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1. 发明申请

WO2006083833A3 VALVES AND RESERVOIRS FOR MICROFLUIDIC SYSTEMS 审中-公开
标题翻译：微流体系统的阀门和储存器
公开(公告)号：WO2006083833A3
公开(公告)日：2007-02-22
申请号：PCT/US2006003354
申请日：2006-01-31
申请人： HARVARD COLLEGE , WEIBEL DOUGLAS B , LEE ANDREW , POTENTA SCOTT , SIEGEL ADAM , KRUITHOF MAARTEN , WHITESIDES GEORGE M
发明人： WEIBEL DOUGLAS B , LEE ANDREW , POTENTA SCOTT , SIEGEL ADAM , KRUITHOF MAARTEN , WHITESIDES GEORGE M
IPC分类号： F16K3/24
CPC分类号： F15B1/04 , B01L3/502738 , B01L3/502746 , B01L2200/0636 , B01L2300/0867 , B01L2400/0487 , B01L2400/0655 , B01L2400/082 , F15B2201/21 , F15B2201/305 , F15B2201/4053 , F16K99/0001 , F16K99/0026 , F16K99/0034 , F16K2099/0074 , F16K2099/0078 , F16K2099/0084 , Y10T137/0318 , Y10T137/0396 , Y10T137/2213 , Y10T137/4824 , Y10T137/6161
摘要： A microfluidic valve assembly includes a structure defining a microfluidic fluid path and an actuator that can be moved between different positions controlling flow through the channel. In one embodiment, the actuator can be threaded into at least a portion of the structure, and can be moved rotationally between a first position, causing relatively greater constriction of a microfluidic fluid path, and a second position causing relatively lesser constriction of the fluid path. Actuating the actuator, e.g., by rotation, can deform material between the valve and the fluid path, thereby constricting at least a portion of the underlying fluid path and regulating the flow of a fluid in the fluid path. In another aspect, the invention provides a reservoir into which fluid can be placed and from which fluid can be introduced into a microfluidic system. In one embodiment, the reservoir is expandable and thereby able to store fluid under pressure for delivery to a microfluidic system.
摘要翻译：微流体阀组件包括限定微流体流体路径的结构和可以在控制流过通道的不同位置之间移动的致动器。在一个实施例中，致动器可以被螺纹连接到结构的至少一部分中，并且可以在第一位置和第二位置之间旋转地移动，第一位置引起微流体流体路径的相对较大的收缩，并且引起相对较小的流体路径收缩的第二位置。例如通过旋转来致动致动器可以在阀和流体路径之间变形材料，从而收缩下面的流体路径的至少一部分并且调节流体路径中的流体的流动。在另一方面，本发明提供了一种储存器，流体可以放置在该储存器中，并且可以从该储存器将流体引入到微流体系统中。在一个实施例中，储存器是可膨胀的并且因此能够在压力下存储流体以递送到微流体系统。

