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1. 发明申请

WO2007044699A1 PARALLEL INTEGRATED BIOREACTOR DEVICE AND METHOD 审中-公开
标题翻译：并行集成生物反应器装置及方法
公开(公告)号：WO2007044699A1
公开(公告)日：2007-04-19
申请号：PCT/US2006/039475
申请日：2006-10-10
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , LEE, Harry , RAM, Rajeev, J. , JENSEN, Klavs, F.
发明人： LEE, Harry , RAM, Rajeev, J. , JENSEN, Klavs, F.
IPC分类号： C12M3/00
CPC分类号： B01F11/0045 , B01F13/0059 , B01F2215/0431 , B01F2215/0454 , B01L3/5025 , B01L3/5027 , B01L3/50273 , B01L3/502738 , B01L7/00 , B01L2300/0867 , B01L2300/10 , B01L2400/0487 , C12M23/16 , C12M23/22 , C12M23/40 , C12M23/44 , C12M27/02 , C12M29/14 , C12M29/26 , C12M33/07 , C12M41/26 , C12M41/34 , C12M41/40
摘要： In one embodiment, the present invention introduces integrated fluid injection and mixing devices to enable pH control in a miniature parallel integrated bioreactor array system. In another embodiment, the environmental conditions of the growth chamber is enabled through fluidic injections in a miniature parallel cell culture system. In still another embodiment, the present invention utilizes gas switches to control oxygen concentration within a miniature parallel integrated bioreactor array.
摘要翻译：在一个实施例中，本发明引入集成的流体注入和混合装置，以在微型并联的集成生物反应器阵列系统中实现pH控制。在另一个实施方案中，通过在微型平行细胞培养系统中流体注射能够实现生长室的环境条件。在另一个实施方案中，本发明利用气体开关来控制微型并联的综合生物反应器阵列内的氧浓度。

2. 发明申请

WO2010042784A3 METHOD OF HYDROLYTICALLY STABLE BONDING OF ELASTOMERS TO SUBSTRATES 审中-公开
公开(公告)号：WO2010042784A3
公开(公告)日：2010-04-15
申请号：PCT/US2009/060107
申请日：2009-10-09
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , LEE, Kevin, S. , LEE, Harry , RAM, Rajeev, J.
发明人： LEE, Kevin, S. , LEE, Harry , RAM, Rajeev, J.
IPC分类号： C08J5/12 , B81B7/00 , B29C65/02
摘要： Active devices such as pumps and mixers have been fabricated in plastic-PDMS hybrid devices. By utilizing functionalized bis-silane primers, bond strength between Polycarbonate or PMMA and PDMS improved in dry and aqueous environments. Plastic-primer-PDMS layers exposed to acid and base solutions at 70°C for 2 hours showed no signs of delamination at 30 psi for pH -1 to 15 and 60 psi for pH 0 to 15. A peristaltic pump fabricated in polycarbonate achieved consistent flow rates up to peristaltic cycle frequencies of 10 Hz in water, 1OM HCl, and 1OM NaOH solutions.

3. 发明申请

WO2021141661A2 FORWARD-BIASED MODULATOR FOR CRYOGENIC OPTICAL READOUT 审中-公开
公开(公告)号：WO2021141661A2
公开(公告)日：2021-07-15
申请号：PCT/US2020/059479
申请日：2020-11-06
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , RAM, Rajeev, J. , GRAY, Dodd, Joseph , ATABAKI, Amir, Hi , DE CEA FALCO, Marc
发明人： RAM, Rajeev, J. , GRAY, Dodd, Joseph , ATABAKI, Amir, Hi , DE CEA FALCO, Marc
IPC分类号： G02B6/12 , G02B6/132 , G02B6/134 , H01L33/58 , H01L31/0216 , H01L33/10 , H01S5/20 , H01S5/06 , G02F1/0102 , G02F1/0123 , G02F1/212 , G02F1/2257 , G02F2202/10
摘要： Optical read-out of a cryogenic device (such as a superconducting logic or detector element) can be performed with a forward-biased optical modulator that is directly coupled to the cryogenic device without any intervening electrical amplifier. Forward-biasing at cryogenic temperatures enables very high modulation efficiency (1,000-10,000 pm/V) of the optical modulator, and allows for optical modulation with millivolt driving signals and microwatt power dissipation in the cryogenic environment. Modulated optical signals can be coupled out of the cryostat via an optical fiber, reducing the thermal load on the cryostat. Using optical fiber instead of electrical wires can increase the communication bandwidth between the cryogenic environment and room- temperature environment to bandwidth densities as high as Tbps/mm2 using wavelength division multiplexing. Sensitive optical signals having higher robustness to noise and crosstalk, because of their immunity to electromagnetic interference, can be carried by the optical fiber.

