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1. 发明申请

WO2008086375A3 NON-INVASIVE VASCULAR TREATMENT SYSTEMS, DEVICES, AND METHODS OF USING THE SAME 审中-公开
标题翻译：非侵入性血管治疗系统，装置和使用它们的方法
公开(公告)号：WO2008086375A3
公开(公告)日：2008-10-09
申请号：PCT/US2008050544
申请日：2008-01-08
申请人： LIGHT SCIENCES ONCOLOGY INC , KELTNER LLEW , CHEN JAMES C
发明人： KELTNER LLEW , CHEN JAMES C
IPC分类号： A61N5/06
CPC分类号： A61N5/062 , A61B18/203 , A61B2018/00452 , A61B2018/0047 , A61B2090/0436 , A61B2090/049 , A61N5/0616 , A61N2005/0645 , A61N2005/0652
摘要： An energy treatment system to treat a patient includes an energy delivery device having a plurality of energy emitters used in combination with an energy activatable drug. A mask can be used to define a treatment area. Energy from the energy emitters passes through an optical window of the mask to activate a cosmetically and/or therapeutically effective amount of the activatable drug at the target site to bring about a desired change of tissue, for example, to reduce visibility of one or more blood vessels, while energy from the energy emitters directed outside of the target site is blocked by the mask.
摘要翻译：治疗患者的能量治疗系统包括具有与能量可激活药物组合使用的多个能量发射器的能量输送装置。面罩可用于定义治疗区域。来自能量发射器的能量穿过面罩的光学窗口以激活目标部位处的可活化药物的化妆和/或治疗有效量以实现组织的期望改变，例如以降低一个或多个血管，而来自能量发射器的指向目标部位外的能量被面罩阻挡。

2. 发明申请

WO2007084608A3 METHOD AND APPARATUS FOR LIGHT-ACTIVATED DRUG THERAPY 审中-公开
标题翻译：用于轻活化药物治疗的方法和装置
公开(公告)号：WO2007084608A3
公开(公告)日：2008-01-31
申请号：PCT/US2007001324
申请日：2007-01-18
申请人： LIGHT SCIENCES ONCOLOGY INC , KELTNER LLEW , WINSHIP JAY , HAGSTROM S ERIK , ZHENG FRANK , CHEN JAMES C
发明人： KELTNER LLEW , WINSHIP JAY , HAGSTROM S ERIK , ZHENG FRANK , CHEN JAMES C
IPC分类号： A61B18/18
CPC分类号： A61N5/0601 , A61B2017/00084 , A61B2017/00274 , A61B2017/22068 , A61B2018/00285 , A61B2018/00547 , A61B2018/00821 , A61N5/062 , A61N2005/061 , A61N2005/0652
摘要： A prostate treatment system having a light delivery device positionable in a transurethral device for treatment of benign prostatic hyperplasia (BPH). The light delivery device includes light generator, such as light emitting diodes (LED), laser diodes (LDs) or a diffusion quartz fiber tip connected to a light generator or a light emitting polymer which produces light at a selected wavelength or waveband or alternative sources of suitable light energy. The treatment device may further include a temperature monitoring system for monitoring the temperature at the treatment site. A light-activated drug is administered to the treatment site prior to light activation. The light-activated drug therapy induces cell death of the target tissue. The device provides a minimally invasive transurethral method for treatment of BPH or prostate cancer.
摘要翻译：一种前列腺治疗系统，其具有定位在经尿道装置中的光输送装置，用于治疗良性前列腺增生（BPH）。光输送装置包括光发生器，例如发光二极管（LED），激光二极管（LD）或连接到光产生器或发光聚合物的扩散石英光纤尖端，其产生在所选波长或波段或替代光源合适的光能。治疗装置还可以包括用于监测治疗部位的温度的温度监测系统。光活化药物在光活化之前施用于治疗部位。光激活药物疗法诱导靶组织的细胞死亡。该装置提供用于治疗BPH或前列腺癌的微创经尿道方法。

