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1. 发明申请

WO2013049663A1 GRAPHENE OXIDE AS A SULFUR IMMOBILIZER IN HIGH PERFORMANCE LITHIUM/SULFUR CELLS 审中-公开
标题翻译：石墨氧化物作为高性能锂/硫电池中的硫磺固化剂
公开(公告)号：WO2013049663A1
公开(公告)日：2013-04-04
申请号：PCT/US2012/058047
申请日：2012-09-28
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , ZHANG, Yuegang , CAIRNS, Elton, J. , JI, Liwen , RAO, Mumin
发明人： ZHANG, Yuegang , CAIRNS, Elton, J. , JI, Liwen , RAO, Mumin
IPC分类号： H01M4/583
CPC分类号： H01M4/364 , C01B31/043 , C01B32/23 , C01B32/70 , C01P2002/72 , C01P2002/82 , C01P2002/85 , C01P2002/88 , C01P2004/03 , C01P2004/04 , C01P2006/40 , C07D303/38 , H01M2/1653 , H01M4/382 , H01M4/583 , H01M4/587 , H01M4/625 , H01M10/0525 , H01M10/0566 , H01M2300/0045
摘要： The loss of sulfur cathode material as a result of polysulfide dissolution causes significant capacity fading in rechargeable lithium/sulfur cells. Embodiments of the invention use a chemical approach to immobilize sulfur and lithium polysulfides via the reactive functional groups on graphene oxide. This approach obtains a uniform and thin (∼ tens of nanometers) sulfur coating on graphene oxide sheets by a chemical reaction-deposition strategy and a subsequent low temperature thermal treatment process. Strong interaction between graphene oxide and sulfur or polysulfides demonstrate lithium/sulfur cells with a high reversible capacity of 950 - 1400 mAh g -1 , and stable cycling for more than 50 deep cycles at 0.1C.
摘要翻译：由于多硫化物溶解导致硫阴极材料的损失导致可再充电锂/硫电池的显着的容量衰减。本发明的实施方案使用化学方法通过氧化石墨烯上的反应性官能团来固定硫和多硫化锂。该方法通过化学反应沉积策略和随后的低温热处理工艺，在氧化石墨烯片上获得均匀且薄（〜几十纳米）的硫涂层。石墨烯氧化物和硫或多硫化物之间的强相互作用证明具有950-1400mAh g-1的高可逆容量的锂/硫电池，并且在0.1C下稳定循环超过50个深循环。

2. 发明申请

WO2008106151A2 CO-CRYSTALS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME 审中-公开
标题翻译：共晶体和包含其的药物组合物
公开(公告)号：WO2008106151A2
公开(公告)日：2008-09-04
申请号：PCT/US2008/002568
申请日：2008-02-27
申请人： VERTEX PHARMACEUTICALS INCORPORATED , CONNELLY, Patrick, R. , KADIYALA, Irina , STAVROPOLUS, Kathy , ZHANG, Yuegang , JOHNSTON, Steve , BHISETTI, Govinda, Rao , JURKAUSKAS, Valdas , ROSE, Peter
发明人： CONNELLY, Patrick, R. , KADIYALA, Irina , STAVROPOLUS, Kathy , ZHANG, Yuegang , JOHNSTON, Steve , BHISETTI, Govinda, Rao , JURKAUSKAS, Valdas , ROSE, Peter
CPC分类号： C07K5/0812 , C07D403/12
摘要： The invention relates to compositions and co-crystals each comprising VX-950 and a co-crystal former selected from the group consisting of 4-hydroxybenzoic acid, 4-amino salicylic acid, phenylalanine, threonline, tartaric acid, adipic acid, succinic acetate, proline, methyl 4-hydroxybenzoate, anthranilic acid, and d-Biotin. Also within the scope of this invention are methods of making and using the same.
摘要翻译：本发明涉及各自包含VX-950和选自4-羟基苯甲酸，4-氨基水杨酸，苯丙氨酸，苏氨酸，酒石酸的共晶体形成物的组合物和共晶体酸，己二酸，琥珀酸乙酸酯，脯氨酸，4-羟基苯甲酸甲酯，邻氨基苯甲酸和d-生物素。也在本发明的范围内的是制造和使用它们的方法。

