专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2009120313A2 IDENTIFICATION OF HUMAN T2R RECEPTORS THAT RESPOND TO BITTER LIGANDS IN SOY AND RELATED ASSAYS FOR IDENTIFYING BITTER TASTE MODULATORS 审中-公开
标题翻译：响应大豆中苦味配体的人类T2R受体的鉴定以及鉴定苦味调节剂的相关试验
公开(公告)号：WO2009120313A2
公开(公告)日：2009-10-01
申请号：PCT/US2009/001829
申请日：2009-03-24
申请人： SENOMYX, INC. , LI, Xiaodong , XU, Hong , ZHANG, Lan , LIU, Hanghui , WU, Keping
发明人： LI, Xiaodong , XU, Hong , ZHANG, Lan , LIU, Hanghui , WU, Keping
IPC分类号： C12Q1/68 , G01N33/567 , G01N33/566 , C12Q1/00 , C07K14/705 , A61K36/48 , A23L1/20
CPC分类号： C12Q1/6895 , G01N33/5008 , G01N33/566 , G01N2500/00
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in hydrolyzed soy protein derived materials. The invention further relates to the use of these T2R receptors in assays for identifying ligands that modulate the activation of these taste receptors by specific bitter ligands present in hydrolyzed soy protein materials and derivatives thereof and related compounds. These compounds may be used as additives and/or removed from soy-based foods, beverages, cosmetics and medicinals in order to modify (block) T2R-associated bitter taste elicited by bitter ligands present in hydrolyzed soy protein materials. Also these T2R ligands potentially may be used as therapeutics to treat and modulate hT2R1, hT2R8, hT2R14, hT2R44, hT2R55, hT2R61, hT2R63, hT2R64, hT2R67 and hT2R71 associated gastrointestinal and metabolic functions such as serum cholesterol levels as well as treat gastrointestinal and metabolic diseases such as eating disorders, food sensing, food absorption, obesity, diabetes, Crohn's disease, celiac disease, et al.
摘要翻译：本发明涉及T2R味觉受体家族中的特定人味受体对存在于水解的大豆蛋白衍生物质中的特定苦味化合物的反应。本发明进一步涉及这些T2R受体在测定中用于鉴定配体的用途，所述配体通过存在于水解大豆蛋白材料及其衍生物和相关化合物中的特定苦味配体调节这些味觉受体的活化。这些化合物可用作添加剂和/或从大豆基食品，饮料，化妆品和药物中除去，以修饰（阻断）水解大豆蛋白材料中存在的苦配体引起的T2R相关的苦味。此外，这些T2R配体可用作治疗剂以治疗和调节hT2R1，hT2R8，hT2R14，hT2R44，hT2R55，hT2R61，hT2R63，hT2R64，hT2R67和hT2R71相关的胃肠和代谢功能如血清胆固醇水平以及治疗胃肠和代谢疾病如进食障碍，食物感应，食物吸收，肥胖症，糖尿病，克罗恩氏病，乳糜泻等等。

