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1. 发明申请

WO2007044699A1 PARALLEL INTEGRATED BIOREACTOR DEVICE AND METHOD 审中-公开
标题翻译：并行集成生物反应器装置及方法
公开(公告)号：WO2007044699A1
公开(公告)日：2007-04-19
申请号：PCT/US2006/039475
申请日：2006-10-10
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , LEE, Harry , RAM, Rajeev, J. , JENSEN, Klavs, F.
发明人： LEE, Harry , RAM, Rajeev, J. , JENSEN, Klavs, F.
IPC分类号： C12M3/00
CPC分类号： B01F11/0045 , B01F13/0059 , B01F2215/0431 , B01F2215/0454 , B01L3/5025 , B01L3/5027 , B01L3/50273 , B01L3/502738 , B01L7/00 , B01L2300/0867 , B01L2300/10 , B01L2400/0487 , C12M23/16 , C12M23/22 , C12M23/40 , C12M23/44 , C12M27/02 , C12M29/14 , C12M29/26 , C12M33/07 , C12M41/26 , C12M41/34 , C12M41/40
摘要： In one embodiment, the present invention introduces integrated fluid injection and mixing devices to enable pH control in a miniature parallel integrated bioreactor array system. In another embodiment, the environmental conditions of the growth chamber is enabled through fluidic injections in a miniature parallel cell culture system. In still another embodiment, the present invention utilizes gas switches to control oxygen concentration within a miniature parallel integrated bioreactor array.
摘要翻译：在一个实施例中，本发明引入集成的流体注入和混合装置，以在微型并联的集成生物反应器阵列系统中实现pH控制。在另一个实施方案中，通过在微型平行细胞培养系统中流体注射能够实现生长室的环境条件。在另一个实施方案中，本发明利用气体开关来控制微型并联的综合生物反应器阵列内的氧浓度。

2. 发明申请

WO2010042784A3 METHOD OF HYDROLYTICALLY STABLE BONDING OF ELASTOMERS TO SUBSTRATES 审中-公开
公开(公告)号：WO2010042784A3
公开(公告)日：2010-04-15
申请号：PCT/US2009/060107
申请日：2009-10-09
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , LEE, Kevin, S. , LEE, Harry , RAM, Rajeev, J.
发明人： LEE, Kevin, S. , LEE, Harry , RAM, Rajeev, J.
IPC分类号： C08J5/12 , B81B7/00 , B29C65/02
摘要： Active devices such as pumps and mixers have been fabricated in plastic-PDMS hybrid devices. By utilizing functionalized bis-silane primers, bond strength between Polycarbonate or PMMA and PDMS improved in dry and aqueous environments. Plastic-primer-PDMS layers exposed to acid and base solutions at 70°C for 2 hours showed no signs of delamination at 30 psi for pH -1 to 15 and 60 psi for pH 0 to 15. A peristaltic pump fabricated in polycarbonate achieved consistent flow rates up to peristaltic cycle frequencies of 10 Hz in water, 1OM HCl, and 1OM NaOH solutions.

3. 发明申请

WO2007106451A2 APPARATUS AND METHOD FOR DISSOLVED OXYGEN CONTROL IN PARALLEL INTEGRATED BIOREACTOR ARRAY 审中-公开
标题翻译：平行整合生物反应器阵列中溶解氧的控制方法及方法
公开(公告)号：WO2007106451A2
公开(公告)日：2007-09-20
申请号：PCT/US2007/006246
申请日：2007-03-09
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , LEE, Harry , SHAO-KWAN LEE, Kevin
发明人： LEE, Harry , SHAO-KWAN LEE, Kevin
IPC分类号： C12M3/00
CPC分类号： B01F11/0045 , B01F3/04269 , B01F13/0059 , B01F2003/04404 , B01L3/5027 , C12M23/24 , C12M23/34 , C12M29/04 , C12M41/32
摘要： Parallel, integrated bioreactor. The bioreactor includes a plurality of growth chambers, each growth chamber associated with a peristaltic oxygenating mixer and separated therefrom by a porous membrane. Each oxygenating mixture has a gas inlet and a gas outlet with the gas inlet in fluid communication with a gas reservoir. A gas mixer switch is provided for controlling oxygen concentration in the reservoir. The apparatus and methods disclosed in the application allow precise control over dissolved oxygen concentration with a quick response time.
摘要翻译：平行，综合生物反应器。生物反应器包括多个生长室，每个生长室与蠕动氧合混合器相关联，并通过多孔膜与其分离。每个氧化混合物具有气体入口和气体出口，气体入口与气体储存器流体连通。提供一种气体混合器开关用于控制储存器中的氧气浓度。本申请中公开的装置和方法允许以较快的响应时间精确控制溶解氧浓度。

