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1. 发明申请

WO1997023507A3 NEW FORM OF AMPHIREGULIN, METHODS FOR PRODUCING AND USING THE SAME AND COMPOSITIONS COMPRISING THE SAME 审中-公开
公开(公告)号：WO1997023507A3
公开(公告)日：1997-07-03
申请号：PCT/EP1996005831
申请日：1996-12-23
申请人： INNOGENETICS N.V. , DELAEY, Bernard , RAYMACKERS, Jos , VAN HEUVERSWYN, Hugo
发明人： INNOGENETICS N.V.
IPC分类号： C07K14/485

2. 发明申请

WO1991011531A1 HYBRIDIZATION PROBES FOR THE DETECTION OF BRANHAMELLA CATARRHALIS STRAINS 审中-公开
标题翻译：用于检测BRANHAMELLA CATARRHALIS菌株的杂交探针
公开(公告)号：WO1991011531A1
公开(公告)日：1991-08-08
申请号：PCT/EP1991000211
申请日：1991-02-01
申请人： N.V. INNOGENETICS S.A. , ROSSAU, Rudi , VAN HEUVERSWYN, Hugo
发明人： N.V. INNOGENETICS S.A.
IPC分类号： C12Q01/68
CPC分类号： C12Q1/689
摘要： The invention relates to hybridization probes for detecting Branhamella catarrhalis strains. Representative probes of the invention are characterized by the following nucleotides sequences (I):
摘要翻译：本发明涉及用于检测卡他氏菌菌株的杂交探针。本发明的代表性探针的特征在于以下核苷酸序列（I）：

3. 发明申请

WO1996000298A1 SIMULTANEOUS DETECTION, IDENTIFICATION AND DIFFERENTIATION OF EUBACTERIAL TAXA USING A HYBRIDIZATION ASSAY 审中-公开
标题翻译：使用杂交测定法同时检测，鉴定和鉴定非特异性TAXA
公开(公告)号：WO1996000298A1
公开(公告)日：1996-01-04
申请号：PCT/EP1995002452
申请日：1995-06-23
申请人： INNOGENETICS N.V. , JANNES, Geert , ROSSAU, Rudi , VAN HEUVERSWYN, Hugo
发明人： INNOGENETICS N.V.
IPC分类号： C12Q01/68
CPC分类号： C12Q1/689 , C12Q1/6888 , C12Q2600/16
摘要： The present invention relates to a method for detection and identification of at least one microorganism, or for the simultaneous detection of several microorganisms in a sample, comprising the steps of: (i) if need be releasing, isolating or concentrating the polynucleic acids present in the sample; (ii) if need be amplifying the 16S-23S rRNA spacer region, or a part of it, with at least one suitable primer pair; (iii) hybridizing the polynucleic acids of step (i) or (ii) with at least one and preferably more than one of the spacer probes as mentioned in table 1a or equivalents of thereof, under the appropriate hybridization and wash conditions, and/or with a taxon-specific probe derived from any of the spacer sequences as represented in figs. 1-103 under the same hybridization and wash conditions; (iv) detecting the hybrids formed in step (iii) with each of the probes used under appropriate hybridization and wash conditions; (v) identification of the microorganism(s) present in the sample from the differential hybridization signals obtained in step (iv).
摘要翻译：本发明涉及用于检测和鉴定至少一种微生物或同时检测样品中几种微生物的方法，包括以下步骤：（i）如果需要释放，分离或浓缩存在于例子; （ii）如果需要用至少一个合适的引物对扩增16S-23S rRNA间隔区或其一部分; （iii）在合适的杂交和洗涤条件下，将步骤（i）或（ii）的多核酸与表1a或其等同物中所提及的至少一种并优选多于一种的间隔探针杂交，和/或具有从图中所示的任何间隔序列衍生的分类群特异性探针。 1-103在相同的杂交和洗涤条件下; （iv）在适当的杂交和洗涤条件下使用每种探针检测在步骤（iii）中形成的杂交体; （v）从步骤（iv）中获得的差异杂交信号鉴定样品中存在的微生物。

