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1. 发明申请

WO1998029442A1 ANNEXIN V-BINDING POLYPEPTIDES DERIVED FROM HBsAg AND THEIR USES 审中-公开
标题翻译：来自HBsAg及其用途的新型V-结合多肽
公开(公告)号：WO1998029442A1
公开(公告)日：1998-07-09
申请号：PCT/EP1997007268
申请日：1997-12-23
申请人： INNOGENETICS N.V. , DEPLA, Erik , MAERTENS, Geert , YAP, Sing-Hien , DE MEYER, Sandra
发明人： INNOGENETICS N.V.
IPC分类号： C07K14/02
CPC分类号： C07K14/005 , A61K39/00 , C12N2730/10122
摘要： Polypeptides derived from hepatitis B surface antigen which are able to compete with the hepatitis B surface antigen/annexin V interaction, or which are able to bind a compound or antibody competing with the hepatitis B surface antigen/annexin V interaction are described. The use of these polypeptides, and antibodies against them, in order to diagnose, treat and vaccinate against an infection with hepatitis B virus and/or hepatitis delta virus is also disclosed.
摘要翻译：描述了能够与乙型肝炎表面抗原/膜联蛋白V相互作用竞争或能够结合与乙型肝炎表面抗原/膜联蛋白V相互作用竞争的化合物或抗体的乙型肝炎表面抗原的多肽。还公开了使用这些多肽以及针对它们的抗体来诊断，治疗和接种针对乙型肝炎病毒和/或乙型肝炎病毒感染的疫苗。

2. 发明申请

WO1996004385A2 PURIFIED HEPATITIS C VIRUS ENVELOPE PROTEINS FOR DIAGNOSTIC AND THERAPEUTIC USE 审中-公开
标题翻译：纯化的乙型肝炎病毒包膜蛋白用于诊断和治疗用途
公开(公告)号：WO1996004385A2
公开(公告)日：1996-02-15
申请号：PCT/EP1995003031
申请日：1995-07-31
申请人： INNOGENETICS N.V. , MAERTENS, Geert , BOSMAN, Fons , DE MARTYNOFF, Guy , BUYSE, Marie-Ange
发明人： INNOGENETICS N.V.
IPC分类号： C12N15/40
CPC分类号： C07K16/109 , A61K39/00 , A61K39/12 , A61K39/29 , A61K2039/5256 , C07K14/005 , C07K2317/34 , C12N2710/24143 , C12N2770/24222 , C12N2770/24234 , C12N2770/24243 , Y10S435/803 , Y10S435/81 , Y10S435/915 , Y10S435/975
摘要： The present invention relates to a method for purifying recombinant HCV single or specific oligomeric envelope proteins selected from the group consisting of E1 and/or E2 and/or E1/E2, characterized in that upon lysing the transformed host cells to isolate the recombinantly expressed protein a disulphide bond cleavage or reduction step is carried out with a disulphide bond cleavage agent. The present invention also relates to a composition isolated by such a method. The present invention also relates to the diagnostic and therapeutic application of these compositions. Furthermore, the invention relates to the use of HCV E1 protein and peptides for prognosing and monitoring the clinical effectiveness and/or clinical outcome of HCV treatment.
摘要翻译：本发明涉及一种纯化选自E1和/或E2和/或E1 / E2的重组HCV单一或特异性寡聚包膜蛋白的方法，其特征在于在裂解转化的宿主细胞以分离重组表达的蛋白质二硫键裂解或还原步骤用二硫键切割剂进行。本发明还涉及通过这种方法分离的组合物。本发明还涉及这些组合物的诊断和治疗应用。此外，本发明涉及HCV E1蛋白和肽用于预测和监测HCV治疗的临床有效性和/或临床结果的用途。

3. 发明申请

WO1997040193A3 METHOD FOR TYPING AND DETECTING HBV 审中-公开
公开(公告)号：WO1997040193A3
公开(公告)日：1997-10-30
申请号：PCT/EP1997002002
申请日：1997-04-21
申请人： INNOGENETICS N.V. , STUYVER, Lieven , ROSSAU, Rudi , MAERTENS, Geert
发明人： INNOGENETICS N.V.
IPC分类号： C12Q01/70

4. 发明申请

WO1996013590A3 NEW SEQUENCES OF HEPATITIS C VIRUS GENOTYPES AND THEIR USE AS PROPHYLACTIC, THERAPEUTIC AND DIAGNOSTIC AGENTS 审中-公开
公开(公告)号：WO1996013590A3
公开(公告)日：1996-05-09
申请号：PCT/EP1995004155
申请日：1995-10-23
申请人： INNOGENETICS N.V. , MAERTENS, Geert , STUYVER, Lieven
发明人： INNOGENETICS N.V.
IPC分类号： C12N15/40

