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1. 发明申请

WO2008036939A3 ONLINE ANALYTE DETECTION BY SURFACE ENHANCED RAMAN SCATTERING (SERS) 审中-公开
标题翻译：通过表面增强拉曼散射（SERS）进行在线分析检测
公开(公告)号：WO2008036939A3
公开(公告)日：2008-05-08
申请号：PCT/US2007079226
申请日：2007-09-21
申请人： INTEL CORP , ZHANG JINGWU , NGOLA SARAH , SU XING
发明人： ZHANG JINGWU , NGOLA SARAH , SU XING
IPC分类号： G01N21/65 , G01N30/74
CPC分类号： G01N30/74 , B01J2220/54 , G01N21/658 , G01N27/44721 , G01N30/52 , G01N30/6082 , G01N30/7233 , G01N30/78 , G01N2030/525 , G01N2030/746
摘要： Devices and methods for separating and detecting analytes in a sample. The separation can be accomplished utilizing capillary electrophoresis (CE) or high-performance liquid chromatography (HPLC). The detection can be accomplished by surface enhanced Raman scattering.
摘要翻译：用于分离和检测样品中分析物的设备和方法。可以使用毛细管电泳（CE）或高效液相色谱（HPLC）来实现分离。检测可以通过表面增强拉曼散射来实现。

2. 发明申请

WO2006128135A3 LINEAR VALVE-COUPLED TWO-DIMENSIONAL SEPARATION DEVICE AND SEPARATION MATRIX AND METHOD 审中-公开
标题翻译：线性阀联轴器二维分离装置和分离矩阵及方法
公开(公告)号：WO2006128135A3
公开(公告)日：2007-04-26
申请号：PCT/US2006020831
申请日：2006-05-25
申请人： INTEL CORP , SU XING
发明人： SU XING
IPC分类号： G01N27/447
CPC分类号： G01N27/44773
摘要： A two-dimensional separation apparatus includes first and second modules operating respectively to seperate a sample amount in a first dimension and a second dimension. A valve structure controllably isolates the first separation module from the second separation module.
摘要翻译：二维分离装置包括第一和第二模块，其分别操作以在第一维度和第二维度中分离样品量。阀结构可控地将第一分离模块与第二分离模块隔离。

3. 发明申请

WO2006071946A3 ELECTRICALLY ACTIVE COMBINATORIAL-CHEMICAL (EACC) CHIP FOR BIOCHEMICAL ANALYTE DETECTION 审中-公开
标题翻译：用于生物化学分析检测的电活性组合化学（EACC）芯片
公开(公告)号：WO2006071946A3
公开(公告)日：2006-12-14
申请号：PCT/US2005047278
申请日：2005-12-28
申请人： INTEL CORP , SU XING , SUN LEI , GEORGER JACQUE
发明人： SU XING , SUN LEI , GEORGER JACQUE
IPC分类号： G01N33/543 , B01J19/00 , B01L3/00 , C12Q1/68
CPC分类号： C12Q1/6837 , B01J19/0046 , B01J2219/00317 , B01J2219/00527 , B01J2219/00596 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00653 , B01J2219/00659 , B01J2219/00662 , B01J2219/00704 , B01J2219/00722 , B01L3/5085 , B01L2300/0636 , B01L2300/0819 , B82Y15/00 , B82Y30/00 , G01N33/5438 , C12Q2565/601
摘要： Apparatus and methods are disclosed for electrically active combinatorial-chemical (EACC) chips for biochemical analyte detection. An apparatus includes a substrate that has an array of regions defining multiple cells, wherein each of the cells includes a reaction cavity that contains multiple functional binding groups. A method of detecting an analyte providing the reaction cavity between a source and a drain or a pair of electrodes, applying a voltage and monitoring a parameter indicative of an analyte characteristic. A process of fabricating an EACC include bonding an analyte to the multiple functional binding groups of each reaction cavity, and forming an analyte sensing structure including the substrate.
摘要翻译：公开了用于生化分析物检测的电活性组合化学（EACC）芯片的装置和方法。一种装置包括具有限定多个细胞的区域阵列的基底，其中每个细胞包括含有多个功能性结合基团的反应腔。一种检测在源极和漏极或一对电极之间提供反应腔的分析物的方法，施加电压并监测指示分析物特征的参数。制备EACC的方法包括将分析物结合到每个反应腔的多个功能性结合基团，以及形成包括该基质的分析物感测结构。

