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1. 发明申请

WO2015030891A3 INDUCTANCE-TUNED ELECTRO-OPTIC MODULATORS 审中-公开
标题翻译：电感式电光调制器
公开(公告)号：WO2015030891A3
公开(公告)日：2015-07-16
申请号：PCT/US2014040655
申请日：2014-06-03
申请人： MASSACHUSETTS INST TECHNOLOGY , HOLLIS MARK A , SWINT REUEL B , SIRIANI DOMINIC , DONNELLY JOSEPH P , JUODAWLKIS PAUL WILLIAM
发明人： HOLLIS MARK A , SWINT REUEL B , SIRIANI DOMINIC , DONNELLY JOSEPH P , JUODAWLKIS PAUL WILLIAM
IPC分类号： G02F1/035
CPC分类号： G02F1/2255 , G02B6/14 , G02B2006/12097 , G02F1/01708 , G02F1/01716 , G02F1/2257 , G02F2001/212 , G02F2201/12
摘要： An electro-optic modulator imparts the information contained in an electrical signal traveling along a transmission line onto an optical carrier by using signal-related variations in the electrical signal's voltage to modulate the refractive index or absorption in an electro-optic material through which the optical carrier propagates. For optimal bandwidth and modulation efficiency, the microwave and optical waves should be matched in velocity. However, conventional microwave transmission lines have a microwave velocity that is somewhat higher than the optical group velocity in typical optical waveguides. Tuning a microwave transmission line's capacitance reduces the microwave velocity, but also reduces the impedance below the 50 Ω impedance of most microwave components. Conversely, tuning the microwave transmission line's inductance makes it possible to match the microwave velocity to the optical group velocity over bandwidths of 100 GHz or greater while maintaining a microwave impedance of 50 Ω.
摘要翻译：电光调制器通过使用电信号电压中的信号相关变化将包含在沿着传输线行进的电信号中的信息传递到光载体上，以调制电光材料中的折射率或吸收，通过光电材料载波传播。为了获得最佳的带宽和调制效率，微波和光波的速度应该匹配。然而，传统的微波传输线的微波速度略高于典型光波导中的光群速度。调谐微波传输线的电容降低了微波速度，同时也降低了阻抗大多数微波元件50Ω阻抗的阻抗。相反，调谐微波传输线的电感可以使微波速度与100 GHz或更大带宽上的光学组速度相匹配，同时保持微波阻抗为50Ω。

2. 发明申请

WO2007046825A3 OPTOELECTRONIC DETECTION SYSTEM 审中-公开
标题翻译：光电检测系统
公开(公告)号：WO2007046825A3
公开(公告)日：2007-07-26
申请号：PCT/US2005043343
申请日：2005-11-30
申请人： MASSACHUSETTS INST TECHNOLOGY , SCHWOEBEL ERIC D , HARPER JAMES D , PETROVICK MARTHA S , NARGI FRANCES E , RIDER TODD H , HOGAN KRISTINE E , MATHEWS RICHARD H , LACIRIGNOLA JOSEPH , HENNESSY MARK , VIAN TRINA R , JOSEPH ROSE M , UTTARO RAYMOND , SHAUN BERRY , HOLLIS MARK A , JOHNSON BERNADETTE
发明人： SCHWOEBEL ERIC D , HARPER JAMES D , PETROVICK MARTHA S , NARGI FRANCES E , RIDER TODD H , HOGAN KRISTINE E , MATHEWS RICHARD H , LACIRIGNOLA JOSEPH , HENNESSY MARK , VIAN TRINA R , JOSEPH ROSE M , UTTARO RAYMOND , SHAUN BERRY , HOLLIS MARK A , JOHNSON BERNADETTE
IPC分类号： C12Q1/68
CPC分类号： G01N33/5304 , C12M1/3461 , C12M1/3476 , C12Q1/6825 , G01N21/6428 , G01N21/6454 , G01N33/582 , C12Q2565/619 , C12Q2563/131
摘要： The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.
摘要翻译：本文所述的发明提供了用于检测可溶性抗原的方法。特别是，这些方法提供了可溶性蛋白质和化学品的检测。另外，本发明提供了检测样品中的核酸序列的方法。还描述了包含Fc受体和发射体分子的发射体细胞，用于检测样品中的目标颗粒，其中待检测的目标颗粒被一种或多种抗体结合。还提供了一种用于检测多个样本中的目标粒子的光电子传感器装置。