5. 发明申请

WO1995012677A2 IMMUNODOMINANT HUMAN T-CELL EPITOPES OF HEPATITIS C VIRUS 审中-公开
标题翻译：免疫调节性HEPATITIS C病毒的人T细胞抗原
公开(公告)号：WO1995012677A2
公开(公告)日：1995-05-11
申请号：PCT/EP1994003555
申请日：1994-10-28
申请人： INNOGENETICS N.V. , LEROUX-ROELS, Geert , DELEYS, Robert , MAERTENS, Geert
发明人： INNOGENETICS N.V.
IPC分类号： C12N15/40
CPC分类号： C07K14/005 , A61K39/00 , C07K2319/00 , C12N2770/24222 , C12N2770/36022 , Y10S530/806 , Y10S530/826
摘要： The present invention relates to a polypeptide of about 8 to about 100 amino acids comprising or consisting of at least 8 contiguous amino acids selected from the core, and/or the E1, and/or E2, and/or the NS3 regions of the HCV polyprotein, with said contiguous amino acids containing a T-cell stimulating epitope.
摘要翻译：本发明涉及包含或由选自核心和/或E1，和/或E2和/或HCV的NS3区域中的至少8个连续氨基酸组成或由其组成的约8至约100个氨基酸的多肽多蛋白，其中所述连续氨基酸含有T细胞刺激表位。

6. 发明申请

WO1992010514A2 SYNTHETIC ANTIGENS FOR THE DETECTION OF ANTIBODIES TO HEPATITIS C VIRUS 审中-公开
标题翻译：用于检测丙型肝炎病毒抗体的合成抗生素
公开(公告)号：WO1992010514A2
公开(公告)日：1992-06-25
申请号：PCT/EP1991002409
申请日：1991-12-13
申请人： INNOGENETICS N.V. , DELEYS, Robert, J. , POLLET, Dirk , MAERTENS, Geert , VAN HEUVERSWIJN, Hugo
发明人： INNOGENETICS N.V.
IPC分类号： C07K07/08
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/24222 , Y10S436/82
摘要： Peptide sequences are provided which are capable of mimicking proteins encoded by HCV for use as reagents for screening of blood and blood products for prior exposure to HCV. The peptides are at least 5 amino acids long and can be used in various specific assays for the detection of antibodies to HCV, for the detection of HCV antigens, or as immunogens.

7. 发明申请

WO1995033851A2 METHOD FOR THE DETECTION OF THE ANTIBIOTIC RESISTANCE SPECTRUM OF MYCOBACTERIUM SPECIES 审中-公开
标题翻译：检测MYCOBACTERIUM物种抗生素抗性谱的方法
公开(公告)号：WO1995033851A2
公开(公告)日：1995-12-14
申请号：PCT/EP1995002230
申请日：1995-06-09
申请人： INNOGENETICS N.V. , DE BEENHOUWER, Hans , PORTAELS, Françoise , MACHTELINCKX, Lieve , JANNES, Geert , ROSSAU, Rudi
发明人： INNOGENETICS N.V.
IPC分类号： C12Q01/68
CPC分类号： C12Q1/689 , C12Q2600/156
摘要： Method for the detection of the antibiotic resistance spectrum of Mycobacterium species present in a sample, possibly coupled to the identification of the Micobacterium species involved, comprising the steps of: (i) if need be releasing, isolating or concentrating the polynucleic acids present in the sample; (ii) if need be amplifying the relevant part of the antibiotic resistance genes present in said sample with at least one suitable primer pair; (iii) hybridizing the polynucleic acids of step (i) or (ii) with at least one of the rpo B gene probes, as specified in table 2, under the appropriate hybridization and wash conditions; (iv) detecting the hybrids formed in step (iii); (v) inferring the Mycobacterium antibiotic resistance spectrum, and possibly the Mycobacterium species involved from the differential hybridization signal(s) obtained in step (iv).
摘要翻译：检测样品中存在的分枝杆菌属的抗生素抗性谱的方法，可能与所涉及的微杆菌属物种的鉴定相结合，包括以下步骤：（i）如果需要释放，分离或浓缩存在于样品; （ii）如果需要用至少一个合适的引物对扩增所述样品中存在的抗生素抗性基因的相关部分; （iii）在合适的杂交和洗涤条件下，将步骤（i）或（ii）的多核酸与表2中规定的至少一种rpoB基因探针杂交; （iv）检测步骤（iii）中形成的杂交体; （v）推断出分枝杆菌抗生素抗性谱，以及可能的步骤（iv）中获得的差异杂交信号所涉及的分枝杆菌属物种。