4. 发明申请

WO2006099453A1 HIGH PERFORMANCE CCD-BASED THERMOREFLECTANCE IMAGING USING STOCHASTIC RESONANCE 审中-公开
标题翻译：使用STOCHASTIC共振的高性能基于CCD的热变像成像
公开(公告)号：WO2006099453A1
公开(公告)日：2006-09-21
申请号：PCT/US2006/009235
申请日：2006-03-15
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY (MIT) , LUEERSSEN, Dietrich , RAM, Rajeev, J. , HUDGINGS, Janice, A. , MAYER, Peter, M.
发明人： LUEERSSEN, Dietrich , RAM, Rajeev, J. , HUDGINGS, Janice, A. , MAYER, Peter, M.
IPC分类号： G01N21/17 , G01N25/18 , G06T5/50
CPC分类号： G01J5/0003 , G01K11/125 , G01N21/1717 , G01N21/55 , G01N25/18 , G01N2021/1731
摘要： The invention is directed to systems and methods of digital signal processing and in particular to systems and methods for measurements of thermoreflectance signals, even when they are smaller than the code width of a digital detector used for detection. For example, in some embodiments, the number of measurements done is selected to be sufficiently large so as to obtain an uncertainty less than the code width of the detector. This allows for obtaining images having an enhanced temperature resolution. The invention is also directed to methods for predicting the uncertainty in measurement of the signal based on one or more noise variables associated with the detection process and the number of measurement iterations.
摘要翻译：本发明涉及数字信号处理的系统和方法，特别涉及用于测量热反射信号的系统和方法，即使它们小于用于检测的数字检测器的代码宽度。例如，在一些实施例中，完成的测量数量被选择为足够大，以便获得小于检测器的代码宽度的不确定性。这允许获得具有增强的温度分辨率的图像。本发明还涉及用于基于与检测过程相关联的一个或多个噪声变量和测量迭代次数来预测信号测量的不确定性的方法。

5. 发明申请

WO2022265722A1 INTEGRATED DUAL-WAVEGUIDE ACOUSTO-OPTIC MODULATOR 审中-公开
公开(公告)号：WO2022265722A1
公开(公告)日：2022-12-22
申请号：PCT/US2022/025025
申请日：2022-04-15
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , WEST, Gavin , RAM, Rajeev, J.
发明人： WEST, Gavin , RAM, Rajeev, J.
IPC分类号： G02F1/335 , G02F1/125 , G02F1/33 , G02F1/11
摘要： An integrated acousto-optic modulator operates with an extremely high extinction ratio (e.g., > 50 dB) thanks to two widely separated two-dimensional (2D) waveguides. These 2D waveguides are formed on or adjacent to a one-dimensional (ID) waveguide far enough apart (e.g., 10-100 pm apart) to prevent evanescent coupling between them. An acoustic transducer formed on the surface of the ID waveguide switches light from one 2D waveguide to the other 2D waveguide via the ID waveguide. The acoustic wave emitted by the acoustic transducer forms a traveling grating that overlaps with one 2D waveguide, diffracting light from that 2D waveguide into the ID waveguide, which guides the light to the other 2D waveguide. A lateral grating coupler diffracts this light from the ID waveguide into a mode guided by the other 2D waveguide. This acoustic modulator acts as a switch suitable for use in quantum and atomic systems.

6. 发明申请

WO2022026053A1 MULTIPLEXED SENSOR NETWORK USING SWEPT SOURCE RAMAN SPECTROSCOPY 审中-公开
公开(公告)号：WO2022026053A1
公开(公告)日：2022-02-03
申请号：PCT/US2021/035105
申请日：2021-06-01
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , RAM, Rajeev, J. , ATABAKI, Amir, H. , PERSITS, Nili , KIM, Jaehwan
发明人： RAM, Rajeev, J. , ATABAKI, Amir, H. , PERSITS, Nili , KIM, Jaehwan
IPC分类号： G01J3/44 , G01J3/02 , G01J3/06 , G01J3/36
摘要： Swept-source Raman spectroscopy uses a tunable laser and a fixed-wavelength detector instead of a spectrometer or interferometer to perform Raman spectroscopy with the throughput advantage of Fourier transform Raman spectroscopy without bulky optics or moving mirrors. Although the tunable laser can be larger and more costly than a fixed wavelength diode laser used in other Raman systems, it is possible to split and switch the laser light to multiple ports simultaneously and/or sequentially. Each site can be monitored by its own fixed-wavelength detector. This architecture can be scaled by cascading fiber switches and/or couplers between the tunable laser and measurement sites. By multiplexing measurements at different sites, it is possible to monitor many sites at once. Moreover, each site can be meters to kilometers from the tunable laser. This makes it possible to perform swept-source Raman spectroscopy at many points across a continuous flow manufacturing environment with a single laser.

