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1. 发明申请

WO2005039664A2 MEDICAL DEVICE 审中-公开
标题翻译：医疗装置
公开(公告)号：WO2005039664A2
公开(公告)日：2005-05-06
申请号：PCT/US2004033949
申请日：2004-10-14
申请人： CUBE MEDICAL AS , UNIV AKRON , ANDERSEN ERIK , SMITH DANIEL , RENEKER DARRELL
发明人： ANDERSEN ERIK , SMITH DANIEL , RENEKER DARRELL
IPC分类号： A61B17/00 , A61B17/12 , A61F2/00 , A61F2/82 , A61L29/08 , A61L29/14 , A61L29/16 , A61L31/10 , A61L31/14 , A61L31/16 , A61M25/00 , A61M25/09 , A61L29/00
CPC分类号： A61L31/10 , A61B17/12022 , A61B17/1215 , A61B17/12172 , A61B17/12177 , A61B17/12186 , A61B2017/00004 , A61B2017/00893 , A61F2/82 , A61F2250/0067 , A61L29/085 , A61L29/16 , A61L31/16 , A61L2300/00 , A61L2400/12 , A61M25/0043 , A61M25/09 , C08L79/02
摘要： A medical device, such as a guide wire, an embolization device, or a guide shaft for a micro .catheter, comprises a solid and/or non-expandable core member made from e.g. metal, such as tantalum, and an outer surface layer, which Is formed by electrospun nanofibers. The outer surface layer may incorporate a pharmaceutically active substance, such as a nitric oxide (NO) donor for release in the vascular or neurovascular system of a living being. The NO donor may be incorporated in a polymer, such as a polymeric linear poly(ethyleni mine) diazeniumdiolate.
摘要翻译：用于微型导管的医疗装置，例如导丝，栓塞装置或导向轴，包括由例如导管制成的固体和/或不可膨胀的芯构件。金属，如钽，以及由电纺丝纳米纤维形成的外表面层。外表面层可以并入药物活性物质，例如用于在生物体的血管或神经血管系统中释放的一氧化氮（NO）供体。 NO供体可以掺入聚合物中，例如聚合物线性聚（乙烯）二氮烯鎓二醇酯。

2. 发明申请

WO2005037339A9 A BALLOON FOR USE IN ANGIOPLASTY 审中-公开
标题翻译：一种用于血管成形术的球囊
公开(公告)号：WO2005037339A9
公开(公告)日：2005-10-13
申请号：PCT/US2004033851
申请日：2004-10-14
申请人： CUBE MEDICAL AS , UNIV AKRON , ANDERSEN ERIK , SMITH DANIEL , RENEKER DARRELL
发明人： ANDERSEN ERIK , SMITH DANIEL , RENEKER DARRELL
IPC分类号： A61B17/00 , A61B17/12 , A61F2/00 , A61F2/82 , A61L29/08 , A61L29/14 , A61L29/16 , A61L31/10 , A61L31/14 , A61L31/16 , A61M25/00 , A61M25/09 , A61F2/06
CPC分类号： A61L31/10 , A61B17/12022 , A61B17/1215 , A61B17/12172 , A61B17/12177 , A61B17/12186 , A61B2017/00004 , A61B2017/00893 , A61F2/82 , A61F2250/0067 , A61L29/085 , A61L29/16 , A61L31/16 , A61L2300/00 , A61L2400/12 , A61M25/0043 , A61M25/09 , C08L79/02
摘要： An expandable balloon for use in angioplasty procedures comprises a balloon having an outer surface layer, the outer surface layer being made from electrospun nanofibers and incorporating at least one pharmaceutically active substance, such as nitric oxide (NO). The outer surface layer may be formed on a separate flexible tubular member or sock, which is slipped over the balloon. An acidic agent, such as ascorbic acid, may be included in the balloon for enhancing NO release. A method of treating cell disorders in tubular structures of a living being comprises the steps of placing a coated balloon at a treatment site within the tubular structures, expanding the balloon at the treatment site, and releasing the pharmaceutically active substance at the treatment site. Optionally, a stent may be crimped onto the balloon prior to insertion of the balloon and stent into the tubular structures of the living being.
摘要翻译：用于血管成形术过程的可膨胀球囊包括具有外表面层的球囊，所述外表面层由电纺纳米纤维制成并掺入至少一种药物活性物质，例如一氧化氮（NO）。外表面层可以形成在滑过气囊的单独的柔性管状构件或袜子上。酸性试剂如抗坏血酸可包含在气囊中用于增强NO释放。治疗生物体的管状结构中的细胞紊乱的方法包括以下步骤：将涂布的球囊放置在管状结构内的治疗部位上，在治疗部位处扩张球囊，并在治疗部位释放药物活性物质。可选地，可以在将球囊和支架插入生物的管状结构之前将支架卷曲到球囊上。

