专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO1997040193A3 METHOD FOR TYPING AND DETECTING HBV 审中-公开
公开(公告)号：WO1997040193A3
公开(公告)日：1997-10-30
申请号：PCT/EP1997002002
申请日：1997-04-21
申请人： INNOGENETICS N.V. , STUYVER, Lieven , ROSSAU, Rudi , MAERTENS, Geert
发明人： INNOGENETICS N.V.
IPC分类号： C12Q01/70

2. 发明申请

WO1996013590A3 NEW SEQUENCES OF HEPATITIS C VIRUS GENOTYPES AND THEIR USE AS PROPHYLACTIC, THERAPEUTIC AND DIAGNOSTIC AGENTS 审中-公开
公开(公告)号：WO1996013590A3
公开(公告)日：1996-05-09
申请号：PCT/EP1995004155
申请日：1995-10-23
申请人： INNOGENETICS N.V. , MAERTENS, Geert , STUYVER, Lieven
发明人： INNOGENETICS N.V.
IPC分类号： C12N15/40

3. 发明申请

WO1997027332A1 METHOD FOR DETECTION OF DRUG-INDUCED MUTATIONS IN THE REVERSE TRANSCRIPTASE GENE 审中-公开
标题翻译：用于检测逆转录酶基因中药物诱导突变的方法
公开(公告)号：WO1997027332A1
公开(公告)日：1997-07-31
申请号：PCT/EP1997000211
申请日：1997-01-17
申请人： INNOGENETICS N.V. , STUYVER, Lieven , LOUWAGIE, Joost , ROSSAU, Rudi
发明人： INNOGENETICS N.V.
IPC分类号： C12Q01/70
CPC分类号： C12Q1/703
摘要： The present invention relates to a method for the rapid and reliable detection of drug-induced mutations in the reverse transcriptase gene allowing the simultaneous characterization of a range of codons involved in drug resistance using specific sets of probes optimized to function together in a reverse-hybridization assay. More particularly, the present invention relates to a method for determining the susceptibility to antiviral drugs of HIV strains present in a biological sample, comprising: (i) if need be releasing, isolating or concentrating the polynucleic acids present in the sample; (ii) if need be amplifying the relevant part of the reverse transcriptase genes present in said sample with at least one suitable primer pair; (iii) hybridizing the polynucleic acids of step (i) or (ii) with at least two RT gene probes hybridizing specifically to one or more target sequences with said probes being applied to known locations on a solid support and with said probes being capable of simultaneously hybridizing to their respective target regions under appropriate hybridization and wash conditions allowing the detection of homologous targets, or said probes hybridizing specifically with a sequence complementary to any of said target sequences, or a sequence wherein T is replaced by U; (iv) detecting the hybrids formed in step (iii); (v) inferring the nucleotide sequence at the codons of interest and/or the amino acids of the codons of interest and/or antiviral drug resistance spectrum, and possibly the type of HIV isolates involved from the differential hybridization signal(s) obtained in step (iv).
摘要翻译：本发明涉及用于快速和可靠地检测逆转录酶基因中的药物诱发突变的方法，其允许使用经优化以在反向杂交中一起起作用的特定的探针组来同时表征涉及耐药性的一系列密码子检测。更具体地说，本发明涉及确定存在于生物样品中的HIV病毒抗病毒药物易感性的方法，其包括：（i）如果需要释放，分离或浓缩样品中存在的多核酸; （ii）如果需要用至少一个合适的引物对扩增所述样品中存在的逆转录酶基因的相关部分; （iii）将步骤（i）或（ii）中的多核苷酸与至少两个与一个或多个靶序列特异性杂交的RT基因探针杂交，所述探针被施加到固体支持物上的已知位置，并且所述探针能够在适当的杂交和洗涤条件下同时与其各自的靶区域杂交，允许检测同源靶标，或所述探针与与任何所述靶序列互补的序列特异性杂交，或其中T被U替代的序列; （iv）检测步骤（iii）中形成的杂交体; （v）推断感兴趣的密码子和/或感兴趣的密码子的氨基酸和/或抗病毒药物抗性谱的核苷酸序列，以及可能的步骤中获得的差异杂交信号所涉及的HIV分离物的类型（ⅳ）。