3. 发明申请

WO2005045075A3 SAMPLE PREPARATION METHODS AND DEVICES 审中-公开
标题翻译：样品制备方法和装置
公开(公告)号：WO2005045075A3
公开(公告)日：2005-12-15
申请号：PCT/US2004026068
申请日：2004-08-12
申请人： MASSACHUSETTS INST TECHNOLOGY , HOLLIS MARK A , FREELAND JUDSON NICHOLAS , RUDZINSKI CHRISTINA MARIE , PAREMESWARAN LALITHA , FEDYNYSHYN THEODORE , CABRERA CATHERINE , BORTOLIN LAURA T
发明人： HOLLIS MARK A , FREELAND JUDSON NICHOLAS , RUDZINSKI CHRISTINA MARIE , PAREMESWARAN LALITHA , FEDYNYSHYN THEODORE , CABRERA CATHERINE , BORTOLIN LAURA T
IPC分类号： B01L3/00 , C12M1/34 , C12Q1/68 , C12Q1/70 , G01N33/53 , G01N33/543
CPC分类号： G01N33/54326 , B01L3/502 , C12Q1/6806 , C12Q2563/143 , C12Q2527/113
摘要： The present invention provides improved methods, compositions, and devices for separating and/or detecting targets from biological, environmental, or chemical samples, involving organosilicon-coated materials.
摘要翻译：本发明提供用于从包括有机硅涂覆材料的生物，环境或化学样品中分离和/或检测靶的改进的方法，组合物和装置。

4. 发明申请

WO2007097740A2 SAMPLE PREPARATION METHODS AND DEVICES 审中-公开
标题翻译：样品制备方法和装置
公开(公告)号：WO2007097740A2
公开(公告)日：2007-08-30
申请号：PCT/US2006005033
申请日：2006-02-10
申请人： MASSACHUSETTS INST TECHNOLOGY , HOLLIS MARK A , FREELAND JUDSON NICHOLAS MATTH , RUDZINSKI CHRISTINA MARIE , PARAMESWARAN LALITHA , FEDYNYSHYN THEODORE H , CABRERA CATHERINE REGINA , BORTOLIN LAURA T , KING ROBERT , ANGEL MATTHEW M
发明人： HOLLIS MARK A , FREELAND JUDSON NICHOLAS MATTH , RUDZINSKI CHRISTINA MARIE , PARAMESWARAN LALITHA , FEDYNYSHYN THEODORE H , CABRERA CATHERINE REGINA , BORTOLIN LAURA T , KING ROBERT , ANGEL MATTHEW M
IPC分类号： C12M1/34 , C12Q1/68 , C12Q1/70 , G01N33/53 , G01N33/543
CPC分类号： C12M47/04 , G01N33/54326
摘要： The present invention provides improved devices for separating and/or detecting targets from biological, environmental, or chemical samples.
摘要翻译：本发明提供了用于从生物，环境或化学样品分离和/或检测靶的改进装置。