4. 发明申请

WO1991001002A1 CHEMILUMINESCENT COMPOSITIONS, CHEMILUMINESCENT PROCESSES AND THEIR USES IN ANALYTICAL ASSAYS 审中-公开
标题翻译：亮度成分，亮度分析方法及其在分析测定中的应用
公开(公告)号：WO1991001002A1
公开(公告)日：1991-01-24
申请号：PCT/EP1990001139
申请日：1990-07-12
申请人： N.V. INNOGENETICS S.A. , ROELANT, Chris , VAN DE VOORDE, André , VAN HEUVERSWYN, Hugo
发明人： N.V. INNOGENETICS S.A.
IPC分类号： G01N33/52
CPC分类号： G01N33/582 , C12Q1/42 , C12Q1/58 , C12Q1/6816 , G01N33/52 , G01N33/581 , C12Q2563/103 , C12Q2545/101
摘要： The invention relates to a homogeneous hydroalcoholic chemiluminescent composition which can comprise: a solution containing an acridine derivative, a water-miscible alcohol, a reducing agent. The chemiluminescent compositions of the invention are used particularly for the determination and quantification of reducing agents, pH variations in small samples, antigens or antibodies, and hybridization reactions.

5. 发明申请

WO1991016454A1 HYBRIDIZATION PROBES DERIVED FROM THE SPACER REGION BETWEEN THE 16S AND 23S rRNA GENES FOR THE DETECTION OF NON-VIRAL MICROORGANISMS 审中-公开
标题翻译：从16S和23S RRNA基因间隔区获得的用于检测非病毒微生物的杂交探针
公开(公告)号：WO1991016454A1
公开(公告)日：1991-10-31
申请号：PCT/EP1991000743
申请日：1991-04-18
申请人： N.V. INNOGENETICS S.A. , ROSSAU, Rudi , VAN HEUVERSWYN, Hugo
发明人： N.V. INNOGENETICS S.A.
IPC分类号： C12Q01/68
CPC分类号： C12Q1/6888 , C12Q1/689
摘要： The invention relates to a probe consisting of at least about 15 nucleotides from the spacer region between rRNA genes of a non-viral organism, particularly prokaryotic organism and more particularly bacteria, and preferably from about 15 nucleotides to about the maximum number of nucleotides of the spacer region and more preferably from about 15 to about 100 nucleotides to be used for the detection of non-viral microorganisms.

6. 发明申请

WO1991008749A1 NOVEL PROCEDURE FOR OBTAINING PROTEINS STARTING FROM AN EXTRACT OF NON-COLLAGENOUS PROTEINS FROM BONY MATERIAL AND ITS USE FOR THE PREPARATION OF A NOVEL PROTEIN INHIBITING THE PROLIFERATION OF OSTEOBLASTS 审中-公开
标题翻译：从蛋白质提取物中提取非蛋白质蛋白质的蛋白质的新方法及其用于制备新蛋白质抑制骨质疏松症的增殖
公开(公告)号：WO1991008749A1
公开(公告)日：1991-06-27
申请号：PCT/EP1990002295
申请日：1990-12-20
申请人： N.V. INNOGENETICS S.A. , MAHY, Patrick , VAN HEUVERSWYN, Hugo
发明人： N.V. INNOGENETICS S.A.
IPC分类号： A61K35/32
CPC分类号： C07K14/51 , C07K14/4703
摘要： The invention relates to a procedure for obtaining a protein purified to a satisfactory homogeneous state, starting from an extract of non-collagenous proteins of bone matrix. Another subject of the invention is a device for the implementation of the procedure of the invention, a protein inhibiting the proliferation of osteoblasts likely to be obtained by the above-mentioned procedure. The procedure described in the present invention is characterized in that it comprises the following steps: the extract of non-collagenous proteins, solubilized beforehand in a solvent, is subjected to a preparative chromatography in the liquid phase on a column of gel with the aid of an elution buffer and an electric field, under conditions such that the desired protein is eluted, and is found, during or at the end of the chromatography, to be present in solution in the elution buffer, alone and free from contaminants, in at least one of the fractions collected at the exit of the column, the fraction containing the desired protein in solution in the elution buffer is recovered, the elution buffer is removed and the desired protein is recovered which, if necessary, is subjected to a renaturation step and/or a reactivation step.
摘要翻译：本发明涉及从骨基质的非胶原性蛋白质的提取物开始获得纯化至令人满意的均匀状态的蛋白质的方法。本发明的另一主题是用于实施本发明方法的装置，其是抑制可能通过上述方法获得的成骨细胞增殖的蛋白质。本发明描述的方法的特征在于其包括以下步骤：预先在溶剂中增溶的非胶原蛋白的提取物在凝胶柱上经液相制备色谱，借助于洗脱缓冲液和电场，在所需蛋白质被洗脱的条件下，并且在色谱法期间或结束时发现，至少存在于洗脱缓冲液的溶液中，单独且不含污染物在塔的出口收集的级分之一，回收洗脱缓冲液中含有溶液中所需蛋白质的级分，除去洗脱缓冲液，回收所需的蛋白质，如果需要，其进行复性步骤和 /或重新激活步骤。