8. 发明申请

WO1997023507A3 NEW FORM OF AMPHIREGULIN, METHODS FOR PRODUCING AND USING THE SAME AND COMPOSITIONS COMPRISING THE SAME 审中-公开
公开(公告)号：WO1997023507A3
公开(公告)日：1997-07-03
申请号：PCT/EP1996005831
申请日：1996-12-23
申请人： INNOGENETICS N.V. , DELAEY, Bernard , RAYMACKERS, Jos , VAN HEUVERSWYN, Hugo
发明人： INNOGENETICS N.V.
IPC分类号： C07K14/485

9. 发明申请

WO1996021675A2 CAPTURING OF MICROORGANISMS USING COMPLEMENT COMPONENTS 审中-公开
标题翻译：使用补充组件捕获微生物
公开(公告)号：WO1996021675A2
公开(公告)日：1996-07-18
申请号：PCT/EP1996000137
申请日：1996-01-15
申请人： INNOGENETICS N.V. , DELFT DIAGNOSTIC LABORATORY B.V. , HERBRINK, Paul , VAN DEN MUNCKHOF, Henk , QUINT, Wilhelmus
发明人： INNOGENETICS N.V. , DELFT DIAGNOSTIC LABORATORY B.V.
IPC分类号： C07K14/47
CPC分类号： G01N33/54326 , C12Q1/24 , G01N33/569
摘要： The invention relates to the field of detection of pathogenic microorganisms in biological samples. More particularly, it relates to the use of complement components or fragments thereof, possibly bound to a solid phase, for capturing a wide range of microorganisms from a sample, said complement components being preferably C1 or C1Q or C3b; as well as to the same components for use in the preparation of a diagnostic device, agent or kit.
摘要翻译：本发明涉及生物样品中病原微生物的检测领域。更具体地说，本发明涉及使用可能与固相结合的补体成分或其片段，从样品中捕获多种微生物，所述补体成分优选为C1或C1Q或C3b; 以及用于制备诊断装置，试剂或试剂盒的相同组分。

10. 发明申请

WO1996004309A1 MONOCLONAL ANTIBODIES SPECIFIC FOR AN EPITOPE OF A PARTICULAR SUBCLASS OR FORM OF PHOSPHORYLATED TAU, HYBRIDOMAS SECRETING THEM, ANTIGEN RECOGNITION OF THESE ANTIBODIES AND THEIR APPLICATIONS 审中-公开
标题翻译：特异性抗体特异性特异性单克隆抗体或磷酸化TAU的混合物，其分泌型抗体，抗原鉴定及其应用
公开(公告)号：WO1996004309A1
公开(公告)日：1996-02-15
申请号：PCT/EP1995003032
申请日：1995-07-31
申请人： INNOGENETICS N.V. , VANMECHELEN, Eugeen , VAN DE VOORDE, Andre
发明人： INNOGENETICS N.V.
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , C07K14/4711 , C12N9/12 , Y10S435/975 , Y10S436/811
摘要： The present invention relates to a monoclonal antibody which forms an immunological complex with a phosphorylated epitope of a particular subclass or form of phosphorylated tau protein without forming an immunological complex with (i) fetal tau or (ii) biopsy or autopsy derived brain material from patients having died or suffering from diseases in which NFT is not a pathological hallmark. The invention also relates to a process for diagnosing brain diseases involving monoclonal antibodies of the invention. The invention also relates to a region of the tau molecule which is specifically recognized by the monoclonal antibodies of the invention. The invention also relates to kinases or phosphorylases which specifically react with the epitope recognized by these monoclonal antibodies as well as to a method for screening compounds which interfere with the activity of these kinases and phosphorylases.
摘要翻译：本发明涉及与特定亚类或磷酸化tau蛋白形式的磷酸化表位形成免疫复合物的单克隆抗体，而不形成免疫复合物（i）胎儿tau或（ii）来自患者的活组织检查或尸体解剖衍生的脑材料已经死亡或患有NFT不是病理学标志的疾病。本发明还涉及涉及本发明的单克隆抗体的脑疾病的诊断方法。本发明还涉及由本发明的单克隆抗体特异性识别的tau分子的区域。本发明还涉及与这些单克隆抗体识别的表位特异性反应的激酶或磷酸酶，以及用于筛选干扰这些激酶和磷酸酶的活性的化合物的方法。

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