3. 发明申请

WO2011133951A1 PHARMACEUTICAL COMPOSITIONS AND ADMINISTRATIONS THEREOF 审中-公开
标题翻译：药物组合物及其药理学
公开(公告)号：WO2011133951A1
公开(公告)日：2011-10-27
申请号：PCT/US2011/033687
申请日：2011-04-22
申请人： VERTEX PHARMACEUTICALS INCORPORATED , VAN GOOR, Fredrick, F. , ALARGOVA, Rossitza, Gueorguieva , ALCACIO, Tim, Edward , AREKAR, Sneha, G. , JOHNSTON, Steven, C. , KADIYALA, Irina, Nikolaevna , KESHAVARZ-SHOKRI, Ali , KRAWIEC, Mariusz , LEE, Elaine, Chungmin , MEDEK, Ales , MUDUNURI, Praveen , SULLIVAN, Mark, Jeffrey , ZAMAN, Noreen, Tasneem , ZHANG, Beili , ZHANG, Yuegang , ZLOKARNIK, Gregor
发明人： VAN GOOR, Fredrick, F. , ALARGOVA, Rossitza, Gueorguieva , ALCACIO, Tim, Edward , AREKAR, Sneha, G. , JOHNSTON, Steven, C. , KADIYALA, Irina, Nikolaevna , KESHAVARZ-SHOKRI, Ali , KRAWIEC, Mariusz , LEE, Elaine, Chungmin , MEDEK, Ales , MUDUNURI, Praveen , SULLIVAN, Mark, Jeffrey , ZAMAN, Noreen, Tasneem , ZHANG, Beili , ZHANG, Yuegang , ZLOKARNIK, Gregor
IPC分类号： A61K31/4704 , A61K31/404 , A61K31/443
CPC分类号： A61K31/47 , A61K31/404 , A61K31/443 , A61K31/4433 , A61K31/4704 , G01N33/5032 , G01N2500/04 , A61K2300/00
摘要： The present invention relates to pharmaceutical compositions comprising a compound of Formula I in combination with one or both of a Compound of Formula II and/or a Compound of Formula III. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis.
摘要翻译：本发明涉及药物组合物，其包含与式II化合物和/或式III化合物中的一种或两种结合的式I化合物。本发明还涉及固体形式及其药物制剂，以及使用这些组合物治疗CFTR介导的疾病，特别是囊性纤维化的方法。

4. 发明申请

WO2011119984A1 SOLID FORMS OF (R)-1(2,2-DIFLUOROBENZO[D][1,3]DIOXOL-5-YL)-N-(1-(2,3-DIHYDEROXYPROPYL)-6-FLUORO-2-(1-HYDROXY-2-METHYLPROPAN-2-YL)-1H-INDOL-5-YL) CYCLOPROPANECARBOXAMIDE 审中-公开
标题翻译：（R）-1（2,2-二氟苯并[D] [1,3]二氧杂环戊烯-5-基）-N-（1-（2,3-二羟基丙基）-6-氟-2-（1 - 羟基-2-甲基丙-2-炔基）-1H-吲哚-5-基）环丙烷甲酰胺
公开(公告)号：WO2011119984A1
公开(公告)日：2011-09-29
申请号：PCT/US2011/030032
申请日：2011-03-25
申请人： VERTEX PHARMACEUTICALS INCORPORATED , KESHAVARZ-SHOKRI, Ali , ZHANG, Beili , ALCACIO, Tim, Edward , LEE, Elaine, Chungmin , ZHANG, Yuegang , KRAWIEC, Mariusz
发明人： KESHAVARZ-SHOKRI, Ali , ZHANG, Beili , ALCACIO, Tim, Edward , LEE, Elaine, Chungmin , ZHANG, Yuegang , KRAWIEC, Mariusz
IPC分类号： C07D405/12 , A61K31/404 , A61P11/00
CPC分类号： C07D405/12
摘要： The present invention relates to solid forms of ( R )-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2- methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1) in substantially crystalline form (Form A) or amorphous form, pharmaceutical compositions thereof, and methods of treatment therewith.
摘要翻译：本发明涉及（R）-1-（2,2-二氟苯并[d] [1,3]间二氧杂环戊烯-5-基）-N-（1-（2,3-二羟丙基）-6- （A型）或无定形形式的2-氟-2-（1-羟基-2-甲基丙-2-基）-1H-吲哚-5-基）环丙烷甲酰胺（化合物1）及其药物组合物，以及治疗。