4. 发明申请

WO2008085538A3 NEW ASSAY PLATFORMS AND DETECTION METHODOLOGY USING SURFACE ENHANCED RAMAN SCATTERING (SERS) UPON SPECIFIC BIOCHEMICAL INTERACTIONS 审中-公开
标题翻译：使用表面增强拉曼散射（SERS）与特定生化相互作用的新测定平台和检测方法学
公开(公告)号：WO2008085538A3
公开(公告)日：2008-11-20
申请号：PCT/US2007072298
申请日：2007-06-27
申请人： INTEL CORP , ZHANG JINGWU , LI HANDONG , SUNDARARAJAN NARAYAN , SU XING , SUN LEI
发明人： ZHANG JINGWU , LI HANDONG , SUNDARARAJAN NARAYAN , SU XING , SUN LEI
IPC分类号： G01N21/66 , G01J3/44 , G01N21/956
CPC分类号： G01N33/585 , C12Q1/6816 , G01N21/658 , G01N33/54373 , C12Q2563/155 , C12Q2565/632
摘要： The embodiments of the invention are directed to a SERS cluster comprising a capture particle that is at least partially surrounded by analyte molecules, wherein both the capture particle and the analyte molecules surrounding the capture particle are at least partially surrounded by enhancer particles, wherein a majority of the analyte molecules are either sandwiched between capture and enhancer particles or located between junctions of the enhancer particles. The embodiments of the invention also relate to methods of manufacturing and detecting the SERS cluster. The embodiments of the invention also relate to a SERS active particle comprising a tag molecule comprising a Raman active compound and a probe or a linker having a specific biochemical binding capability and to a method for detecting of a target molecule using a SERS active particle having a tag molecule comprising a Raman active compound and a probe or a linker.
摘要翻译：本发明的实施方案涉及包含至少部分被分析物分子包围的捕获颗粒的SERS簇，其中捕获颗粒和围绕捕获颗粒的分析物分子至少部分被增强剂颗粒包围，其中大部分的分析物分子夹在捕获和增强剂颗粒之间或位于增强剂颗粒的连接点之间。本发明的实施例还涉及制造和检测SERS群集的方法。本发明的实施方案还涉及包含标签分子的SERS活性颗粒，所述标签分子包含拉曼活性化合物和具有特定生物化学结合能力的探针或接头，并涉及使用SERS活性颗粒检测靶分子的方法，所述SERS活性颗粒具有标签分子，其包含拉曼活性化合物和探针或接头。

