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1. 发明申请

WO2012087451A1 DUAL HEAT STABILED POLYMER SENSOR FILMS 审中-公开
标题翻译：双热稳定聚合物传感器膜
公开(公告)号：WO2012087451A1
公开(公告)日：2012-06-28
申请号：PCT/US2011/060153
申请日：2011-11-10
申请人： GENERAL ELECTRIC COMPANY , CHEN, Bingzhi , SUNDARESAN, Vidyasankar , BOYETTE, Scott, Martell , CLEMENS, Janine , XU, Hong
发明人： CHEN, Bingzhi , SUNDARESAN, Vidyasankar , BOYETTE, Scott, Martell , CLEMENS, Janine , XU, Hong
IPC分类号： G01N31/22
CPC分类号： G01N31/22
摘要： Methods are provided for improving the stability and shelf life of film sensors. The film sensors include a combination of polymeric matrix film material, analyte indicator, and solvent which has been heated in a first heat treatment application to volatilize most of the solvent and to solidify the analyte indicator to form the film sensor. The improvement comprises subjecting the film sensor to a second heat treatment to set the film and improve stability and shelf life.
摘要翻译：提供了用于提高薄膜传感器的稳定性和保质期的方法。膜传感器包括聚合物基质膜材料，分析物指示剂和在第一热处理应用中被加热以溶解大部分溶剂并固化分析物指示剂以形成膜传感器的溶剂的组合。改进之处在于使薄膜传感器进行第二次热处理以设置薄膜并提高稳定性和保质期。

2. 发明申请

WO2012016350A1 SIMULTANEOUS DETERMINATION OF MULTIPLE ANALYTES IN INDUSTRIAL WATER SYSTEM 审中-公开
标题翻译：同时确定工业水系统中的多种分析仪
公开(公告)号：WO2012016350A1
公开(公告)日：2012-02-09
申请号：PCT/CN2010/001170
申请日：2010-08-03
申请人： GENERAL ELECTRIC COMPANY , XIAO, Caibin , CHEN, Bingzhi , YU, Chunbo , XU, Hong
发明人： XIAO, Caibin , CHEN, Bingzhi , YU, Chunbo , XU, Hong
IPC分类号： G01N21/78 , G01N21/80 , G01N31/22 , G01N33/18
CPC分类号： G01N31/22 , G01N21/78 , G01N21/80 , G01N31/221 , G01N33/18 , G01N33/182 , Y10T436/16 , Y10T436/193333
摘要： A multi-purpose reagent composition is used for simultaneously determining concentrations of at least two analytes in a water sample. The two analytes are selected from the group consisting of free chlorine, pH, anionic polymer and phosphates. In one embodiment, the multi-purpose reagent composition is for simultaneously determining the concentration of free chlorine and pH and comprises a free chlorine sensitive dye and pH indicator. In another embodiment, the reagent composition is for simultaneously determining of free chlorine and anionic polymer and includes a free chlorine sensitive dye, a pH buffer, cationic dye and organic co-solvent. Thus, the pairs of free chlorine and pH or free chlorine and anionic polymer are determined using a single reagent composition. The reagent composition can also be the main reagent for one analyte analysis when it is used exclusively and also function as an ancillary reagent when it is combined with a second reagent composition for the determination of another analyte.
摘要翻译：多用途试剂组合物用于同时测定水样中至少两种分析物的浓度。两种分析物选自游离氯，pH，阴离子聚合物和磷酸盐。在一个实施方案中，多用途试剂组合物用于同时测定游离氯和pH的浓度并且包含游离氯敏感染料和pH指示剂。在另一个实施方案中，试剂组合物用于同时测定游离氯和阴离子聚合物，并且包括游离氯敏感染料，pH缓冲剂，阳离子染料和有机共溶剂。因此，使用单一试剂组合物测定游离氯和pH或游离氯和阴离子聚合物对。当单独使用时，试剂组合物也可以是用于一种分析物分析的主要试剂，并且当其与用于测定另一种分析物的第二试剂组合物组合时，其也可用作辅助试剂。