5. 发明申请

WO2009032198A1 CO-CRYSTALS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME 审中-公开
标题翻译：包括其的CO晶体和药物组合物
公开(公告)号：WO2009032198A1
公开(公告)日：2009-03-12
申请号：PCT/US2008/010254
申请日：2008-08-29
申请人： VERTEX PHARMACEUTICALS INCORPORATED , ZHANG, Yuegang , CONNELY, Patrick, R. , JOHNSTON, Steve
发明人： ZHANG, Yuegang , CONNELY, Patrick, R. , JOHNSTON, Steve
IPC分类号： C07D403/12 , A61K31/454 , A61P1/16
CPC分类号： C07D403/12
摘要： The invention relates to co-crystals and compositions each comprising VX-950 and a co-crystal former selected from the group consisting of 3-methoxy-4-hydroxybenzoic acid, 2,4-dihydroxybenzoic acid, and 2,5-dihydroxybenzoic acid. Also within the scope of this invention are methods of making and using the same.
摘要翻译：本发明涉及共晶和组合物，其各自包含VX-950和选自3-甲氧基-4-羟基苯甲酸，2,4-二羟基苯甲酸和2,5-二羟基苯甲酸的共晶体形成剂。在本发明的范围内也是制造和使用本发明的方法。

6. 发明申请

WO2011133956A1 PHARMACEUTICAL COMPOSITIONS AND ADMINISTRATIONS THEREOF 审中-公开
标题翻译：药物组合物及其药理学
公开(公告)号：WO2011133956A1
公开(公告)日：2011-10-27
申请号：PCT/US2011/033693
申请日：2011-04-22
申请人： VERTEX PHARMACEUTICALS INCORPORATED , VAN GOOR, Fredrick, F. , ALARGOVA, Rossitza, Gueorguieva , ALCACIO, Tim, Edward , BINCH, Hayley, Marie , BOTFIELD, Martyn, Curtis , FANNING, Lev Tyler, Dewey , GROOTENHUIS, Peter Diederik, Jan , HURLEY, Dennis, James , KADIYALA, Irina, Nikolaevna , KAUSHIK, Ritu, Rohit , KESHAVARZ-SHOKRI, Ali , KRAWIEC, Mariusz , LEE, Elaine, Chungmin , LUISI, Brian , MEDEK, Ales , NUMA, Mehdi , SHETH, Urvi, Jagdishbhai , SILINA, Alina , VERWIJS, Marinus, Jacobus , YANG, Xiaoqing , YOUNG, Christopher Ryan , ZAMAN, Noreen, Tasneem , ZHANG, Beili , ZHANG, Yuegang , ZLOKARNIK, Gregor
发明人： VAN GOOR, Fredrick, F. , ALARGOVA, Rossitza, Gueorguieva , ALCACIO, Tim, Edward , BINCH, Hayley, Marie , BOTFIELD, Martyn, Curtis , FANNING, Lev Tyler, Dewey , GROOTENHUIS, Peter Diederik, Jan , HURLEY, Dennis, James , KADIYALA, Irina, Nikolaevna , KAUSHIK, Ritu, Rohit , KESHAVARZ-SHOKRI, Ali , KRAWIEC, Mariusz , LEE, Elaine, Chungmin , LUISI, Brian , MEDEK, Ales , NUMA, Mehdi , SHETH, Urvi, Jagdishbhai , SILINA, Alina , VERWIJS, Marinus, Jacobus , YANG, Xiaoqing , YOUNG, Christopher Ryan , ZAMAN, Noreen, Tasneem , ZHANG, Beili , ZHANG, Yuegang , ZLOKARNIK, Gregor
IPC分类号： A61K31/4704 , A61K31/404 , A61K31/443
CPC分类号： A61K31/4709 , A61K31/404 , A61K31/443 , A61K31/4704 , A61K45/06 , C07D405/12 , C12Q1/34 , G01N2500/04 , G01N2500/20 , A61K2300/00
摘要： The present invention relates to pharmaceutical compositions comprising a compound of Formula I in combination with one or both of a Compound of Formula II and/or a Compound of Formula III. The invention also relates to solid forms and to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis.(Formula I), (Formula II), (Formula III).
摘要翻译：本发明涉及药物组合物，其包含与式II化合物和/或式III化合物中的一种或两种结合的式I化合物。本发明还涉及固体形式及其药物制剂，以及使用这些组合物治疗CFTR介导的疾病，特别是囊性纤维化的方法（式I），（式II），（式III）。