5. 发明申请

WO2005066367A3 METHODS OF PRODUCING CARBON NANOTUBES USING PEPTIDE OR NUCLEIC ACID MICROPATTERNING 审中-公开
标题翻译：使用肽或核酸微生物生产碳纳米管的方法
公开(公告)号：WO2005066367A3
公开(公告)日：2007-03-01
申请号：PCT/US2004043364
申请日：2004-12-24
申请人： INTEL CORP , SU XING , SUNDARARAJAN NARAYAN , YAMAKAWA MINEO , BERLIN ANDREW , SUN LEI , ZHANG YUEGANG
发明人： SU XING , SUNDARARAJAN NARAYAN , YAMAKAWA MINEO , BERLIN ANDREW , SUN LEI , ZHANG YUEGANG
IPC分类号： C01B31/02 , C12Q1/68 , D01F9/127 , H01L51/00 , H01L51/30
CPC分类号： B82Y40/00 , B82Y10/00 , B82Y30/00 , C01B32/162 , C01B2202/08 , C01B2202/36 , D01F9/127 , H01L51/0048 , H01L51/0052
摘要： The methods, apparatus and systems disclosed herein concern ordered arrays of carbon nanotubes. In particular embodiments of the invention, the nanotube arrays are formed by a method comprising attaching catalyst nanoparticles (140, 230) to polymer (120, 210) molecules, attaching the polymer (120, 210) molecules to a substrate, removing the polymer (120, 210) molecules and producing carbon nanotubes on the catalyst nanoparticles (140, 230). The polymer (120, 210) molecules alignment techniques. The nanotube arrays can be attached to selected areas (110, 310) of the substrate. Within the selected areas (110, 310), the nanotubes are distributed non-randomly. Other embodiments disclosed herein concern apparatus that include ordered arrays of nanotubes attached to a substrate and systems that include ordered arrays of carbon nanotubes attached to a substrate, produced by the claimed methods. In certain embodiments, provided herein are methods for aligning a molecular wire, by ligating the molecular wire to a double stranded DNA molecule.
摘要翻译：本文公开的方法，装置和系统涉及碳纳米管的有序阵列。在本发明的具体实施方案中，纳米管阵列通过包括将催化剂纳米颗粒（140,230）附着到聚合物（120,210）分子上的方法形成，将聚合物（120,210）分子附着到基底上，去除聚合物 120,210）分子并在催化剂纳米颗粒（140,230）上产生碳纳米管。聚合物（120,210）分子对齐技术。纳米管阵列可以附着到基板的选定区域（110,310）。在所选择的区域（110,310）内，纳米管是非随机分布的。本文公开的其它实施方案涉及包括连接到衬底的纳米管的有序阵列和包括通过所要求保护的方法产生的连接到衬底的碳纳米管的有序阵列的系统的装置。在某些实施方案中，本文提供了通过将分子线连接到双链DNA分子来对齐分子线的方法。

6. 发明申请

WO2004085988A2 CHEMICAL ENHANCEMENT IN SURFACE ENHANCED RAMAN SCATTERING USING LITHIUM CHLORIDE 审中-公开
标题翻译：使用氯化锂的表面增强拉曼散射中的化学增强
公开(公告)号：WO2004085988A2
公开(公告)日：2004-10-07
申请号：PCT/US2004002989
申请日：2004-02-04
申请人： INTEL CORP
发明人： SU XING , SUN LEI , KOO TAE-WOONG , CHAN SELANA
IPC分类号： G01J3/44 , G06F11/00 , G06F11/07 , G01N
CPC分类号： G01J3/44 , B82Y15/00 , C12Q1/6825 , G01N21/658
摘要： The intensity of the signals from surface enhanced Raman spectroscopy is increased by using lithium chloride (122) as an enhancer to activate a metallic structure (212) used for surface enhanced Raman spectroscopy (116). The increased signal intensity allows surface enhanced Raman spectroscopy to be utilized to detect individual analytes (120) such as nucleotides, for example in DNA sequencing without requiring a dye or radioactive label.
摘要翻译：通过使用氯化锂（122）作为增强剂来激活用于表面增强拉曼光谱的金属结构（212），增强了来自表面增强拉曼光谱的信号的强度（116）。增加的信号强度允许表面增强拉曼光谱法用于检测单个分析物（120），例如核苷酸，例如在DNA测序中，而不需要染料或放射性标记。