5. 发明申请

WO2007046825A9 OPTOELECTRONIC DETECTION SYSTEM 审中-公开
标题翻译：光电检测系统
公开(公告)号：WO2007046825A9
公开(公告)日：2007-06-21
申请号：PCT/US2005043343
申请日：2005-11-30
申请人： MASSACHUSETTS INST TECHNOLOGY , SCHWOEBEL ERIC D , HARPER JAMES D , PETROVICK MARTHA S , NARGI FRANCES E , RIDER TODD H , HOGAN KRISTINE E , MATHEWS RICHARD H , LACIRIGNOLA JOSEPH , HENNESSY MARK , VIAN TRINA R , JOSEPH ROSE M , UTTARO RAYMOND , SHAUN BERRY , HOLLIS MARK A , JOHNSON BERNADETTE
发明人： SCHWOEBEL ERIC D , HARPER JAMES D , PETROVICK MARTHA S , NARGI FRANCES E , RIDER TODD H , HOGAN KRISTINE E , MATHEWS RICHARD H , LACIRIGNOLA JOSEPH , HENNESSY MARK , VIAN TRINA R , JOSEPH ROSE M , UTTARO RAYMOND , SHAUN BERRY , HOLLIS MARK A , JOHNSON BERNADETTE
IPC分类号： C12Q1/68
CPC分类号： G01N33/5304 , C12M1/3461 , C12M1/3476 , C12Q1/6825 , G01N21/6428 , G01N21/6454 , G01N33/582 , C12Q2565/619 , C12Q2563/131
摘要： The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.
摘要翻译：本文描述的本发明提供了用于检测可溶性抗原的方法。特别地，该方法提供了可溶性蛋白质和化学物质的检测。此外，本发明提供了检测样品中核酸序列的方法。还描述了包含Fc受体和发射体分子的发射体细胞，用于检测样品中的靶颗粒，其中待检测的靶颗粒被一种或多种抗体结合。还提供了一种用于检测多个样品中的目标颗粒的光电传感器装置。

6. 发明申请

WO03033740A2 APPARATUS AND METHOD FOR ISOLATING A NUCLEIC ACID 审中-公开
标题翻译：用于分离核酸的装置和方法
公开(公告)号：WO03033740A2
公开(公告)日：2003-04-24
申请号：PCT/US0221715
申请日：2002-07-10
申请人： MASSACHUSETTS INST TECHNOLOGY
发明人： PARAMESWARAN LALITHA , YOUNG ALBERT , BORTOLIN LAURA T , HOLLIS MARK A , HARPER JAMES , BOBROW JOHANNA
IPC分类号： B01L3/00 , B01L3/02 , C12N1/08 , C12N15/10 , C12P19/34 , C12Q1/68
CPC分类号： B01L3/0282 , B01L3/0241 , B01L3/5023 , B01L2400/0406 , B01L2400/0415 , B01L2400/049 , C12Q1/6806 , C12Q2565/137 , C12Q2549/125
摘要： A method for preparing a nucleic acid component of a sample for amplification includes contacting the sample with a porous support that deactivates a nucleic acid amplification inhibitor component of the sample and directing a fluid through the porous support, whereby the nucleic acid component of the sample is directed through at least a portion of the porous support and is separated from the support, thereby preparing the nucleic acid component for amplification. The method can be conducted in an apparatus that includes a porous support having a component that deactivates a nucleic acid amplification inhibitor component of a sample contacting the porous support and a housing having an opening and defining an interior, said interior being in fluid communication with the porous support, whereby at least a portion of a fluid directed through the opening is directed through at least a portion of the porous support and separates at least a portion of a nucleic acid component of a sample contacting the porous support from the support, thereby preparing the nucleic acid component for amplification.
摘要翻译：用于制备用于扩增的样品的核酸组分的方法包括使样品与多孔载体接触，多孔载体使样品的核酸扩增抑制剂组分失活并引导流体通过多孔载体，由此样品的核酸组分为引导通过多孔载体的至少一部分并与载体分离，由此制备用于扩增的核酸组分。该方法可以在包括多孔载体的装置中进行，所述多孔载体具有使与多孔载体接触的样品的核酸扩增抑制剂组分失活的组分和具有开口并限定内部的壳体，所述内部与多孔载体，其中通过开口引导的流体的至少一部分被引导通过多孔载体的至少一部分，并将与多孔载体接触的样品的核酸组分的至少一部分与载体分离，由此制备用于扩增的核酸组分。