3. 发明申请

WO2007130072A2 LIGHT TRANSMISSION SYSTEM FOR PHOTOREACTIVE THERAPY 审中-公开
标题翻译：用于光敏治疗的光传输系统
公开(公告)号：WO2007130072A2
公开(公告)日：2007-11-15
申请号：PCT/US2006018570
申请日：2006-05-15
申请人： LIGHT SCIENCES ONCOLOGY INC , CHEN JAMES C , DALY STEVEN ROSS , GUO ZIHONG , KELTNER LLEW , STORM JEFFREY ROBIN
发明人： CHEN JAMES C , DALY STEVEN ROSS , GUO ZIHONG , KELTNER LLEW , STORM JEFFREY ROBIN
IPC分类号： A61N5/06
CPC分类号： A61N5/062 , A61B50/30 , A61N5/0601 , A61N2005/0645 , A61N2005/0652
摘要： A light transmission system to provide photodynamic treatment to a patient includes a single use integrated control module and catheter assembly having a plurality of light emitting diodes (LEDs) to transmit light toward target cells within a patient. The integrated light catheter and control module are used in combination with a light activated drug. Selected operating parameters may be programmed into the control module, or it may be wirelessly programmable in situ prior to use to allow user flexibility to tailor treatment for a particular patient or condition. Among the features that prevent reuse are that the control module lacks access to recharge the power source, and it may include a deactivation module that destroys circuitry or software when triggered. To prevent patient interference when in use, the control module may also be configured to selectively deactivate.
摘要翻译：向患者提供光动力治疗的光传输系统包括具有多个发光二极管（LED）的单次使用的集成控制模块和导管组件，用于向患者内的靶细胞透射光。集成光导管和控制模块与光活化药物组合使用。所选择的操作参数可以被编程到控制模块中，或者可以在使用之前在现场进行无线可编程地编程，以允许用户灵活地为特定患者或病症定制治疗。防止重复使用的功能之一是控制模块缺少对电源进行充电的功能，并且可能包括在触发时破坏电路或软件的停用模块。为了在使用时防止患者干扰，控制模块还可以被配置为选择性地停用。

4. 发明申请

WO2006089118A3 PHOTOREACTIVE SYSTEM AND METHODS FOR PROPHYLACTIC TREATMENT OF ATHEROSCLEROSIS 审中-公开
标题翻译：光学治疗系统和方法治疗甲状腺功能亢进
公开(公告)号：WO2006089118A3
公开(公告)日：2007-11-15
申请号：PCT/US2006005648
申请日：2006-02-17
申请人： LIGHT SCIENCES ONCOLOGY INC , CHEN JAMES C , YEO NICHOLAS , BURWELL PHILLIP , WENGER THOMAS
发明人： CHEN JAMES C , YEO NICHOLAS , BURWELL PHILLIP , WENGER THOMAS
IPC分类号： A61M29/00
CPC分类号： A61K41/0071 , A61N5/0601 , A61N5/062 , A61N2005/0602 , A61N2005/0651 , A61N2005/0661
摘要： The present invention provides a prophylactic light activated treatment method for subjects at risk of a plaque-mediated thrombotic event, such as acute coronary syndromes. In one embodiment, the subject receives a dose of photosensitizer sufficient to result in a concentration of photosensitizer in the neovascularization associated with atherosclerotic disease to permit effective photodynamic therapy. Light of a wavelength that excites the photosensitizer, but that does not to any significant extent penetrate to an adventitial layer of the blood vessel, is applied to the region of the blood vessel. The therapeutic light dose, which may be applied in sequential stages, is sufficient to cause closure of neovasculature leakage and lead to plaque stabilization and reduced adverse clinical outcomes. The present invention further provides light transmission devices and systems useful in carrying out the methods of the present invention.
摘要翻译：本发明为患有斑块介导的血栓形成事件风险的受试者，例如急性冠状动脉综合征提供预防性光活化治疗方法。在一个实施方案中，受试者接受足以导致与动脉粥样硬化疾病相关的新血管形成中的光敏剂浓度以允许有效的光动力疗法的剂量的光敏剂。激发光敏剂的波长的光被施加到血管的区域，而不是任何显着程度的透射到血管的外膜层。可以按顺序施用的治疗光剂量足以引起新血管渗漏的闭合并导致斑块稳定化并减少不良临床结果。本发明还提供了用于实施本发明的方法的光传输装置和系统。