4. 发明申请

WO1996004385A2 PURIFIED HEPATITIS C VIRUS ENVELOPE PROTEINS FOR DIAGNOSTIC AND THERAPEUTIC USE 审中-公开
标题翻译：纯化的乙型肝炎病毒包膜蛋白用于诊断和治疗用途
公开(公告)号：WO1996004385A2
公开(公告)日：1996-02-15
申请号：PCT/EP1995003031
申请日：1995-07-31
申请人： INNOGENETICS N.V. , MAERTENS, Geert , BOSMAN, Fons , DE MARTYNOFF, Guy , BUYSE, Marie-Ange
发明人： INNOGENETICS N.V.
IPC分类号： C12N15/40
CPC分类号： C07K16/109 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/5256 , C07K14/005 , C07K2317/34 , C12N2710/24143 , C12N2770/24222 , C12N2770/24234 , C12N2770/24243 , Y10S435/803 , Y10S435/81 , Y10S435/915 , Y10S435/975
摘要： The present invention relates to a method for purifying recombinant HCV single or specific oligomeric envelope proteins selected from the group consisting of E1 and/or E2 and/or E1/E2, characterized in that upon lysing the transformed host cells to isolate the recombinantly expressed protein a disulphide bond cleavage or reduction step is carried out with a disulphide bond cleavage agent. The present invention also relates to a composition isolated by such a method. The present invention also relates to the diagnostic and therapeutic application of these compositions. Furthermore, the invention relates to the use of HCV E1 protein and peptides for prognosing and monitoring the clinical effectiveness and/or clinical outcome of HCV treatment.
摘要翻译：本发明涉及一种纯化选自E1和/或E2和/或E1 / E2的重组HCV单一或特异性寡聚包膜蛋白的方法，其特征在于在裂解转化的宿主细胞以分离重组表达的蛋白质二硫键裂解或还原步骤用二硫键切割剂进行。本发明还涉及通过这种方法分离的组合物。本发明还涉及这些组合物的诊断和治疗应用。此外，本发明涉及HCV E1蛋白和肽用于预测和监测HCV治疗的临床有效性和/或临床结果的用途。

5. 发明申请

WO1995012677A2 IMMUNODOMINANT HUMAN T-CELL EPITOPES OF HEPATITIS C VIRUS 审中-公开
标题翻译：免疫调节性HEPATITIS C病毒的人T细胞抗原
公开(公告)号：WO1995012677A2
公开(公告)日：1995-05-11
申请号：PCT/EP1994003555
申请日：1994-10-28
申请人： INNOGENETICS N.V. , LEROUX-ROELS, Geert , DELEYS, Robert , MAERTENS, Geert
发明人： INNOGENETICS N.V.
IPC分类号： C12N15/40
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N2770/24222 , C12N2770/36022 , Y10S530/806 , Y10S530/826
摘要： The present invention relates to a polypeptide of about 8 to about 100 amino acids comprising or consisting of at least 8 contiguous amino acids selected from the core, and/or the E1, and/or E2, and/or the NS3 regions of the HCV polyprotein, with said contiguous amino acids containing a T-cell stimulating epitope.
摘要翻译：本发明涉及包含或由选自核心和/或E1，和/或E2和/或HCV的NS3区域中的至少8个连续氨基酸组成或由其组成的约8至约100个氨基酸的多肽多蛋白，其中所述连续氨基酸含有T细胞刺激表位。

6. 发明申请

WO1992010514A2 SYNTHETIC ANTIGENS FOR THE DETECTION OF ANTIBODIES TO HEPATITIS C VIRUS 审中-公开
标题翻译：用于检测丙型肝炎病毒抗体的合成抗生素
公开(公告)号：WO1992010514A2
公开(公告)日：1992-06-25
申请号：PCT/EP1991002409
申请日：1991-12-13
申请人： INNOGENETICS N.V. , DELEYS, Robert, J. , POLLET, Dirk , MAERTENS, Geert , VAN HEUVERSWIJN, Hugo
发明人： INNOGENETICS N.V.
IPC分类号： C07K07/08
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/24222 , Y10S436/82
摘要： Peptide sequences are provided which are capable of mimicking proteins encoded by HCV for use as reagents for screening of blood and blood products for prior exposure to HCV. The peptides are at least 5 amino acids long and can be used in various specific assays for the detection of antibodies to HCV, for the detection of HCV antigens, or as immunogens.

7. 发明申请

WO1998029442A1 ANNEXIN V-BINDING POLYPEPTIDES DERIVED FROM HBsAg AND THEIR USES 审中-公开
标题翻译：来自HBsAg及其用途的新型V-结合多肽
公开(公告)号：WO1998029442A1
公开(公告)日：1998-07-09
申请号：PCT/EP1997007268
申请日：1997-12-23
申请人： INNOGENETICS N.V. , DEPLA, Erik , MAERTENS, Geert , YAP, Sing-Hien , DE MEYER, Sandra
发明人： INNOGENETICS N.V.
IPC分类号： C07K14/02
CPC分类号： C07K14/005 , A61K39/00 , C12N2730/10122
摘要： Polypeptides derived from hepatitis B surface antigen which are able to compete with the hepatitis B surface antigen/annexin V interaction, or which are able to bind a compound or antibody competing with the hepatitis B surface antigen/annexin V interaction are described. The use of these polypeptides, and antibodies against them, in order to diagnose, treat and vaccinate against an infection with hepatitis B virus and/or hepatitis delta virus is also disclosed.
摘要翻译：描述了能够与乙型肝炎表面抗原/膜联蛋白V相互作用竞争或能够结合与乙型肝炎表面抗原/膜联蛋白V相互作用竞争的化合物或抗体的乙型肝炎表面抗原的多肽。还公开了使用这些多肽以及针对它们的抗体来诊断，治疗和接种针对乙型肝炎病毒和/或乙型肝炎病毒感染的疫苗。

