常，本发明涉及用于检测和解决起搏器综合征的技术。当起搏器检测到起搏器综合征的风险时，心脏起搏器会使心脏的一个或多个腔室起搏，以降低起搏器综合征的风险。一种起搏技术是应用心室起搏，从而减少心房激活与心室激活之间的延迟。接受心房起搏的患者可获得的另一种技术是降低心房起搏率。

10. 发明申请

WO2003089058A1 CARDIAC RESYNCHRONIZATION WITH ADAPTIVE A1-A2 AND/OR V1-V2 INTERVALS 审中-公开
标题翻译：具有自适应A1-A2和/或V1-V2间隔的心脏再生
公开(公告)号：WO2003089058A1
公开(公告)日：2003-10-30
申请号：PCT/US2003/012244
申请日：2003-04-17
申请人： MEDTRONIC, INC.
发明人： BOUTE, Willem , CORBUCCI, Giorgio
IPC分类号： A61N1/368
CPC分类号： A61N1/3627 , A61N1/36542 , A61N1/3684
摘要： In a system that provides bi-atrial and/or bi-ventricular pacing, the system adjusts an interval between paces delivered to the atria, and/or an interval between paces delivered to the ventricles, as a function of heart rate. By adjusting the interval between paces as a function of heart rate, the atria and/or ventricles may be activated in a more synchronous and more hemodynamically efficient fashion.
摘要翻译：在提供双心房和/或双心室起搏的系统中，该系统调整作为心率的函数的递送到心房的步调之间的间隔和/或递送至心室的间隔。通过调整步速之间的间隔作为心率的函数，心房和/或心室可以以更同步和更有血液动力学有效的方式被激活。

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