7. 发明申请

WO8906444A3 VERTICAL POWER TRANSISTOR AND FABRICATION METHODS 审中-公开
标题翻译：垂直功率晶体管和制造方法
公开(公告)号：WO8906444A3
公开(公告)日：1989-09-08
申请号：PCT/US8804703
申请日：1988-12-29
申请人： MASSACHUSETTS INST TECHNOLOGY
发明人： BOZLER CARL O , RABE STEVEN , HOLLIS MARK A , HARRIS CHRISTOPHER T , NICHOLS KIRBY B
IPC分类号： H01L21/28 , H01L21/335 , H01L29/06 , H01L29/41 , H01L29/737 , H01L29/772 , H01L29/80 , H01L21/285 , H01L21/31 , H01L21/76 , H01L29/08 , H01L29/40 , H01L29/72
CPC分类号： H01L29/66454 , H01L21/28 , H01L29/0649 , H01L29/0692 , H01L29/41 , H01L29/7371 , H01L29/7722
摘要： A power permeable base transistor comprising: a base layer formed as comb structures with grating teeth (50, 52, 54, 56) of the combs extending into active regions (34, 36, 38, 40) of semiconductor material and extended active regions (34, 36, 38, 40) separated by inactive regions (35, 37, 39, 41, 43) over which collector contacts (24, 26, 28) extend. These features improve heat dissipation in operation. Current density can also be reduced by provision of thick gold collector contacts (24, 26, 28). Large devices have digitated base layers. A processing method of forming a layer of material having a pattern of high resolution portions and lesser resolution portions, comprising the steps of sputtering a uniform layer of tungsten, forming a nickel mask over the tungsten by both X-ray and photolithography techniques, and etching the tungsten exposed by the nickel mask. The resulting patterned layer can be the aforesaid comb structure. A method of forming alloyed contacts with partial ohmic contact to a semiconductor layer having proton bombarded insulating regions formed therein. A heterojuncction bipolar transistor with extended active regions (152, 154) separated by inactive regions (132) over which collector contacts (144, 146) extend is also disclosed.

8. 发明申请

WO2015105591A3 METALLIC PHOTOVOLTAICS 审中-公开
标题翻译：金属光伏
公开(公告)号：WO2015105591A3
公开(公告)日：2015-09-03
申请号：PCT/US2014066842
申请日：2014-11-21
申请人： MASSACHUSETTS INST TECHNOLOGY
发明人： MILLIS JESSE H , COOMBS JEREMY S , WILSON JOSHUA L , HOLLIS MARK A , BUSSE FRANZ , DIEST KENNETH ALEXANDER
IPC分类号： H01L31/0687 , H01L31/056 , H01L31/07
CPC分类号： H01L31/07 , H01L31/0547 , H01L31/056 , H01L31/0687 , H01L31/18 , Y02E10/52 , Y02E10/544
摘要： According to some aspects, an apparatus for converting electromagnetic radiation into electric power is provided, comprising a first layer comprising a first semiconductor material, an absorber in contact with the first layer, a second layer comprising a second semiconductor material, the second layer being in contact with the absorber, and a reflector to reflect at least a portion of electromagnetic radiation passing through the second layer. According to some aspects, a method of forming an apparatus for converting electromagnetic radiation into electric power is provided, comprising forming a reflector on a substrate, forming a first layer in contact with the reflector, the first layer comprising a first semiconductor material, forming an absorber in contact with the first layer, and forming a second layer in contact with the absorber, the second layer comprising a second semiconductor material.
摘要翻译：根据一些方面，提供了一种用于将电磁辐射转换成电力的装置，包括第一层，包括第一半导体材料，与第一层接触的吸收体，第二层包括第二半导体材料，第二层位于与吸收器接触，以及反射器以反射通过第二层的电磁辐射的至少一部分。根据一些方面，提供一种形成用于将电磁辐射转换成电力的装置的方法，包括在基板上形成反射器，形成与所述反射器接触的第一层，所述第一层包括第一半导体材料，形成第吸收体与第一层接触，以及形成与吸收体接触的第二层，第二层包括第二半导体材料。