7. 发明申请

WO2009038683A2 SOLID FORMS OF N-[2,4-BIS(1,1-DIMETHYLETHYL)-5-HYDROXYPHENYL]-1,4-DIHYDRO-4-OXOQUINOLINE-3-CARBOXAMIDE 审中-公开
标题翻译： N- [2,4-BIS（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-羧酰胺的固体形式
公开(公告)号：WO2009038683A2
公开(公告)日：2009-03-26
申请号：PCT/US2008/010728
申请日：2008-09-15
申请人： VERTEX PHARMACEUTICALS INCORPORATED , DEMATTEI, John , FENG, Yushi , HARRISON, Cristian , LOOKER, Adam , MUDUNURI, Praveen , ROEPER, Stefanie , ZHANG, Yuegang
发明人： DEMATTEI, John , FENG, Yushi , HARRISON, Cristian , LOOKER, Adam , MUDUNURI, Praveen , ROEPER, Stefanie , ZHANG, Yuegang
IPC分类号： A61K31/47 , C07D215/233 , A61P3/00 , A61P35/00 , A61P25/28 , A61P27/02 , A61P3/10
CPC分类号： C07D215/56 , A61K31/47 , A61K45/06 , C07D215/233
摘要： Solid forms of N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide are described herein, including crystalline forms thereof.
摘要翻译：本文描述了固体形式的N- [2,4-双（1,1-二甲基乙基）-5-羟基苯基] -1,4-二氢-4-氧代喹啉-3-甲酰胺，包括其结晶形式。

8. 发明申请

WO2006135426A9 APPLICATION OF STATIC LIGHT TO A FLUID FLOW OF CNTs FOR PURPOSES OF SORTING THE CNTs 审中-公开
标题翻译：将静态光应用于碳纳米管的流体流中，用于分配CNT的用途
公开(公告)号：WO2006135426A9
公开(公告)日：2007-02-22
申请号：PCT/US2005035403
申请日：2005-09-30
申请人： INTEL CORP , ZHANG YUEGANG , LOPEZ HERMAN , TAN SHIDA
发明人： ZHANG YUEGANG , LOPEZ HERMAN , TAN SHIDA
IPC分类号： C01B31/02
CPC分类号： B07C5/344 , B82Y30/00 , B82Y40/00 , C01B32/172 , G01N2030/0035 , Y10S977/845
摘要： A method is described that comprises sorting carbon nanotubes (CNTs) within a fluidic flow for a targeted subset of CNTs. The sorting comprises attracting at least a portion of the CNTs within the fluidic flow in a direction of increasing intensity of an electric field component of a substantially stationary beam of light. The electric field component has a frequency that is less than one or more resonant frequencies of the CNTs within the portion.
摘要翻译：描述了一种方法，其包括在CNT的靶向子集的流体流中分选碳纳米管（CNT）。排序包括在基本上静止的光束的电场分量的强度增加的方向上吸引流体流中的至少一部分CNT _{。电场分量具有小于该部分内的CNT _{的一个或多个谐振频率的频率。}}