3. 发明申请

WO2012096724A1 METHODS OF USING CYANINE DYES FOR THE DETECTION OF ANALYTES 审中-公开
标题翻译：使用氰胺染料检测分析物的方法
公开(公告)号：WO2012096724A1
公开(公告)日：2012-07-19
申请号：PCT/US2011/063371
申请日：2011-12-06
申请人： GENERAL ELECTRIC COMPANY , CHEN, Bingzhi , AGREE, Alan, Michael , XIAO, Caibin , YU, Chunbo , XU, Hong
发明人： CHEN, Bingzhi , AGREE, Alan, Michael , XIAO, Caibin , YU, Chunbo , XU, Hong
IPC分类号： G01N31/22 , G01N21/64
CPC分类号： G01N31/22 , G01N21/274 , G01N21/77 , G01N21/78 , G01N21/80 , G01N33/18 , G01N2021/7786 , Y10T436/193333
摘要： The present invention concerns a method of measuring the concentration of an analyte in an aqueous solution that comprises the steps of: obtaining an aqueous solution containing an analyte, providing a cyanine indicator, placing the aqueous solution in fluid communication with the cyanine indicator, measuring a detectable property change of the cyanine indicator, and comparing the detectable property change of the cyanine indicator with a calibration curve of the detectable property change of samples containing known concentrations of the analyte to determine the concentration of the analyte, wherein the detectable property change is proportional to the concentration of the analyte in said aqueous solution.
摘要翻译：本发明涉及一种测量水溶液中分析物浓度的方法，包括以下步骤：获得含有分析物的水溶液，提供花青指示剂，将水溶液与花青指示剂流体连通，测量并且将花青指示剂的可检测性质变化与含有已知浓度分析物的样品的可检测性质变化的校准曲线进行比较以确定分析物的浓度，其中可检测的性质变化是成比例的与所述水溶液中分析物的浓度。

4. 发明申请

WO2012083492A1 METHODS OF CATIONIC POLYMER DETECTION 审中-公开
标题翻译：阳离子聚合物检测方法
公开(公告)号：WO2012083492A1
公开(公告)日：2012-06-28
申请号：PCT/CN2010/002112
申请日：2010-12-21
申请人： GENERAL ELECTRIC COMPANY , ZHANG, Guixi , WANG, Sijing , XU, Hong , TANG, Xiaofeng
发明人： ZHANG, Guixi , WANG, Sijing , XU, Hong
IPC分类号： G01N31/22
CPC分类号： G01N21/49
摘要： A method of detecting cationic polymers involves: obtaining a target water sample containing a cationic polymer; adding a polymer dispersant solution and a phosphate solution to the target water sample, the polymer dispersant solution is comprised of a polymer dispersant with calcium and magnesium hardness and the phosphate solution is comprised of a phosphate; standing the target water sample; and measuring the turbidity of the target water sample; comparing the turbidity of said target water sample with a calibration curve of the turbidity of samples containing known concentrations of cationic polymers to determine the concentration of cationic polymers in said target water sample.
摘要翻译：检测阳离子聚合物的方法包括：获得含有阳离子聚合物的目标水样品; 将聚合物分散剂溶液和磷酸盐溶液加入到目标水样品中，聚合物分散剂溶液由具有钙和镁硬度的聚合物分散剂组成，磷酸盐溶液由磷酸盐组成; 站在目标水样上; 并测量目标水样品的浊度; 将所述目标水样品的浊度与含有已知浓度的阳离子聚合物的样品的浊度的校准曲线进行比较，以确定所述目标水样品中阳离子聚合物的浓度。