5. 发明申请

WO2007056498A3 LIGHT DELIVERY APPARATUS 审中-公开
标题翻译：光传送装置
公开(公告)号：WO2007056498A3
公开(公告)日：2007-10-11
申请号：PCT/US2006043588
申请日：2006-11-07
申请人： LIGHT SCIENCES ONCOLOGY INC , BARNARD WILLIAM LOUIS , BURWELL PHILLIP , CHEN JAMES C , CHRISTOPHERSEN JULENE S , GEMBALA WILLIAM L , SHINE DAVID B
发明人： BARNARD WILLIAM LOUIS , BURWELL PHILLIP , CHEN JAMES C , CHRISTOPHERSEN JULENE S , GEMBALA WILLIAM L , SHINE DAVID B
IPC分类号： A61N5/06 , A61B5/00
CPC分类号： A61N5/0603 , A61N5/0601 , A61N5/062
摘要： A light delivery apparatus to provide light treatment to a patient includes a catheter assembly having a light source that transmit light towards a target site within a patient. A balloon surrounds the light source and has a plurality of tissue engaging elements movable between first positions and second positions. In one embodiment, each element extends radially inward in the first position and radially outward in the second position. An insertion tool is used to deliver the light delivery apparatus. During use, the light delivery apparatus is rotationally locked with the insertion tool for improved steering, navigation, and aiming of emitted light.
摘要翻译：向患者提供光治疗的光输送装置包括导管组件，该导管组件具有将光发射到患者体内的目标部位的光源。气囊围绕光源并且具有可在第一位置和第二位置之间移动的多个组织接合元件。在一个实施例中，每个元件在第一位置处径向向内延伸并且在第二位置中径向向外延伸。插入工具用于输送光输送装置。在使用期间，光输送装置与插入工具旋转地锁定，以改善对发射光的转向，导航和瞄准。

6. 发明申请

WO2011020064A3 LOW-PROFILE INTRALUMINAL LIGHT DELIVERY SYSTEM AND METHODS OF USING THE SAME 审中-公开
标题翻译：低剖面内光交付系统及其使用方法
公开(公告)号：WO2011020064A3
公开(公告)日：2011-07-07
申请号：PCT/US2010045529
申请日：2010-08-13
申请人： LIGHT SCIENCES ONCOLOGY INC , CHEN JAMES C , BARNARD WILLIAM LOUIS , SHINE DAVID B , MIAZGA JAY
发明人： CHEN JAMES C , BARNARD WILLIAM LOUIS , SHINE DAVID B , MIAZGA JAY
IPC分类号： A61N5/06
CPC分类号： A61B5/411 , A61B5/0071 , A61B5/0084 , A61B5/0086 , A61B5/415 , A61B5/418 , A61B2017/00057 , A61B2017/003 , A61B2090/374 , A61B2090/3782 , A61N5/0601 , A61N5/062 , A61N2005/063
摘要： A light delivery system to provide light treatment to a patient includes an elongated catheter having a light emitter that transmits light towards a target site within a patient. The catheter is sized and configured to pass through anatomical body structures to reduce or eliminate trauma associated with the delivery procedure. A visualization system of the catheter can assist a user before, during, and/or after performing light therapy. The visualization system includes sensors that provide real-time imaging or feedback.
摘要翻译：向患者提供光治疗的光输送系统包括细长导管，其具有将光发射到患者体内的目标部位的光发射器。导管的尺寸和构造被设计成通过解剖体部结构以减少或消除与递送过程相关的创伤。导管的可视化系统可以在进行光疗之前，期间和/或之后帮助用户。可视化系统包括提供实时成像或反馈的传感器。