2. 发明申请

WO2009025793A2 IDENTIFICATION OF HUMAN T2R RECEPTORS THAT RESPOND TO BITTER COMPOUNDS THAT ELICIT THE BITTER TASTE IN COMPOSITIONS, AND THE USE THEREOF IN ASSAYS TO IDENTIFY COMPOUNDS THAT INHIBIT (BLOCK) BITTER TASTE IN COMPOSITIONS AND USE THEREOF 审中-公开
标题翻译：识别符合组合物中双歧杆菌组合物的双特异度化合物的人类T2R受体，以及其在测定中的用途，以鉴定组合物中的禁止（块状）双歧杆菌组合物及其用途的化合物
公开(公告)号：WO2009025793A2
公开(公告)日：2009-02-26
申请号：PCT/US2008/009864
申请日：2008-08-19
申请人： SENOMYX, INC. , LI, Xiaodong , PATRON, Andrew , TACHDJIAN, Catherine , XU, Hong , LI, Qing , PRONIN, Alexey , SERVANT, Guy , ZHANG, Lan , BRADY, Thomas , DARMOHUSODO, Vincent , ARELLANO, Melissa , SELCHAU, Victor , CHING, Brett Weylan , KARANEWSKY, Donald S. , BRUST, Paul , LING, Jing , ZHAO, Wen , PRIEST, Chad
发明人： LI, Xiaodong , PATRON, Andrew , TACHDJIAN, Catherine , XU, Hong , LI, Qing , PRONIN, Alexey , SERVANT, Guy , ZHANG, Lan , BRADY, Thomas , DARMOHUSODO, Vincent , ARELLANO, Melissa , SELCHAU, Victor , CHING, Brett Weylan , KARANEWSKY, Donald S. , BRUST, Paul , LING, Jing , ZHAO, Wen , PRIEST, Chad
IPC分类号： C12Q1/68
CPC分类号： C07C311/17 , A23L27/86 , A61K8/46 , A61K8/466 , A61K8/4933 , A61K8/494 , A61K8/4973 , A61K8/498 , A61K8/4986 , A61K31/135 , A61K31/4439 , A61K31/485 , A61K31/60 , A61K31/704 , A61K45/06 , A61Q11/00 , C07C233/73 , C07C311/04 , C07C311/13 , C07C311/16 , C07C311/18 , C07C311/19 , C07C311/20 , C07C311/21 , C07C311/29 , C07C311/46 , C07C323/49 , C07C335/16 , C07C335/18 , C07D213/42 , C07D213/71 , C07D217/08 , C07D223/18 , C07D307/14 , C07D307/52 , C07D317/58 , C07D333/20 , C07D333/34 , A61K2300/00
摘要： The present invention relates to the discovery that specific human taste receptors in the T2R taste receptor family respond to particular bitter compounds present in, e.g., coffee. Also, the invention relates to the discovery of specific compounds and compositions containing that function as bitter taste blockers and the use thereof as bitter taste blockers or flavor modulators in, e.g., coffee and coffee flavored foods, beverages and medicaments. Also, the present invention relates to the discovery of a compound that antagonizes numerous different human T2Rs and the use thereof in assays and as a bitter taste blocker in compositions for ingestion by humans and animals.
摘要翻译：本发明涉及T2R味觉受体家族中的特定人味受体对存在于例如咖啡中的特定苦味化合物的反应的发现。此外，本发明涉及含有作为苦味抑制剂的特定化合物和组合物的发现，以及其作为例如咖啡和咖啡风味食品，饮料和药物中的苦味抑制剂或风味调节剂的用途。此外，本发明涉及一种拮抗多种不同人类T2R的化合物的发现及其在测定中的用途以及用于摄取人类和动物的组合物中的苦味阻滞剂。

3. 发明申请

WO2018170256A1 HERPES SIMPLEX VIRUS VACCINE 审中-公开
公开(公告)号：WO2018170256A1
公开(公告)日：2018-09-20
申请号：PCT/US2018/022622
申请日：2018-03-15
申请人： MODERNATX, INC. , BETT, Andrew, J. , CASIMIRO, Danilo, R. , WANG, Dai , ZHANG, Lan
发明人： BETT, Andrew, J. , CASIMIRO, Danilo, R. , WANG, Dai , ZHANG, Lan , CIARAMELLA, Giuseppe , JOHN, Shinu
IPC分类号： A61K39/245 , A61K31/7105 , A61K31/7115 , A61K9/51 , A61P31/22
摘要： The disclosure relates to herpes simplex virus (HSV) ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccines. In a preferred embodiment, the vaccine is formulated as a lipid nanoparticle comprising at least one cationic lipid.