7. 发明申请

WO2006023458A9 DETECTION AND IDENTIFICATION OF PEPTIDE AND PROTEIN MODIFICATIONS 审中-公开
标题翻译：肽和蛋白质修饰的检测和鉴定
公开(公告)号：WO2006023458A9
公开(公告)日：2006-04-06
申请号：PCT/US2005029019
申请日：2005-08-13
申请人： INTEL CORP , SUNDARARAJAN NARAYAN , SUN LEI , SU XING , YAMAKAWA MINEO , JINGWU ZHANG , CHAN SELENA , BERLIN ANDREW , KOO TAE-WOONG , ROTH MARK , GAFEN PHIL
发明人： SUNDARARAJAN NARAYAN , SUN LEI , SU XING , YAMAKAWA MINEO , JINGWU ZHANG , CHAN SELENA , BERLIN ANDREW , KOO TAE-WOONG , ROTH MARK , GAFEN PHIL
IPC分类号： G01N33/68 , G01N21/65
CPC分类号： G01N33/6851 , G01N21/658 , G01N33/54373 , G01N33/68 , G01N33/6842 , G01N33/6848 , Y02A90/26
摘要： Embodiments of the present invention provide devices and methods for detecting, identifying, distinguishing, and quantifying modification states of proteins and peptides using Surface Enhanced Raman (SERS) and Raman spectroscopy. Applications of embodiments of the present invention include, for example, proteome wide modification profiling and analyses with applications in disease diognosis, prognosis and drug efficacy studies, emzymatic activity profiling and assays.
摘要翻译：本发明的实施方案提供了使用表面增强拉曼（SERS）和拉曼光谱法检测，鉴定，区分和定量蛋白质和肽的修饰状态的装置和方法。本发明的实施方案的应用包括例如蛋白质组广泛的修饰分析和分析，其应用于疾病预后，预后和药物功效研究，酶活性分析和测定。

8. 发明申请

WO2005066369A3 NUCLEIC ACID SEQUENCING BY RAMAN MONITORING OF UPTAKE OF NUCLEOTIDES DURING MOLECULAR REPLICATION 审中-公开
标题翻译：在分子复制期间通过拉曼监测核酸摄取的核酸序列
公开(公告)号：WO2005066369A3
公开(公告)日：2006-02-02
申请号：PCT/US2004043633
申请日：2004-12-28
申请人： INTEL CORP , BERLIN ANDREW , SU XING , CHAN SELENA , KOO TAE-WOONG , SUN LEI , SUNDARARAJAN NARAYAN
发明人： BERLIN ANDREW , SU XING , CHAN SELENA , KOO TAE-WOONG , SUN LEI , SUNDARARAJAN NARAYAN
IPC分类号： C12Q1/68 , G01N21/65
CPC分类号： G01N21/658 , C12Q1/6869 , C12Q2565/632 , C12Q2533/101
摘要： The methods and apparatus disclosed herein are useful for detecting nucleotides, nucleosides, and bases and for nucleic acid sequence determination. The methods involve detection of a nucleotide, nucleoside, or base using surface enhanced Raman spectroscopy (SERS) or surface enhanced coherent anti-Stokes Raman spectroscopy (SECARS). The detection can be part of a nucleic acid sequencing reaction to detect uptake of a deoxynucleotide triphosphate during a nucleic acid polymerization reaction, such as a nucleic acid sequencing reaction. The nucleic acid sequence of a synthesized nascent strand, and the complementary sequence of the template strand, can be determined by tracking the order of incorporation of nucleotides during the polymerization reaction. Methods for enhancing the SERS signal of a nucleotide or nucleoside by cleaving the base from a sugar moiety are provided. Furthermore, methods for detecting single base repeats are provided.
摘要翻译：本文公开的方法和装置可用于检测核苷酸，核苷和碱基并用于核酸序列测定。该方法涉及使用表面增强拉曼光谱（SERS）或表面增强相干抗斯托克斯拉曼光谱（SECARS）检测核苷酸，核苷或碱基。检测可以是在核酸聚合反应（例如核酸测序反应）期间检测脱氧核苷酸三磷酸的摄取的核酸测序反应的一部分。合成的新生链的核酸序列和模板链的互补序列可以通过跟踪聚合反应期间核苷酸掺入的顺序来确定。提供了通过从糖部分切割碱来增强核苷酸或核苷的SERS信号的方法。此外，提供了用于检测单碱基重复的方法。