2. 发明申请

WO2007061448A3 FABRICATION OF CONDUCTIVE PATHWAYS, MICROCIRCUITS AND MICROSTRUCTURES IN MICROFLUIDIC NETWORKS 审中-公开
标题翻译：微流控网络中导电路径，微型计算机和微结构的制造
公开(公告)号：WO2007061448A3
公开(公告)日：2008-08-28
申请号：PCT/US2006019787
申请日：2006-05-18
申请人： HARVARD COLLEGE , BRUZEWICZ DEREK A , BONCHEVA-BETTEX MILA , WHITESIDES GEORGE M , SIEGEL ADAM , WEIBEL DOUGLAS B , SHEVKOPLYAS SERGEY , MARTINEZ ANDRES
发明人： BRUZEWICZ DEREK A , BONCHEVA-BETTEX MILA , WHITESIDES GEORGE M , SIEGEL ADAM , WEIBEL DOUGLAS B , SHEVKOPLYAS SERGEY , MARTINEZ ANDRES
IPC分类号： H05K3/10 , B01F13/00 , B01L3/00 , B29C39/12
CPC分类号： H05K3/101 , B01L3/5027 , B01L3/502707 , B01L2200/12 , B01L2300/0645 , B01L2300/0816 , B01L2300/0874 , B01L2400/0415 , B33Y80/00 , H05K1/0272 , H05K1/032 , H05K3/389 , H05K2201/0162 , H05K2201/0305 , H05K2203/128 , Y10T29/49117
摘要： Disclosed herein are a variety of microfluidic devices and solid, typically electrically conductive devices that can be formed using such devices as molds. In certain embodiments, the devices that are formed comprise conductive pathways formed by solidifying a liquid metal present in one or more microfluidic channels (such devices hereinafter referred to as "microsolidic" devices). In certain such devices, in which electrical connections can be formed and/or reformed between regions in a microfluidic structure; in some cases, the devices/circuits formed may be flexible and/or involve flexible electrical components. In certain embodiments, the solid metal wires/conductive pathways formed in microfluidic channel(s) may remain contained within the microfluidic structure. In certain such embodiments, the conductive pathways formed may be located in proximity to other microfluidic channel(s) of the structure that carry flowing fluid, such that the conductive pathway can create energy (e.g. electromagnetic and/or thermal energy) that interacts withy and/or affects the flowing fluid and/or a component contained therein or carried thereby. In other embodiments, a microsolidic structure may be removed from a microfluidic mold to form a stand-alone structure. In certain embodiments, the solid metal structures formed may interact with light energy incident upon a structure or may be used to fabricate a light-weight electrode. Another aspect of the invention relates to the formation of self-assembled structures that may comprise these electrically conductive pathways/connections.
摘要翻译：本文公开了各种微流体装置和可以使用诸如模具的装置形成的固体，通常导电的装置。在某些实施方案中，形成的装置包括通过固化存在于一个或多个微流体通道（这种装置在下文中称为“微溶体”装置）中的液态金属形成的导电通路。在某些这样的装置中，其中可以在微流体结构的区域之间形成和/或重组电连接; 在一些情况下，所形成的器件/电路可能是柔性的和/或涉及柔性电气部件。在某些实施方案中，在微流体通道中形成的固体金属线/导电路径可以保持在微流体结构内。在某些这样的实施例中，所形成的导电路径可以位于结构的其它微流体通道附近，其携带流动的流体，使得导电路径可以产生与...相互作用的能量（例如电磁和/或热能） /或影响流动的流体和/或其中所含的或由其携带的部件。在其它实施方案中，微溶体结构可以从微流体模具中移除以形成独立结构。在某些实施方案中，形成的固体金属结构可与入射到结构上的光能相互作用，或者可用于制造轻质电极。本发明的另一方面涉及可以包括这些导电路径/连接的自组装结构的形成。