9. 发明申请

WO8907341A3 HIGH MOBILITY TRANSISTOR WITH OPPOSED GATES 审中-公开
标题翻译：具有对称门的高移动性晶体管
公开(公告)号：WO8907341A3
公开(公告)日：1989-11-02
申请号：PCT/US8900283
申请日：1989-01-23
申请人： MASSACHUSETTS INST TECHNOLOGY
发明人： HOLLIS MARK A , GOODHUE WILLIAM D , NICHOLS KIRBY B , BERGERON NORMAND J JR
IPC分类号： C23C14/22 , H01L21/285 , H01L21/335 , H01L21/338 , H01L29/06 , H01L29/10 , H01L29/423 , H01L29/778 , H01L29/812 , H01L29/80 , H01L21/28 , H01L29/60
CPC分类号： C23C14/225 , H01L21/28587 , H01L21/28593 , H01L29/0653 , H01L29/0657 , H01L29/1029 , H01L29/42316 , H01L29/66462 , H01L29/66856 , H01L29/7785 , H01L29/7787 , H01L29/7788 , H01L29/7789 , H01L29/8122 , Y10S438/944
摘要： Horizontal and vertical transistors, such as, HEMT/SDHT devices are described with opposed gates for preventing substrate leakage current along with the methods for making same. Also a process for making single gate angled V-HEMT devices is described.

10. 发明申请

WO9322678A3 OPTICAL AND ELECTRICAL METHODS AND APPARATUS FOR MOLECULE DETECTION 审中-公开
标题翻译：光电检测方法及装置
公开(公告)号：WO9322678A3
公开(公告)日：1994-02-03
申请号：PCT/US9303829
申请日：1993-04-23
申请人： MASSACHUSETTS INST TECHNOLOGY
发明人： HOLLIS MARK A , EHRLICH DANIEL J , MURPHY ALLEN R , KOSICKI BERNARD B , RATHMAN DENNIS D , CHEN CHANG-LEE , MATHEWS RICHARD H , BURKE BARRY E , EGGERS MITCH D , HOGAN MICHAEL E , VARMA RAJENDER SINGH
IPC分类号： G01N21/64 , B01J19/00 , C12M1/00 , C12M1/34 , C12N11/00 , C12N15/09 , C12Q1/02 , C12Q1/68 , C40B40/06 , C40B60/14 , G01N5/02 , G01N21/25 , G01N21/27 , G01N21/78 , G01N22/00 , G01N27/00 , G01N27/02 , G01N27/22 , G01N27/27 , G01N27/327 , G01N29/00 , G01N29/12 , G01N33/483 , G01N33/50 , G01N33/53 , G01N33/543 , G01N33/566 , G01N37/00 , G01N21/75 , G01N27/07
CPC分类号： G01N33/5438 , B01J19/0046 , B01J19/0093 , B01J2219/00317 , B01J2219/00511 , B01J2219/00527 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00659 , B01J2219/00689 , B01J2219/00702 , B01J2219/00711 , B01J2219/00713 , B01J2219/00722 , B01J2219/00828 , B01J2219/00853 , C12Q1/6825 , C12Q1/6832 , C12Q1/6837 , C12Q1/6874 , C40B40/06 , C40B60/14 , G01N21/253 , G01N21/6454 , G01N27/221 , G01N27/226 , G01N33/54373 , Y10S436/806 , Y10S436/807 , C12Q2565/607
摘要： A method and apparatus are disclosed for identifying molecular structures within a sample substance using a monolithic array of test sites formed on a substrate upon which the sample substance is applied. Each test site includes probes formed therein to bond with a predetermined target molecular structure or structures. A signal is applied to the test sites and certain electrical, mechanical and/or optical properties of the test sites are detected to determine which probes have bonded to an associated target molecular structure.

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