3. 发明申请

WO2007133570A3 ELECTROSPUN STRUCTURES AND METHODS FOR FORMING AND USING SAME 审中-公开
标题翻译：用于形成和使用它们的电极结构和方法
公开(公告)号：WO2007133570A3
公开(公告)日：2008-01-24
申请号：PCT/US2007011158
申请日：2007-05-09
申请人： UNIV AKRON , RENEKER DARRELL , HAN TAO , SMITH DANIEL , ERTLEY CAMDEN , RENEKER JOSEPH W
发明人： RENEKER DARRELL , HAN TAO , SMITH DANIEL , ERTLEY CAMDEN , RENEKER JOSEPH W
IPC分类号： B32B9/00
CPC分类号： D01D5/0092 , Y10T428/2918 , Y10T428/292 , Y10T428/2927
摘要： The present invention relates to structures that contain one or more fiber and/or nanofiber structures where such structures can be formed on a wide variety of structures or surfaces (e.g., asperities, flat surfaces, angled surface, hierarchical structures, etc.). In one embodiment, the present invention relates to a process for forming one or more fibers, nanofibers or structures made therefrom on a wide variety of structures or surfaces (e.g., asperities, flat surfaces, angled surface, hierarchical structures, etc.). In another embodiment, the present invention relates to a process for forming one or more fibers, nanofibers or structures made therefrom on a wide variety of structures or surfaces (e.g., asperities, flat surfaces, angled surface, hierarchical structures, etc.) where such fibers and/or structures are designed to sequester, carry and/or encapsulate one or more substances. In still another embodiment, the present invention relates to structures that contain one or more fiber and/or nanofiber structures on asperities where the nanofiber and/or fiber structures are designed to sequester, carry and/or encapsulate one or more substances.
摘要翻译：本发明涉及包含一种或多种纤维和/或纳米纤维结构的结构，其中这种结构可以形成在各种各样的结构或表面（例如，凹凸，平坦表面，成角度的表面，分级结构等）上。在一个实施方案中，本发明涉及在各种结构或表面（例如，凹凸，平坦表面，倾斜表面，分层结构等）上形成一种或多种纤维，纳米纤维或由其制成的结构的方法。在另一个实施方案中，本发明涉及一种在多种结构或表面（例如，凹凸，平坦表面，成角度表面，分级结构等）上形成一种或多种纤维，纳米纤维或由其制成的结构的方法，纤维和/或结构被设计成隔离，携带和/或封装一种或多种物质。在另一个实施方案中，本发明涉及在凹凸上含有一种或多种纤维和/或纳米纤维结构的结构，其中纳米纤维和/或纤维结构被设计为螯合，携带和/或包封一种或多种物质。