3. 发明申请

WO2007061448A9 FABRICATION OF CONDUCTIVE PATHWAYS, MICROCIRCUITS AND MICROSTRUCTURES IN MICROFLUIDIC NETWORKS 审中-公开
标题翻译：导电路径的制造，微流控网络中的微处理器和微结构
公开(公告)号：WO2007061448A9
公开(公告)日：2007-07-26
申请号：PCT/US2006019787
申请日：2006-05-18
申请人： HARVARD COLLEGE , BRUZEWICZ DEREK A , BONCHEVA-BETTEX MILA , WHITESIDES GEORGE M , SIEGEL ADAM , WEIBEL DOUGLAS B , SHEVKOPLYAS SERGEY , MARTINEZ ANDRES
发明人： BRUZEWICZ DEREK A , BONCHEVA-BETTEX MILA , WHITESIDES GEORGE M , SIEGEL ADAM , WEIBEL DOUGLAS B , SHEVKOPLYAS SERGEY , MARTINEZ ANDRES
IPC分类号： H05K3/10
CPC分类号： H05K3/101 , B01L3/5027 , B01L3/502707 , B01L2200/12 , B01L2300/0645 , B01L2300/0816 , B01L2300/0874 , B01L2400/0415 , B33Y80/00 , H05K1/0272 , H05K1/032 , H05K3/389 , H05K2201/0162 , H05K2201/0305 , H05K2203/128 , Y10T29/49117
摘要： Disclosed herein are a variety of microfluidic devices and solid, typically electrically conductive devices that can be formed using such devices as molds. In certain embodiments, the devices that are formed comprise conductive pathways formed by solidifying a liquid metal present in one or more microfluidic channels (such devices hereinafter referred to as "microsolidic" devices). In certain such devices, in which electrical connections can be formed and/or reformed between regions in a microfluidic structure; in some cases, the devices/circuits formed may be flexible and/or involve flexible electrical components. In certain embodiments, the solid metal wires/conductive pathways formed in microfluidic channel(s) may remain contained within the microfluidic structure. In certain such embodiments, the conductive pathways formed may be located in proximity to other microfluidic channel(s) of the structure that carry flowing fluid, such that the conductive pathway can create energy (e.g. electromagnetic and/or thermal energy) that interacts withy and/or affects the flowing fluid and/or a component contained therein or carried thereby. In other embodiments, a microsolidic structure may be removed from a microfluidic mold to form a stand-alone structure. In certain embodiments, the solid metal structures formed may interact with light energy incident upon a structure or may be used to fabricate a light-weight electrode. Another aspect of the invention relates to the formation of self-assembled structures that may comprise these electrically conductive pathways/connections.
摘要翻译：本文公开了各种微流体装置和可以使用诸如模具的装置形成的固体，通常导电的装置。在某些实施方案中，所形成的装置包括通过固化存在于一个或多个微流体通道中的液体金属形成的导电通路（以下称为“微溶体”装置）。在某些这样的器件中，其中可以在微流体结构中的区域之间形成和/或重组电连接; 在一些情况下，形成的器件/电路可以是柔性的和/或涉及柔性电气部件。在某些实施方案中，在微流体通道中形成的固体金属线/导电路径可以保持在微流体结构内。在某些这样的实施例中，所形成的导电路径可以位于结构的其他微流体通道附近，该流体通道携带流动的流体，使得导电路径可产生与其相互作用的能量（例如电磁和/或热能） /或影响流动的流体和/或其中所含的或由其携带的部件。在其它实施方案中，微溶体结构可以从微流体模具中移除以形成独立结构。在某些实施方案中，所形成的固体金属结构可与入射到结构上的光能相互作用，或者可用于制造轻质电极。本发明的另一方面涉及可以包括这些导电路径/连接的自组装结构的形成。

4. 发明申请

WO2009121037A3 THREE-DIMENSIONAL MICROFLUIDIC DEVICES 审中-公开
标题翻译：三维微流体器件
公开(公告)号：WO2009121037A3
公开(公告)日：2009-12-17
申请号：PCT/US2009038693
申请日：2009-03-27
申请人： HARVARD COLLEGE , CARRILHO EMANUEL , MARTINEZ ANDRES W , MIRICA KATHERINE A , PHILLIPS SCOTT T , SIEGEL ADAM C , WILEY BENJAMIN , WHITESIDES GEORGE M
发明人： CARRILHO EMANUEL , MARTINEZ ANDRES W , MIRICA KATHERINE A , PHILLIPS SCOTT T , SIEGEL ADAM C , WILEY BENJAMIN , WHITESIDES GEORGE M
IPC分类号： G01N35/00 , G01N33/48
CPC分类号： B01L3/502707 , B01L3/5023 , B01L3/502738 , B01L7/525 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/126 , B01L2300/1855 , B01L2300/1877 , B01L2400/0406 , B01L2400/0633 , B01L2400/0672 , F16K99/0001 , F16K99/0015 , F16K99/0025 , F16K2099/008
摘要： Three-dimensional microfluidic devices including by a plurality of patterned porous, hydrophilic layers and a fluid-impermeable layer disposed between every two adjacent patterned porous, hydrophilic layers are described. Each patterned porous, hydrophilic layer has a fluid-impermeable barrier which substantially permeates the thickness of the porous, hydrophilic layer and defines boundaries of one or more hydrophilic regions within the patterned porous, hydrophilic layer. The fluid-impermeable layer has openings which are aligned with at least part of the hydrophilic region within at least one adjacent patterned porous, hydrophilic layer. Microfluidic assay device, microfluidic mixer, microfluidic flow control device are also described.
摘要翻译：描述了包括由多个图案化的多孔亲水层和设置在每两个相邻的图案化多孔亲水层之间的流体不可渗透层的三维微流体装置。每个图案化的多孔亲水层具有流体不可渗透的屏障，其基本上渗透多孔亲水层的厚度并限定图案化多孔亲水层内的一个或多个亲水区域的边界。不透流体层具有与至少一个相邻图案化多孔亲水层内的亲水区域的至少一部分对齐的开口。还描述了微流体测定装置，微流体混合器，微流体控制装置。