5. 发明申请

WO2014058760A2 PRELOADED TEST SUBSTRATES FOR TESTING LAL-REACTIVE SUBSTANCES, METHODS OF USE, AND METHODS OF MAKING 审中-公开
标题翻译：用于测试乳酸反应物质的预先测试底物，使用方法和制备方法
公开(公告)号：WO2014058760A2
公开(公告)日：2014-04-17
申请号：PCT/US2013/063649
申请日：2013-10-07
申请人： GENERAL ELECTRIC COMPANY
发明人： GODEC, Richard Douglas , MELANSON, Paul Charles , STONESMITH, Matthew Kaddeland , XU, Hong , HUANG, Yan
IPC分类号： G01N33/579 , B01L3/00
CPC分类号： G01N33/56911 , B01L3/5027 , B01L3/502715 , B01L3/5085 , B01L2200/0605 , B01L2200/0684 , B01L2300/021 , B01L2300/0816 , B01L2300/0829 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/16 , B01L2400/0406 , B01L2400/0409 , B01L2400/0487 , B01L2400/049 , B01L2400/0622 , B01L2400/0688 , B01L2400/0694 , G01N21/17 , G01N33/579 , G01N2400/10 , G01N2400/50 , Y10T436/2575
摘要： A test substrate for detecting a LAL-reactive substance, wherein at least a portion of said test substrate has been preloaded with at least one LAL reagent and/or at least one LAL-reactive standard. Methods of use of the test substrate are disclosed. Methods of depositing test reagents on a test substrate are also disclosed.
摘要翻译：一种用于检测LAL反应物质的测试基底，其中所述测试基底的至少一部分已经预加载了至少一种LAL试剂和/或至少一种LAL反应性标准物。公开了使用测试基板的方法。还公开了将测试试剂沉积在测试基底上的方法。

6. 发明申请

WO2014058750A1 MICROFLUIDIC LAL-REACTIVE SUBSTANCES TESTING METHOD AND APPARATUS 审中-公开
标题翻译：微流体反应物质测试方法和装置
公开(公告)号：WO2014058750A1
公开(公告)日：2014-04-17
申请号：PCT/US2013/063625
申请日：2013-10-07
申请人： GENERAL ELECTRIC COMPANY
发明人： GODEC, Richard Douglas , MELANSON, Paul Charles , STONESMITH, Matthew Kaddeland , HUANG, Yan , SUNDARESAN, Vidyasankar , DENG, Shouquan , XU, Hong , LI, Ruiqing
IPC分类号： G01N33/579 , B01L3/00
CPC分类号： G01N33/56911 , B01L3/5027 , B01L3/502715 , B01L3/5085 , B01L2200/0605 , B01L2200/0684 , B01L2300/021 , B01L2300/0816 , B01L2300/0829 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2300/16 , B01L2400/0406 , B01L2400/0409 , B01L2400/0487 , B01L2400/049 , B01L2400/0622 , B01L2400/0688 , B01L2400/0694 , G01N21/17 , G01N33/579 , G01N2400/10 , G01N2400/50 , Y10T436/2575
摘要： A microfluidic testing cartridge for testing LAL-reactive substances in fluid samples is provided. The cartridge may comprise at least two (2) testing modules, wherein each testing module includes at least one inlet port for receiving one of the fluid samples, and at least four (4) testing channels in fluid communication with the inlet port. Each of the testing channels may include a metering portion for metering an aliquot of the fluid sample, an analyzing portion, and a mixing portion, wherein a valve is positioned between the metering portion and the analyzing portion to selectively fluidly separate the metering portion from the analyzing portion. The cartridge is insertable into an optical reader which performs optical measurements of the fluid sample within each testing channel during a testing process.
摘要翻译：提供了一种用于在流体样品中测试LAL反应物质的微流体测试盒。所述盒可以包括至少两个（2）测试模块，其中每个测试模块包括用于接收流体样本中的一个的至少一个入口端口和与入口端口流体连通的至少四个（4）测试通道。每个测试通道可以包括计量部分，用于计量流体样本的等分试样，分析部分和混合部分，其中阀定位在计量部分和分析部分之间，以选择性地将计量部分与分析部分。该盒可插入光学阅读器中，该读取器在测试过程中对每个测试通道内的流体样品执行光学测量。