7. 发明申请

WO2005055040A3 DECREASED RESPONSE TIME FOR PPRC WRITE OPERATION 审中-公开
标题翻译：降低PPRC写入操作的响应时间
公开(公告)号：WO2005055040A3
公开(公告)日：2005-12-08
申请号：PCT/EP2004052800
申请日：2004-11-04
申请人： IBM , IBM FRANCE , CHEN JAMES C , HUYNH MINH-NGOC L , KALOS MATTHEW J , FUNG CHUNG M
发明人： CHEN JAMES C , HUYNH MINH-NGOC L , KALOS MATTHEW J , FUNG CHUNG M
IPC分类号： G06F3/06 , H04L12/56
CPC分类号： G06F3/065 , G06F3/0611 , G06F3/067 , G06F3/0689 , H04L47/10
摘要： Methods, system and computer program product are provided to improve, the efficiency of data transfers in a PPRC environment. Any or all of three features may be implemented, each of which reduces the number of round trips required for the exchange of handshaking, data and control information. A first feature includes disabling the "transfer ready" acknowledgment which normally occurs between a primary storage controller and a secondary storage controller. A second feature includes pre-allocating payload and data buffers in the secondary storage controller. A third feature includes packaging write control information with a write command in an extended command descriptor block (CDB). Such a step eliminated the need for a separate transmission of the write control information. The CDB is transmitted along with a data block from the primary storage controller to the secondary storage controller and placed in the respective, pre-allocated buffers. Data may also be pipelined to the secondary. By decreasing the response time for data transfers, the distance separating the primary and secondary storage controllers may be increased.
摘要翻译：提供了方法，系统和计算机程序产品，以提高PPRC环境中数据传输的效率。可以实现三个特征中的任何一个或全部特征，其中每个特征都减少交换握手，数据和控制信息所需的往返次数。第一个特征包括禁用通常在主存储控制器和辅助存储控制器之间发生的“传输就绪”确认。第二个功能包括在辅助存储控制器中预先分配有效负载和数据缓冲区。第三特征包括利用写入命令在扩展命令描述符块（CDB）中打包写入控制信息。这样的步骤消除了对写入控制信息的单独传输的需要。 CDB与数据块一起从主存储控制器传输到辅助存储控制器，并放置在各自的预先分配的缓冲区中。数据也可以流水到次要位置。通过减少数据传输的响应时间，可以增加分隔主存储控制器和辅助存储控制器的距离。

8. 发明申请

WO2005030254A2 SINGLET OXYGEN PHOTOSENSITIZERS ACTIVATED BY TARGET BINDING ENHANCING THE SELECTIVITY OF TARGETED PDT AGENTS 审中-公开
标题翻译：通过目标结合激活的单链氧化物光敏增强靶向PDT剂的选择性
公开(公告)号：WO2005030254A2
公开(公告)日：2005-04-07
申请号：PCT/US2004031342
申请日：2004-09-23
申请人： LIGHT SCIENCES CORP , PALLENBERG ALEXANDER J , CHEN JAMES C
发明人： PALLENBERG ALEXANDER J , CHEN JAMES C
IPC分类号： A61K41/00 , A61K49/06
CPC分类号： A61K49/0021 , A61K41/0057 , A61K41/0071 , A61K41/0076 , A61K49/005
摘要： Provided herein are conjugates, kits, articles of manufacture and methods for detection, diagnosis and treatment by photodynamic therapy of certain undesired biological substrate targets, including, but not limited to bacteria, viruses, and other pathogenic microorganisms, tumors and hyperproliferative tissue. In particular, the conjugates provided include a fluorophore or photosensitizer linked to a targeting moiety and a quenching agent in such a way that activation of the fluorophore or the photosensitizer is quenched unless the targeting moiety is bound to a target, whereupon the quenching agent dissociates or moves away from the photosensitizer, enabling activation of the photosensitizer upon irradiation with light of a suitable wavelength.
摘要翻译：本文提供了缀合物，试剂盒，制品和用于通过光动力学治疗某些不期望的生物底物靶（包括但不限于细菌，病毒和其它病原微生物，肿瘤和过度增生组织）进行检测，诊断和治疗的方法。特别地，提供的缀合物包括与靶向部分和猝灭剂连接的荧光团或光敏剂，使得荧光团或光敏剂的活化被淬灭，除非靶向部分结合到靶上，随后猝灭剂解离或远离光敏剂，能够在用合适波长的光照射时激活光敏剂。