5. 发明申请

WO2009121041A3 PAPER-BASED MICROFLUIDIC SYSTEMS 审中-公开
标题翻译：基于纸张的微流体系统
公开(公告)号：WO2009121041A3
公开(公告)日：2009-12-17
申请号：PCT/US2009038699
申请日：2009-03-27
申请人： HARVARD COLLEGE , SIEGEL ADAM C , PHILLIPS SCOTT T , DICKEY MICHAEL D , ROZKIEWICZ DOROTA , WILEY BENJAMIN , WHITESIDES GEORGE M , MARTINEZ ANDRES W
发明人： SIEGEL ADAM C , PHILLIPS SCOTT T , DICKEY MICHAEL D , ROZKIEWICZ DOROTA , WILEY BENJAMIN , WHITESIDES GEORGE M , MARTINEZ ANDRES W
IPC分类号： G01N35/00 , G01N27/26 , G01N33/48
CPC分类号： B01L3/502707 , B01L2200/027 , B01L2200/0642 , B01L2200/10 , B01L2200/12 , B01L2200/16 , B01L2300/025 , B01L2300/0636 , B01L2300/0645 , B01L2300/0809 , B01L2300/0819 , B01L2300/087 , B01L2300/12 , B01L2300/126 , B01L2300/161 , B01L2300/1827 , B01L2400/0406 , Y10T436/25 , Y10T436/2575
摘要： The invention features an assay device, a microfluidic device, and a method of detecting the presence of high electrolyte concentration in a fluid sample. The assay device comprises a porous, hydrophilic substrate; a fluid-impermeable barrier defining a boundary of an assay region and a boundary of a main channel region, the main channel region fluidically connected to the assay region; and a strip of conductive material disposed on the porous, hydrophilic substrate. The microfluidic device comprises a porous, hydrophilic substrate; a fluid-impermeable barrier, the barrier permeating the thickness of the porous, hydrophilic substrate and defining within the porous, hydrophilic substrate a boundary of an open-ended channel having first and second lateral walls; and an electrically conductive pathway disposed on the porous, hydrophilic substrate, the electrically conductive pathway comprising (i) a strip of conductive material forming an open circuit in the absence of an electrically conductive material bridging the first and second lateral walls; and (ii) a battery, an electrically-responsive indicator, and a resistor electrically connected to the strip of conductive material.
摘要翻译：本发明的特征在于测定装置，微流体装置和检测流体样品中高电解质浓度的存在的方法。测定装置包括多孔亲水底物; 限定测定区域和主通道区域边界的流体不渗透屏障，主通道区域与流体连接到测定区域的主通道区域; 以及设置在多孔亲水基底上的导电材料条。微流体装置包括多孔的亲水基底; 流体不可渗透的屏障，所述屏障渗透所述多孔亲水基底的厚度，并且在所述多孔亲水基底内限定具有第一和第二侧壁的开放式通道的边界; 以及设置在所述多孔亲水基底上的导电通路，所述导电路径包括（i）在桥接所述第一和第二侧壁的导电材料不存在的情况下形成开路的导电材料条; 以及（ii）电池，电响应指示器和电连接到导电材料条的电阻器。