4. 发明申请

WO2005049803A2 PERISTALTIC MIXING AND OXYGENATION SYSTEM 审中-公开
标题翻译：周期性混合和氧化系统
公开(公告)号：WO2005049803A2
公开(公告)日：2005-06-02
申请号：PCT/US2004/038432
申请日：2004-11-16
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , LEE, Harry
发明人： LEE, Harry
IPC分类号： C12N
CPC分类号： B01F11/0045 , B01F13/0059 , B01F2215/0431 , B01F2215/0454 , C12M23/24 , C12M23/26 , C12M23/40
摘要： The present invention provides devices and methods for achieving mixing and gas exchange in chambers having a small volume. According to the invention a chamber includes one or more walls that are made of a gas-permeable material and that include multiple portions that are selectively deflectable into the interior of the chamber. The deflectable portions are in communication with a hollow cavity or space that can be pressurized. Pressurization results in deflection of the deflectable portion into the chamber. Pressurization is achieved using a gas or fluid that contains a gas of interest such as oxygen. The portions are deflected in a sequence that results in peristaltic action that mixes and oxygenates the contents of the chamber. In a preferred embodiment of the invention the hollow cavities are an assembly of tubes that deflect into a plurality of chambers. A particular use for the invention is as a culture vessel for cells such as bacteria.
摘要翻译：本发明提供用于在具有小体积的室中实现混合和气体交换的装置和方法。根据本发明，腔室包括由透气材料制成的一个或多个壁，并且包括可选择性地偏转到腔室内部的多个部分。可偏转部分与可被加压的中空腔或空间连通。加压导致可偏转部分偏转到室中。使用包含目标气体（例如氧气）的气体或流体来实现加压。这些部分以导致蠕动作用的顺序偏转，其混合并充氧室内的物质。在本发明的优选实施例中，中空腔是偏转到多个腔室中的管组件。本发明的特定用途是作为诸如细菌的细胞的培养容器。

5. 发明申请

WO2009021145A1 FLUID INJECTION PORT 审中-公开
标题翻译：流体注射口
公开(公告)号：WO2009021145A1
公开(公告)日：2009-02-12
申请号：PCT/US2008/072535
申请日：2008-08-07
申请人： MASSACHUSETTS INSTUTUTE OF TECHNOLOGY , LEE, Harry
发明人： LEE, Harry
IPC分类号： B01L3/02
CPC分类号： B01L3/502715 , B01L3/502723 , B01L2200/027 , B01L2300/044 , B01L2300/123
摘要： Fluid injection port. An elastomeric injection nipple is supported within a compression fitting and the injection nipple includes a slit. A first via is provided that connects the slit in the nipple to a flow channel leading into a fluid reservoir. A venting channel is provided in fluid communication with the fluid reservoir and also in fluid communication with a second via. When a pipette is inserted into the slit in the injection nipple, the nipple deforms allowing the second via to be in fluid communication with space on either side of the pipette tip whereby air can be discharged.
摘要翻译：流体注射口。弹性体注射接头支撑在压缩配件内，并且注射接头包括狭缝。提供了将乳头中的狭缝连接到通向流体储存器的流动通道的第一通孔。提供通气通道与流体储存器流体连通并且还与第二通孔流体连通。当移液管插入注射嘴中的狭缝中时，乳头变形，允许第二通孔与移液管尖端两侧的空间流体连通，从而可以排出空气。

6. 发明申请

WO2007013912A2 PIN SITE WOUND PROTECTION SYSTEM 审中-公开
标题翻译：引脚伤害保护系统
公开(公告)号：WO2007013912A2
公开(公告)日：2007-02-01
申请号：PCT/US2006/028004
申请日：2006-07-19
申请人： 3D MEDICAL CONCEPTS, LLC , LEE, Harry , REARDON, Joshua , PALEY, Dror
发明人： LEE, Harry , REARDON, Joshua , PALEY, Dror
IPC分类号： A61F13/02
CPC分类号： A61F15/006 , A61B17/60 , A61B17/84
摘要： An improved disposable pin site wound protection system for covering the entry or exit site of a surgical pin, wherein the system substantially reduces the time required to change a dressing at a pin site wound. The invention comprises a sponge (11) and clip (21), both of which are designed to be attached to a pin (15) adjacent a wound. The clip (21), when compressed, crosses the legs (23, 25) of the clip and when released will attach to the full-range of external fixation pins and wires. This reverse action of the clip, opening when compressed and closing when released, is a self-closing and self-holding clip that can be applied and removed with one hand. The sponge (11) is preferably cylindrical or hemispherical in shape, and may include a spiral cut (12) to resist accidental displacement from the pin.
摘要翻译：一种改进的一次性针式部位伤口保护系统，用于覆盖手术针的进入或退出部位，其中该系统大大减少了在针部位伤口处更换敷料所需的时间。本发明包括海绵（11）和夹子（21），两者均被设计成附接到邻近伤口的销（15）。夹子（21）在被压缩时穿过夹子的腿部（23,25），并且当被释放时将附接到全部范围的外部固定销和电线。夹子的这种相反的动作，在压缩时打开，在松开时闭合，是一个可以用一只手施加和移除的自闭合自夹持夹。海绵（11）的形状最好是圆柱形或半球形，并且可以包括螺旋形切口（12）以防止从销上意外移动。

7. 发明申请

WO2008005478A3 TREATMENT OF NEUROLOGICAL DISORDERS VIA ELECTRICAL STIMULATION, AND METHODS RELATED THERETO 审中-公开
公开(公告)号：WO2008005478A3
公开(公告)日：2008-01-10
申请号：PCT/US2007/015446
申请日：2007-07-05
申请人： BRAINVITAL CORPORATION , LEE, Harry , FOREMAN, Allan , DAUM, Wolfgang , COHEN, Richard , GOTMAN, Jean , COLE, Andrew James
发明人： LEE, Harry , FOREMAN, Allan , DAUM, Wolfgang , COHEN, Richard , GOTMAN, Jean , COLE, Andrew James
IPC分类号： A61N1/08 , A61B5/0476
摘要： Disclosed are medical devices for the prevention and/or treatment of neurological disorders via electrical stimulation, and methods related thereto. The devices may also be utilized to detect disorders before the prevention or treatment of a neurological disorder. These devices are minimally or non-invasive. The present medical devices comprise various components, which include electrodes and control electronics. The electrodes are targeting electrodes constructed from ring type structures or virtually connected disc type arrays. The electrodes are located entirely outside the skull. The present medical devices also comprise one or more subsystems, a control system, a battery unit, and wires connecting the one or more subsystems. These devices may also be used for acute seizure control.

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