4. 发明申请

WO2005070008A8 POLYMER NO DONOR PREDRUG NANOFIBER COATING FOR MEDICAL DEVICES AND THERAPY 审中-公开
标题翻译：聚合物无配体预处理用于医疗器械和治疗的纳米纤维涂层
公开(公告)号：WO2005070008A8
公开(公告)日：2006-10-26
申请号：PCT/US2005002266
申请日：2005-01-24
申请人： UNIV AKRON , RENEKER DARRELL
发明人： RENEKER DARRELL , SMITH DANIEL J
IPC分类号： A61K31/78 , A61K45/06 , A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16
CPC分类号： A61K31/78 , A61K45/06 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/114 , A61L2400/12 , A61K2300/00 , C08L79/02
摘要： The present invention relates to nanofibers that produce therapeutic amounts of nitric oxide after a delay period, which allows time to install or implant the device into a patient. The nitric oxide release is thus localized to the area of the organism where NO dosing is indicated. The delay time is achieved by cospinning the NO-producing fiber with a fiber that tends to sequester the former's NO-producing functional groups. Fibers of the present invention may be incorporated into medical devices such as stents or other implantable medical devices to prevent the formation of adhesions or scarring in the area of the implant.
摘要翻译：本发明涉及在延迟期后产生治疗量的一氧化氮的纳米纤维，其允许将装置安装或植入患者体内的时间。一氧化氮释放因此定位于生物体的指示NO给药的区域。延迟时间是通过用容易隔离前者的NO产生官能团的纤维共纺生产NO的纤维实现的。本发明的纤维可以结合到诸如支架或其它可植入医疗装置的医疗装置中，以防止在植入物区域中形成粘连或疤痕。

5. 发明申请

WO03106655A2 FIBROUS PROTEIN-IMMOBILIZATION SYSTEMS 审中-公开
标题翻译：纤维蛋白固定系统
公开(公告)号：WO03106655A2
公开(公告)日：2003-12-24
申请号：PCT/US0319197
申请日：2003-06-18
申请人： UNIV AKRON , WANG PING , RENEKER DARRELL , JIA HONGFEI , ZHU GUANGYU
发明人： WANG PING , RENEKER DARRELL , JIA HONGFEI , ZHU GUANGYU
IPC分类号： G01N33/544 , C12N
CPC分类号： C12N11/02 , C12N11/08 , G01N33/544
摘要： The present invention provides a fibrous protein-immobilization system composition comprising a fiber comprising fiber-forming material, and a protein attached to the fiber-forming material.
摘要翻译：本发明提供一种纤维蛋白固定系统组合物，其包含含纤维形成材料的纤维和附着于纤维形成材料的蛋白质。

6. 发明申请

WO2007084742A3 METHOD OF MAKING COILED AND BUCKLED ELECTROSPUN FIBER STRUCTURES 审中-公开
标题翻译：制造卷绕和绞合电纺纤维结构的方法
公开(公告)号：WO2007084742A3
公开(公告)日：2007-11-29
申请号：PCT/US2007001590
申请日：2007-01-22
申请人： UNIV AKRON , RENEKER DARRELL
发明人： RENEKER DARRELL
IPC分类号： B32B1/00 , D02G3/00
CPC分类号： D01D5/0038 , D01D5/0092 , D01F1/106
摘要： An apparatus and method for making coiled and buckled electrospun fiber including (a) providing a solution of a polymer in an organic solvent and a device for electrospinning fiber; b) subjecting the polymer solution to an electric field such that at least one fiber is electrospun; (c) subjecting the so formed fiber to electrical bending and mechanical buckling instability to hereby form a coiled and buckled fiber; (d) collecting the at least one fiber on a collector, such that a fiber structure is produced.
摘要翻译：一种用于制造卷曲和弯曲的电纺纤维的装置和方法，包括（a）提供聚合物在有机溶剂中的溶液和用于静电纺丝的装置; b）使聚合物溶液进行电场，使得至少一种纤维是静电纺丝的; （c）使这样形成的纤维经受电弯曲和机械屈曲不稳定性，从而形成卷曲和弯曲的纤维; （d）在收集器上收集至少一根纤维，从而产生纤维结构。

