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1. 发明申请

WO2004024084A3 RB PAHTWAY AND CHROMATIN REMODELING GENES THAT ANTAGONIZE LET-60 RAS SIGNALING 审中-公开
标题翻译： RB PAHTWAY和铬铁蛋白重塑基因，阻止LET-60 RAS信号传导
公开(公告)号：WO2004024084A3
公开(公告)日：2004-09-02
申请号：PCT/US0328626
申请日：2003-09-12
申请人： MASSACHUSETTS INST TECHNOLOGY , HORVITZ H ROBERT PH D , CEOL CRAIG , ANDERSEN ERIK
发明人： HORVITZ H ROBERT PH D , CEOL CRAIG , ANDERSEN ERIK
IPC分类号： A01K67/00 , A61K20060101 , C07K14/47 , C07K16/18 , C12N1/00 , C12N5/10 , C12N15/11 , C12N15/12 , C12N15/63 , C12Q1/02 , C12Q1/68 , G01N33/00 , G01N33/574
CPC分类号： C07K14/47
摘要： In general, the invention provides methods and compositions useful in the treatment of a neoplasia. These compositions include new components of the Rb pathway that function in chromatin remodeling and antagonize Ras signaling.
摘要翻译：通常，本发明提供可用于治疗瘤形成的方法和组合物。这些组合物包括在染色质重塑中起作用并拮抗Ras信号传导的Rb途径的新组分。

2. 发明申请

WO2004024084A9 RB PAHTWAY AND CHROMATIN REMODELING GENES THAT ANTAGONIZE LET-60 RAS SIGNALING 审中-公开
标题翻译： RB PAHTWAY和CHROMATIN重建基因，这些基因是ANTAGONIZE LET-60 RAS信号
公开(公告)号：WO2004024084A9
公开(公告)日：2004-06-03
申请号：PCT/US0328626
申请日：2003-09-12
申请人： MASSACHUSETTS INST TECHNOLOGY , HORVITZ H ROBERT PH D , CEOL CRAIG , ANDERSEN ERIK
发明人： HORVITZ H ROBERT PH D , CEOL CRAIG , ANDERSEN ERIK
IPC分类号： A01K67/00 , A61K20060101 , C07K14/47 , C07K16/18 , C12N1/00 , C12N5/10 , C12N15/11 , C12N15/12 , C12N15/63 , C12Q1/02 , C12Q1/68 , G01N33/00 , G01N33/574 , A61K
CPC分类号： C07K14/47
摘要： In general, the invention provides methods and compositions useful in the treatment of a neoplasia. These compositions include new components of the Rb pathway that function in chromatin remodeling and antagonize Ras signaling.
摘要翻译：通常，本发明提供了可用于治疗瘤形成的方法和组合物。这些组合物包括在染色质重塑和拮抗Ras信号传导中起作用的Rb通路的新成分。

3. 发明申请

WO2004034931A2 STENT ASSEMBLY 审中-公开
标题翻译：支架组件
公开(公告)号：WO2004034931A2
公开(公告)日：2004-04-29
申请号：PCT/DK0300698
申请日：2003-10-14
申请人： CUBE MEDICAL AS , ANDERSEN ERIK , WEN NING
发明人： ANDERSEN ERIK , WEN NING
IPC分类号： A61F2/07 , A61F2/91 , A61F2/915 , A61F2/06
CPC分类号： A61F2/07 , A61F2/91 , A61F2/915
摘要： A stent assembly comprises an expandable tubular stent (21), an external surface of which is provided with a fabric (5) which may constitute a reservoir to hold drugs to be released in the intravascular system of a living. The fabric (5) may be made from a filamentary material, such as multifilament yarn (6). Electrospinning of nanofibers of, e.g., polymer may be employed for manufacturing the fabric. The stent may comprise an assembly of radially expandable, tubular elements (1) aligned along a common longitudinal axis and successively joined together in pairs by respective sets of linking members (4), e.g. forming a zigzag corrugation. The stent may be crimped onto a balloon.
摘要翻译：支架组件包括可扩张的管状支架（21），其外表面设置有织物（5），该织物可以构成容器以容纳待释放在活体血管内系统中的药物。织物（5）可以由丝状材料如多丝纱（6）制成。例如聚合物的纳米纤维的静电纺丝可用于制造织物。该支架可以包括沿着共同的纵向轴线对齐的径向可扩张的管状元件（1）的组件，并且通过相应的连接构件组（4）成对连续地连接在一起。形成锯齿波纹。支架可以卷曲到气球上。