6. 发明申请

WO2006113727A3 FLUIDIC STRUCTURES INCLUDING MEANDERING AND WIDE CHANNELS 审中-公开
标题翻译：流体结构包括测量和宽频道
公开(公告)号：WO2006113727A3
公开(公告)日：2007-02-15
申请号：PCT/US2006014583
申请日：2006-04-19
申请人： HARVARD COLLEGE , LINDER VINCENT , SIA SAMUEL K , WHITESIDES GEORGE M , NAROVLYANSKY MAX , SIEGEL ADAM
发明人： LINDER VINCENT , SIA SAMUEL K , WHITESIDES GEORGE M , NAROVLYANSKY MAX , SIEGEL ADAM
IPC分类号： G01N21/59 , B01L3/00 , G01N33/543 , G01N33/553
CPC分类号： G01N33/54366 , B01L3/502746 , B01L2300/0636 , B01L2300/0654 , B01L2300/0816 , B01L2300/0861 , B01L2300/0883 , B01L2400/0406 , G01N21/01 , G01N21/82 , G01N33/54373
摘要： The present invention relates generally to microfluidic structures, and more specifically, to microfluidic structures and methods including meandering and wide channels. Microfluidic systems can provide an advantageous environment for performing various reactions and analyses due to a reduction in sample and reagent quantities that are required, a reduction in the size of the operating system, and a decrease in reaction time compared to conventional systems. Unfortunately, the small size of microfluidic channels can sometimes result in difficulty in detecting a species without magnifying optics (such as a microscope or a photomultiplier). A series of tightly packed microchannels, i.e., a meandering region, or a wide channel having a dimension on the order of millimeters, can serve as a solution to this problem by creating a wide measurement area. Although this invention mainly describes the use of meandering and wide channels in heterogeneous immunoassays on a microfluidic chip, this invention could be used for amplifying optical signals for other types of reactions and/or assays.
摘要翻译：本发明一般涉及微流体结构，更具体地涉及包括曲折和宽通道的微流体结构和方法。微流控系统可以提供用于执行各种反应和分析的有利环境，这是由于与常规系统相比所需的样品和试剂量的减少，操作系统尺寸的减小以及反应时间的减少。不幸的是，微量流体通道的小尺寸有时会导致在不放大光学器件（例如显微镜或光电倍增管）的情况下检测物质的困难。一系列紧密包装的微通道，即曲折区域或具有大约毫米数量级的宽通道可以通过创建宽的测量区域来解决这个问题。尽管本发明主要描述了在微流体芯片上的异源免疫测定中使用曲折和宽通道，但是本发明可用于放大用于其他类型反应和/或测定的光学信号。

7. 发明申请

WO2008127649A3 SYSTEMS AND METHODS FOR ASSEMBLY VIA CONTACT ELECTRIFICATION 审中-公开
标题翻译：通过接触电气组装的系统和方法
公开(公告)号：WO2008127649A3
公开(公告)日：2009-06-04
申请号：PCT/US2008004704
申请日：2008-04-11
申请人： HARVARD COLLEGE , WHITESIDES GEORGE M , MCCARTY LOGAN S , THOMAS SAMUEL W , RECHES MEITAL , KAUFMAN GEORGE K
发明人： WHITESIDES GEORGE M , MCCARTY LOGAN S , THOMAS SAMUEL W , RECHES MEITAL , KAUFMAN GEORGE K
IPC分类号： C08J5/12 , B05D1/04 , C08J7/00
CPC分类号： C08J5/12 , B05D3/14 , B05D7/02 , B05D2401/32 , C08J7/047 , C08J2327/18 , C08J2433/12
摘要： The present invention generally relates to the charging of materials via contact electrification, including systems and methods of assembly using contact electrification. One aspect of the present invention is directed to systems and methods of identifying and synthesizing nonionic polymeric materials that can be charged using contact electrification. Another aspect of the present invention is directed to methods of localizing charged particles or other materials on such surfaces, for example, in the presence of a controlled humidity environment. Yet another aspect of the present invention is directed to a surface comprising positively and negatively charged regions. Oppositely charged materials may be attracted to those regions. Other aspects of the invention are directed to methods of making, using, and promoting such materials, or kits containing such materials.
摘要翻译：本发明一般涉及通过接触带电充电材料，包括使用接触带电装配的系统和组装方法。本发明的一个方面涉及鉴定和合成可以使用接触带电充电的非离子聚合物材料的系统和方法。本发明的另一方面涉及将带电粒子或其它材料定位在这些表面上的方法，例如在受控湿度环境的存在下。本发明的另一方面涉及包括正带电和带负电荷的区域的表面。对这些区域可能会吸引相反电荷的材料。本发明的其它方面涉及制造，使用和促进这些材料或包含这种材料的试剂盒的方法。