7. 发明申请

WO2008137848A3 OPTICAL CHARACTERIZATION OF PHOTONIC INTEGRATED CIRCUITS 审中-公开
公开(公告)号：WO2008137848A3
公开(公告)日：2008-11-13
申请号：PCT/US2008/062660
申请日：2008-05-05
申请人： MASSCHUSETTS INSTITUTE OF TECHNOLOGY (MIT) , HOLYOKE, Mount , HUDGINGS, Janice, A. , FARZANEH, Maryam , RAM, Rajeev, J.
发明人： HUDGINGS, Janice, A. , FARZANEH, Maryam , RAM, Rajeev, J.
IPC分类号： G01K11/12 , G01N25/72
摘要： In one aspect, the present invention provides techniques and apparatus for optical characterization of photonic devices and/or circuits. By way of example, the techniques can be used to identify damaged devices in photonic integrated circuits. In some embodiments, thermal imaging is employed as a diagnositic tool for characterizing the devices/ciccuits under investigation. For example, in one embodiment, integrated cascaded semiconductor amplifiers can be characterized using amplied spontaneous emission from one amplifier as a thermal modulation input to another amplifier. A thermoreflectance image of the second amplifier can reveal flaws, if present. Further, in some embodiments, thermal imaging in conjunction with a total energy model can be employed to charaterize the elements of photonic circuits optically and/or to map the optical power distribution throughout the circuits.

8. 发明申请

WO2021236015A1 EARLY DIAGNOSIS AND MANAGEMENT OF NITROGEN DEFICIENCY IN PLANTS UTILIZING RAMAN SPECTROSCOPY 审中-公开
公开(公告)号：WO2021236015A1
公开(公告)日：2021-11-25
申请号：PCT/SG2021/050276
申请日：2021-05-20
申请人： TEMASEK LIFE SCIENCES LABORATORY LIMITED , MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： PARK, Bong Soo , RAM, Rajeev, J. , HUANG, Chung Hao , SINGH, Gajendra Pratap , CHUA, Nam-Hai
IPC分类号： G01N21/65 , A01C21/00
摘要： The present invention relates to the use of a Raman spectral signature of nitrate, as a biomarker for an early, real-time diagnosis of nitrogen status in growing plants in a non-invasive or non-destructive way in order to detect nitrogen deficiency before the onset of any visible symptoms. The early, real-time diagnosis of nitrogen deficiency in plants makes it possible to correct nitrogen deficiency for the avoidance of negative effects on the yield and biomass of growing plants or leafy vegetables.

9. 发明申请

WO2015017653A1 OPTOELECTRONIC FILTER 审中-公开
标题翻译：光电滤波器
公开(公告)号：WO2015017653A1
公开(公告)日：2015-02-05
申请号：PCT/US2014/049141
申请日：2014-07-31
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： LOH, William , YEGNANARAYANAN, Siva , RAM, Rajeev, J. , JUODAWLKIS, Paul, William
IPC分类号： G02F1/035
CPC分类号： G02F1/2255 , G02F1/035 , G02F1/21 , G02F2001/212
摘要： An optoelectronic filter having at least one input and an output includes a modulator circuit having at least first and second inputs with a first one of the modulator circuit inputs adapted to couple to a respective one of the at least one input of the optoelectronic filter. The modulator circuit receives at least a first radio frequency (RF) signal having a first power level and a second RF signal having a second, different power level at the first one of the modulator circuit inputs and in response thereto generates a modulated signal at an output thereof. The first RF signal is suppressed relative to the second RF signal in the modulated signal. The optoelectronic filter additionally includes a light source adapted to couple to a second one of the modulator circuit inputs. A corresponding method is also provided.
摘要翻译：具有至少一个输入和输出的光电滤波器包括具有至少第一和第二输入的调制器电路，其中第一个调制器电路输入适于耦合到光电滤波器的至少一个输入端中的相应一个输入端。调制器电路在调制器电路输入的第一个处接收至少具有第一功率电平的第一射频（RF）信号和具有第二不同功率电平的第二RF信号，并响应于此产生调制信号输出。第一RF信号相对于调制信号中的第二RF信号被抑制。光电子滤波器还包括适于耦合到第二调制器电路输入的光源。还提供了相应的方法。

10. 发明申请

WO2003069377A3 METHOD AND APPARATUS FOR CHARACTERIZATION OF DEVICES AND CIRCUITS 审中-公开
公开(公告)号：WO2003069377A3
公开(公告)日：2003-08-21
申请号：PCT/US2003/004089
申请日：2003-02-12
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人： PIPE, Kevin, P. , RAM, Rajeev, J.
IPC分类号： H01S5/024
摘要： A method and apparatus for performing characterization of devices is presented. The characteristic of the device are determined by obtaining a first temperature measurement in a first location of a device, obtaining a second temperature measurement, computing the difference between the temperature measurements and, using the temperatures and/or the temperature difference, a characteristic of the device is determined.

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