4. 发明申请

WO2005037339A9 A BALLOON FOR USE IN ANGIOPLASTY 审中-公开
标题翻译：一种用于血管成形术的球囊
公开(公告)号：WO2005037339A9
公开(公告)日：2005-10-13
申请号：PCT/US2004033851
申请日：2004-10-14
申请人： CUBE MEDICAL AS , UNIV AKRON , ANDERSEN ERIK , SMITH DANIEL , RENEKER DARRELL
发明人： ANDERSEN ERIK , SMITH DANIEL , RENEKER DARRELL
IPC分类号： A61B17/00 , A61B17/12 , A61F2/00 , A61F2/82 , A61L29/08 , A61L29/14 , A61L29/16 , A61L31/10 , A61L31/14 , A61L31/16 , A61M25/00 , A61M25/09 , A61F2/06
CPC分类号： A61L31/10 , A61B17/12022 , A61B17/1215 , A61B17/12172 , A61B17/12177 , A61B17/12186 , A61B2017/00004 , A61B2017/00893 , A61F2/82 , A61F2250/0067 , A61L29/085 , A61L29/16 , A61L31/16 , A61L2300/00 , A61L2400/12 , A61M25/0043 , A61M25/09 , C08L79/02
摘要： An expandable balloon for use in angioplasty procedures comprises a balloon having an outer surface layer, the outer surface layer being made from electrospun nanofibers and incorporating at least one pharmaceutically active substance, such as nitric oxide (NO). The outer surface layer may be formed on a separate flexible tubular member or sock, which is slipped over the balloon. An acidic agent, such as ascorbic acid, may be included in the balloon for enhancing NO release. A method of treating cell disorders in tubular structures of a living being comprises the steps of placing a coated balloon at a treatment site within the tubular structures, expanding the balloon at the treatment site, and releasing the pharmaceutically active substance at the treatment site. Optionally, a stent may be crimped onto the balloon prior to insertion of the balloon and stent into the tubular structures of the living being.
摘要翻译：用于血管成形术过程的可膨胀球囊包括具有外表面层的球囊，所述外表面层由电纺纳米纤维制成并掺入至少一种药物活性物质，例如一氧化氮（NO）。外表面层可以形成在滑过气囊的单独的柔性管状构件或袜子上。酸性试剂如抗坏血酸可包含在气囊中用于增强NO释放。治疗生物体的管状结构中的细胞紊乱的方法包括以下步骤：将涂布的球囊放置在管状结构内的治疗部位上，在治疗部位处扩张球囊，并在治疗部位释放药物活性物质。可选地，可以在将球囊和支架插入生物的管状结构之前将支架卷曲到球囊上。

5. 发明申请

WO2005039664A2 MEDICAL DEVICE 审中-公开
标题翻译：医疗装置
公开(公告)号：WO2005039664A2
公开(公告)日：2005-05-06
申请号：PCT/US2004033949
申请日：2004-10-14
申请人： CUBE MEDICAL AS , UNIV AKRON , ANDERSEN ERIK , SMITH DANIEL , RENEKER DARRELL
发明人： ANDERSEN ERIK , SMITH DANIEL , RENEKER DARRELL
IPC分类号： A61B17/00 , A61B17/12 , A61F2/00 , A61F2/82 , A61L29/08 , A61L29/14 , A61L29/16 , A61L31/10 , A61L31/14 , A61L31/16 , A61M25/00 , A61M25/09 , A61L29/00
CPC分类号： A61L31/10 , A61B17/12022 , A61B17/1215 , A61B17/12172 , A61B17/12177 , A61B17/12186 , A61B2017/00004 , A61B2017/00893 , A61F2/82 , A61F2250/0067 , A61L29/085 , A61L29/16 , A61L31/16 , A61L2300/00 , A61L2400/12 , A61M25/0043 , A61M25/09 , C08L79/02
摘要： A medical device, such as a guide wire, an embolization device, or a guide shaft for a micro .catheter, comprises a solid and/or non-expandable core member made from e.g. metal, such as tantalum, and an outer surface layer, which Is formed by electrospun nanofibers. The outer surface layer may incorporate a pharmaceutically active substance, such as a nitric oxide (NO) donor for release in the vascular or neurovascular system of a living being. The NO donor may be incorporated in a polymer, such as a polymeric linear poly(ethyleni mine) diazeniumdiolate.
摘要翻译：用于微型导管的医疗装置，例如导丝，栓塞装置或导向轴，包括由例如导管制成的固体和/或不可膨胀的芯构件。金属，如钽，以及由电纺丝纳米纤维形成的外表面层。外表面层可以并入药物活性物质，例如用于在生物体的血管或神经血管系统中释放的一氧化氮（NO）供体。 NO供体可以掺入聚合物中，例如聚合物线性聚（乙烯）二氮烯鎓二醇酯。

6. 发明申请

WO2005018600A2 METHOD OF TREATING A PATIENT SUFFERING FROM A SOLID TUMOUR 审中-公开
标题翻译：治疗来自固体肿瘤的患者的方法
公开(公告)号：WO2005018600A2
公开(公告)日：2005-03-03
申请号：PCT/DK2004000560
申请日：2004-08-23
申请人： CUBE MEDICAL AS , ANDERSEN ERIK
发明人： ANDERSEN ERIK
IPC分类号： A61K9/16 , A61K9/50 , A61K9/52 , A61M25/00 , A61K9/00
CPC分类号： A61K9/50 , A61K9/1623
摘要： Disclosed is treatment of a patient suffering from a solid tumour, where microparticles are administered which have a diametrical size that results in retention of the particles in the tumour's arterioles, so as to release a chemotherapeutical agent to the surrounding tumour tissue while minimally compromising surrounding non-tumour tissue. Preferred embodiments entail that encapsulating microspheres are rendered leaky for the chemotherapeutic agent by means of an electromagnetic or ultrasound shock wave. Other embodiments comprise co-administration to the patient of at least one therapeutic agent comprised in particles to provide an anti-inflammatory effect or inhibition of cell death.
摘要翻译：公开了治疗患有实体瘤的患者，其中施用微粒，其具有导致颗粒保留在肿瘤小动脉中的直径尺寸，以便将化学治疗剂释放到周围肿瘤组织，同时最小限度地损害周围的非小细胞肿瘤组织。优选的实施方案需要通过电磁或超声冲击波使包封微球体对于化学治疗剂泄漏。其它实施方案包括向患者共同施用包含在颗粒中的至少一种治疗剂以提供抗炎作用或抑制细胞死亡。

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