7. 发明申请

WO2007088099A2 USE OF COMPOUNDS IN THE TREATMENT OF ISCHEMIA AND NEURODEGENERATION 审中-公开
标题翻译：化合物在治疗异位症和神经细胞增生中的应用
公开(公告)号：WO2007088099A2
公开(公告)日：2007-08-09
申请号：PCT/EP2007/050364
申请日：2007-01-15
申请人： ONCOREG AB , GLAS, Rickard , XU, Hong
发明人： GLAS, Rickard , XU, Hong
CPC分类号： A61K38/06 , A61N5/10 , A61N2005/1098
摘要： TPP II (tripeptidyl peptidase II) inhibitors are useful in the treatment of a neurodegenerative disease, for example Alzheimer's, Parkinson's or Huntingdon's disease or an ischemic condition, for example stroke and cardiac infarction. Suitable compounds comprise tripeptide compounds of general formula R N1 R N2 N-A 1 -A 2 -A 3 -CO-R C1 wherein R N1 , R N2 , A 1 , A 2 , A 3 and R C1 are as defined herein, and which include for example the tripeptide sequences GLA and GPG.
摘要翻译： TPP II（三肽基肽酶II）抑制剂可用于治疗神经变性疾病，例如阿尔茨海默病，帕金森病或亨廷顿氏症或缺血性疾病，例如中风和心肌梗死。合适的化合物包括通式为N 1，N 2，N 2，...，N 2，其中R 1，N 2，N 2，A 1，...， SUP> 2，A 3和R 0 C1如本文所定义，并且其包括例如三肽序列GLA和GPG。

8. 发明申请

WO2007086823A2 METHOD AND SYSTEM FOR DYNAMIC PROBABILISTIC RISK ASSESSMENT 审中-公开
标题翻译：动态概率风险评估方法与系统
公开(公告)号：WO2007086823A2
公开(公告)日：2007-08-02
申请号：PCT/US2005/046643
申请日：2005-12-21
申请人： UNIVERSITY OF VIRGINIA PATENT FOUNDATION , DUGAN, Joanne, Bechta , XU, Hong
发明人： DUGAN, Joanne, Bechta , XU, Hong
IPC分类号： G06F17/11
CPC分类号： G06Q40/08 , G06Q10/0635
摘要： The DEFT methodology, system and computer readable medium extends the applicability of the PRA (Probabilistic Risk Assessment) methodology to computer-based systems, by allowing DFT (Dynamic Fault Tree) nodes as pivot nodes in the Event Tree (ET) model. DEFT includes a mathematical model and solution algorithm, supports all common PRA analysis functions and cutsets. Additional capabilities enabled by the DFT include modularization, phased mission analysis, sequence dependencies, and imperfect coverage.
摘要翻译：通过在事件树（ET）模型中允许DFT（动态故障树）节点作为枢纽节点，DEFT方法，系统和计算机可读介质将PRA（概率风险评估）方法的适用性扩展到基于计算机的系统。 DEFT包括数学模型和解算法，支持所有常见的PRA分析功能和切割。 DFT支持的附加功能包括模块化，分阶段任务分析，序列依赖性和不完全覆盖。

9. 发明申请

WO2012092163A1 PHOTODEFINED APERTURE PLATE AND METHOD FOR PRODUCING THE SAME 审中-公开
标题翻译：光电孔板及其制造方法
公开(公告)号：WO2012092163A1
公开(公告)日：2012-07-05
申请号：PCT/US2011/067106
申请日：2011-12-23
申请人： NOVARTIS AG , XU, Hong
发明人： XU, Hong
IPC分类号： B41J2/16 , B05B17/06 , C25D5/02 , C25D5/10
CPC分类号： C25D7/00 , B05B17/0646 , B41J2/162 , B41J2/1625 , B41J2/1629 , B41J2/1631 , C25D1/003 , C25D3/38 , C25D3/46 , C25D3/48 , C25D3/54 , C25D5/022 , C25D5/10 , C25D5/34 , C25D5/48 , C25D5/54
摘要： In one embodiment, a method for manufacturing an aperture plate includes depositing a releasable seed layer above a substrate, applying a first patterned photolithography mask above the releasable seed layer, the first patterned photolithography mask having a negative pattern to a desired aperture pattern, electroplating a first material above the exposed portions of the releasable seed layer and defined by the first mask, applying a second photolithography mask above the first material, the second photolithography mask having a negative pattern to a first cavity, electroplating a second material above the exposed portions of the first material and defined by the second mask, removing both masks, and etching the releasable seed layer to release the first material and the second material. The first and second material form an aperture plate for use in aerosolizing a liquid. Other aperture plates and methods of producing aperture plates are described according to other embodiments.
摘要翻译：在一个实施例中，一种用于制造孔板的方法包括在衬底上沉积可释放种子层，在可释放种子层上方施加第一图案化光刻掩模，将第一图案化光刻掩模具有到所需孔径图案的负图案，电镀a 第一材料在可释放种子层的暴露部分上方并由第一掩模限定，在第一材料上方施加第二光刻掩模，第二光刻掩模具有负图案到第一空腔，将第二材料电镀在第第一材料并由第二掩模限定，去除两个掩模，以及蚀刻可释放种子层以释放第一材料和第二材料。第一和第二材料形成用于雾化液体的孔板。根据其他实施例描述其它孔板和制造孔板的方法。