7. 发明申请

WO1997027300A1 TOXOPLASMA GONDII ANTIGEN Tg20 审中-公开
公开(公告)号：WO1997027300A1
公开(公告)日：1997-07-31
申请号：PCT/EP1997000394
申请日：1997-01-27
申请人： INNOGENETICS N.V. , JACOBS, Dirk , SAMAN, Eric , VAN HEUVERSWYN, Hugo
发明人： INNOGENETICS N.V.
IPC分类号： C12N15/30
CPC分类号： C07K14/45 , A61K39/00 , A61K48/00 , A61K2039/51 , C07K2319/00 , Y10S435/961 , Y10S435/968 , Y10S435/971 , Y10S435/973 , Y10S435/975
摘要： The present invention relates to isolated and pure Toxoplasma gondii antigenic fragments, recombinant polypeptides, nucleic acids encoding them, primers and probes derived from the same, as well as the use of these polypeptides, nucleic acids, primers and probes in methods and kits for the diagnosis and prevention of T. gondii infection in mammals (humans and animals).
摘要翻译：本发明涉及分离和纯的弓形体抗原片段，重组多肽，编码它们的核酸，来自其的引物和探针，以及这些多肽，核酸，引物和探针在用于诊断和预防哺乳动物（人和动物）感染弓形虫感染。

8. 发明申请

WO1994012670A2 PROCESS FOR TYPING OF HCV ISOLATES 审中-公开
标题翻译：分离型HCV的方法
公开(公告)号：WO1994012670A2
公开(公告)日：1994-06-09
申请号：PCT/EP1993003325
申请日：1993-11-26
申请人： N.V. INNOGENETICS S.A. , MAERTENS, Geert , STUYVER, Lieven , ROSSAU, Rudi , VAN HEUVERSWYN, Hugo
发明人： N.V. INNOGENETICS S.A.
IPC分类号： C12Q01/70
CPC分类号： C12Q1/707 , C12Q1/6834 , C12Q2563/131 , C12Q2545/101 , C12Q2525/101 , C12Q2531/113
摘要： The invention relates to a process for genotyping any HCV isolate present in a biological sample, previously identified as being HCV positive, and for classifying said isolate according to the percentage of homology with other HCV isolates, comprising the steps of: contacting said sample in which the ribonucleotides or deoxyribonucleotides have been made accessible, if need be, under suitable denaturation, with at least one probe from about 10 to about 40 nucleotides, with said probe being liable to hybridize to a region being in the domain extending from nucleotide at position -291 to nucleotide at position -66 of the 5' untranslated region of one of the HCV isolates represented by their cDNA sequences, with said numbering of position beginning with the first ATG codon of the open reading frame encoding the HCV polyprotein, or with said probe being complementary to the above-defined probes; detecting the complexes possibly formed between said probe and the nucleotide sequence of the HCV isolate to be identified.
摘要翻译：本发明涉及用于对先前鉴定为HCV阳性的生物样品中存在的任何HCV分离物进行基因分型的方法，以及根据与其它HCV分离株的同源性百分比对所述分离物进行分类的方法，包括以下步骤：如果需要的话，核糖核苷酸或脱氧核糖核苷酸可以在合适的变性下与至少一个约10至约40个核苷酸的探针接触，所述探针易于与位置延伸的结构域延伸的区域杂交。 291到由其cDNA序列表示的HCV分离物之一的5'非翻译区的-66位的核苷酸，其中所述编号的位置开始于编码HCV多蛋白的开放阅读框的第一个ATG密码子，或与所述探针与上述探针互补; 检测可能形成在所述探针和待鉴定的HCV分离物的核苷酸序列之间的复合物。