7. 发明申请

WO2007030669A3 FLEXIBLE CERAMIC FIBERS AND A PROCESS FOR MAKING SAME 审中-公开
标题翻译：柔性陶瓷纤维及其制备方法
公开(公告)号：WO2007030669A3
公开(公告)日：2007-08-09
申请号：PCT/US2006034946
申请日：2006-09-07
申请人： UNIV AKRON , RENEKER DARRELL , CHASE GEORGE , KATAPHINAN WORAPHON , KATTA PRATHYUSHA
发明人： RENEKER DARRELL , CHASE GEORGE , KATAPHINAN WORAPHON , KATTA PRATHYUSHA
IPC分类号： B05B1/28
CPC分类号： D01D5/003 , C04B35/62231 , C04B35/62236 , C04B35/6224 , C04B35/62245 , C04B35/6225 , C04B35/62259 , C04B35/62263 , C04B35/63444 , C04B2235/5252 , C04B2235/526 , C04B2235/5264 , C04B2235/6562 , D01F9/08 , Y10T428/2913 , Y10T442/681
摘要： The present invention is generally directed to ceramic fibers, which when employed in sheets to provide flexibility and to methods for making same. In one embodiment, the present invention relates to ceramic fibers that are heat and chemical resistant, and to a method for making same. In another embodiment, the present invention relates to ceramic nanofibers and ceramic nanofiber sheets, and to a method for making same. In still another embodiment, the present invention relates to electrospun ceramic nanofibers and nanofiber sheets, products that include such fibers, and to methods of making same.
摘要翻译：本发明总体上涉及陶瓷纤维，当其用于片材以提供柔性时，以及制造陶瓷纤维的方法。在一个实施方案中，本发明涉及耐热和耐化学腐蚀的陶瓷纤维，并且涉及制造陶瓷纤维的方法。在另一个实施方案中，本发明涉及陶瓷纳米纤维和陶瓷纳米纤维片材及其制造方法。在又一个实施方案中，本发明涉及电纺纳米纤维和纳米纤维片材，包含这种纤维的产品以及制造它们的方法。

8. 发明申请

WO0126702A3 NITRIC OXIDE-MODIFIED LINEAR POLY(ETHYLENIMINE) FIBERS AND USES THEREFOR 审中-公开
标题翻译：一氧化氮改性线性聚（乙烯）纤维及其用途
公开(公告)号：WO0126702A3
公开(公告)日：2001-12-13
申请号：PCT/US0027769
申请日：2000-10-06
申请人： UNIV AKRON
发明人： SMITH DANIEL , RENEKER DARRELL
IPC分类号： A61L15/26 , A61L15/44 , A61L17/14 , A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16
CPC分类号： D01F6/96 , A61L15/26 , A61L15/44 , A61L17/145 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/114 , A61L2300/606 , A61L2300/624 , Y10S623/926 , Y10S977/89 , Y10T428/2998 , C08L79/02
摘要： A novel coating for medical devices provides nitric oxide delivery using nanofibers of linear poly(ethylenimine)diazeniumdiolate. Linear poly(ethylenimine)diazeniumdiolate releases nitric oxide (NO) in a controlled manner to tissues and organs to aid the healing process and to prevent injury to tissues at risk of injury. Electrospun nanofibers of linear poly(ethylenimine)diazeniumdiolate deliver therapeutic levels of NO to the tissues surrounding a medical device while minimizing the alteration of the properties of the device. A nanofiber coating, because of the small size and large surface area per unit mass of the nanofibers, provides a much larger surface area per unit mass while minimizing changes in other properties of the device.
摘要翻译：用于医疗装置的新型涂层使用线性聚（乙烯亚胺）二醇二氮烯鎓的纳米纤维提供一氧化氮递送。线性聚（乙烯亚胺）二醇二氮烯鎓以受控的方式向组织和器官释放一氧化氮（NO），以帮助愈合过程并防止受到损伤风险的组织的伤害。线性聚（乙烯亚胺）二醇二氮烯鎓的电纺纳米纤维将治疗水平的NO递送至医疗装置周围的组织，同时最小化装置性质的改变。由于纳米纤维的小尺寸和每单位质量的大表面积，纳米纤维涂层提供了大得多的单位质量表面积，同时使装置的其他性质的变化最小化。

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