8. 发明申请

WO2008051432A3 PATTERNING OF IONIC POLYMERS 审中-公开
标题翻译：离子聚合物的构图
公开(公告)号：WO2008051432A3
公开(公告)日：2009-04-09
申请号：PCT/US2007022219
申请日：2007-10-18
申请人： HARVARD COLLEGE , LAHAV MICHAL , WINKLEMAN ADAM , NAROVLYANSKY MAX , PEREZ-CASTILLEJOS RAQUEL , WEISS EMILY A , RODRIGUEZ LEONARD N J , WHITESIDES GEORGE M
发明人： LAHAV MICHAL , WINKLEMAN ADAM , NAROVLYANSKY MAX , PEREZ-CASTILLEJOS RAQUEL , WEISS EMILY A , RODRIGUEZ LEONARD N J , WHITESIDES GEORGE M
IPC分类号： G03F7/00
CPC分类号： G03F7/0002 , B82Y10/00 , B82Y40/00 , Y10T428/24479
摘要： In one aspect, methods of patterning of thin films of an ionotropic polymer (e.g., poly(acrylic acid)) are provided. These processes can create micron or sub-micron-scale patterns of ionotropic polymers such as cation crosslinked poly(acrylic acid) (CCL- PAA). In one embodiment, patterning may be performed within microfluidic channels by flowing a solution of crosslinking agent (e.g., metal cations such as Ag+, Ca2+, Pd2+, Al3+, La3+, and Ti4+) that can crosslink a portion of an ionotropic polymer in contact with the solution. In another embodiment, methods of patterning ionotropic polymers involve photolithography. Upon patterning a positive photoresist (e.g., diazonaphthoquinone- novolac resin) on a film of CCL-PAA, the exposed regions of CCL-PAA can be etched by an aqueous solution. Advantageously, the patterned, crosslinked polymer may also serve as both a reactant and a matrix for subsequent chemistry. For example, in some embodiments, the initial crosslinking cation can be exchanged for a second cation that could not be patterned photolithographically. Patterned films of CCL-PAA can also be used to host and template the reduction of metallic cations to metallic nanoparticles, and to fabricate porous, low-k dielectric substrates.
摘要翻译：一方面，提供了离子型聚合物（例如聚（丙烯酸））的薄膜图案化方法。这些方法可以产生离子型聚合物如阳离子交联的聚（丙烯酸）（CCL-PAA）的微米级或亚微米级的图案。在一个实施方案中，可以在微流体通道内通过使交联剂（例如金属阳离子如Ag +，Ca 2+，Pd 2+，Al 3+，La 3+和Ti 4+）的溶液流过微流体通道，所述溶液可以将部分离子型聚合物与解决方案。在另一个实施方案中，构图离子型聚合物的方法涉及光刻。在CCL-PAA膜上形成正性光致抗蚀剂（例如重氮萘酚 - 酚醛清漆树脂）之后，CCL-PAA的曝光区域可以通过水溶液进行蚀刻。有利地，图案化的交联聚合物也可以用作反应物和用于后续化学的基质。例如，在一些实施方案中，可以将初始交联阳离子交换为不能光刻图案化的第二阳离子。 CCL-PAA的图案化膜也可用于将金属阳离子还原为金属纳米颗粒，并制备多孔，低k电介质基底。