10. 发明申请

WO2009120313A2 IDENTIFICATION OF HUMAN T2R RECEPTORS THAT RESPOND TO BITTER LIGANDS IN SOY AND RELATED ASSAYS FOR IDENTIFYING BITTER TASTE MODULATORS 审中-公开
标题翻译：响应大豆中苦味配体的人类T2R受体的鉴定以及鉴定苦味调节剂的相关试验
公开(公告)号：WO2009120313A2
公开(公告)日：2009-10-01
申请号：PCT/US2009/001829
申请日：2009-03-24
申请人： SENOMYX, INC. , LI, Xiaodong , XU, Hong , ZHANG, Lan , LIU, Hanghui , WU, Keping
发明人： LI, Xiaodong , XU, Hong , ZHANG, Lan , LIU, Hanghui , WU, Keping
IPC分类号： C12Q1/68 , G01N33/567 , G01N33/566 , C12Q1/00 , C07K14/705 , A61K36/48 , A23L1/20
CPC分类号： C12Q1/6895 , G01N33/5008 , G01N33/566 , G01N2500/00
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in hydrolyzed soy protein derived materials. The invention further relates to the use of these T2R receptors in assays for identifying ligands that modulate the activation of these taste receptors by specific bitter ligands present in hydrolyzed soy protein materials and derivatives thereof and related compounds. These compounds may be used as additives and/or removed from soy-based foods, beverages, cosmetics and medicinals in order to modify (block) T2R-associated bitter taste elicited by bitter ligands present in hydrolyzed soy protein materials. Also these T2R ligands potentially may be used as therapeutics to treat and modulate hT2R1, hT2R8, hT2R14, hT2R44, hT2R55, hT2R61, hT2R63, hT2R64, hT2R67 and hT2R71 associated gastrointestinal and metabolic functions such as serum cholesterol levels as well as treat gastrointestinal and metabolic diseases such as eating disorders, food sensing, food absorption, obesity, diabetes, Crohn's disease, celiac disease, et al.
摘要翻译：本发明涉及T2R味觉受体家族中的特定人味受体对存在于水解的大豆蛋白衍生物质中的特定苦味化合物的反应。本发明进一步涉及这些T2R受体在测定中用于鉴定配体的用途，所述配体通过存在于水解大豆蛋白材料及其衍生物和相关化合物中的特定苦味配体调节这些味觉受体的活化。这些化合物可用作添加剂和/或从大豆基食品，饮料，化妆品和药物中除去，以修饰（阻断）水解大豆蛋白材料中存在的苦配体引起的T2R相关的苦味。此外，这些T2R配体可用作治疗剂以治疗和调节hT2R1，hT2R8，hT2R14，hT2R44，hT2R55，hT2R61，hT2R63，hT2R64，hT2R67和hT2R71相关的胃肠和代谢功能如血清胆固醇水平以及治疗胃肠和代谢疾病如进食障碍，食物感应，食物吸收，肥胖症，糖尿病，克罗恩氏病，乳糜泻等等。

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