4. 发明申请

WO2018170245A1 BROAD SPECTRUM INFLUENZA VIRUS VACCINE 审中-公开
公开(公告)号：WO2018170245A1
公开(公告)日：2018-09-20
申请号：PCT/US2018/022605
申请日：2018-03-15
申请人： MODERNATX, INC. , BABAOGLU, Kerim , FLYNN, Jessica, Anne , ZHANG, Lan , NICKLE, David
发明人： BABAOGLU, Kerim , FLYNN, Jessica, Anne , ZHANG, Lan , NICKLE, David , CIARAMELLA, Giuseppe , HUANG, Eric, Yi-chun
IPC分类号： A61K39/145 , A61K31/7105 , A61K31/7115 , A61K9/51 , A61P31/16
CPC分类号： A61K45/06 , A61K9/5123 , A61K31/7105 , A61K31/7115 , A61K39/12 , A61K2039/53 , A61K2039/543 , A61K2039/55555 , A61K2039/575 , A61P31/16 , C12N2760/16134 , C12N2760/16234
摘要： The disclosure relates to broad spectrum influenza virus ribonucleic acid (RNA) vaccines, as well as methods of using the vaccines and compositions comprising the vaccine. In a preferred embodiment, the vaccine is formulated as a lipid nanoparticle comprising at least one cationic lipid.

5. 发明申请

WO2018200613A1 HSV ANTIGENIC PEPTIDES AND HSV PROTEIN VACCINES 审中-公开
公开(公告)号：WO2018200613A1
公开(公告)日：2018-11-01
申请号：PCT/US2018/029269
申请日：2018-04-25
申请人： MERCK SHARP & DOHME CORP. , WANG, Dai , ZHANG, Lan
发明人： WANG, Dai , ZHANG, Lan
IPC分类号： A61K39/12 , A61K39/245
摘要： The disclosure relates to HSV glycoprotein B and HSV glycoprotein C antigenic peptide constructs, HSV protein vaccines, and HSV DNA vaccines, as well as methods of using the vaccines and compositions comprising the vaccines.

6. 发明申请

WO2017075124A1 ANTIBODY NEUTRALIZING HUMAN RESPIRATORY SYNCYTIAL VIRUS 审中-公开
标题翻译：抗体中和人呼吸道合胞病毒
公开(公告)号：WO2017075124A1
公开(公告)日：2017-05-04
申请号：PCT/US2016/058975
申请日：2016-10-27
申请人： MERCK SHARP & DOHME CORP. , VORA, Kalpit, A. , COX, Kara, S. , TANG, Aimin , CHEN, Zhifeng , DISTEFANO, Daniel , ZHANG, Lan , SU, Hua-Poo
发明人： VORA, Kalpit, A. , COX, Kara, S. , TANG, Aimin , CHEN, Zhifeng , DISTEFANO, Daniel , ZHANG, Lan , SU, Hua-Poo
IPC分类号： C07K16/10 , A61P31/14
CPC分类号： C07K16/1027 , A61K39/42 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K2317/14 , C07K2317/21 , C07K2317/34 , C07K2317/41 , C07K2317/524 , C07K2317/565 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to monoclonal antibodies which have high anti-RSV neutralizing titers. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. The invention yet further provides for diagnostic, prophylactic and therapeutic methods employing the antibodies and nucleic acids of the invention, particularly as a passive immunotherapy agent in infants and the elderly.
摘要翻译：本发明涉及具有高抗RSV中和滴度的单克隆抗体。本发明进一步提供了编码本发明抗体的分离的核酸和用其转化的宿主细胞。本发明进一步提供了采用本发明的抗体和核酸的诊断，预防和治疗方法，特别是作为婴幼儿和老年人的被动免疫治疗剂。

7. 发明申请

WO2016081327A3 RECOMBINANT EXPRESSION OF CHLAMYDIA MOMP ANTIGEN 审中-公开
公开(公告)号：WO2016081327A3
公开(公告)日：2016-05-26
申请号：PCT/US2015/060780
申请日：2015-11-16
申请人： MERCK SHARP & DOHME CORP. , ZHANG, Lan , WEN, Zhiyun , PRZYSIECKI, Craig, T. , KHANDELWAL, Puneet , QIU, Ping
发明人： ZHANG, Lan , WEN, Zhiyun , PRZYSIECKI, Craig, T. , KHANDELWAL, Puneet , QIU, Ping
IPC分类号： A61K48/00 , C12N1/20 , C12P21/06 , C12N15/00 , C07H21/04
摘要： The present invention relates to methods for the recombinant expression of chlamydia major outer membrane protein (MOMP) comprising transforming a population of E. coli host cells with an expression vector comprising a nucleic acid molecule that encodes chlamydia MOMP and encodes a leader sequence for targeting the MOMP to the outer membrane of the cell, wherein the nucleic acid molecule is operatively linked to a promoter. The method of the invention allows expression of MOMP in the outer membrane of the cell, which leads to protein folding that is more like native MOMP relative to a MOMP protein that is expressed intracellularly. Also provided by the invention are uses of the recombinant MOMP in pharmaceutical compositions and methods for the treatment and/or prophylaxis of chlamydia infection and/or the effects thereof.