9. 发明申请

WO2006127018A2 REAL-TIME MONITORING OPTICALLY TRAPPED CARBON NANOTUBES 审中-公开
标题翻译：实时监测光学捕获碳纳米管
公开(公告)号：WO2006127018A2
公开(公告)日：2006-11-30
申请号：PCT/US2005021626
申请日：2005-06-17
申请人： INTEL CORP , TAN SHIDA , ZHANG YUEGANG
发明人： TAN SHIDA , ZHANG YUEGANG
CPC分类号： B82B3/00 , B81C99/002 , B82Y15/00 , B82Y30/00 , B82Y40/00 , Y10S977/842 , Y10S977/88 , Y10S977/881
摘要： An embodiment of the present invention is a technique to monitor carbon nanotubes (CNTs). A carbon nanotube (CNT) is manipulated in a fluid by a laser beam. An illuminating light from a light source is aligned along axis of the CNT to produce an optical response from the CNT. The CNT is monitored using an optical sensor according to the optical response.
摘要翻译：本发明的一个实施例是一种监测碳纳米管（CNT）的技术。通过激光束在流体中操纵碳纳米管（CNT）。来自光源的照明光沿着CNT的轴线排列以产生来自CNT的光学响应。根据光学响应使用光学传感器监测CNT。

10. 发明申请

WO2005066367A2 METHODS OF PRODUCING CARBON NANOTUBES USING PEPTIDE OR NUCLEIC ACID MICROPATTERNING 审中-公开
标题翻译：使用肽或核酸微生物生产碳纳米管的方法
公开(公告)号：WO2005066367A2
公开(公告)日：2005-07-21
申请号：PCT/US2004/043364
申请日：2004-12-24
申请人： INTEL CORPORATION , SU, Xing , SUNDARARAJAN, Narayan , YAMAKAWA, Mineo , BERLIN, Andrew , SUN, Lei , ZHANG, Yuegang
发明人： SU, Xing , SUNDARARAJAN, Narayan , YAMAKAWA, Mineo , BERLIN, Andrew , SUN, Lei , ZHANG, Yuegang
IPC分类号： C12Q1/68
CPC分类号： B82Y40/00 , B82Y10/00 , B82Y30/00 , C01B32/162 , C01B2202/08 , C01B2202/36 , D01F9/127 , H01L51/0048 , H01L51/0052
摘要： The methods, apparatus and systems disclosed herein concern ordered arrays of carbon nanotubes. In particular embodiments of the invention, the nanotube arrays are formed by a method comprising attaching catalyst nanoparticles (140, 230) to polymer (120, 210) molecules, attaching the polymer (120, 210) molecules to a substrate, removing the polymer (120, 210) molecules and producing carbon nanotubes on the catalyst nanoparticles (140, 230). The polymer (120, 210) molecules alignment techniques. The nanotube arrays can be attached to selected areas (110, 310) of the substrate. Within the selected areas (110, 310), the nanotubes are distributed non-randomly. Other embodiments disclosed herein concern apparatus that include ordered arrays of nanotubes attached to a substrate and systems that include ordered arrays of carbon nanotubes attached to a substrate, produced by the claimed methods. In certain embodiments, provided herein are methods for aligning a molecular wire, by ligating the molecular wire to a double stranded DNA molecule.
摘要翻译：本文公开的方法，装置和系统涉及碳纳米管的有序阵列。在本发明的具体实施方案中，通过包括将催化剂纳米颗粒（140,230）附着到聚合物（120,210）分子上的方法形成纳米管阵列，将聚合物（120,210）分子连接到基底上，去除聚合物 120,210）分子并在催化剂纳米颗粒（140,230）上产生碳纳米管。聚合物（120,210）分子对齐技术。纳米管阵列可以附着到基板的选定区域（110,310）。在所选择的区域（110,310）内，纳米管是非随机分布的。本文公开的其它实施方案涉及包括连接到衬底的纳米管的有序阵列的装置以及包括通过所要求保护的方法产生的连接到衬底的碳纳米管的有序阵列的系统。在某些实施方案中，本文提供了通过将分子线连接到双链DNA分子来对齐分子线的方法。

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