9. 发明申请

WO2004030588A3 EXCITATION OF PHOTOREACTIVE COMPOUNDS IN EYE TISSUE 审中-公开
标题翻译：眼部组织中光敏化合物的激发
公开(公告)号：WO2004030588A3
公开(公告)日：2004-08-05
申请号：PCT/US0331234
申请日：2003-10-02
申请人： LIGHT SCIENCES CORP , HEACOCK GREGORY L , HUSTON DARRIN , CHEN JAMES C , DALY STEVEN R
发明人： HEACOCK GREGORY L , HUSTON DARRIN , CHEN JAMES C , DALY STEVEN R
IPC分类号： A61F9/008 , A61N5/06
CPC分类号： A61F9/008 , A61F9/009 , A61F2009/00844 , A61F2009/00863 , A61F2009/00868 , A61F2009/00891 , A61N5/062 , A61N2005/0652
摘要： A system and method for excitation of photosensitizers is configured to provide desired illumination on targeted eye tissue. The excitation system includes an optical module that generates illumination and a controller to power the optical module and control the shape, intensity or energy level, and duration of the illumination. The optical module includes a contact portion for interfacing with the eye, a treatment beam portion including a light emitter array to generate shaped light patterns and optics to focus the light patterns onto the eye, and a visualization portion to provide visual feedback of treatment through a visualization interface coupled with a microscope. A typical treatment involves the optical module being placed on a diseased eye of a patient by a clinician to project illumination on a diseased portion of the eye. The clinician typically views the eye through the microscope and the optical module during treatment.
摘要翻译：用于激发光敏剂的系统和方法被配置为在目标眼睛组织上提供期望的照明。励磁系统包括产生照明的光学模块和用于为光学模块供电并控制形状，强度或能量水平以及照明持续时间的控制器。光学模块包括用于与眼睛接口的接触部分，包括光发射器阵列以产生成形光图案的光束部分和用于将光图案聚焦到眼睛上的光学元件，以及可视化部分，以通过可视化界面与显微镜相结合。典型的治疗包括光学模块被临床医生放置在患者的患病眼睛上以在眼睛的患病部分上投射照明。临床医生通常在治疗期间通过显微镜和光学模块观察眼睛。

10. 发明申请

WO2006086770A3 CUSTOMIZED NUTRIENTS FOR WEIGHT REDUCTION, CONTROL AND BEHAVIOR MODIFICATION 审中-公开
标题翻译：用于减肥，控制和行为改变的定制营养
公开(公告)号：WO2006086770A3
公开(公告)日：2006-12-14
申请号：PCT/US2006005023
申请日：2006-02-13
申请人： LIGHT SCIENCES CORP , CHEN JAMES C , CHRISTOPHERSEN JULENE
发明人： CHEN JAMES C , CHRISTOPHERSEN JULENE
IPC分类号： A23B4/00
CPC分类号： A23L35/00 , A23L33/185 , A23L33/30 , A23V2002/00 , A23V2200/30 , A23V2200/332 , A23V2200/08
摘要： The invention relates to customized nutritional foods, both solid and liquid, and in particular to foods (IQQ) (and packaging) that are designed for weight loss, weight control and behavior modification. The food (100) comprises first (101), second (102), third (103), fourth (104), fifth (10S), and last (106) edible sections.
摘要翻译：本发明涉及定制的固体和液体营养食品，特别涉及为减肥，体重控制和行为改变设计的食品（IQQ）（和包装）。食物（100）包括第一（101），第二（102），第三（103），第四（104），第五（10S）和最后（106）可食用部分。

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