8. 发明申请

WO1995033851A2 METHOD FOR THE DETECTION OF THE ANTIBIOTIC RESISTANCE SPECTRUM OF MYCOBACTERIUM SPECIES 审中-公开
标题翻译：检测MYCOBACTERIUM物种抗生素抗性谱的方法
公开(公告)号：WO1995033851A2
公开(公告)日：1995-12-14
申请号：PCT/EP1995002230
申请日：1995-06-09
申请人： INNOGENETICS N.V. , DE BEENHOUWER, Hans , PORTAELS, Françoise , MACHTELINCKX, Lieve , JANNES, Geert , ROSSAU, Rudi
发明人： INNOGENETICS N.V.
IPC分类号： C12Q01/68
CPC分类号： C12Q1/689 , C12Q2600/156
摘要： Method for the detection of the antibiotic resistance spectrum of Mycobacterium species present in a sample, possibly coupled to the identification of the Micobacterium species involved, comprising the steps of: (i) if need be releasing, isolating or concentrating the polynucleic acids present in the sample; (ii) if need be amplifying the relevant part of the antibiotic resistance genes present in said sample with at least one suitable primer pair; (iii) hybridizing the polynucleic acids of step (i) or (ii) with at least one of the rpo B gene probes, as specified in table 2, under the appropriate hybridization and wash conditions; (iv) detecting the hybrids formed in step (iii); (v) inferring the Mycobacterium antibiotic resistance spectrum, and possibly the Mycobacterium species involved from the differential hybridization signal(s) obtained in step (iv).
摘要翻译：检测样品中存在的分枝杆菌属的抗生素抗性谱的方法，可能与所涉及的微杆菌属物种的鉴定相结合，包括以下步骤：（i）如果需要释放，分离或浓缩存在于样品; （ii）如果需要用至少一个合适的引物对扩增所述样品中存在的抗生素抗性基因的相关部分; （iii）在合适的杂交和洗涤条件下，将步骤（i）或（ii）的多核酸与表2中规定的至少一种rpoB基因探针杂交; （iv）检测步骤（iii）中形成的杂交体; （v）推断出分枝杆菌抗生素抗性谱，以及可能的步骤（iv）中获得的差异杂交信号所涉及的分枝杆菌属物种。

9. 发明申请

WO1997023507A3 NEW FORM OF AMPHIREGULIN, METHODS FOR PRODUCING AND USING THE SAME AND COMPOSITIONS COMPRISING THE SAME 审中-公开
公开(公告)号：WO1997023507A3
公开(公告)日：1997-07-03
申请号：PCT/EP1996005831
申请日：1996-12-23
申请人： INNOGENETICS N.V. , DELAEY, Bernard , RAYMACKERS, Jos , VAN HEUVERSWYN, Hugo
发明人： INNOGENETICS N.V.
IPC分类号： C07K14/485

10. 发明申请

WO1996021675A2 CAPTURING OF MICROORGANISMS USING COMPLEMENT COMPONENTS 审中-公开
标题翻译：使用补充组件捕获微生物
公开(公告)号：WO1996021675A2
公开(公告)日：1996-07-18
申请号：PCT/EP1996000137
申请日：1996-01-15
申请人： INNOGENETICS N.V. , DELFT DIAGNOSTIC LABORATORY B.V. , HERBRINK, Paul , VAN DEN MUNCKHOF, Henk , QUINT, Wilhelmus
发明人： INNOGENETICS N.V. , DELFT DIAGNOSTIC LABORATORY B.V.
IPC分类号： C07K14/47
CPC分类号： G01N33/54326 , C12Q1/24 , G01N33/569
摘要： The invention relates to the field of detection of pathogenic microorganisms in biological samples. More particularly, it relates to the use of complement components or fragments thereof, possibly bound to a solid phase, for capturing a wide range of microorganisms from a sample, said complement components being preferably C1 or C1Q or C3b; as well as to the same components for use in the preparation of a diagnostic device, agent or kit.
摘要翻译：本发明涉及生物样品中病原微生物的检测领域。更具体地说，本发明涉及使用可能与固相结合的补体成分或其片段，从样品中捕获多种微生物，所述补体成分优选为C1或C1Q或C3b; 以及用于制备诊断装置，试剂或试剂盒的相同组分。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式