9. 发明申请

WO1993022437A1 NEW POLYPEPTIDES AND PEPTIDES, NUCLEIC ACIDS CODING FOR THEM, AND THEIR USE IN THE FIELD OF TUMOR THERAPY, INFLAMMATION OR IMMUNOLOGY 审中-公开
标题翻译：新的多肽和肽，它们的核酸编码及其在肿瘤治疗领域的使用，炎症或免疫学
公开(公告)号：WO1993022437A1
公开(公告)日：1993-11-11
申请号：PCT/EP1993001022
申请日：1993-04-28
申请人： N.V. INNOGENETICS S.A. , FRANSEN, Lucia , DEVOS, Kathleen , VAN DE VOORDE, André , VAN HEUVERSWYN, Hugo
发明人： N.V. INNOGENETICS S.A.
IPC分类号： C12N15/19
CPC分类号： C07K14/52 , A01K2217/05 , A61K38/00 , C07K14/525 , C07K2319/00 , C07K2319/75 , C07K2319/91
摘要： The invention relates: to a polypeptide containing in its peptidic chain the amino acid sequence of 311 amino acids of figure 3, or a fragment of this sequence, with said fragment being such that it is liable to produce antibodies capable of forming a complex with the amino acid sequence of figure 3, or an amino acid sequence having a percentage of homology of at least 50 %, preferably 75 %, and advantageously 90 % with the amino acid sequence of figure 3, and to pharmaceutical compositions containing, as active substance, at least one of the polypeptides of the invention or of the antagonists of the polypeptides of the invention as antitumor compounds, or antiinflammatory compounds or as growth activators of T-cells and B-cells, as bone repair compounds as inducer of immunosuppressive cells, as inhibitors of anti-colony stimulating factor; or as trypanocidal agents; or part of the polypeptides of the invention, capable of binding to the above-defined receptor.
摘要翻译：本发明涉及：在其肽链中含有图3的311个氨基酸的氨基酸序列或该序列的片段的多肽，其中所述片段使得其易于产生能与其形成复合物的抗体图3的氨基酸序列或与图3的氨基酸序列具有至少50％，优选75％，有利地90％的同源性百分比的氨基酸序列，以及含有作为活性物质的药物组合物，本发明多肽或本发明多肽的拮抗剂作为抗肿瘤化合物或抗炎化合物或T细胞和B细胞的生长激活剂中的至少一种作为免疫抑制细胞诱导剂的骨修复化合物，作为抗集落刺激因子抑制剂; 或作为杀虫剂; 或本发明的多肽的一部分，其能够结合上述限定的受体。

10. 发明申请

WO1989012094A1 HIV-3 RETROVIRUS AND ITS USE 审中-公开
标题翻译： HIV-3 RETROVIRUS及其使用
公开(公告)号：WO1989012094A1
公开(公告)日：1989-12-14
申请号：PCT/EP1989000643
申请日：1989-06-08
申请人： INNOGENETICS N.V. , DE LEYS, Robert , VANDERBORGHT, Bart , SAMAN, Eric , VAN HEUVERSWYN, Hugo
发明人： INNOGENETICS N.V.
IPC分类号： C12N07/00
CPC分类号： C07K14/005 , A61K39/00 , A61K2039/505 , C07K16/1045 , C07K16/1054 , C12N7/00 , C12N2740/16021 , C12N2740/16122 , C12N2740/16222 , G01N33/56988 , G01N2333/16 , Y10S435/974 , Y10S435/975 , Y10S530/809
摘要： Described is a new retrovirus designated HIV-3 and deposited in the European Collection of Animal Cell Cultures (ECACC) under V88060301. Further described are antigens obtained from the virus, particularly proteins p12, p16, p26 and glycoproteins gp41 and gp120 to be used in the diagnosis of ARC or AIDS caused by HIV-3. Immunogenic compositions to be used as vaccines contain an envelope glycoprotein of HIV-3 such as gp41 or gp120.

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