9. 发明申请

WO2005066370A3 METHODS FOR DETERMINING NUCLEOTIDE SEQUENCE INFORMATION 审中-公开
标题翻译：确定核酸序列信息的方法
公开(公告)号：WO2005066370A3
公开(公告)日：2005-11-03
申请号：PCT/US2004043730
申请日：2004-12-24
申请人： INTEL CORP , SU XING
发明人： SU XING
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6818 , C12Q1/6874 , C12Q2565/632
摘要： Provided herein, is a nucleic acid sequencing method based on detection of Raman signatures of oligonucleotide probes. Raman signatures of individually captured nucleic acid probes, optionally labeled by a Raman label or a positively charged enhancer, are detected. The sequences of captured probes are used to identify the nucleotide sequences of captured probes and complementary target nucleic acids, which are then aligned and used to obtain nucleic acid sequence information. In another embodiment, a method is provided for determining a nucleotide occurrence at a target nucleotide position of a target nucleic acid, that utilizes binding of the target nucleic acid to a labeled oligonucleotide probe that binds to the target nucleic acid, wherein the labeled oligonucleotide probe includes a first label and a second label, the first label being capable of affecting an optical property of the second label.
摘要翻译：本文提供了基于检测寡核苷酸探针的拉曼特征的核酸测序方法。检测单独捕获的核酸探针的拉曼特征，任选由拉曼标记或带正电荷的增强子标记。捕获的探针的序列用于鉴定捕获的探针和互补靶核酸的核苷酸序列，然后将其对准并用于获得核酸序列信息。在另一个实施方案中，提供了用于确定靶核酸的靶核苷酸位置上的核苷酸发生的方法，其利用靶核酸与结合靶核酸的标记的寡核苷酸探针的结合，其中标记的寡核苷酸探针包括第一标签和第二标签，第一标签能够影响第二标签的光学性质。

10. 发明申请

WO2005065541A2 METHODS FOR USING RAMAN SPECTROSCOPY TO OBTAIN A PROTEIN PROFILE OF A BIOLOGICAL SAMPLE 审中-公开
标题翻译：使用拉曼光谱法获得生物样品的蛋白质谱的方法
公开(公告)号：WO2005065541A2
公开(公告)日：2005-07-21
申请号：PCT/US2004043769
申请日：2004-12-29
申请人： INTEL CORP , BERLIN ANDREW , SU XING , CHAN SELENA , KOO TAE-WOONG , SUN LEI , SUNDARARAJAN NARAYAN , YAMAKAWA MINEO
发明人： BERLIN ANDREW , SU XING , CHAN SELENA , KOO TAE-WOONG , SUN LEI , SUNDARARAJAN NARAYAN , YAMAKAWA MINEO
IPC分类号： G01N21/65 , G01N33/58 , G01N33/68 , A61B5/00
CPC分类号： G01N21/658 , G01N33/6803 , G01N2021/653 , G01N2021/655 , G01N2021/656
摘要： The invention provides methods for analyzing the protein content of a biological sample, for example to obtain a protein profile of a sample provided by a particular individual. The proteins and protein fragments in the sample are separated on the basis of chemical and/or physical properties and maintained in a separated state at discrete locations on a solid substrate or within a stream of flowing liquid. Raman spectra are then detected as produced by the separated proteins or fragments at the discrete locations such that a spectrum from a discrete location provides information about the structure or identity of one or more particular proteins or fragments at the discrete location. The proteins or fragments at discrete locations can be coated with a metal, such as gold or silver, and/or the separated proteins can be contacted with a chemical enhancer to provide SERS spectra. Method and kits for practicing the invention are also provided.
摘要翻译：本发明提供了用于分析生物样品的蛋白质含量的方法，例如获得由特定个体提供的样品的蛋白质谱。样品中的蛋白质和蛋白质片段基于化学和/或物理性质分离，并在固体基质上或流动液体流中的离散位置处保持分离状态。然后检测拉曼光谱，由离散位置处的分离的蛋白质或片段产生，使得离散位置的光谱提供关于在离散位置处的一种或多种特定蛋白质或片段的结构或身份的信息。离散位置处的蛋白质或片段可以用金属（例如金或银）涂覆，和/或分离的蛋白质可与化学增强剂接触以提供SERS光谱。还提供了用于实施本发明的方法和试剂盒。

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