8. 发明申请

WO2022173714A2 ANTIBODIES THAT BIND METAPNEUMOVIRUS, ANTIGENIC METAPNEUMOVIRUS PROTEINS, AND USES THEREOF 审中-公开
公开(公告)号：WO2022173714A2
公开(公告)日：2022-08-18
申请号：PCT/US2022/015565
申请日：2022-02-08
申请人： MERCK SHARP & DOHME LLC , CHEN, Zhifeng , COX, Kara, S. , FRIDMAN, Arthur , GALLI, Jennifer Dawn , SU, Hua-Poo , TANG, Aimin , VORA, Kalpit , WEN, Zhiyun , XIAO, Xiao , ZHANG, Lan
发明人： CHEN, Zhifeng , COX, Kara, S. , FRIDMAN, Arthur , GALLI, Jennifer Dawn , SU, Hua-Poo , TANG, Aimin , VORA, Kalpit , WEN, Zhiyun , XIAO, Xiao , ZHANG, Lan
IPC分类号： A61K39/395 , C07K16/1018 , C07K16/1027 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to anti-human metapneumovirus (hMPV) antibodies, as well as use of such antibodies in the treatment of viral infections. The invention also includes antigenic hMPV proteins and immunogenic compositions comprising such antigenic hMPV proteins, and the use of such antigenic hMPV proteins and related compositions for preventing or treating viral infection in a subject.

9. 发明申请

WO2021015987A1 ANTIGENIC GLYCOPROTEIN E POLYPEPTIDES, COMPOSITIONS, AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2021015987A1
公开(公告)日：2021-01-28
申请号：PCT/US2020/041889
申请日：2020-07-14
申请人： MERCK SHARP & DOHME CORP. , FRIDMAN, Arthur , GALLI, Jennifer Dawn , WANG, Dai , ZHANG, Lan
发明人： FRIDMAN, Arthur , GALLI, Jennifer Dawn , WANG, Dai , ZHANG, Lan
IPC分类号： A61K38/00 , A61K39/12 , A61K39/245 , C07K14/035 , C12N15/09 , C12N15/38
摘要： The disclosure relates to HSV glycoprotein E antigenic peptide constructs and HSV protein vaccines, as well as methods of using the vaccines and compositions comprising the vaccines. The present invention directed to immunogenic polypeptides of use for a vaccine against Herpes Simplex Virus (HSV). The polypeptides are glycoprotein E peptides that are mutated to reduce their binding to antibody Fc domain.

10. 发明申请

WO2019148101A1 RSV RNA VACCINES 审中-公开
公开(公告)号：WO2019148101A1
公开(公告)日：2019-08-01
申请号：PCT/US2019/015412
申请日：2019-01-28
申请人： MODERNATX, INC. , ESPESETH, Amy , BETT, Andrew J. , CEJAS, Pedro , ZHANG, Lan , SHAW, Christine
发明人： ESPESETH, Amy , BETT, Andrew J. , CEJAS, Pedro , ZHANG, Lan , SHAW, Christine , CIARAMELLA, Giuseppe , BAHL, Kapil
IPC分类号： A61K31/7105 , A61K39/155 , A61P31/14 , A61K31/7115
摘要： The disclosure relates to respiratory syncytial virus (RSV) ribonucleic acid (RNA) vaccines as well as methods of using the vaccines and compositions comprising the vaccines. The vaccine can be formulated in a lipid nanoparticle.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式