9. 发明申请

WO2008060449A2 MICROFLUIDIC DETECTOR 审中-公开
标题翻译：微流体检测器
公开(公告)号：WO2008060449A2
公开(公告)日：2008-05-22
申请号：PCT/US2007023595
申请日：2007-11-09
申请人： HARVARD COLLEGE , BUTTE MANISH J , WONG AMY P , SHARPE ARLENE H , WHITESIDES GEORGE M
发明人： BUTTE MANISH J , WONG AMY P , SHARPE ARLENE H , WHITESIDES GEORGE M
IPC分类号： G01N33/543 , G01N33/569
CPC分类号： G01N33/56972 , G01N33/54373 , G01N2333/16 , G01N2333/70503 , G01N2800/24
摘要： Articles and methods for determining an analyte indicative of a disease condition are provided. In some embodiments, articles and methods described herein can be used for determining a presence, qualitatively or quantitatively, of a component, such as a particular type of cell, in a fluid sample. In one particular embodiment, a low-cost microfluidic system for rapid detection of T cells is provided. The microfluidic system may use immobilized antibodies and adhesion molecules in a channel to capture T cells from a fluid sample such as a small volume of blood. The captured T cells may be labeled with a metal colloid (e.g., gold nanoparticles) using an antibody specific for the T Cell Receptor (TCR), and metallic silver can be catalytically precipitated onto the cells. The number of T cells captured can be counted and may indicate a disease condition of a patient such as severe combined immune deficiency or human immunodeficiency virus.
摘要翻译：提供了用于确定指示疾病状况的分析物的文章和方法。在一些实施方案中，本文描述的制品和方法可以用于确定流体样品中组分（例如特定类型的细胞）的定性或定量存在。在一个特定实施例中，提供了用于快速检测T细胞的低成本微流体系统。微流体系统可以在通道中使用固定的抗体和粘附分子以从流体样本（例如小体积血液）捕获T细胞。捕获的T细胞可以使用对T细胞受体（TCR）特异性的抗体用金属胶体（例如金纳米颗粒）标记，并且可以将金属银催化沉淀到细胞上。捕获的T细胞的数量可以被计数，并且可以指示患者的疾病状况，例如严重的联合免疫缺陷或人类免疫缺陷病毒。

10. 发明申请

WO2004002627A2 METHOD AND APPARATUS FOR FLUID DISPERSION 审中-公开
标题翻译：流体分散方法及装置
公开(公告)号：WO2004002627A2
公开(公告)日：2004-01-08
申请号：PCT/US0320542
申请日：2003-06-30
申请人： HARVARD COLLEGE , STONE HOWARD A , ANNA SHELLY L , BONTOUX NATHALIE , LINK DARREN ROY , WEITZ DAVID A , GITLIN IRINA , GARSTECKI PIOTR , DILUZIO WILLOW , WHITESIDES GEORGE M , KUMACHEVA EUGENIA
发明人： STONE HOWARD A , ANNA SHELLY L , BONTOUX NATHALIE , LINK DARREN ROY , WEITZ DAVID A , GITLIN IRINA , GARSTECKI PIOTR , DILUZIO WILLOW , WHITESIDES GEORGE M , KUMACHEVA EUGENIA
IPC分类号： B01F3/08 , B01F5/06 , B01F13/00 , B01L3/00 , B05B7/04
CPC分类号： B01L3/5027 , B01F3/0807 , B01F5/0682 , B01F5/0688 , B01F13/0062 , B01F2215/0431 , B01F2215/045 , B05B7/0408 , B05B7/0416 , B05B7/0441 , Y10S516/924 , Y10S516/927 , Y10T29/49002 , Y10T137/0324 , Y10T137/0329 , Y10T137/206 , Y10T137/87346 , Y10T436/2575
摘要： A microfluidic method and device for focusing and/or forming discontinuous sections of similar or dissimilar size in a fluid is provided. The device can be fabricated simply from readily-available, inexpensive material using simple techniques.
摘要翻译：提供了用于在流体中聚焦和/或形成类似或不同尺寸的不连续部分的微流体方法和装置。该装置可以简单地使用简单的技术从容易获得的廉价材料制造。

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